EPS-TAG-00068
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-TAG-00068
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN269.81.2E-801158158
StatusUnreviewed
Ensembl ProteinENSTGUP00000005142
UniProt AccessionH0Z3J8;
Protein Name
Protein Synonyms/Alias
Gene NamePTEN
Gene Synonyms/Alias PTEN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000004977ENSTGUP00000005142ENSTGUT00000005193
OrganismTaeniopygia guttata
Functional Description
Protein Length376
Protein Sequence
(FASTA)
IYPNIIAMGF PAERLEGVYR NNIDDVVRFL DSKHKNHYKI YNLCAERHYD TAKFNCRVAQ 60
YPFEDHNPPQ LELIKPFCED LDQWLSEDDN HVAAIHCKAG KGRTGVMICA YLLHRGKFLR 120
AQEALDFYGE VRTRDKKGVT IPSQRRYVYY YSYLLKNHLD YRPVALLFHK MMFETIPMFS 180
SGTCNPQFVV YQLKVKIFTS PSGPSRREDK YMYFEFPQPL PVCGDIKVEF FHKQNKMLKK 240
DKMFHFWVNT FFIGLDENSD KVENGSLVAD QELDGIFSTE RSDNDKEYLI LTLTKNDLDK 300
ANKDKANRYF SPNFKVKLFF TKTVEEPSNP EASSSTSVTP DVSDNEPDHY RYSDTTDSDP 360
ENEPFDEDQH TQITKV 376
Nucleotide Sequence
(FASTA)
ATTTATCCAA ACATAATTGC TATGGGCTTT CCTGCGGAGA GGCTTGAAGG AGTGTACCGG 60
AACAACATTG ATGATGTAGT AAGGTTTTTG GATTCAAAGC ATAAAAACCA TTACAAGATA 120
TACAATCTAT GTGCTGAAAG ACATTATGAC ACCGCCAAAT TTAACTGCAG AGTTGCACAG 180
TACCCTTTTG AAGACCATAA CCCACCACAG CTGGAGCTCA TCAAACCTTT TTGTGAAGAT 240
CTTGACCAGT GGCTAAGTGA AGATGACAAT CATGTGGCAG CAATCCACTG TAAAGCTGGA 300
AAGGGACGAA CTGGTGTAAT GATTTGTGCA TATTTGTTGC ATCGAGGCAA GTTTTTAAGG 360
GCCCAAGAAG CCCTAGATTT CTATGGGGAA GTAAGGACCA GAGACAAGAA GGGAGTGACA 420
ATTCCCAGTC AGAGACGCTA CGTGTACTAC TATAGCTACC TGTTAAAGAA TCACCTGGAT 480
TACAGACCAG TGGCACTGCT GTTCCACAAG ATGATGTTTG AAACAATTCC CATGTTCAGC 540
AGCGGAACTT GCAATCCTCA GTTTGTGGTG TACCAGCTAA AGGTAAAGAT ATTCACCTCC 600
CCTTCAGGAC CCTCGCGACG TGAAGACAAG TACATGTACT TTGAATTCCC TCAACCTTTG 660
CCGGTATGCG GTGATATCAA AGTGGAATTC TTCCACAAAC AGAACAAGAT GTTGAAAAAG 720
GACAAAATGT TTCACTTTTG GGTAAATACA TTCTTCATAG GACTGGATGA AAATTCAGAC 780
AAAGTAGAAA ATGGAAGTCT AGTTGCAGAT CAGGAACTTG ATGGTATTTT CAGTACAGAG 840
CGCTCAGATA ATGATAAGGA ATATTTAATC CTTACATTAA CAAAAAACGA TCTAGACAAA 900
GCAAATAAAG ACAAAGCCAA CAGATATTTC TCTCCAAACT TCAAGGTGAA GCTATTTTTC 960
ACAAAAACAG TAGAAGAGCC ATCAAACCCA GAGGCTAGCA GTTCAACTTC TGTAACACCA 1020
GATGTTAGTG ACAATGAACC TGATCATTAT AGATACTCTG ACACCACTGA CTCTGATCCA 1080
GAGAATGAAC CTTTTGATGA AGATCAGCAT ACGCAGATTA CAAAAGTCTG A 1131
Domain Profile
S: 15    vteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltklnakvae  74
         ++++iia++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+er+yd++k+n++va+
Q: 1     IYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQ  60
         799*********************************************************
S: 75    fgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayllaseisak  134
         +++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv++cayll++++++ 
Q: 61    YPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLR  120
         ************************************************************
S: 135   adealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         a+eald++ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 121   AQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  158
         *****************..******************986
Domain Sequence
(FASTA)
IYPNIIAMGF PAERLEGVYR NNIDDVVRFL DSKHKNHYKI YNLCAERHYD TAKFNCRVAQ 60
YPFEDHNPPQ LELIKPFCED LDQWLSEDDN HVAAIHCKAG KGRTGVMICA YLLHRGKFLR 120
AQEALDFYGE VRTRDKKGVT IPSQRRYVYY YSYLLKNH 158
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00070
EPS-ANC-00070
EPS-BOT-00060
EPS-CAE-00090
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-CIS-00020
EPS-DAR-00104
EPS-DIO-00023
EPS-DRM-00027
EPS-EQC-00058
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAG-00064
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORA-00063
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-RAN-00059
EPS-SAH-00057
EPS-SUS-00058
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
EPS-SCP-00017
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287; F:magnesium ion binding
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0043542; P:endothelial cell migration
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0060291; P:long-term synaptic potentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
KEGG
InterPros
IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
PS51181; PPASE_TENSIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
Prints
Created Date20-Feb-2013