EKS-TAG-00328

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00328

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	350.5	4.9E-105	250	501	252

Status

Unreviewed

Ensembl Protein

ENSTGUP00000006017

UniProt Accession

H0Z619;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2

Gene Synonyms/Alias

PAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000005832	ENSTGUP00000006017	ENSTGUT00000006076

Organism

Taeniopygia guttata

Functional Description

Protein Length

525

Protein Sequence
(FASTA)

MSDNGELEDK PPAPPVRMSS AIFSAGGKDQ LVTNNSFKPL PSVPEERKPR HKIISIFYSN 60

EKALVKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120

QAVLDVLKFY DSKDTAKQKY LSFSAPEKDG FPSGTPTTNA KGSEPSTAVA DDDEDDEEAP 180

PPVIAPRPDH TKSIYTRSVI DPIPAPAGDT CADSASKAGD KQKKKTKMSD EDIMEKLRTI 240

VSIGDPKKKY TRYEKIGQGA SGTVFTAIDV ATGQEVAIKQ INLQKQPKKE LIINEILVMK 300

ELKNPNIVNF LDSYLVGDEL FVVMEYLAGG SLTDVVTETC MDEAQIAAVC RECLQALEFL 360

HANQVIHRDI KSDNVLLGMD GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA 420

YGPKVDIWSL GIMAIEMVEG EPPYLNENPL RALYLIATNG TPELQNPEKL SPIFRDFLNR 480

CLEMDVEKRG SAKELLQHPF LKLAKPLSSL TPLILAAKEA MKSNR 525

Nucleotide Sequence
(FASTA)

ATGTCTGACA ACGGAGAACT GGAAGACAAG CCCCCCGCCC CTCCTGTCCG GATGAGCAGT 60

GCTATCTTCA GTGCAGGGGG CAAAGACCAG TTGGTGACCA ACAACAGCTT TAAACCCCTG 120

CCCTCTGTCC CAGAAGAGAG GAAACCCAGG CATAAAATCA TCTCCATATT CTATAGCAAT 180

GAAAAAGCTT TGGTAAAGAA GGAAAAGGAA AGGCCAGAAA TCTCCCCACC GTCAGATTTT 240

GAGCACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AGTTCACTGG AATGCCAGAA 300

CAATGGGCTC GGTTGCTTCA GACCTCAAAT ATCACCAAGC TAGAACAGAA GAAAAACCCC 360

CAGGCGGTAC TAGATGTGCT GAAATTCTAC GACTCCAAAG ACACAGCAAA ACAGAAATAT 420

CTGAGTTTTT CTGCTCCAGA AAAAGATGGT TTCCCTTCAG GAACACCAAC GACCAATGCC 480

AAAGGTTCAG AACCATCAAC AGCTGTGGCA GATGATGATG AGGATGATGA AGAGGCTCCT 540

CCTCCTGTGA TTGCTCCACG GCCAGATCAC ACAAAATCGA TTTACACCCG CTCTGTCATT 600

GACCCCATCC CTGCCCCGGC CGGTGACACC TGCGCCGACA GCGCCTCCAA AGCAGGGGAC 660

AAGCAGAAAA AGAAAACCAA GATGTCAGAT GAAGACATCA TGGAAAAACT ACGTACTATT 720

GTAAGCATAG GAGATCCTAA GAAAAAATAC ACCAGATATG AAAAAATCGG GCAGGGGGCT 780

TCAGGTACAG TTTTCACAGC TATTGATGTG GCAACAGGAC AGGAGGTGGC TATTAAACAG 840

ATCAATTTGC AGAAACAGCC CAAGAAGGAG CTGATAATTA ATGAGATCTT GGTAATGAAG 900

GAGCTAAAGA ACCCCAACAT AGTCAACTTC CTGGACAGTT ACCTCGTAGG GGATGAGTTG 960

TTTGTGGTGA TGGAGTATCT GGCTGGAGGC TCTCTAACAG ATGTGGTCAC AGAGACGTGT 1020

ATGGATGAAG CACAGATTGC TGCTGTCTGC AGAGAGTGCT TGCAAGCGCT TGAGTTCCTC 1080

CATGCCAACC AGGTGATCCA CAGGGACATA AAGAGTGACA ATGTGCTGTT AGGAATGGAT 1140

GGATCAGTTA AATTAACTGA CTTTGGGTTC TGTGCCCAGA TCACCCCTGA GCAAAGCAAG 1200

CGCAGCACCA TGGTGGGAAC TCCATACTGG ATGGCTCCCG AGGTGGTCAC ACGGAAAGCC 1260

TACGGCCCCA AAGTGGACAT CTGGTCCCTG GGCATCATGG CTATTGAGAT GGTGGAAGGA 1320

GAGCCCCCAT ACCTCAACGA GAACCCCCTG AGGGCTTTAT ATTTGATAGC AACTAATGGC 1380

ACACCAGAAC TCCAGAACCC CGAGAAACTG TCCCCAATAT TCCGGGATTT CTTGAACCGA 1440

TGTTTGGAGA TGGATGTGGA AAAAAGAGGA TCAGCCAAAG AATTGCTACA GCATCCCTTC 1500

TTGAAACTGG CCAAACCTCT GTCCAGCTTG ACGCCACTGA TCCTGGCAGC CAAAGAAGCA 1560

ATGAAGAGTA ACCGCTAA 1578

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a ++ tg+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 250   YTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  309

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+s+l+ +el++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++vi

Q: 310   FLDSYLVGDELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVI  366

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 367   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  424

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 425   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM  484

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 485   DVEKRGSAKELLQHPFL  501

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTAID VATGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSYLVGDE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030296	; F:protein tyrosine kinase activator activity
GO:0043066	; P:negative regulation of apoptotic process
GO:2001271	; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:2001238	; P:positive regulation of extrinsic apoptotic signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013