EKS-TAG-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	343.3	9.1E-103	848	1121	274

Status

Unreviewed

Ensembl Protein

ENSTGUP00000005279

UniProt Accession

H0Z3Y5;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000005043	ENSTGUP00000005279	ENSTGUT00000005331

Organism

Taeniopygia guttata

Functional Description

Protein Length

1131

Protein Sequence
(FASTA)

TMACLTMTNM ESTATSTVRQ NGDIRGNSSA PKQTEPLLQV YLYHSPGKTE GDYLQFSAGE 60

YVAEEICAVA CKACGIMPVY HNMFALMNET DRMWYPPNHI FHVDETTRLI LIYRIRFYFP 120

HWYCSGSNRA YRYGILRGAE SPVLDDLVMS YLFAQWRTDF LDGWVQMPVT HETQEECLGM 180

AVLDMMRVAK EKDQTPMAIY NSVSYKMFLP KCVRAKIQDY HILTRKRIRY RFRKFIQQFG 240

QCKATARNLK LKYLINLETL QPAFYSEVFE VKEPGGGPSG EESFATVVIT GNGGIQCSRG 300

KLKDCETLGE QDLQTYCDFP DIIDVSIKQA SQEGSSERRI VTIHKQDSKN LEAEFQSLRE 360

ALSFVSLIDG YYRLTADAHH YLCKEVAPPS VLENIQSNCH GPIFMDFAIS KLKKAGNQTG 420

FYVLRCSPKD FKKYFLTFAI ERDSTTDYKH CLITKNENGE YNLSGTKRSF SNLKDLLTCY 480

QTETVRSDSI IFQFVKCCPP KPKDKSNLLV FRSNSVSDVS SSPMLQRHNN VNQMVFHKIR 540

NEDLIFEESL GQGTFTKIFK GVRKEVGDYG QLHQTEVLLK VLDKVHRNYS ESFFEAASMM 600

SQLSYKHLVL NYGVCVCGEE NILVQEYVKF GSLDTYLKKN KNVINILWKL EVAKQLALAM 660

HFLEDKGLVH GNVCAKNILL IREEDRKSGN LPFIKLSDPG ISITVLPRDI LLERIPWVPP 720

ECIENPKQLS LATDKWSFGT TLWEICSGGD KPLSALDSSR KLQFYEDRHQ LPAPNWTELA 780

NLINNCMDYE PDFRPSFRAI IRDLNSLFTP DYELLTESDM LPNMRIGALG FSGAFEDRDP 840

TQFEERHLKF LQQLGKGNFG SVEMCRYDPL QDNTGEVVAV KKLQHSTEEH LRDFEREIEI 900

LKSLQHDNIV KYKGVCYSAG RRNLRLIMEY LPYGSLRDYL QKHKERLDHK KLLLYASQIC 960

KGMEYLGTKR YVHRDLATRN ILVENENRVK IGDFGLTKVL PQDKEYYKVK EPGESPIFWY 1020

APESLTESKF SVASDVWSFG VVLYELFTYI DKSKSPPAEF MRMIGNDKQG QMIVFHLIEL 1080

LKNNGRLPRP DGCPDEIYAI MKECWNNNVS QRPTFRDLSQ RVDHIRENMG G 1131

Nucleotide Sequence
(FASTA)

ACTATGGCTT GTCTTACAAT GACAAATATG GAAAGTACAG CAACTTCTAC TGTCCGCCAG 60

AATGGTGACA TCCGTGGAAA TAGCAGTGCA CCCAAGCAGA CAGAACCATT GCTTCAAGTG 120

TACCTTTATC ATTCTCCTGG GAAGACAGAA GGAGATTACC TTCAGTTTTC AGCTGGAGAA 180

TATGTTGCAG AAGAGATTTG CGCTGTTGCC TGTAAAGCCT GTGGTATCAT GCCAGTGTAT 240

CATAACATGT TTGCACTCAT GAATGAAACA GACAGAATGT GGTATCCCCC AAATCACATC 300

TTCCATGTAG ATGAGACAAC CAGACTCATC CTAATTTACC GGATAAGGTT TTATTTTCCC 360

CACTGGTATT GCAGTGGCAG CAACAGAGCA TACCGGTATG GCATTCTTCG TGGTGCAGAA 420

AGCCCCGTCC TTGATGATCT TGTCATGTCT TACCTATTTG CACAGTGGCG AACTGATTTT 480

TTGGATGGAT GGGTACAGAT GCCTGTTACT CATGAAACAC AAGAAGAATG CCTTGGAATG 540

GCTGTTCTAG ATATGATGAG AGTGGCCAAA GAAAAGGACC AAACCCCAAT GGCTATTTAC 600

AATTCAGTCA GCTACAAAAT GTTTTTACCT AAGTGTGTGC GAGCAAAAAT CCAAGACTAC 660

CATATTTTGA CCCGAAAAAG AATAAGGTAC AGATTCCGCA AATTTATACA ACAGTTTGGC 720

CAATGCAAAG CTACTGCCAG AAACCTGAAA CTCAAGTATC TCATAAATCT GGAAACCCTT 780

CAGCCTGCCT TCTATTCAGA GGTTTTTGAA GTAAAAGAAC CTGGTGGAGG TCCTTCTGGA 840

GAGGAAAGTT TTGCAACTGT TGTAATAACT GGAAATGGAG GAATTCAGTG CTCAAGAGGA 900

AAACTTAAAG ATTGTGAAAC ACTTGGAGAG CAGGATTTAC AAACATACTG TGATTTTCCT 960

GATATCATTG ATGTCAGCAT TAAACAGGCG AGCCAAGAAG GCTCCAGTGA GAGAAGAATT 1020

GTCACCATTC ACAAACAAGA CAGCAAGAAT CTGGAGGCTG AATTTCAGTC ATTAAGAGAA 1080

GCTCTCTCCT TTGTATCATT AATTGATGGA TATTACAGAT TAACAGCGGA TGCACATCAT 1140

TATCTCTGTA AAGAAGTAGC ACCACCATCA GTCCTTGAAA ATATCCAAAG CAACTGTCAT 1200

GGACCAATTT TCATGGACTT TGCTATCAGT AAACTGAAGA AAGCTGGTAA TCAGACTGGT 1260

TTCTACGTTC TTCGTTGCAG TCCTAAAGAT TTTAAAAAAT ACTTCCTTAC CTTTGCTATA 1320

GAGCGTGACA GTACTACAGA TTATAAGCAC TGTTTAATTA CGAAGAATGA GAACGGAGAA 1380

TATAATCTTA GTGGAACCAA GAGAAGTTTT AGTAATCTTA AGGATCTCTT GACCTGTTAC 1440

CAGACAGAAA CTGTCCGTTC AGACAGCATA ATTTTCCAGT TCGTCAAATG CTGTCCTCCG 1500

AAACCAAAAG ATAAATCAAA TCTCCTTGTT TTCAGAAGCA ATAGCGTTTC CGATGTATCT 1560

TCATCACCTA TGCTACAGAG GCACAATAAT GTCAATCAAA TGGTCTTTCA TAAAATCCGT 1620

AATGAGGACT TGATATTCGA GGAGAGTCTT GGACAGGGCA CATTTACTAA GATTTTCAAA 1680

GGTGTAAGGA AAGAAGTGGG AGACTATGGC CAGCTCCATC AAACTGAAGT TCTTTTAAAG 1740

GTGCTGGATA AAGTGCACAG AAACTACTCT GAGTCCTTTT TTGAAGCAGC AAGTATGATG 1800

AGCCAGCTTT CTTACAAACA TTTGGTGTTG AATTATGGAG TCTGTGTTTG TGGAGAAGAG 1860

AATATCCTTG TACAAGAATA TGTAAAATTT GGATCCTTGG ACACATATTT GAAAAAGAAC 1920

AAAAATGTTA TCAATATCTT GTGGAAGCTG GAAGTAGCCA AACAGTTGGC ATTAGCCATG 1980

CATTTTCTGG AGGATAAAGG TCTTGTTCAT GGGAATGTCT GTGCAAAAAA CATCTTGCTT 2040

ATCAGAGAGG AAGACAGGAA GTCTGGAAAC CTCCCGTTTA TAAAGCTGAG TGATCCTGGC 2100

ATCAGTATTA CAGTTTTGCC AAGAGATATT CTTCTGGAGA GAATACCCTG GGTTCCCCCT 2160

GAATGTATTG AGAATCCCAA ACAGCTAAGC CTAGCTACAG ACAAGTGGAG TTTTGGTACC 2220

ACTTTGTGGG AAATCTGCAG TGGAGGAGAC AAACCCCTGA GTGCACTAGA TTCTTCAAGA 2280

AAACTACAAT TTTATGAAGA CAGGCACCAG CTTCCTGCCC CCAACTGGAC AGAACTTGCA 2340

AACCTCATAA ACAACTGCAT GGATTATGAG CCAGATTTCA GGCCTTCTTT TAGAGCAATT 2400

ATACGTGATT TGAACAGTTT GTTCACTCCA GATTACGAGC TATTGACAGA AAGTGATATG 2460

TTGCCAAATA TGAGAATTGG AGCACTTGGA TTTTCTGGCG CTTTTGAAGA TCGGGACCCA 2520

ACACAATTTG AAGAAAGACA TCTTAAGTTT TTACAGCAAC TTGGCAAGGG AAATTTTGGC 2580

AGCGTTGAGA TGTGCCGGTA TGACCCGCTG CAGGATAATA CTGGGGAGGT GGTGGCTGTG 2640

AAAAAGCTGC AACATAGCAC AGAAGAGCAC CTTAGGGACT TTGAAAGAGA AATTGAAATA 2700

CTTAAATCAC TGCAGCATGA TAACATCGTT AAATACAAAG GAGTATGCTA CAGTGCAGGA 2760

CGTAGGAATC TAAGATTAAT TATGGAATAC TTACCATACG GAAGTTTACG CGATTATCTG 2820

CAGAAACACA AGGAGAGGCT GGACCACAAG AAGCTTTTAC TGTATGCGTC TCAGATATGC 2880

AAGGGCATGG AGTATCTGGG TACAAAAAGA TATGTTCACC GGGATTTGGC AACAAGAAAT 2940

ATCTTGGTGG AGAATGAGAA CAGAGTTAAA ATTGGAGATT TTGGATTGAC GAAAGTCTTG 3000

CCACAAGACA AAGAATACTA CAAAGTAAAA GAACCTGGTG AAAGTCCTAT ATTTTGGTAC 3060

GCTCCAGAAT CTCTGACAGA AAGCAAATTT TCTGTGGCCT CGGATGTGTG GAGCTTTGGT 3120

GTGGTCTTGT ATGAACTTTT CACCTATATT GACAAAAGCA AAAGCCCACC AGCTGAATTC 3180

ATGCGCATGA TTGGCAATGA TAAACAAGGG CAGATGATTG TATTTCATTT GATAGAGCTT 3240

TTGAAGAATA ATGGACGACT GCCGAGACCA GATGGATGCC CTGATGAGAT TTATGCTATC 3300

ATGAAAGAAT GCTGGAACAA TAATGTTTCC CAGCGCCCCA CCTTTCGGGA TCTTTCTCAG 3360

CGAGTGGATC ATATAAGGGA AAACATGGGT GGATGA 3396

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 848   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  907

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke+l++++ll +a+q++k+meYL+

Q: 908   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYASQICKGMEYLG  967

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k++vhrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 968   TKRYVHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1021

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1022  PESLTESK-FSVASDVWSFGVVLYELFTyIDKSKSPpaefMRMIGNDkqgqmivfHLIEL  1080

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264

         l+++ rlp+p+ cp+e++ +m++c++++ sqrp+Fr++ ++

Q: 1081  LKNNGRLPRPDgCPDEIYAIMKECWNNNVSQRPTFRDLSQR  1121

         *************************************9765

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERL DHKKLLLYAS QICKGMEYLG 120

TKRYVHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIDKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YAIMKECWNN NVSQRPTFRD LSQR 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0030154	; P:cell differentiation
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013