EKS-TAG-00330
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00330
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20348.71.8E-10428279252
StatusUnreviewed
Ensembl ProteinENSTGUP00000005243
UniProt AccessionH0Z3U9;
Protein Name
Protein Synonyms/Alias
Gene NameSTK4
Gene Synonyms/Alias STK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000005057ENSTGUP00000005243ENSTGUT00000005295
OrganismTaeniopygia guttata
Functional Description
Protein Length485
Protein Sequence
(FASTA)
VIISLSYPYR QLKKLDEDSL TKQPEEVFDV LEKLGEGSYG SVFKAIHKET GQVVAIKQVP 60
VESDLQEIIK EISIMQQCDS PHVVKYYGSY FKNTDLWIVM EYCGAGSVSD IIRLRNKTLT 120
EEEIATIVQS TLKGLEYLHF MRKIHRDIKA GNILLNTEGH AKLADFGVAG QLTDTMAKRN 180
TVIGTPFWMA PEVIQEIGYN CVADIWSLGI TAIEMAEGKP PYADIHPMRA IFMIPTNPPP 240
TFRKPELWSD NFTDFVKQCL VKSPEQRATA TQLLQHPFVK SAKGVSILRD LINEAMDIKL 300
KRQEAQQREL DQEDEENSEE DETDSGTMVR ASGDETGTIR AVNTMSDGAN TMIEHDGTLE 360
SQLGTMVINT EEEEEEGTMK RRDETMQPAR PSFLEYFEQK EKENQINSFG KNVSGQTKNS 420
SDWKVPQDGD YEFLKSWSVD ELQKRLSALD PMMEQEIEEI RQKYQSKRQP ILDAIEAKKR 480
RQQNF 485
Nucleotide Sequence
(FASTA)
GTAATAATTT CTCTCTCTTA CCCATACAGG CAGCTGAAGA AGTTAGATGA AGACAGTTTA 60
ACAAAACAGC CTGAAGAAGT ATTTGATGTC CTGGAGAAGC TTGGAGAAGG TTCTTATGGC 120
AGTGTGTTCA AAGCCATCCA TAAAGAAACG GGTCAAGTTG TTGCAATTAA ACAAGTTCCT 180
GTGGAATCTG ACCTGCAAGA AATTATCAAG GAAATATCCA TAATGCAACA ATGCGATAGT 240
CCTCATGTGG TGAAATACTA CGGCAGCTAT TTTAAGAACA CAGACCTGTG GATAGTCATG 300
GAATACTGTG GTGCTGGATC TGTGTCTGAC ATTATTCGGT TACGAAACAA AACTCTCACA 360
GAGGAGGAAA TTGCTACAAT AGTGCAATCG ACTCTGAAAG GACTGGAGTA CCTGCATTTT 420
ATGAGGAAAA TACACAGGGA CATCAAAGCT GGAAATATAT TGCTAAATAC AGAGGGACAT 480
GCTAAGCTTG CTGATTTTGG AGTGGCAGGA CAACTTACAG ACACCATGGC AAAGCGGAAC 540
ACAGTCATAG GGACCCCATT TTGGATGGCT CCAGAAGTGA TTCAGGAAAT TGGGTATAAT 600
TGTGTGGCAG ACATCTGGTC CCTGGGAATC ACTGCAATAG AAATGGCTGA AGGAAAGCCA 660
CCATATGCAG ATATTCATCC CATGAGGGCA ATTTTCATGA TTCCTACCAA TCCACCTCCA 720
ACATTCCGGA AACCGGAGCT GTGGTCGGAC AATTTTACAG ACTTTGTGAA GCAGTGTCTC 780
GTGAAGAGCC CGGAGCAGAG AGCCACTGCA ACACAGCTGC TGCAGCATCC ATTTGTTAAA 840
AGTGCCAAAG GAGTATCAAT TCTGCGGGAC CTGATTAATG AAGCAATGGA CATCAAGCTG 900
AAACGCCAAG AGGCACAACA GCGTGAGCTT GATCAAGAGG ATGAAGAAAA TTCAGAGGAG 960
GATGAGACGG ATTCGGGTAC CATGGTGAGG GCGAGTGGAG ATGAAACTGG CACAATCAGA 1020
GCAGTGAACA CCATGAGTGA TGGAGCCAAC ACCATGATAG AACACGATGG CACCCTGGAG 1080
TCCCAGCTGG GCACAATGGT CATCAACACC GAGGAGGAAG AGGAGGAGGG CACCATGAAA 1140
AGGAGGGACG AAACAATGCA GCCAGCCAGA CCATCATTCC TTGAATACTT TGAACAGAAA 1200
GAGAAGGAGA ATCAAATCAA TAGCTTTGGG AAGAATGTTT CTGGCCAGAC AAAAAATTCA 1260
TCTGATTGGA AAGTACCACA GGATGGAGAC TACGAATTTC TGAAGTCTTG GAGCGTGGAT 1320
GAGCTGCAGA AGAGGCTCTC TGCCCTGGAC CCCATGATGG AGCAGGAGAT CGAGGAGATT 1380
CGCCAGAAGT ACCAGTCCAA GCGGCAGCCG ATCCTCGATG CCATCGAAGC CAAGAAGCGG 1440
CGGCAGCAGA ACTTCTGA 1458
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+v++a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 28    FDVLEKLGEGSYGSVFKAIHKETGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  85
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+Ee+ia+i++++lk+LeylH +++i
Q: 86    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEEEIATIVQSTLKGLEYLHFMRKI  144
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 145   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  202
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         aDiwslGItaie+aeg+pP++d++p++a+++i++n+pp++++++ +s++f++fv++cl k
Q: 203   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVK  262
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         +pe+R++a++ll+h+F+
Q: 263   SPEQRATATQLLQHPFV  279
         ****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVFKAIH KETGQVVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEEEIATI VQSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITAIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEL WSDNFTDFVK QCLVKSPEQR 240
ATATQLLQHP FV 252
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00294
EKS-ANC-00306
EKS-BOT-00313
EKS-CAE-00261
EKS-CAJ-00321
EKS-CAF-00316
EKS-CAP-00348
EKS-CII-00180
EKS-CIS-00082
EKS-DAR-00665
EKS-DRM-00159
EKS-EQC-00306
EKS-FEC-00300
EKS-GAM-00197
EKS-GAG-00267
EKS-GAA-00391
EKS-GOG-00309
EKS-HOS-00321
EKS-ICT-00294
EKS-LAC-00325
EKS-LOA-00325
EKS-MAM-00328
EKS-MEG-00256
EKS-MOD-00310
EKS-MUM-00346
EKS-MUP-00308
EKS-MYL-00313
EKS-NOL-00288
EKS-ORN-00415
EKS-ORA-00276
EKS-ORC-00297
EKS-ORL-00377
EKS-OTG-00323
EKS-PAT-00297
EKS-PES-00280
EKS-POA-00303
EKS-RAN-00329
EKS-SAH-00293
EKS-SOA-00034
EKS-SUS-00276
EKS-TAR-00411
EKS-TEN-00410
EKS-TUT-00072
EKS-XIM-00408
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0035329; P:hippo signaling cascade
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0018105; P:peptidyl-serine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013