EKS-TAG-00531

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00531

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.4	1.6E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSTGUP00000006999

UniProt Accession

H0Z8U6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000006789	ENSTGUP00000006999	ENSTGUT00000007068

Organism

Taeniopygia guttata

Functional Description

Protein Length

721

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSR LTDDVGSLTE LNCVYIVQEY METDLANLLE 120

QGPLLEDHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH IYNWERYHES 360

QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTHFS 420

TEPCWQYSDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCEKNGL VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ 540

HESTDVDKLN DLNSSVSQIE LKGIISKSVS REKQEKGMAN LAQLEALYQT SWDSQFVSGG 600

EGCFLIDQFC CEVRKDEQVE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG KLGEKEREES 660

FLSNSGELLF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH KTYSSILKHL 720

N 721

Nucleotide Sequence
(FASTA)

ATGGCAGAAA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTCGGTAT 60

ATGGACTTAA AACCACTGGG CTGTGGTGGA AACGGCTTAG TTTTTTCTGC TGTCGATAAT 120

GACTGTGACA AAAGAGTAGC TGTCAAGAAA ATTGTCCTGA CAGATCCCCA GAGTGTTAAA 180

CATGCTCTAC GTGAGATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTCAAAGTA 240

TTTGAAATTC TTGGTCCCAG TGGAAGCCGG TTAACAGATG ACGTGGGCTC CCTGACAGAA 300

TTGAACTGTG TTTACATTGT CCAGGAATAC ATGGAGACAG ATCTGGCTAA TTTGCTAGAG 360

CAAGGCCCTT TACTGGAAGA TCATGCCAGA CTTTTCATGT ACCAGCTGCT ACGTGGGCTC 420

AAGTATATTC ACTCTGCAAA TGTTCTGCAT AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACTGAAG ACTTGGTGCT GAAGATTGGT GACTTCGGTC TTGCACGAAT CATGGATCCT 540

CATTATTCCC ACAAGGGCCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCGCCC 600

CGGCTTTTGC TTTCTCCTAA CAACTACACT AAAGCCATTG ACATGTGGGC TGCAGGTTGC 660

ATCTTTGCTG AAATGCTGAC TGGGAAAACA CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGTTGA TTCTAGAATC AATTCCTGTC GTACATGAGG AGGACCGTCA GGAGCTTCTC 780

AATGTAATTC CAGTTTACAT TAGAAATGAT ATGACTGAGC CACACAAACC TTTAACTCAG 840

TTGCTTCCAG GCATCAGTCC TGAAGCACTG GACTTTCTGG AGCAAATTTT GACATTTAGT 900

CCCATGGATC GATTGACAGC AGAAGAAGCT TTGTCCCATC CTTATATGAG CATTTATTCC 960

TTTCCAACGG ATGAGCCTAT TTCAAGTCAT CCTTTTCACA TTGAAGATGA GGTTGATGAT 1020

ATTCTGCTAA TGGATGAAAG TCACAGCCAT ATTTATAATT GGGAAAGATA CCATGAAAGT 1080

CAGTTTTCAG ACCATGACTG GCCTATTCAT AATAACTATG AAGCTGATGA AGTTCAGCGT 1140

GATCCAAGGG CTCTTTCTGA CGTAACTGAT GAAGAAGAAG TGCAGGTAGA TCCTCGCAAA 1200

TATTTGGATG GAGATCGTGA AAAGTACCTG GAGGATCCTG CCTTTGACAC CCACTTCTCT 1260

ACTGAGCCTT GCTGGCAGTA TTCAGATCAC CACGAAAACA AGTATTGTGA TCTGGAGTGT 1320

AGTCACACTT GTAATTACAA AATGAGATCC TCTTCATACC TAGATAATTT AGTTTGGCGA 1380

GACAGTGAAG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTTTC AAACTGGAAG 1440

GAACAAAGCA AAGAAAAGTC TGACAAGAAA GGCAAGTCTA AATGTGAAAA GAATGGGTTG 1500

GTGAAAGCTC AGATAGCACT TGAGGAAGCA TCACAGCAAC TTGTTGAAAA AGAAAGGGAG 1560

AAGAATCAGG GGTTTGACTT TGATTCTTTT ATAGCAGAAA CCATCCAGCT TAGTTTACAA 1620

CATGAGTCTA CTGATGTTGA TAAATTAAAT GACTTGAATA GTTCAGTGTC TCAGATAGAG 1680

TTGAAAGGAA TAATATCAAA GTCGGTAAGC AGAGAGAAAC AGGAGAAAGG AATGGCCAAC 1740

TTGGCACAGT TAGAAGCTCT GTACCAAACT TCTTGGGACA GTCAGTTTGT CAGTGGTGGG 1800

GAGGGATGCT TCCTCATAGA CCAGTTCTGT TGCGAAGTAA GGAAAGATGA ACAAGTTGAA 1860

AAAGAAAATA CTTACACCAG TTATTTGGAC AAATTTTTTA GTAAGAAAGA AGATGCTGAA 1920

ATGCTAGAAC CTGAGCCAGT AGAAGAGGGG AAGCTTGGGG AGAAGGAAAG AGAAGAGAGC 1980

TTTCTCAGTA ACAGTGGGGA ACTCCTCTTC AACAAGCAGC TTGAGGCTAT AGGTATTCCT 2040

CAGTTTCACA GCCCTGTTGG CTCTCCTCTC AAATCCATCC AGGCCACACT AACGCCTTCT 2100

GCTATGAAAT CATCTCCCCA GATTCCCCAC AAAACCTACA GCAGCATTCT GAAACATCTA 2160

AACTAA 2166

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el+ vY+v+e+metdL++++++  l ++h++l++yq+l

Q: 78    VKVFEILGPSGsrltddvgSLTELNCVYIVQEYMETDLANLLEQGPLLEDHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ +  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLNV-IPVYIRNDMTEPHKPLTQLLPGISPEALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS RLTDDVGSLT ELNCVYIVQE YMETDLANLL EQGPLLEDHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LNVIPVYIRN DMTEPHKPLT QLLPGISPEA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity

KEGG

tgu:100218726

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013