EKS-TAG-00152
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00152
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met476.81.5E-14310791339261
StatusUnreviewed
Ensembl ProteinENSTGUP00000005389
UniProt AccessionH0Z494;
Protein Name
Protein Synonyms/Alias
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000005136ENSTGUP00000005389ENSTGUT00000005443
OrganismTaeniopygia guttata
Functional Description
Protein Length1382
Protein Sequence
(FASTA)
MKPFTAYPSG FIVFLFALLQ RSHGQCKEAA KKSEMNLGVK YDLPNFIADT PIQNVVLYKH 60
HVYIGAVNKI YVLNETLQNI SVYKTGPVLE NPDCAPCEDC REKANLSNSI WKDNVNMALL 120
LETYYDDQLI SCGSVSGGIC HRHIIHPDNP ADIESEVHCM YSPQADGEAD NCPDCVVSTL 180
GTKVLVTEKD RFVNFFVGNT VTSTFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ 240
FRDSYPIRYV HAFENDHFVY FLTVQRETLD SQSFHTRIIR FCTLDSEMRS YMEMPLECIF 300
TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLNDD ILYGVFAQSK PDSSEPTNRS 360
AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKESKYCLNR AFSRNASYCR AQDDEYRLEV 420
TTPLQRVDLF MGQFNSVLLT SISVFTKGNL TIANLGTSEG RFMQIVVSRS ESTTPHVSFQ 480
LDSHPISPQV VVKNSLADDG YTLVVTGKKI TKIPLKGPGC HHFRSCSQCL LAPAFMQCGW 540
CSQQCLRSSE CPSNTWTQDT CLPRVYEILP SSAPIEGGTK LTLCGWDFGF SKNNRFELKS 600
TVVHIGGQIC PLEVKSSNKN RLECTVPAAK SPSFNISSSV SVGHGKTLFN TFSYVNPVIT 660
SISPSYGPKS GGTLLTVSGK YLDSGKSMRI FVGEQPCTLK SISASTVECY TPAQQFPQEF 720
RVRMEIDEAI RDTSSHFTYR EDPVVLKIHP AKSFLSGGST ITAQGINLNS LCFPQMVITV 780
PKLGMNFSVA CSHRSSSEII CCTTPSLKDF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP 840
VFKHFEKTVF ISRGNQNVLE IKGNYIDSEA VKGEVLKVGN KSCENLLLQS ESILCTVPSD 900
LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGIL STSILIFIFL VFFFWRRKKK 960
QIKDLGSDLV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE SVDYRSTFLE DQFPSMSQNG 1020
SCRPAQYPHS DLSPILSSGD SDLASPLLQS NVHIDISALN PDLVKEVQHV VIGADSLIVH 1080
FSEVIGRGHF GCVYHGTLLD NDSRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV 1140
LSLLGICLPN EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200
FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260
FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320
WHPKPEMRPA FSELVSKIST IFSTFVGEHY VHVNATYVNV KCIAPYPSLL SSQDNTDVDV 1380
DT 1382
Nucleotide Sequence
(FASTA)
ATGAAGCCTT TTACTGCATA TCCTTCTGGG TTTATCGTAT TCCTGTTTGC CTTGCTGCAG 60
AGGAGCCATG GACAATGCAA AGAAGCAGCT AAAAAATCAG AGATGAATCT TGGTGTAAAA 120
TATGATCTTC CTAACTTCAT TGCAGACACA CCAATTCAGA ATGTAGTTTT ATACAAGCAT 180
CATGTTTATA TTGGAGCAGT GAATAAGATT TACGTACTAA ATGAAACTCT CCAGAACATT 240
TCTGTGTACA AGACTGGGCC TGTTTTGGAG AACCCTGACT GTGCACCATG TGAAGACTGC 300
CGAGAAAAAG CCAATTTATC TAACAGCATA TGGAAGGATA ACGTCAACAT GGCACTGCTT 360
TTAGAAACTT ATTATGATGA TCAACTCATC AGCTGTGGTA GTGTGTCCGG AGGCATCTGC 420
CACCGTCACA TCATTCACCC TGACAACCCT GCTGACATTG AAAGTGAGGT GCACTGCATG 480
TACTCACCCC AGGCAGATGG AGAAGCAGAC AACTGTCCTG ATTGTGTTGT TAGCACGTTA 540
GGAACCAAAG TTTTGGTGAC TGAAAAGGAC AGGTTTGTCA ACTTTTTTGT TGGAAATACT 600
GTGACATCTA CATTTCAACC TCCCCATGTG CTGCATTCAA TATCGGTTAG AAGATTAAAA 660
GAAACGCAGG ATGGTTTTGA GTTTCTCACA GATCAATCTT ATATAGATAT CCTCCCTCAG 720
TTCCGTGACT CATATCCTAT TAGGTATGTC CATGCCTTTG AAAACGATCA CTTTGTCTAT 780
TTTTTGACTG TACAGAGAGA AACTCTTGAC TCACAATCTT TTCACACTAG AATTATCCGC 840
TTCTGCACTT TAGACTCAGA GATGCGTTCC TACATGGAAA TGCCTCTTGA GTGCATTTTT 900
ACTGAAAAGC GAAGGAAGAG GTCCATCCGA AAGGAGGTAT TCAACATTTT GCAAGCTGCC 960
TATGTAAGCA AGCCTGGTGC AGCTCTAGCA CATGAAATGG GCCTTGGGCT CAACGATGAT 1020
ATCCTCTATG GTGTTTTTGC ACAAAGCAAA CCAGACTCTT CTGAACCAAC TAACCGATCT 1080
GCTGTCTGCG CCGTCTCTGT GCGAACCATC AATGAGTTCT TCAACAAGAT TGTTGACAAG 1140
CAGAACATGA AATGCCTCCA ACACTTTTAC GGGAAAGAGA GCAAATACTG CTTGAACAGG 1200
GCTTTTTCAA GAAATGCTTC GTACTGCAGA GCACAAGATG ATGAATATCG CTTAGAAGTT 1260
ACGACTCCTC TGCAGAGGGT AGACTTGTTC ATGGGCCAGT TCAACAGTGT CCTGTTGACT 1320
TCGATATCCG TCTTCACTAA AGGGAACCTT ACCATTGCTA ACCTGGGAAC TTCAGAGGGC 1380
CGCTTCATGC AGATAGTGGT TTCCCGTTCA GAATCCACAA CTCCACATGT CAGCTTTCAG 1440
CTAGACTCCC ACCCCATCTC TCCCCAGGTT GTTGTCAAGA ATTCATTAGC AGATGATGGC 1500
TATACCCTGG TAGTGACTGG GAAAAAGATA ACAAAAATCC CTCTGAAGGG GCCAGGCTGC 1560
CATCACTTCA GGTCCTGCAG CCAGTGCCTC CTGGCACCAG CCTTCATGCA GTGTGGCTGG 1620
TGCAGCCAGC AATGCCTCAG ATCTTCTGAG TGCCCCAGCA ACACCTGGAC CCAGGACACC 1680
TGCTTGCCTA GGGTTTATGA GATTCTCCCA AGCAGCGCTC CCATAGAAGG CGGGACAAAA 1740
TTGACACTGT GTGGATGGGA CTTTGGATTC AGCAAAAATA ACAGATTTGA ATTAAAAAGT 1800
ACAGTAGTCC ATATTGGAGG ACAAATTTGT CCTCTGGAAG TGAAATCTAG CAACAAAAAT 1860
AGGCTGGAAT GCACAGTTCC TGCTGCAAAA AGTCCAAGTT TTAATATATC CAGTAGTGTT 1920
TCTGTTGGAC ATGGCAAAAC ACTATTCAAT ACATTTTCAT ATGTGAATCC TGTAATAACA 1980
AGTATATCTC CCAGCTATGG CCCCAAATCT GGAGGAACAT TGTTGACTGT ATCTGGAAAA 2040
TACCTAGACA GTGGGAAATC CATGAGGATT TTTGTCGGGG AGCAGCCGTG TACTTTGAAA 2100
AGTATATCGG CGAGCACTGT GGAGTGCTAC ACTCCAGCAC AGCAATTTCC CCAGGAATTT 2160
CGTGTGAGAA TGGAAATCGA TGAAGCTATT CGAGACACGA GCAGCCATTT CACATACAGG 2220
GAAGATCCAG TTGTTTTAAA AATTCATCCA GCCAAATCTT TTCTTAGTGG TGGAAGTACA 2280
ATCACAGCTC AGGGAATCAA CTTGAACTCA TTGTGTTTTC CTCAGATGGT GATTACTGTA 2340
CCTAAACTAG GAATGAACTT CTCTGTGGCA TGTAGCCACC GCTCTAGCTC AGAGATAATC 2400
TGCTGTACAA CACCTTCACT GAAAGATTTC AATCTCCAAC CACCCTTTGT GACCAAAGTG 2460
TTCTTTATTT TTGATGGTGT CAGCTCCCTG TACTTTGATT TTGATTACGT AAATAATCCT 2520
GTATTTAAGC ATTTTGAAAA GACAGTGTTC ATCTCAAGAG GCAACCAAAA TGTTCTGGAA 2580
ATTAAGGGAA ATTATATTGA TTCAGAAGCT GTTAAAGGTG AAGTCCTAAA AGTTGGAAAC 2640
AAAAGCTGTG AAAACCTTCT CCTACAGTCA GAATCAATTC TGTGTACGGT TCCCAGTGAT 2700
CTCCTGAAAT CCAACAGTGA GCTAAATATA GAGTGGAAGC AAGAAGTTTT GTCAACAGTT 2760
ATCGGAAAAG TGCTGATCCG GCAAGATCAG AATTTCACGG GACTAATTGC TGGAATTCTT 2820
TCAACATCAA TCTTAATTTT CATCTTTTTG GTGTTTTTCT TCTGGAGAAG GAAGAAGAAA 2880
CAAATTAAAG ATCTGGGAAG TGACCTAGTT CGTTATGATG GCAGAGTGCA CACTCCTCAC 2940
CTGGACAGGC TGGTGAGTGC AAGGAGTGTA AGTCCAACAA CAGAAATGGT TTCAAGCGAA 3000
TCTGTAGACT ACAGATCAAC TTTTCTAGAA GATCAGTTTC CAAGCATGTC TCAGAATGGA 3060
TCGTGCAGAC CTGCCCAGTA TCCTCACTCT GACCTCTCCC CGATTCTGTC TAGCGGAGAC 3120
TCAGACTTAG CCAGTCCACT TCTCCAAAGT AATGTCCACA TAGACATCAG TGCCTTAAAT 3180
CCCGACCTGG TCAAAGAAGT GCAGCACGTG GTTATTGGTG CTGACAGTCT GATTGTGCAC 3240
TTCAGTGAAG TAATAGGAAG AGGACATTTT GGCTGTGTGT ACCATGGGAC ATTGCTGGAT 3300
AACGATAGCA GGAAAATTCA TTGTGCTGTG AAGTCACTGA ATAGGATTAC AGACCTGGAA 3360
GAAGTAGCTC AGTTTCTGAA AGAAGGAATA ATCATGAAAG ATTTCACTCA TCCCAATGTT 3420
CTGTCACTCC TGGGAATCTG TTTGCCCAAT GAAGGATCCC CATTGGTTGT TCTTCCATAC 3480
ATGAAACATG GAGATCTTCG AAACTTCATT AGGAATGAGA CTCACAATCC AACAGTAAAA 3540
GATTTAATTG GATTTGGCCT TCAGGTTGCA AAAGGAATGA AATACCTTGC AAGTAAAAAG 3600
TTTGTCCATA GAGATCTGGC AGCAAGAAAC TGTATGTTGG ATGAAAAATT TACTGTCAAG 3660
GTTGCTGATT TTGGTCTTGC TAGAGATGTC TATGATAAAG AATACTACAG TGTGCACAAT 3720
AAAACAGGAG CTAAACTGCC AGTGAAATGG ATGGCTTTAG AAAGTTTACA AACTCAGAAG 3780
TTCACAACAA AGTCAGATGT GTGGTCCTTT GGTGTATTGT TATGGGAACT TATGACACGA 3840
GGGGCACCAC CTTATCCTGA TGTAAATTCT TTTGATATAA CTGTTTACTT ACTACAAGGA 3900
AGAAGGCTGC TGCAACCTGA ATACTGCCCG GATCCACTGT ATGAAGTCAT GCTGAAGTGC 3960
TGGCATCCGA AACCTGAGAT GCGTCCCGCA TTTTCTGAAC TTGTTTCAAA AATATCAACA 4020
ATCTTCTCCA CTTTTGTTGG GGAACACTAT GTTCATGTCA ATGCTACTTA TGTCAATGTC 4080
AAGTGCATTG CTCCCTATCC TTCTCTTCTA TCATCACAAG ACAACACAGA TGTGGATGTT 4140
GACACATGA 4149
Domain Profile
S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60
         v+++eviG+GhfG+vy+g+l+d++s+ki++avksl+ritd+e+v +fl+eg++mk++ hp
Q: 1079  VHFSEVIGRGHFGCVYHGTLLDNDSRKIHCAVKSLNRITDLEEVAQFLKEGIIMKDFTHP  1138
         7999********************************************************
S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120
         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas
Q: 1139  NVLSLLGICLPNEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198
         ************************************************************
S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180
         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt
Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  1258
         ************************************************************
S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240
         +k fttksdvwsfGvllwel+trga+py++v+sfd+t+yl +grrl +peycpd ly+vm
Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNSFDITVYLLQGRRLLQPEYCPDPLYEVM  1317
         **.*********************************************************
S: 241   lkcwkakpaerpqfsdlvsiis  262
         lkcw++kp++rp fs+lvs+is
Q: 1318  LKCWHPKPEMRPAFSELVSKIS  1339
         *******************997
Domain Sequence
(FASTA)
VHFSEVIGRG HFGCVYHGTL LDNDSRKIHC AVKSLNRITD LEEVAQFLKE GIIMKDFTHP 60
NVLSLLGICL PNEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120
KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180
QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NSFDITVYLL QGRRLLQPEY CPDPLYEVML 240
KCWHPKPEMR PAFSELVSKI S 261
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-CII-00062
EKS-CIS-00142
EKS-DAR-00379
EKS-ECT-00004
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-PTV-00106
EKS-RAN-00120
EKS-SAH-00115
EKS-SOA-00004
EKS-SUS-00109
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
EKS-XIM-00148
Gene Ontology
GO:0009925; C:basal plasma membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005008; F:hepatocyte growth factor-activated receptor activity
GO:0000187; P:activation of MAPK activity
GO:0042593; P:glucose homeostasis
GO:0007275; P:multicellular organismal development
GO:0014812; P:muscle cell migration
GO:0051450; P:myoblast proliferation
GO:0010828; P:positive regulation of glucose transport
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
KEGG
tgu:100227998;
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 2.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013