EKS-TAG-00554

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00554

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	384.5	1.7E-115	18	273	256

Status

Unreviewed

Ensembl Protein

ENSTGUP00000004017

UniProt Accession

H0Z0D0;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003881	ENSTGUP00000004017	ENSTGUT00000004061

Organism

Taeniopygia guttata

Functional Description

Protein Length

894

Protein Sequence
(FASTA)

MFPLKDTVMG ASTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYIDLT 60

RGKHERLVVA AEHCEKSLED LLRERKPVSS SRILCIAYEV LQGLQYMNKH GMVHRALSPC 120

NILLDRKGHV KLAKFGLYHM TAQGVDVDFP IGYPSYLAPE VIAQGIGKPS DHTQCEKPLP 180

SGPKSDLWSL GIILFELCMG RKLFQSLEIA ERLKFILMLG CVDDIVTVLA EEHGCLDIIK 240

DLSENVIALL KKCLTFQPSK RQVFKELLHH SLFSEVSPLY PPFHKPAGLF SSSPRCANLT 300

LPEDISQLCK DEDNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PVCTLPSFLL 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQPA LPHSNSSNEL 420

SAAAALPLII RERDTEYQLN RIVLFDRLLK AYPYKKNQIW KEARIDIPPL LRGITWAALL 480

GVEGAIEAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

NLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FRWTPKSATY RQYAQPPRPA 720

ADSSGTRSSS LSCFSADYQE APRSDLSRDS IKLDDLKAEV SPRISAEDLI DLCELTGPSH 780

SKTPVKKTKP SKPKLLVVDI RNSEDFNRGH ISGSINVPFA SAFTAEGDLI QCPATATLQS 840

FKGRVVVIVG NAVKNTAAFA AHLVKNKYPR VCILDGGINK IKPTGLLTVP SPQI 894

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TAAAAGACAC TGTGATGGGT GCCTCCACAT TCTTTGCCTC TGCTCTGCCG 60

CATGATGTCT GTGGAAGTAA TGGCCTCCCT CTAACGCCTA ACTCCATAAA AATTCTGGGG 120

AGATTTCAAA TCCTTAAAAC AATCACCCAT CCCAGACTTT GCCAGTACAT TGACCTTACC 180

AGAGGTAAAC ATGAGAGACT GGTTGTGGCA GCTGAACACT GTGAGAAGAG TCTGGAAGAT 240

TTGCTACGAG AAAGAAAGCC TGTCAGTTCT TCAAGGATCT TATGCATAGC ATATGAGGTT 300

TTGCAAGGTT TGCAGTATAT GAATAAGCAT GGAATGGTCC ACCGAGCACT CTCCCCTTGC 360

AATATTCTTT TGGATCGAAA GGGACATGTG AAGTTGGCTA AATTTGGACT CTACCACATG 420

ACTGCTCAAG GTGTTGATGT TGATTTTCCT ATAGGGTACC CATCATATCT GGCACCTGAA 480

GTAATTGCAC AGGGAATTGG CAAACCAAGT GATCACACCC AGTGTGAGAA GCCGCTGCCT 540

TCTGGCCCTA AATCAGATCT GTGGTCTCTT GGTATCATAT TATTTGAGCT TTGCATGGGG 600

AGAAAATTAT TTCAGAGTTT GGAGATAGCA GAAAGATTGA AATTTATACT TATGTTAGGC 660

TGTGTAGATG ATATTGTAAC TGTATTGGCT GAGGAACATG GTTGCCTTGA TATTATTAAG 720

GACCTTTCTG AAAATGTCAT AGCTCTACTT AAGAAATGCC TTACGTTCCA GCCTTCTAAG 780

AGGCAAGTAT TCAAGGAATT GCTACATCAC AGTTTGTTCA GTGAAGTATC CCCACTATAT 840

CCTCCCTTCC ACAAACCTGC TGGTCTGTTC TCATCTTCTC CAAGGTGTGC GAATTTAACA 900

CTACCTGAAG ACATAAGTCA ATTATGTAAA GATGAAGATA ATGATTACCT AGCAGAAAGA 960

TCAATTGAAG AGGTTTATTA TCTCTGGTGC TTGGCTGGAG GAGACTTGGA GAAAGAACTT 1020

GTCAACAAAG AAATCATTAG ATCAAAGCCA CCTGTCTGCA CACTTCCCAG CTTTCTATTA 1080

GAAGATGGTG AGAGCTTTGG GCAAGGACGA GATAGAAGTT CCCTCTTAGA TGACACAACT 1140

GTGACTTTGT CTCTGTGCCA GCTCCGAAAT AGACTGAAGG ATGTTGGTGG AGAAGCATTT 1200

TATCCATTGC TTGAAGATGA CCAGCCAGCT TTACCTCATT CCAATAGTAG CAATGAGCTC 1260

TCTGCAGCTG CTGCTCTTCC TCTGATCATC CGGGAGAGGG ACACAGAGTA CCAGCTAAAT 1320

AGAATTGTCC TGTTTGACAG GCTGTTGAAG GCCTACCCGT ACAAGAAAAA CCAAATTTGG 1380

AAAGAAGCCA GGATTGACAT CCCTCCCCTT CTGAGAGGCA TAACCTGGGC TGCCTTGTTG 1440

GGTGTTGAGG GTGCCATAGA AGCAAAATAT GATGCCATTG ATAAAGACAC ACCGATTCCT 1500

ACAGACAGAC AAATTGAAGT TGATATTCCT CGTTGCCATC AATATGATGA ACTGCTGTCA 1560

TCACCAGAGG GTCATGCAAA GTTCAGACGT GTATTGAAGG CCTGGGTTGT TTCCCATCCT 1620

AATTTGGTGT ACTGGCAAGG TCTTGACTCT CTTTGTGCAC CATTTCTGTA CTTGAATTTT 1680

AACAATGAAG CTCTGGCATA CGCCTGCATG TCTGCTTTTA TTCCAAAGTA TTTGTATAAC 1740

TTCTTTCTGA AGGATAATTC TCATGTTATT CAAGAGTATC TGACGGTGTT TTCCCAGATG 1800

ATTGCATTCC ATGATCCAGA GCTGAGTAAC CACCTCAATG AAATTGGGTT TATTCCAGAT 1860

CTTTATGCAA TTCCTTGGTT TCTTACAATG TTTACACATG TCTTTCCTTT GCACAAAATT 1920

TTTCACTTGT GGGATACATT ACTCCTTGGA AATTCCTCCT TCCCATTCTG TATTGGAGTT 1980

GCCATACTTC AACAGCTGAG GGATCGTCTC CTGGCTAATG GATTCAATGA GTGCATTCTC 2040

CTTTTTTCAG ACTTGCCAGA GATCGATATT GAGCGTTGTG TTCGCGAGTC GATCAACCTG 2100

TTCCGCTGGA CCCCCAAGAG CGCCACGTAC CGGCAGTACG CGCAGCCCCC GCGGCCGGCC 2160

GCCGACAGCA GCGGCACCAG GAGCTCTTCC CTGTCCTGCT TCTCTGCAGA CTACCAGGAG 2220

GCTCCTCGCA GTGACCTCTC TAGGGACTCC ATTAAGTTGG ATGACCTGAA GGCAGAAGTG 2280

TCCCCACGAA TTTCAGCAGA AGATCTGATA GACTTGTGTG AGTTGACAGG ACCTAGCCAT 2340

TCCAAAACAC CTGTAAAGAA AACAAAGCCG AGCAAGCCAA AGCTGCTGGT GGTGGACATC 2400

CGAAACAGCG AAGACTTTAA CCGTGGCCAC ATTTCTGGCA GCATCAATGT CCCTTTTGCA 2460

TCAGCATTTA CTGCAGAAGG GGATCTCATC CAGTGCCCAG CAACTGCCAC ACTGCAGAGC 2520

TTTAAAGGAA GAGTTGTGGT GATTGTAGGA AATGCAGTGA AGAACACAGC TGCTTTTGCA 2580

GCTCATCTAG TGAAAAACAA GTACCCAAGG GTCTGCATCC TTGATGGAGG AATCAACAAG 2640

ATCAAGCCGA CTGGTCTCCT CACTGTTCCT TCTCCACAAA TCTAA 2685

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+d++rgkher++v aeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYIDLTRGKHERLVVAAEHCEKS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s +l+iayevl+gl+y+nkh++vhral+p +illdrkg+ vkLak+G

Q: 78    LEDLLRERKPVSSSRILCIAYEVLQGLQYMNKHGMVHRALSPCNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G dvdfpigy+sylaPe+i+q+          +k+l++++ksD WsLg+il+e

Q: 137   LYHMTAQGVDVDFPIGYPSYLAPEVIAQGigkpsdhtqCEKPLPSGPKSDLWSLGIILFE  196

         ************************************9999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++l+++erlk++l l++vd+ + +laee++cldiik+l e+++allkkCLt+

Q: 197   LCMGRKLFQSLEIAERLKFILMLGCVDDIVTVLAEEHGCLDIIKDLSENVIALLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

          pskR   +ell++  f

Q: 257   QPSKRQVFKELLHHSLF  273

         ************99865

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYI DLTRGKHERL VVAAEHCEKS 60

LEDLLRERKP VSSSRILCIA YEVLQGLQYM NKHGMVHRAL SPCNILLDRK GHVKLAKFGL 120

YHMTAQGVDV DFPIGYPSYL APEVIAQGIG KPSDHTQCEK PLPSGPKSDL WSLGIILFEL 180

CMGRKLFQSL EIAERLKFIL MLGCVDDIVT VLAEEHGCLD IIKDLSENVI ALLKKCLTFQ 240

PSKRQVFKEL LHHSLF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013