EKS-TAG-00501

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00501

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	322.7	1.7E-96	2	237	236

Status

Unreviewed

Ensembl Protein

ENSTGUP00000004080

UniProt Accession

H0Z0J3;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK3

Gene Synonyms/Alias

ULK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003962	ENSTGUP00000004080	ENSTGUT00000004125

Organism

Taeniopygia guttata

Functional Description

Protein Length

430

Protein Sequence
(FASTA)

QRDTREVVAI KCVNKRSLNR ASVENLLTEI EILKTIRHPN IVELKDFQWD SEHIYLIMEF 60

CAGGDLSRFI RMRRMLPEKV ARVFLQQLAC ALKFLHDRNI SHLDLKPQNI LLSAPENPQL 120

KLADFGFAQY MSPWDEKHVL RGSPLYMAPE MVCRQHYDAR VDLWSVGVIL YEALFGKPPF 180

ASRSFAELEE KIRSDRAVEL PSRPQLSQEC RDLLGQLLER DPRKRISFEC FFAHPFVDME 240

HIPGPESLGK ATDLVVEAVR KDQEGDAGAA FSLYRKALEY FVPALHYESD ARRKEAIRAK 300

VRQYISRAEE LKVLVTSSNK NLLEKGNPAR ELLKEMAKDK PRLYAALEVA SAAIAKEEEG 360

RDDSDALELY QQSLGELLLL LAAEPAGRRR ELLHAEIQTL MARAEYLKDQ IKMREAQSMG 420

KEALAESVRS 430

Nucleotide Sequence
(FASTA)

CAGAGGGACA CGCGTGAGGT GGTGGCCATC AAATGTGTCA ACAAGAGGAG CCTGAACCGG 60

GCATCGGTGG AGAACCTGCT GACAGAGATC GAGATCCTCA AGACCATCCG CCATCCCAAC 120

ATTGTGGAGC TCAAGGACTT CCAGTGGGAC AGTGAGCACA TCTACCTGAT CATGGAGTTC 180

TGCGCCGGGG GGGACCTCTC CCGCTTCATC CGGATGCGCC GGATGCTCCC CGAGAAGGTG 240

GCACGCGTCT TCCTGCAGCA GCTCGCCTGT GCCCTGAAGT TCCTGCACGA CCGCAACATC 300

TCCCACCTGG ACCTGAAGCC GCAGAACATC CTCCTGAGCG CCCCGGAGAA CCCCCAGCTG 360

AAGCTGGCAG ATTTCGGCTT TGCTCAGTAC ATGTCCCCGT GGGACGAGAA GCACGTGCTG 420

CGCGGCTCCC CGCTCTACAT GGCCCCCGAG ATGGTGTGTC GGCAGCACTA CGATGCCCGC 480

GTGGACCTCT GGTCGGTGGG CGTCATCCTT TACGAAGCAC TTTTTGGGAA GCCGCCCTTC 540

GCTTCCCGCT CCTTCGCCGA GCTGGAGGAG AAGATCCGCA GCGACCGGGC TGTGGAGCTC 600

CCCAGCCGGC CCCAGCTCTC TCAGGAATGC CGGGATCTCT TGGGACAGCT GCTGGAGAGG 660

GACCCTCGCA AGCGCATCTC CTTCGAGTGC TTCTTTGCCC ACCCCTTCGT GGACATGGAG 720

CACATCCCCG GCCCCGAGAG CCTGGGCAAG GCGACCGACC TGGTGGTGGA AGCGGTGAGG 780

AAGGATCAGG AGGGAGACGC CGGTGCCGCC TTCTCCCTCT ACCGCAAAGC ACTGGAGTAT 840

TTCGTGCCAG CACTGCACTA TGAAAGCGAC GCACGGCGCA AAGAAGCCAT CCGGGCCAAG 900

GTGAGGCAGT ACATCTCCCG AGCTGAGGAG CTGAAGGTGT TGGTCACCTC CAGCAACAAG 960

AACCTCCTGG AGAAAGGAAA CCCGGCCAGA GAGCTCCTTA AAGAGATGGC CAAGGACAAG 1020

CCCCGGCTCT ACGCGGCGCT GGAAGTGGCT TCAGCTGCCA TCGCCAAGGA GGAGGAAGGC 1080

AGGGATGACA GTGACGCCCT GGAGCTGTAC CAGCAGAGCT TGGGGGAGCT CCTGCTGCTC 1140

CTGGCCGCGG AGCCGGCGGG GCGGCGGCGG GAGCTGCTCC ACGCCGAGAT CCAGACCCTG 1200

ATGGCCCGAG CCGAGTACCT GAAGGATCAG ATCAAGATGC GGGAGGCACA ATCCATGGGC 1260

AAAGAGGCGC TGGCAGAGTC CGTCCGGAGC 1290

Domain Profile

S: 22    kktsqvvAikvvekkkl.kkslenlekeikilkelkhenivalldveetskevylvmeyc  80

         ++t++vvAik+v+k++l ++s+enl +ei+ilk ++h+niv+l+d++++s+++yl+me+c

Q: 2     RDTREVVAIKCVNKRSLnRASVENLLTEIEILKTIRHPNIVELKDFQWDSEHIYLIMEFC  61

         57899************999****************************************

S: 81    aggdLakllkqkkeLsedtvreflqqlasalkaLhskkivhrDlkPqniLlsyadakkel  140

         aggdL+++++ ++ L+e+++r+flqqla alk+Lh+++i+h DlkPqniLls      +

Q: 62    AGGDLSRFIRMRRMLPEKVARVFLQQLACALKFLHDRNISHLDLKPQNILLS------AP  115

         ****************************************************......78

S: 141   kkvtlkladFglarvlkeesmaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellv  200

         ++ +lkladFg+a++++ +++++ l+GsplYmaPE+v++q+yda++DlWS+G+ilye+l+

Q: 116   ENPQLKLADFGFAQYMSPWDEKHVLRGSPLYMAPEMVCRQHYDARVDLWSVGVILYEALF  175

         99**********************************************************

S: 201   GkpPfaaesiseLvekiekndvleppipkeisselkdllqsLLqrdpkkRisfeelfahp  260

         GkpPfa++s+ eL+eki++++++e+p++ ++s+e++dll +LL+rdp+kRisfe +fahp

Q: 176   GKPPFASRSFAELEEKIRSDRAVELPSRPQLSQECRDLLGQLLERDPRKRISFECFFAHP  235

         ************************************************************

S: 261   fl  262

f+

Q: 236   FV  237

Domain Sequence
(FASTA)

RDTREVVAIK CVNKRSLNRA SVENLLTEIE ILKTIRHPNI VELKDFQWDS EHIYLIMEFC 60

AGGDLSRFIR MRRMLPEKVA RVFLQQLACA LKFLHDRNIS HLDLKPQNIL LSAPENPQLK 120

LADFGFAQYM SPWDEKHVLR GSPLYMAPEM VCRQHYDARV DLWSVGVILY EALFGKPPFA 180

SRSFAELEEK IRSDRAVELP SRPQLSQECR DLLGQLLERD PRKRISFECF FAHPFV 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0045880	; P:positive regulation of smoothened signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF04212	; MIT; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00745	; MIT; 2.
SM00220	; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013