EKS-TAG-00288

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00288

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	1.5E-140	180	467	288

Status

Unreviewed

Ensembl Protein

ENSTGUP00000006937

UniProt Accession

H0Z8N4;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000006726	ENSTGUP00000006937	ENSTGUT00000007006

Organism

Taeniopygia guttata

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

AELECYCQLC TKDNFTCMTD GVCFASVTRT ADKIMRNSMC IAEIDLIPRD RPFVCSPSTR 60

DGVHTVSHCC NTPLCNKVEL PIPTPGPTPE KSASNLGPVE LAAVIAGPVC FVCISLMLIL 120

YLCHNRTVIH HRVPSEEDPS LDRPFISEGT TLKDLIYDMT TSGSGSGLPL LVQRTIARTI 180

VLQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 240

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL ALSTASGLAH LHMEIVGTQG 300

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 360

DSINMKHFES FKRADIYAMG LVFWEIARRC SIGGIHEDYQ LPYYDLVPSD PSVEEMRKVV 420

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANGAARLTA LRIKKTLSQL SQQEGIKM 478

Nucleotide Sequence
(FASTA)

GCAGAATTAG AGTGTTACTG CCAGCTATGT ACAAAAGACA ACTTTACATG TATGACAGAT 60

GGAGTATGTT TTGCCTCAGT AACTCGAACT GCAGACAAAA TAATGCGCAA CAGTATGTGT 120

ATAGCAGAAA TTGATCTGAT TCCCCGAGAC AGGCCATTTG TTTGTTCCCC CTCCACCAGA 180

GATGGAGTCC ATACTGTGTC TCATTGCTGT AACACACCTC TCTGCAATAA AGTAGAACTT 240

CCAATTCCAA CACCAGGCCC TACTCCAGAA AAATCAGCTT CTAACCTAGG ACCTGTGGAA 300

CTGGCTGCTG TGATTGCTGG ACCTGTCTGC TTTGTCTGCA TTTCACTGAT GTTGATTCTA 360

TACCTTTGTC ATAATCGTAC TGTAATTCAT CATCGTGTGC CAAGTGAAGA AGACCCTTCA 420

TTGGATCGTC CCTTTATATC AGAAGGAACC ACTTTAAAGG ATTTAATTTA CGATATGACA 480

ACTTCAGGTT CTGGATCAGG TTTACCTTTA CTTGTGCAAA GAACAATCGC AAGAACTATA 540

GTACTTCAAG AAAGCATTGG TAAGGGTCGC TTTGGAGAAG TCTGGCGGGG GAAGTGGAGA 600

GGAGAAGAAG TTGCTGTGAA GATCTTTTCT TCAAGAGAAG AACGATCATG GTTTCGAGAA 660

GCAGAAATTT ATCAGACAGT TATGCTACGT CATGAAAACA TTCTTGGATT TATAGCTGCA 720

GACAACAAAG ACAATGGTAC ATGGACTCAG CTGTGGTTAG TGTCAGACTA TCACGAGCAT 780

GGATCACTCT TTGATTACCT AAACAGGTAT ACAGTAACAG TGGAAGGAAT GATAAAATTA 840

GCTTTGTCCA CTGCCAGTGG TCTTGCTCAT CTGCACATGG AAATTGTTGG CACACAAGGC 900

AAACCAGCAA TTGCCCACAG AGACTTAAAA TCAAAAAACA TATTGGTGAA AAAGAATGGA 960

ACATGCTGCA TTGCAGACCT GGGCTTGGCG GTTAGGCATG ATTCAGCTAC AGACACAATT 1020

GACATTGCCC CAAACCACAG AGTGGGAACA AAAAGGTACA TGGCTCCTGA AGTTCTAGAT 1080

GATTCCATAA ATATGAAACA TTTTGAGTCA TTCAAACGAG CAGACATCTA TGCAATGGGA 1140

TTAGTGTTTT GGGAAATAGC TCGGCGGTGT TCAATTGGTG GAATCCACGA AGATTACCAG 1200

TTGCCATACT ATGACCTCGT TCCTTCAGAC CCTTCTGTTG AAGAAATGAG GAAAGTTGTG 1260

TGTGAACAGA AGTTAAGGCC CAATATTCCA AACAGATGGC AGAGCTGTGA GGCATTACGA 1320

GTGATGGCAA AAATTATGCG GGAATGCTGG TATGCCAATG GAGCTGCTCG GCTGACAGCT 1380

TTGCGCATTA AGAAAACATT ATCACAACTT AGTCAACAGG AGGGGATCAA GATGTAA 1437

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 180   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  239

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 240   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  299

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 300   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  357

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 358   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  416

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 417   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  467

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0043542	; P:endothelial cell migration
GO:0006917	; P:induction of apoptosis
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013