EKS-TAG-00177
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00177
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.71.3E-167476752277
StatusUnreviewed
Ensembl ProteinENSTGUP00000005127
UniProt AccessionH0Z3I3;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000004881ENSTGUP00000005127ENSTGUT00000005177
OrganismTaeniopygia guttata
Functional Description
Protein Length822
Protein Sequence
(FASTA)
MWTWRCLILW AVLVAAALSA ARPAPTLPEQ AVPKAKIEVE SHSAHPGELL QLRCRLRDDV 60
QSINWVHDGV QLAENNRTRI TGEEVEVRDV VPEDSGLYAC MTNSPSGSKT TYFSVNVSDA 120
LPSAEDDDDE DDSSSEEKEA DNTKPNQAIA PYWTYPEKME KKLHAVPAVK TVKFKCPSSG 180
TSNPNLWLKN GKEFKPDHRI GGYKVQGGAG EQLLGVVPSD KGNYTCMWRT STAASTHTYQ 240
LDVVGRKRSP HRPILQAGLP ANKTVALGSN VEFVCKVYSD PQPHIQWLKH IEVNGSKIGP 300
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGISHH SAWLTVLEAI 360
EDTPAMMTSP IYLEIIIYCI GAFLISCMVV TIIIYKLKST TKKTDFNSQL AVHKLAKSIP 420
LRRQRSVSAD SSSSMNSGVM LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLILGK 480
PLGEGCFGQV VLAEAIGLDK DKPNRVTKVA VKMLKSDATE KDLSDLISEM EMMKMIGKHK 540
NIINLLGACT QDGPLYVIVE YASKGNLREY LQARRPPGME YCYNPSRVPE EQLSFKDLVS 600
CAYQVARGME YLASKKCIHR DLAARNVLVT EDNVMKIADF GLARDIHHID YYKKTTNGRL 660
PVKWMAPEAL FDRIYTHQSD VWSFGVLLWE IFTLGGSPYP GVPVEELFKL LKEGHRMDKP 720
SNCTNELYMM MRDCWHAVPS QRPTFKQLVE DLDRIVAMTS NQVGEYLDLS MPLDQYSPGF 780
PDTRSSTCSS GEDSVFSHDP LPDEPCLPKF PPQHSNGGLK RH 822
Nucleotide Sequence
(FASTA)
ATGTGGACCT GGCGGTGCCT CATCCTTTGG GCTGTGCTGG TCGCAGCCGC ACTCTCCGCT 60
GCCCGGCCAG CCCCCACCCT GCCCGAGCAA GCTGTGCCCA AAGCAAAAAT CGAAGTGGAG 120
TCGCACTCGG CCCACCCCGG TGAGCTGCTC CAGCTGCGCT GCCGGCTGCG GGACGACGTG 180
CAGAGCATCA ACTGGGTGCA CGATGGGGTC CAGCTGGCTG AGAACAACCG CACACGCATC 240
ACCGGGGAGG AGGTAGAGGT CAGGGACGTG GTGCCCGAGG ACTCGGGGCT CTACGCCTGC 300
ATGACCAACA GCCCCTCGGG GAGCAAGACC ACCTACTTCT CCGTGAATGT CTCAGACGCT 360
CTCCCCTCTG CAGAGGATGA TGATGATGAA GATGATTCCT CCTCAGAGGA GAAGGAGGCA 420
GATAACACCA AGCCAAACCA GGCCATCGCT CCCTACTGGA CCTATCCTGA GAAGATGGAG 480
AAGAAGCTCC ACGCTGTCCC CGCTGTCAAA ACAGTGAAAT TCAAATGTCC ATCGAGCGGG 540
ACATCCAACC CCAACCTGTG GCTGAAGAAC GGCAAAGAGT TCAAACCTGA TCACCGCATC 600
GGGGGCTACA AGGTACAGGG GGGCGCGGGG GAGCAGCTCC TGGGGGTGGT GCCATCTGAT 660
AAGGGCAACT ACACCTGCAT GTGGAGAACA AGTACGGCAG CATCAACCCA CACCTACCAG 720
CTGGATGTCG TGGGGAGAAA GCGCTCCCCG CACCGGCCCA TCCTGCAGGC AGGGCTGCCT 780
GCCAACAAGA CAGTGGCCCT GGGCAGCAAC GTGGAGTTTG TCTGCAAGGT CTACAGCGAC 840
CCTCAGCCCC ACATCCAGTG GCTGAAGCAC ATTGAGGTGA ACGGCAGCAA GATCGGCCCC 900
GACAACCTGC CCTACGTGCA GATCCTGAAG ACGGCTGGCG TTAACACGAC AGACAAAGAA 960
ATGGAAGTCC TTCACTTAAG GAATGTCTCA TTTGAGGATG CTGGGGAGTA TACATGTTTG 1020
GCGGGTAATT CTATTGGGAT CTCCCATCAC TCTGCATGGT TGACAGTTCT CGAAGCTATT 1080
GAGGACACCC CAGCCATGAT GACGTCTCCC ATCTACCTGG AGATCATCAT CTACTGCATA 1140
GGAGCCTTCC TCATCTCCTG CATGGTGGTG ACCATCATCA TCTACAAGCT GAAGAGCACC 1200
ACCAAGAAGA CGGACTTCAA CAGCCAGCTG GCTGTGCACA AGCTGGCCAA GAGCATCCCC 1260
CTGCGCAGAC AGCGGAGTGT GTCGGCCGAC TCCAGCTCCT CCATGAACTC GGGCGTGATG 1320
CTGGTGCGGC CCTCCCGCCT CTCCTCCAGC GGCACCCCCA TGCTGGCCGG CGTCTCCGAG 1380
TACGAGCTCC CCGAGGACCC GCGCTGGGAG CTGCCCCGGG ACAGGCTGAT CCTGGGCAAG 1440
CCCCTGGGAG AAGGCTGCTT TGGCCAGGTG GTGCTGGCAG AAGCCATCGG CCTCGACAAG 1500
GACAAGCCCA ACCGTGTGAC CAAGGTGGCG GTGAAGATGC TCAAGTCCGA CGCCACGGAG 1560
AAGGACTTGT CTGACCTCAT CTCTGAGATG GAGATGATGA AGATGATCGG CAAGCACAAG 1620
AACATCATCA ACCTGCTGGG AGCCTGCACG CAGGATGGAC CCCTCTATGT GATCGTGGAA 1680
TACGCCAGCA AGGGCAACCT CCGGGAGTAC CTGCAGGCAC GGCGGCCCCC GGGCATGGAG 1740
TACTGCTACA ACCCCAGCCG CGTCCCCGAG GAGCAGCTGT CCTTCAAGGA CCTGGTCTCC 1800
TGTGCCTACC AGGTGGCGCG AGGCATGGAG TACTTGGCCT CCAAGAAGTG CATCCACAGG 1860
GACCTGGCGG CCAGGAACGT GCTGGTGACA GAGGACAACG TGATGAAGAT CGCTGACTTT 1920
GGGCTGGCCC GTGACATCCA CCACATCGAT TACTACAAGA AGACGACAAA TGGTCGCCTG 1980
CCCGTGAAGT GGATGGCCCC CGAGGCTCTC TTTGACAGAA TCTACACCCA CCAGAGTGAT 2040
GTGTGGTCCT TCGGGGTGCT GCTGTGGGAG ATTTTCACGC TGGGTGGCTC ACCCTACCCC 2100
GGTGTGCCCG TTGAGGAGCT CTTCAAGCTG CTGAAGGAGG GTCACAGGAT GGACAAGCCC 2160
AGCAATTGCA CCAACGAGCT GTACATGATG ATGAGGGATT GCTGGCACGC CGTCCCTTCC 2220
CAGAGACCCA CCTTCAAGCA GCTGGTGGAA GACCTAGACA GGATCGTGGC CATGACCTCC 2280
AACCAGGTAG GAGAGTACCT GGACCTGTCC ATGCCGCTGG ATCAGTATTC GCCCGGCTTC 2340
CCGGACACAC GCAGCTCCAC CTGCTCCTCG GGAGAGGACT CTGTGTTCTC CCACGACCCG 2400
CTCCCGGACG AGCCGTGCCT TCCCAAGTTC CCCCCTCAGC ACAGCAATGG TGGACTGAAG 2460
CGACACTGA 2469
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l lgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 476   LILGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  535
         689*********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g+e+++++s+++eeql++
Q: 536   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPSRVPEEQLSF  595
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 596   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  655
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 656   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  715
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 716   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  752
         ***********************************97
Domain Sequence
(FASTA)
LILGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGMEYCYNP SRVPEEQLSF 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-ANC-00142
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CIS-00182
EKS-DAR-00434
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORN-00183
EKS-ORA-00126
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-PES-00133
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0045787; P:positive regulation of cell cycle
GO:0043406; P:positive regulation of MAP kinase activity
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378; P:regulation of lateral mesodermal cell fate specification
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013