EKS-TAG-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	478.5	4.9E-144	283	541	259

Status

Unreviewed

Ensembl Protein

ENSTGUP00000004494

UniProt Accession

H0Z1Q4;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCA

Gene Synonyms/Alias

PRKCA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000004257	ENSTGUP00000004494	ENSTGUT00000004542

Organism

Taeniopygia guttata

Functional Description

Protein Length

616

Protein Sequence
(FASTA)

GFGKQGFQCQ VCCFVVHKRC HEFVTFSCPG ADKGPDTDDP RSKHKFKIHT YGSPTFCDHC 60

GSLLYGLLHQ GMKCDTCDMN VHKQCVINVP SLCGMDHTEK RGRIYLKAEV TGDKLEVTVR 120

EAKNLIPMDP NGLSDPYVKL KLIPDPKNES KQKTKTIRST LNPDWNESFT FKLKPTDKDR 180

RLSVEVWDWD RTTRNDFMGS LSFGVSELMK MPASGWYKLL NQEEGEYYNV PIPDADEDGN 240

AELRQKFEKA KLGPAGNKVI TSTEDKNSSV PSNNLDRVKL TDFNFLMVLG KGSFGKVMLA 300

DRKGTEELYA IKILKKDVVI QDDDVECTMV EKRVLALQDK PPFLTQLHSC FQTVDRLYFV 360

MEYVNGGDLM YHIQQVGKFK EPQAVFYAAE ISIGLFFLHN RGIIYRDLKL DNVMLDSEGH 420

IKIADFGMCK EHMLDGVTTR TFCGTPDYIA PEIIAYQPYG KSVDWWAYGV LLYEMLAGQP 480

PFDGEDEDEL FQSIMEHNVS YPKSLSKEAV SICKGLMTKH PAKRLGCGLE GERDIREHAF 540

FRRIDWEKLE NREIQPPFKP KVCGKGAENF DKFFTRGQPV LTPPDQLVIA NIDQTDFEGF 600

SYVNPQFVHP LVENVA 616

Nucleotide Sequence
(FASTA)

GGATTTGGGA AGCAAGGATT CCAGTGCCAA GTTTGCTGTT TTGTGGTTCA TAAGAGGTGC 60

CATGAGTTCG TTACCTTCTC CTGTCCTGGG GCTGACAAGG GGCCCGACAC TGATGATCCC 120

AGGAGCAAGC ACAAGTTCAA GATCCACACC TATGGGAGCC CCACCTTCTG TGACCATTGT 180

GGATCGCTGC TCTACGGGCT CCTGCACCAG GGGATGAAAT GCGACACCTG TGATATGAAC 240

GTCCACAAGC AATGTGTGAT AAACGTCCCA AGCCTCTGTG GCATGGACCA CACAGAGAAG 300

AGGGGAAGGA TTTATCTGAA AGCTGAAGTC ACTGGTGACA AACTGGAAGT TACAGTGAGA 360

GAAGCAAAAA ACCTCATTCC CATGGATCCA AATGGACTTT CAGATCCTTA TGTCAAACTG 420

AAGCTCATCC CAGATCCTAA GAATGAAAGT AAACAAAAAA CAAAAACCAT CCGTTCTACC 480

CTGAATCCGG ACTGGAATGA GTCATTCACG TTTAAGTTAA AGCCTACAGA CAAAGATCGC 540

CGGTTATCCG TAGAGGTCTG GGACTGGGAT CGAACCACCA GGAATGATTT CATGGGGTCA 600

CTCTCTTTTG GAGTGTCAGA GCTTATGAAA ATGCCAGCCA GTGGATGGTA CAAGCTGCTG 660

AATCAAGAGG AGGGTGAATA CTACAACGTT CCAATTCCAG ATGCTGATGA AGATGGAAAT 720

GCAGAGCTCC GACAGAAGTT TGAGAAAGCC AAACTTGGGC CAGCTGGTAA CAAAGTCATT 780

ACTTCAACAG AAGACAAGAA CTCAAGTGTG CCATCCAACA ATCTGGACAG GGTGAAGCTG 840

ACAGATTTCA ACTTTCTCAT GGTTCTTGGA AAGGGGAGCT TTGGGAAGGT GATGCTGGCG 900

GACAGGAAGG GCACAGAGGA GCTCTATGCA ATCAAAATCC TGAAAAAAGA CGTGGTGATC 960

CAGGATGATG ATGTGGAGTG CACCATGGTT GAGAAACGAG TCCTGGCACT GCAGGATAAG 1020

CCCCCGTTCC TGACACAGCT CCACTCTTGT TTCCAGACAG TTGACCGGCT GTATTTTGTG 1080

ATGGAGTATG TCAATGGTGG GGATCTCATG TATCACATCC AGCAAGTAGG AAAATTTAAG 1140

GAGCCACAAG CAGTGTTCTA TGCAGCTGAG ATCTCAATTG GGTTATTCTT TCTCCATAAC 1200

AGAGGGATTA TTTATAGAGA TCTGAAATTA GATAATGTGA TGTTGGATTC AGAAGGACAC 1260

ATTAAAATTG CTGATTTTGG AATGTGCAAG GAACACATGT TAGATGGAGT AACAACCAGG 1320

ACCTTCTGTG GCACTCCAGA CTACATTGCA CCAGAGATTA TTGCTTACCA GCCCTATGGG 1380

AAGTCTGTGG ATTGGTGGGC ATATGGTGTG CTGCTCTATG AGATGTTGGC TGGCCAGCCT 1440

CCATTTGATG GGGAAGATGA AGATGAACTA TTCCAGTCCA TAATGGAGCA TAATGTTTCC 1500

TACCCAAAAT CATTGTCCAA AGAAGCAGTC TCCATCTGCA AGGGGCTAAT GACTAAACAT 1560

CCTGCAAAAC GCCTGGGCTG TGGCCTGGAA GGTGAAAGAG ACATCAGGGA ACACGCTTTC 1620

TTCAGGAGAA TTGACTGGGA AAAATTGGAG AACAGAGAGA TTCAGCCACC TTTCAAGCCT 1680

AAAGTGTGCG GCAAAGGGGC TGAAAACTTC GATAAGTTCT TCACACGAGG ACAGCCGGTG 1740

TTGACGCCTC CAGATCAGCT GGTCATTGCC AACATAGACC AAACAGATTT TGAAGGGTTC 1800

TCTTACGTCA ACCCCCAGTT CGTGCACCCC CTTGTAGAAA ATGTAGCATG A 1851

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal++k+p

Q: 283   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALQDKPP  342

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g

Q: 343   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHNRG  402

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke++l+g tt+tfcGtPdyiaPei+++++ygks

Q: 403   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMLDGVTTRTFCGTPDYIAPEIIAYQPYGKS  462

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+

Q: 463   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  522

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+  ege+di+ehaff

Q: 523   KRLGCGLEGERDIREHAFF  541

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALQDKPP 60

FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHNRG 120

IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MLDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240

KRLGCGLEGE RDIREHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0030425	; C:dendrite
GO:0005783	; C:endoplasmic reticulum
GO:0005739	; C:mitochondrion
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0001750	; C:photoreceptor outer segment
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004698	; F:calcium-dependent protein kinase C activity
GO:0035403	; F:histone kinase activity (H3-T6 specific)
GO:0008270	; F:zinc ion binding
GO:0006874	; P:cellular calcium ion homeostasis
GO:0071322	; P:cellular response to carbohydrate stimulus
GO:0000188	; P:inactivation of MAPK activity
GO:0050930	; P:induction of positive chemotaxis
GO:0035556	; P:intracellular signal transduction
GO:0008285	; P:negative regulation of cell proliferation
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046325	; P:negative regulation of glucose import
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0030593	; P:neutrophil chemotaxis
GO:0045766	; P:positive regulation of angiogenesis
GO:0043536	; P:positive regulation of blood vessel endothelial cell migration
GO:0045785	; P:positive regulation of cell adhesion
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0050729	; P:positive regulation of inflammatory response
GO:0031666	; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931	; P:positive regulation of mitotic cell cycle
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0006937	; P:regulation of muscle contraction
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330	; P:regulation of platelet aggregation
GO:0002026	; P:regulation of the force of heart contraction
GO:0070555	; P:response to interleukin-1

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013