EKS-TAG-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.5	1.7E-134	233	520	288

Status

Unreviewed

Ensembl Protein

ENSTGUP00000005891

UniProt Accession

H0Z5P5;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000005714	ENSTGUP00000005891	ENSTGUT00000005950

Organism

Taeniopygia guttata

Functional Description

Protein Length

531

Protein Sequence
(FASTA)

MTRLRVHEQL LGAYLLIILH VQGQKPDSML HGTGMKTNSD QKKQANGVTL APEDTLPFLK 60

CYCSGHCPDD AINNTCITNG HCFAIIEEDE HGEPTLASGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTDFC NQDLQPTLPP LDNGLFDGSI RWMAVLISMA VCIIVMVILL SCFCYKHYCK 180

SMAKRHCYNR DLEQDEAFIP AGESLKDLID QSQSSGSGSG LPLLVQRTIA KQIQMVRQVG 240

KGRYGEVWMG KWRGEKVAVK VFFTTEEASW FRETEIYQTV LMRHENILGF IAADIKGTGS 300

WTQLYLITDY HENGSLYDFL KCTTLDNRAL LKLAYSAACG LCHLHTEIYG TQGKPAIAHR 360

DLKSKNILIK KNGTCCIADL GLAVKFNSDT NEVDVPLNTR VGTKRYMAPE VLDESLNKNH 420

FQPYIMADIY SFGLIIWEMA RRCVTGGIVE EYQLPYYDMV PNDPSYEDMR EVVCVKRLRP 480

VVSNRWNSDE CLRAILKLMS ECWAHNPASR LTALRIKKTL AKMVESQDVK I 531

Nucleotide Sequence
(FASTA)

ATGACTCGAT TGAGAGTTCA TGAGCAATTG CTTGGAGCCT ATCTGCTTAT CATTCTCCAT 60

GTTCAAGGTC AAAAGCCAGA CAGCATGCTT CATGGTACAG GAATGAAGAC AAATTCTGAC 120

CAAAAGAAAC AAGCAAATGG AGTAACACTT GCTCCAGAGG ACACCCTACC TTTTCTTAAA 180

TGCTACTGCT CAGGACATTG TCCAGATGAT GCTATTAACA ACACATGCAT AACTAATGGG 240

CATTGCTTTG CAATCATTGA GGAGGATGAA CATGGAGAAC CCACGCTTGC TTCTGGCTGC 300

ATGAAGTATG AAGGTTCAGA CTTCCAGTGC AAGGACTCCC CTAAAGCGCA GTTACGCCGA 360

ACGATTGAGT GCTGTCGCAC TGATTTCTGC AATCAGGATT TGCAACCAAC ATTGCCACCT 420

CTTGATAATG GACTTTTTGA TGGCAGCATT CGTTGGATGG CAGTGTTGAT TTCTATGGCA 480

GTCTGCATAA TTGTCATGGT CATCTTACTT AGCTGCTTTT GTTACAAGCA CTACTGTAAG 540

TCGATGGCAA AGAGGCACTG TTATAATCGT GACCTGGAAC AAGATGAAGC ATTTATTCCA 600

GCTGGGGAGT CATTAAAAGA CCTTATTGAC CAGTCACAGA GTTCTGGGAG TGGATCAGGA 660

CTACCACTGT TGGTTCAGCG TACTATTGCC AAACAAATTC AGATGGTGAG GCAAGTTGGA 720

AAAGGGCGAT ATGGTGAAGT GTGGATGGGC AAATGGAGGG GTGAAAAAGT GGCAGTCAAA 780

GTGTTTTTCA CCACAGAAGA AGCCAGCTGG TTCAGAGAAA CAGAGATTTA CCAAACTGTT 840

CTCATGCGAC ATGAAAACAT CCTCGGTTTC ATAGCAGCAG ATATTAAAGG CACTGGCTCC 900

TGGACACAGC TTTACTTGAT TACGGATTAC CATGAAAACG GATCATTGTA TGATTTTCTG 960

AAGTGCACTA CTCTGGACAA CAGGGCTCTG CTCAAACTGG CCTATTCTGC TGCATGTGGC 1020

CTGTGCCACC TGCACACAGA AATCTATGGG ACACAAGGCA AGCCTGCAAT TGCACACAGG 1080

GACCTGAAGA GTAAAAACAT CTTGATAAAG AAAAACGGAA CCTGCTGCAT TGCGGACTTG 1140

GGTCTTGCAG TCAAGTTCAA CAGTGACACA AACGAAGTTG ACGTTCCCTT GAACACCAGA 1200

GTGGGAACGA AACGTTACAT GGCTCCAGAA GTCCTGGATG AAAGCCTGAA TAAAAACCAT 1260

TTCCAGCCAT ACATCATGGC TGACATCTAC AGTTTTGGGC TGATCATCTG GGAAATGGCT 1320

CGGCGCTGTG TCACAGGAGG TATTGTTGAA GAGTACCAGT TGCCATATTA TGACATGGTG 1380

CCAAATGATC CATCCTATGA GGACATGAGA GAAGTGGTGT GTGTCAAACG CCTGCGCCCC 1440

GTGGTGTCGA ACAGATGGAA CAGCGATGAA TGTTTAAGAG CAATATTGAA GTTGATGTCT 1500

GAGTGCTGGG CTCATAATCC TGCCTCGAGG CTCACTGCCT TGAGGATCAA GAAGACACTT 1560

GCCAAGATGG TGGAATCACA AGATGTAAAG ATTTGA 1596

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 233   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  292

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk +tld + ll+la+s+a+Gl+hLH+ei gt+

Q: 293   ADIKGTGSWTQLYLITDYHENGSLYDFLKCTTLDNRALLKLAYSAACGLCHLHTEIYGTQ  352

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk++tcciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 353   G--KPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  410

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v++dPs+e+m

Q: 411   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCVT-GGIVEEYQLPYYDMVPNDPSYEDM  469

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 470   REVVCVKRLRPVVSNRWNSDECLRAILKLMSECWAHNPASRLTALRIKKTL  520

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC TTLDNRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GTCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIIWEMARR CVTGGIVEEY QLPYYDMVPN DPSYEDMREV 240

VCVKRLRPVV SNRWNSDECL RAILKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005524	; F:ATP binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0030154	; P:cell differentiation
GO:0048589	; P:developmental growth
GO:0006955	; P:immune response
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013