EKS-TAG-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	392.2	1.2E-117	235	527	293

Status

Unreviewed

Ensembl Protein

ENSTGUP00000003689

UniProt Accession

H0YZF5;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003590	ENSTGUP00000003689	ENSTGUT00000003729

Organism

Taeniopygia guttata

Functional Description

Protein Length

557

Protein Sequence
(FASTA)

LPSSLRRLLL RLSLWALMGS SVPALLRGKN KEGGLKMPNL CKFCDIKVTT CSNQHQCKSN 60

CNITSICEKS SEVCVAIWRQ NDENVTLETI CHDPQETLYG HFLDDYKSEQ CLMREKKDDG 120

GLMFMCSCTG EECNDMLIFT SDDPHKPEEK DEISKVTIIS LVPLLVISVA VIVIFYAYRT 180

HKKRKLSKAW EKNVKPKKHK DCSDVCAIML DDDRSDISST CANNINHNTE LLPIELDVVV 240

GKGRFAEVYK AKLKQNTSEQ YETVAVKIFS YEEYASWKTE KDIFSDVNLK HENILQFLTA 300

EERKTDLGKQ YWLITAFHAK GNLQEYLTRH IISWEDLWKL GGSLARGIAH LHSDHTPCGR 360

PKTPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPSLSV DDLANSGQVG TARYMAPEVL 420

ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKEY EPPFGSKVRE HPCVESMKDN 480

VLRDRGRPEI PSSWLNHQGI QMVCETLIEC WDHDPEARLT AQCVAERFSE LKHHDRLSGR 540

SCSEEKIPED GSVTTAK 557

Nucleotide Sequence
(FASTA)

CTGCCGAGCA GCCTGCGGCG GCTGCTGCTG CGCCTCTCCC TCTGGGCGCT CATGGGCAGC 60

TCGGTCCCCG CTCTGCTCCG GGGTAAAAAT AAGGAAGGTG GACTGAAAAT GCCAAACCTA 120

TGCAAATTTT GTGATATTAA AGTAACAACC TGCTCAAACC AACATCAGTG CAAGAGCAAC 180

TGTAACATCA CTTCTATCTG TGAGAAGAGT AGTGAAGTCT GTGTTGCCAT ATGGAGACAG 240

AATGATGAAA ATGTGACATT AGAAACAATA TGCCACGATC CCCAAGAAAC ACTGTATGGT 300

CACTTTTTGG ATGACTATAA ATCAGAGCAG TGTTTGATGA GGGAAAAGAA GGATGATGGG 360

GGATTGATGT TCATGTGTTC CTGCACAGGT GAAGAATGCA ATGATATGCT CATTTTTACA 420

TCAGATGACC CTCATAAGCC AGAGGAGAAA GATGAAATTT CCAAAGTCAC AATCATAAGT 480

CTTGTCCCGT TACTGGTGAT TTCTGTTGCT GTGATTGTTA TCTTTTATGC CTACCGCACT 540

CACAAGAAGA GGAAACTCAG CAAGGCATGG GAGAAGAATG TTAAGCCCAA GAAGCATAAG 600

GACTGCAGTG ATGTCTGTGC CATTATGTTA GATGACGACC GCTCAGACAT CAGCTCCACG 660

TGTGCCAACA ACATCAACCA CAACACAGAG CTGCTGCCCA TTGAGTTGGA CGTTGTTGTT 720

GGCAAAGGAA GGTTTGCTGA AGTGTATAAA GCCAAATTGA AGCAAAACAC ATCAGAACAG 780

TATGAAACTG TGGCAGTCAA GATTTTCTCC TATGAAGAAT ATGCTTCCTG GAAAACTGAG 840

AAAGACATTT TTTCAGATGT AAACCTCAAG CATGAGAACA TACTCCAGTT CTTGACAGCA 900

GAGGAGCGTA AGACAGATCT TGGCAAACAA TATTGGTTGA TCACTGCCTT CCATGCTAAA 960

GGAAACTTGC AGGAATATCT CACACGGCAC ATTATCAGCT GGGAGGACCT CTGGAAACTT 1020

GGCGGGTCCT TGGCCCGAGG GATTGCCCAT CTACACAGTG ATCACACACC CTGTGGTCGT 1080

CCCAAAACAC CAATCGTACA TAGAGACCTA AAGAGTTCCA ACATCCTGGT GAAAAATGAT 1140

TTAACCTGCT GTCTCTGTGA CTTTGGGTTA TCCCTGAGGC TGGACCCTTC CTTGTCTGTG 1200

GATGACTTAG CTAACAGTGG GCAGGTGGGC ACAGCAAGAT ATATGGCCCC TGAGGTTTTG 1260

GAGTCCAGGA TGAACCTGGA GAACATGGAG TCCTTCAAAC AAACAGATGT GTACTCCATG 1320

GCTTTGGTCC TCTGGGAAAT GACATCTCGC TGTAATGCTG TCGGAGAAGT GAAAGAGTAT 1380

GAGCCCCCAT TCGGCTCCAA AGTGCGAGAA CACCCTTGTG TGGAAAGCAT GAAGGACAAT 1440

GTCCTGAGAG ACAGAGGGCG ACCTGAGATC CCCAGCTCCT GGCTTAACCA TCAGGGCATC 1500

CAGATGGTGT GTGAAACCCT CATTGAGTGC TGGGACCACG ACCCCGAGGC CCGGCTGACG 1560

GCACAGTGCG TGGCCGAGCG CTTCAGCGAG CTCAAGCACC ACGACCGGCT CTCGGGGAGG 1620

AGCTGCTCAG AGGAGAAGAT TCCCGAGGAT GGCTCCGTGA CCACTGCGAA GTAG 1674

Domain Profile

S: 2     klleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrheni  55

         +l  ++gkGr++eV+kakl++      e+vAvKifs+e+ aswk+Ek+i++ v+l+heni

Q: 235   ELDVVVGKGRFAEVYKAKLKQntseqyETVAVKIFSYEEYASWKTEKDIFSDVNLKHENI  294

         67789***************99999999********************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         lqf++a+++++d+ ++++l+t++h kg+L++yL+r+++++e+l +l  sla+G+ahLH++

Q: 295   LQFLTAEERKTDLGKQYWLITAFHAKGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSD  354

         ************************************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175

          ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt R

Q: 355   -HTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTAR  413

         .8999*******************************************************

S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235

         YmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev+ey++pf ++v+++P

Q: 414   YMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNA-VGEVKEYEPPFGSKVREHP  472

         ****************************************.999****************

S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++e+mk+ v++++ rP+ip++w +++ +++++++l ecWd+dpeaRlta++v++r

Q: 473   CVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAER  527

         ****************************************************987

Domain Sequence
(FASTA)

ELDVVVGKGR FAEVYKAKLK QNTSEQYETV AVKIFSYEEY ASWKTEKDIF SDVNLKHENI 60

LQFLTAEERK TDLGKQYWLI TAFHAKGNLQ EYLTRHIISW EDLWKLGGSL ARGIAHLHSD 120

HTPCGRPKTP IVHRDLKSSN ILVKNDLTCC LCDFGLSLRL DPSLSVDDLA NSGQVGTARY 180

MAPEVLESRM NLENMESFKQ TDVYSMALVL WEMTSRCNAV GEVKEYEPPF GSKVREHPCV 240

ESMKDNVLRD RGRPEIPSSW LNHQGIQMVC ETLIECWDHD PEARLTAQCV AER 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013