EKS-TAG-00442
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00442
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.71.7E-130230479250
StatusUnreviewed
Ensembl ProteinENSTGUP00000006771
UniProt AccessionH0Z868;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000006558ENSTGUP00000006771ENSTGUT00000006839
OrganismTaeniopygia guttata
Functional Description
Protein Length493
Protein Sequence
(FASTA)
MGCVRSKQAG VQEKMIKTDP DPDPGPTIQQ GHYVRDPTAT NKRGLGDSVV LALYDYEAMN 60
AGDLSFQKGE RMKVLEKSGE WWQARSLVTG HEGFIPSNYV AQENSLETEE WFFKDISRKD 120
AERQLLGPGN MIGSFMIRDS ETTKGSYSLS VRDGDELRGG AVKHYKIRTL DSGGFYISPR 180
NNFNTLQELV QHYKGQSDGL CQKLTHPCRV PKPEKPWEKD AWEIPRESLS LERKLGAGQF 240
GEVWMATYNK HTKVAVKTMK PGSMSVEAFL EEANLMKTLQ HDKLVKLHAV VTREEPILII 300
TEFMEKGSLL DFLKSDEGNK LLLPKLIDFS AQIAEGMAFI EKRNYIHRDL RAANILVSAA 360
LVCKIADFGL ARVIEDTEYT AREGAKFPIK WTAPEAINYG SFTIKSDVWS FGILLTEIIT 420
YGRIPYPGMS NVEVIRALER GYRMPRTDNC PEELYDIMMR CWKIKPEDRP TFEYIQSVLE 480
DFFTATESQY QQQ 493
Nucleotide Sequence
(FASTA)
ATGGGTTGTG TGAGGTCAAA GCAAGCTGGT GTCCAAGAGA AGATGATAAA AACTGATCCT 60
GACCCTGATC CTGGCCCCAC CATCCAGCAG GGCCACTATG TGAGGGACCC CACAGCCACC 120
AACAAGAGGG GCCTGGGGGA CAGCGTGGTG CTGGCACTCT ACGACTACGA GGCCATGAAC 180
GCTGGGGACC TCAGCTTCCA GAAAGGGGAG AGGATGAAGG TCCTGGAGAA GTCAGGGGAA 240
TGGTGGCAAG CACGGTCACT GGTGACAGGA CATGAAGGCT TCATCCCCAG CAACTACGTT 300
GCCCAAGAAA ACTCGCTGGA GACAGAGGAG TGGTTTTTCA AGGACATCAG CCGGAAGGAT 360
GCGGAGCGGC AGCTCCTTGG CCCTGGGAAC ATGATTGGGT CCTTCATGAT AAGGGACAGT 420
GAGACAACAA AAGGCTCATA CTCGCTCTCG GTGCGGGACG GGGACGAGCT GCGGGGCGGG 480
GCAGTGAAGC ACTACAAGAT CCGCACTCTG GACAGCGGTG GCTTCTACAT CTCCCCACGA 540
AACAACTTCA ACACGCTGCA GGAGCTGGTC CAGCACTACA AAGGTCAGAG TGATGGGCTG 600
TGCCAGAAGC TCACCCACCC CTGCCGTGTA CCCAAACCAG AGAAGCCCTG GGAGAAAGAT 660
GCCTGGGAGA TCCCTCGGGA GTCCCTGAGC CTGGAGAGGA AGCTGGGAGC CGGGCAGTTC 720
GGAGAAGTGT GGATGGCTAC CTACAACAAG CACACCAAGG TGGCGGTGAA GACGATGAAG 780
CCGGGCAGCA TGTCCGTGGA AGCCTTCCTG GAGGAGGCAA ACCTGATGAA GACTCTGCAG 840
CACGACAAGC TGGTGAAGCT GCATGCCGTG GTCACCAGGG AGGAGCCCAT CCTCATCATC 900
ACCGAGTTCA TGGAGAAAGG GAGCTTGCTG GATTTCCTGA AGAGTGATGA GGGGAACAAG 960
CTGCTGCTCC CAAAGCTGAT TGACTTCTCT GCCCAGATTG CAGAAGGAAT GGCTTTTATT 1020
GAGAAGAGGA ACTACATCCA CAGAGACCTG AGAGCTGCCA ACATCCTGGT GTCAGCAGCG 1080
CTGGTGTGCA AGATTGCAGA CTTTGGGCTG GCCAGGGTGA TCGAGGACAC CGAGTACACG 1140
GCCCGGGAAG GTGCCAAGTT TCCCATTAAA TGGACTGCAC CTGAAGCCAT CAACTACGGA 1200
TCTTTCACTA TAAAATCGGA TGTCTGGTCC TTTGGGATCC TCCTGACTGA GATCATTACC 1260
TATGGACGCA TCCCTTACCC AGGGATGTCG AACGTGGAGG TGATCAGGGC GCTGGAGCGC 1320
GGATACCGGA TGCCGCGCAC GGACAACTGC CCCGAGGAGC TGTACGACAT CATGATGAGG 1380
TGCTGGAAGA TCAAACCCGA GGATCGCCCC ACTTTTGAGT ACATACAAAG TGTTTTGGAG 1440
GATTTCTTCA CTGCGACAGA GAGCCAGTAC CAGCAGCAG 1479
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l++klG+GqfGevw++++++++kvavkt+k+g++s eafleea+++k+l+h+klvkl+a
Q: 230   SLERKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLEEANLMKTLQHDKLVKLHA  289
         789*********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vv++eePi+i+te+m+kGslldflk++eg+kl lpkl+d++aq+aeGma++e++n+ihrd
Q: 290   VVTREEPILIITEFMEKGSLLDFLKSDEGNKLLLPKLIDFSAQIAEGMAFIEKRNYIHRD  349
         ************************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lv+  lv+k+adfGlar+ied eyta+egak+PikWtaPeai++g+ftiksdvW
Q: 350   LRAANILVSAALVCKIADFGLARVIEDTEYTAREGAKFPIKWTAPEAINYGSFTIKSDVW  409
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGilltei+t+G++PypGm+n ev++++ergyr+pr+++cpeely+++++cwk +pe+r
Q: 410   SFGILLTEIITYGRIPYPGMSNVEVIRALERGYRMPRTDNCPEELYDIMMRCWKIKPEDR  469
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe++q+vl
Q: 470   PTFEYIQSVL  479
         ******9976
Domain Sequence
(FASTA)
SLERKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF LEEANLMKTL QHDKLVKLHA 60
VVTREEPILI ITEFMEKGSL LDFLKSDEGN KLLLPKLIDF SAQIAEGMAF IEKRNYIHRD 120
LRAANILVSA ALVCKIADFG LARVIEDTEY TAREGAKFPI KWTAPEAINY GSFTIKSDVW 180
SFGILLTEII TYGRIPYPGM SNVEVIRALE RGYRMPRTDN CPEELYDIMM RCWKIKPEDR 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-DIO-00065
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MIM-00060
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-SUS-00324
EKS-TAR-00474
EKS-XET-00485
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013