EKS-TAG-00521

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00521

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	495.3	4.0E-149	26	309	284

Status

Unreviewed

Ensembl Protein

ENSTGUP00000004192

UniProt Accession

H0Z0V5;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000004027	ENSTGUP00000004192	ENSTGUT00000004237

Organism

Taeniopygia guttata

Functional Description

Protein Length

1361

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVDSYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA TLSEKAAMLF RQYVRDNLYD RISTRPFLNN 120

IEKRWIAFQI LTAVDQAHKS GVRHGDIKTE NIMVTSWNWV LLTDFASFKP TYLPEDNPAD 180

FNYFFDTSRR RTCYIAPERF VDGSMFATEL ENMRDPSTPL VDLANSNQRT RGELKRAMDI 240

FSAGCVIAEL FTEGVPLFDL SQLLAYRNGL FSPDQVLNKI EDRSIRELVT QMIHREPDKR 300

LAAEDYLKQQ RNNAFPEIFY TFLQPYMAQF AKETFVSADE RILVIRKDLD NIIHNLCGHD 360

RTEKAEGETK ENGLVILVSV ITSCLQTLKY CDSKLAALEL ILHLAPRLSV EILLDRITPY 420

LLHFSNDSVP RVRAESVRTL TKVLALVKEV PRNDINIYPE YILPGIAHLA QDEATIVRLA 480

YAENIALLAE TALRFLELVQ LKNLNMENEP NGEEMDETSH PSDNYDTELQ ALHEMVQQKV 540

VTLLSDPENI VKQTLMENGI TRLCVFFGRQ KANDVLLSHM ITFLNDKNDW HLRGAFFDSI 600

VGVAAYVGWQ SSSILKPLLQ QGLSDAEEFV IYKALNALTC MCQLGLLQKP HIYEFACDIA 660

PFLCHPNLWI CYGAVGFITV VAQYLNIADV YCKLMPYLHP FITQPIIQVD KEIVLLSVLK 720

EPVSRSIFDY VLRSKDIASL FRHLHLRQMK RTGALSECPP PEDPAIAQLL KKLLSQGMTE 780

EEEDKLLALK DFMLKSNKAK ANIVDQSHLH DSSHKGVIDL SALGITGRQV DLVKTKQDSD 840

DKRARKHVKQ DSNVNEEWKS MFGSLEPTNI SQPISKGHGQ TTDPEAIQAG KPLRSESSAG 900

ICATLSSSPQ ASDGAVVQPR KPTLQALSST MSPSAHQLRI TTCKTELQQL IQQKREQCNA 960

ERLAKQMMEN AEWESKPPPP GWRPKGLLVA HLHEHKSAVN RIRVSDEHSI FATCSNDGTV 1020

KVWNSQKMEG KTTTTRSILT YSRIGGHVKT LTFCQGSHYL AIASDNGAIQ LLGIEASKLP 1080

KSPKIHPIQS RSLDLKDDGC VVDIHHFNSG AQSVLAYGTV NGSLVGWDLR SSSNAWTLKH 1140

DLKLGLITSF AVDIHQCWLC IGTSNGTMAC WDMRFQLPIS SHSHPSKARI RRLLMHPVYQ 1200

SWVIAAVQGN NEVSMWDMET GDRRFTLWAS SAPPLSELQP SPHSIHGIYC SPASGNPILL 1260

TAGSDMKIRF WDLAYPERSY VVAGSSNCPS VSYYRKIIEG TEVVQEIQNK QKMGPTDETP 1320

RKGPESLPVG HHDIITDIAT FQTTQGFIVT ASRDGIVKVW K 1361

Nucleotide Sequence
(FASTA)

ATGGGGAACC AGCTGGCTGG CATCGCCCCC TCGCAAATCC TCTCGGTGGA CAGCTACTTC 60

TCGGACATCC ACGACTTCGA GTATGACAAG AGCCTGGGCA GCACCCGCTT CTTCAAGGTG 120

GCCCGAGCCA AGCACCGGGA GGGGCTGGTG GTCGTGAAAG TGTTTGCTAT TCAGGATCCC 180

ACCTTACCCC TGACGAGCTA CAAGCAGGAG CTGGAGGAGC TGAAGATAAG GTTACACTCG 240

GCACAGAACT GCCTCCCCTT CCAGAAAGCC ACCCTGTCCG AGAAGGCCGC CATGCTTTTC 300

AGACAGTACG TACGGGACAA CCTTTATGAC CGGATTAGTA CCAGGCCATT CCTGAACAAC 360

ATTGAGAAAA GGTGGATCGC TTTCCAGATC CTCACTGCGG TGGACCAAGC GCACAAATCT 420

GGAGTCCGCC ACGGTGATAT TAAAACAGAG AACATCATGG TGACCAGCTG GAACTGGGTT 480

CTTCTAACTG ACTTTGCCAG TTTTAAACCA ACTTACCTTC CTGAAGACAA TCCTGCTGAC 540

TTCAATTATT TCTTTGACAC ATCCCGGAGG AGAACATGTT ACATCGCTCC CGAGCGCTTT 600

GTCGATGGCA GCATGTTTGC CACGGAGCTG GAAAACATGC GGGACCCTTC CACTCCTTTG 660

GTAGACTTGG CAAATAGCAA TCAGCGAACA AGAGGAGAGT TAAAACGTGC AATGGATATC 720

TTTTCTGCAG GCTGTGTAAT AGCAGAACTC TTCACAGAAG GTGTACCCTT GTTTGATTTA 780

TCTCAGCTTT TGGCATACAG AAATGGCCTC TTTTCCCCTG ATCAAGTCCT AAACAAAATT 840

GAAGACCGCA GTATCAGAGA ACTGGTCACT CAGATGATCC ATCGAGAGCC AGATAAACGT 900

TTAGCAGCTG AAGATTATTT GAAACAGCAA CGTAACAATG CATTTCCTGA AATATTTTAC 960

ACTTTCCTTC AGCCTTACAT GGCCCAGTTT GCCAAGGAAA CGTTTGTGTC AGCAGATGAA 1020

CGTATATTGG TCATACGTAA AGATCTGGAC AACATCATTC ACAATCTCTG TGGGCACGAT 1080

CGCACAGAGA AGGCCGAGGG AGAGACAAAA GAGAATGGGC TGGTTATTCT AGTGTCTGTG 1140

ATAACTTCCT GTTTACAGAC TCTCAAGTAC TGTGATTCAA AACTGGCTGC TTTGGAGCTA 1200

ATTCTTCATT TAGCACCAAG ATTAAGTGTA GAGATTCTTC TGGATCGTAT TACTCCTTAT 1260

CTGTTACATT TCAGCAATGA CTCTGTGCCC AGGGTGAGGG CAGAATCTGT GAGGACACTA 1320

ACTAAAGTTC TTGCTCTCGT CAAAGAGGTG CCACGCAATG ATATTAACAT TTACCCAGAA 1380

TACATTCTGC CAGGCATTGC ACACTTGGCC CAGGATGAAG CCACCATTGT CAGACTTGCA 1440

TATGCTGAAA ACATAGCATT ATTGGCAGAA ACAGCTCTGA GATTTCTGGA GTTAGTACAG 1500

CTGAAAAATT TGAATATGGA AAATGAACCA AATGGTGAAG AAATGGATGA AACATCTCAC 1560

CCTAGTGATA ACTATGACAC AGAGTTGCAA GCCTTGCATG AAATGGTCCA GCAGAAAGTT 1620

GTGACTTTGC TAAGTGACCC AGAGAATATT GTGAAACAGA CACTGATGGA AAATGGAATA 1680

ACACGTCTGT GTGTCTTTTT TGGACGTCAA AAAGCCAATG ATGTTCTTCT GTCTCATATG 1740

ATCACTTTCT TAAATGACAA GAATGACTGG CATCTTCGAG GAGCTTTCTT TGATAGCATT 1800

GTTGGTGTTG CTGCTTATGT TGGCTGGCAA AGCTCATCAA TACTCAAACC TCTGCTTCAG 1860

CAAGGTCTCA GTGATGCTGA AGAATTTGTC ATTTATAAAG CCCTCAATGC TCTCACTTGT 1920

ATGTGCCAGC TGGGGCTCTT GCAAAAGCCC CATATTTATG AGTTTGCTTG TGATATCGCA 1980

CCATTCCTGT GTCACCCTAA TCTTTGGATA TGTTATGGTG CAGTTGGATT TATCACTGTG 2040

GTGGCACAGT ATTTGAATAT TGCTGATGTC TATTGCAAGC TAATGCCATA CCTCCATCCT 2100

TTTATCACAC AACCAATAAT ACAGGTAGAC AAAGAAATAG TCCTGTTGAG TGTACTTAAG 2160

GAGCCTGTCA GCCGTTCCAT ATTTGATTAT GTCTTAAGAT CAAAGGATAT CGCAAGCCTC 2220

TTCCGACACC TGCACTTGCG TCAAATGAAA AGAACTGGAG CTCTCTCTGA GTGCCCACCC 2280

CCAGAGGACC CTGCCATTGC ACAGCTCTTG AAGAAGCTTC TTTCACAAGG GATGACTGAG 2340

GAAGAAGAAG ACAAACTGTT AGCACTGAAG GACTTTATGT TAAAATCTAA TAAAGCTAAA 2400

GCAAATATTG TGGATCAGAG CCACCTGCAT GATAGCAGTC ACAAAGGGGT GATTGACTTG 2460

TCAGCTCTGG GAATAACTGG AAGACAAGTG GATCTTGTTA AAACAAAGCA GGATTCTGAT 2520

GACAAACGTG CTAGAAAGCA TGTAAAGCAA GATTCAAATG TAAATGAAGA ATGGAAAAGC 2580

ATGTTTGGGT CCCTGGAACC CACAAACATC TCCCAGCCAA TATCCAAAGG ACATGGGCAA 2640

ACTACTGATC CTGAAGCCAT CCAAGCTGGG AAACCACTTC GTTCAGAGTC CTCAGCTGGC 2700

ATTTGTGCCA CTTTGTCATC CTCTCCACAG GCATCTGATG GAGCAGTTGT CCAGCCCAGA 2760

AAACCAACAC TGCAGGCCCT GAGTAGCACA ATGTCCCCAT CTGCACACCA GCTGCGCATC 2820

ACCACCTGCA AAACTGAGCT GCAGCAGCTG ATCCAGCAGA AGAGAGAGCA GTGTAATGCA 2880

GAGAGACTTG CCAAGCAGAT GATGGAGAAT GCTGAGTGGG AGAGCAAACC CCCTCCTCCA 2940

GGATGGCGTC CCAAAGGGTT GTTGGTAGCT CACCTTCATG AACACAAGTC TGCTGTAAAT 3000

CGCATCCGGG TCTCTGATGA GCACTCCATT TTTGCCACTT GCTCAAATGA TGGCACAGTA 3060

AAGGTCTGGA ACAGCCAAAA AATGGAAGGA AAAACCACTA CAACCAGATC AATTTTGACA 3120

TACTCTCGGA TTGGAGGACA TGTAAAGACA CTTACATTTT GCCAAGGCTC ACATTACTTG 3180

GCTATAGCTT CAGATAATGG TGCCATCCAG CTTCTTGGTA TTGAAGCCTC TAAGCTCCCT 3240

AAATCTCCTA AAATTCACCC AATACAAAGC AGGTCATTGG ATCTGAAGGA TGATGGCTGT 3300

GTGGTAGACA TTCATCACTT CAATTCAGGA GCCCAGTCAG TACTGGCTTA TGGAACAGTT 3360

AATGGATCTC TGGTTGGATG GGATTTGAGA TCCAGCAGCA ATGCCTGGAC ACTGAAACAT 3420

GATTTGAAGT TAGGCCTCAT AACTTCATTT GCTGTGGACA TACACCAGTG CTGGCTGTGT 3480

ATTGGAACGA GCAATGGTAC CATGGCATGC TGGGACATGC GGTTTCAGTT ACCTATCTCC 3540

AGCCACTCTC ATCCTTCCAA GGCCCGAATC AGACGCCTGC TCATGCATCC TGTCTATCAG 3600

TCCTGGGTAA TAGCAGCTGT TCAAGGCAAC AATGAAGTCT CCATGTGGGA TATGGAAACT 3660

GGTGATCGAC GCTTCACTCT GTGGGCCAGC AGTGCACCAC CTCTTTCAGA ACTGCAGCCT 3720

TCTCCTCACA GCATCCACGG AATATACTGT AGTCCAGCTT CTGGTAATCC CATATTACTG 3780

ACAGCAGGCT CAGACATGAA AATAAGGTTT TGGGATCTAG CCTACCCTGA GAGATCATAT 3840

GTTGTTGCTG GAAGTTCTAA TTGCCCATCT GTTTCCTACT ACAGGAAGAT AATTGAGGGC 3900

ACAGAGGTGG TTCAGGAAAT TCAGAACAAG CAAAAGATGG GGCCCACTGA TGAGACTCCT 3960

CGGAAGGGTC CAGAGTCCCT CCCAGTTGGG CATCATGATA TTATCACAGA TATTGCGACT 4020

TTCCAGACCA CACAAGGGTT TATAGTAACT GCATCAAGGG ATGGGATTGT TAAAGTGTGG 4080

AAATAA 4086

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhG  120

         pfqk+++ ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+hG

Q: 86    PFQKATLSEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHG  145

         ************************************************************

S: 121   diktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsala  180

         dikten++vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++ +

Q: 146   DIKTENIMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGSM  205

         ************************************************************

S: 181   sdekl...rdgstelvdl.dsiqrlrgelkkamdifsaGcvilelftegrplfelsqlla  236

         ++++l   rd+st+lvdl +s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqlla

Q: 206   FATELenmRDPSTPLVDLaNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLA  265

         **99988899******9758****************************************

S: 237   yrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         yr+g f +++vl+kied+++r+lv+q+i++ep+kr+ aed+lk+

Q: 266   YRNGLFSPDQVLNKIEDRSIRELVTQMIHREPDKRLAAEDYLKQ  309

         ******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKATLSEK AAMLFRQYVR DNLYDRISTR PFLNNIEKRW IAFQILTAVD QAHKSGVRHG 120

DIKTENIMVT SWNWVLLTDF ASFKPTYLPE DNPADFNYFF DTSRRRTCYI APERFVDGSM 180

FATELENMRD PSTPLVDLAN SNQRTRGELK RAMDIFSAGC VIAELFTEGV PLFDLSQLLA 240

YRNGLFSPDQ VLNKIEDRSI RELVTQMIHR EPDKRLAAED YLKQ 284

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

tgu:100221598

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013