EKS-TAG-00013
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00013
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph356.26.8E-107591843253
StatusUnreviewed
Ensembl ProteinENSTGUP00000007088
UniProt AccessionH0Z935;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000006852ENSTGUP00000007088ENSTGUT00000007157
OrganismTaeniopygia guttata
Functional Description
Protein Length941
Protein Sequence
(FASTA)
LMDTRTATAE LGWTANPPSG WEEVSGYDEN LNTIRTYQVC NVFEPNQNNW LLTTFINRRG 60
AHRIYTEMRF TVRDCSSLPN VPGSCKETFN LYYYETDSKS AFWTEAPYLK VDTIAADESF 120
SQVDFGGRLM KVNTEVRSFG PLTRNGFYLA FQDYGACMSL LSVRVFFKKC PSVVQNFAIF 180
PETMTGAEST SLVTARGTCI PNAEEVDVPI KLYCNGDGEW MVPIGRCTCK AGYEPENNVA 240
CKACPAGTFK ASQGAGLCVP CPPNSRSTAE ASPLCACRNG YYRADFDPPA AACTSVPSGP 300
RNVISIVNET SIILEWHPPR ETGGRDDVTY NIVCKKCRSD RRACSRCDDN VDFVPRQLGL 360
TDTRVFISNL WAHTPYTFEI QAVNGVSSKS PFPQQHVSVN ITTNQAGERR VVPECGCPAA 420
GCKLRAQKGR TPSCPQQGQL GCVPPDHNEY NSSMARSQTN TARLEGLRPG MVYVVQVRAR 480
TVAGYGKYSG KMCFQTLTDG ECGLAVPPAR PPALGDERSM SAQPNLCPRA AWREPGDLRR 540
CLVNRPREER SALHLLAPGS PGMKIYIDPF TYEDPNEAVR EFAKEIDVSF VKIEEVIGAG 600
EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP NIIRLEGVVT 660
KSRPVMIITE FMENGALDSC LLQDVLLPSI PCVPAEPGRR VLDVQSAMGG KVRAVVSTNY 720
PFSSSFLEQV QDRFMQLFLA PASLSHQGGK IPVRWTAPEA IAYRKFTSAS DVWSYGIVMW 780
EVMSFGERPY WDMSNQDVIN AIEQDYRLPP PMDCPAALHQ LMLDCWQKDR NTRPRFTEIV 840
NTLDKMIRNP ASLKTPLGAS QVPSQPLLDR SIPDFTAFTS VDDWLSAVKM SQYRDSFLTA 900
GFTSLQLVAQ MTSEDLLRIG VTLAGHQKKI LNSVQSMRVQ M 941
Nucleotide Sequence
(FASTA)
TTAATGGATA CACGGACGGC AACGGCCGAG CTGGGCTGGA CTGCCAACCC ACCTTCAGGG 60
TGGGAAGAAG TCAGTGGCTA CGACGAGAAC CTCAACACCA TCCGTACGTA CCAGGTGTGC 120
AACGTCTTCG AGCCCAACCA GAACAACTGG CTCCTCACCA CCTTCATCAA CCGGCGTGGG 180
GCTCACCGCA TCTACACCGA GATGCGCTTC ACCGTGCGGG ACTGCAGCAG CCTCCCCAAC 240
GTCCCCGGCT CCTGCAAGGA GACCTTCAAC CTCTACTACT ACGAGACAGA CTCTAAGTCT 300
GCCTTCTGGA CAGAGGCACC CTACCTCAAA GTGGACACCA TCGCTGCTGA CGAGAGCTTC 360
TCCCAGGTGG ACTTTGGGGG CCGGCTGATG AAGGTGAACA CGGAAGTGAG AAGTTTCGGG 420
CCCCTGACCC GCAATGGCTT TTACCTGGCT TTCCAGGACT ACGGGGCTTG CATGTCTCTG 480
CTGTCTGTCA GGGTCTTCTT CAAGAAGTGC CCCAGCGTGG TGCAGAACTT CGCCATCTTC 540
CCGGAGACGA TGACGGGTGC GGAGAGCACC TCTCTGGTGA CGGCGCGCGG CACCTGCATC 600
CCCAACGCCG AGGAGGTGGA CGTGCCCATC AAGCTGTACT GCAACGGCGA CGGCGAGTGG 660
ATGGTGCCCA TCGGCCGCTG CACCTGCAAG GCTGGCTACG AGCCCGAGAA CAACGTGGCT 720
TGCAAAGCCT GCCCTGCAGG GACGTTCAAG GCCAGCCAGG GCGCGGGGCT GTGCGTGCCG 780
TGCCCCCCGA ACAGCCGCTC CACCGCCGAG GCCTCTCCGC TCTGCGCCTG CCGCAACGGC 840
TACTACCGGG CAGACTTCGA CCCGCCGGCC GCCGCCTGCA CCAGTGTCCC ATCCGGCCCC 900
CGCAACGTCA TCTCCATCGT CAACGAGACG TCCATCATCC TGGAGTGGCA CCCGCCGCGG 960
GAGACGGGCG GCCGGGACGA CGTCACCTAC AACATCGTCT GCAAGAAGTG CCGCTCGGAC 1020
CGGCGCGCCT GCTCCCGCTG CGACGACAAC GTGGACTTCG TGCCCCGCCA GCTGGGGCTC 1080
ACCGACACCC GCGTCTTCAT CAGCAACCTC TGGGCTCACA CCCCCTACAC CTTCGAGATC 1140
CAGGCGGTCA ACGGCGTGTC CAGCAAGAGC CCCTTCCCGC AGCAGCACGT TTCTGTCAAC 1200
ATCACCACCA ACCAGGCCGG TGAGCGCCGC GTGGTGCCGG AGTGTGGCTG CCCTGCCGCC 1260
GGCTGCAAGC TCCGTGCCCA AAAGGGCCGA ACCCCATCCT GCCCTCAACA GGGACAGCTG 1320
GGCTGTGTTC CCCCTGACCA CAACGAGTAC AACTCATCCA TGGCGCGCAG CCAGACCAAC 1380
ACGGCGCGGC TGGAGGGGCT GCGGCCCGGC ATGGTGTACG TGGTGCAGGT GCGCGCCCGC 1440
ACCGTGGCCG GCTACGGCAA GTACAGCGGC AAGATGTGCT TCCAGACCCT CACCGACGGT 1500
GAGTGCGGCC TGGCTGTGCC TCCAGCCCGG CCTCCTGCTC TGGGGGATGA AAGGAGCATG 1560
TCTGCACAGC CCAACCTGTG TCCCAGGGCA GCGTGGCGGG AGCCTGGTGA TTTACGGCGG 1620
TGTCTCGTTA ACCGCCCGCG GGAGGAGCGA TCCGCCCTCC ATCTCCTGGC TCCAGGGTCT 1680
CCAGGGATGA AGATCTACAT CGATCCCTTC ACCTATGAGG ACCCCAATGA AGCCGTCCGA 1740
GAGTTCGCCA AGGAGATCGA TGTGTCCTTT GTGAAGATTG AAGAAGTCAT TGGGGCAGGG 1800
GAGTTTGGAG AGGTGTATAA AGGGCGCCTG AAGTTGCCAG GCAAGCGGGA GATCTACGTG 1860
GCTATCAAGA CATTGAAGGC CGGGTACTCG GAGAAGCAGC GCCGCGATTT CCTGAGCGAG 1920
GCCAGCATCA TGGGCCAGTT CGACCACCCC AACATCATCC GCCTGGAAGG GGTGGTCACC 1980
AAGAGCCGGC CGGTCATGAT CATCACCGAG TTCATGGAGA ACGGGGCCTT GGACTCGTGC 2040
CTCCTGCAGG ATGTCCTCCT GCCCAGCATT CCCTGTGTAC CTGCTGAACC TGGGAGAAGG 2100
GTGCTGGATG TACAGTCTGC CATGGGTGGG AAGGTCCGGG CTGTAGTTTC CACAAATTAT 2160
CCTTTCTCTT CCTCCTTTTT AGAGCAGGTA CAAGATAGAT TCATGCAGTT GTTTTTGGCT 2220
CCTGCCTCCT TGTCACATCA GGGGGGCAAG ATCCCTGTCA GGTGGACAGC GCCGGAGGCC 2280
ATCGCCTACC GCAAGTTCAC CTCGGCCAGC GACGTCTGGA GCTACGGCAT CGTCATGTGG 2340
GAGGTGATGT CGTTCGGGGA GAGGCCCTAC TGGGACATGT CCAACCAAGA TGTCATCAAC 2400
GCCATCGAGC AGGACTACCG GCTCCCGCCG CCCATGGACT GCCCGGCCGC CCTGCACCAG 2460
CTGATGCTGG ACTGCTGGCA GAAGGACCGC AACACCCGCC CACGCTTCAC CGAGATCGTC 2520
AACACCCTCG ACAAAATGAT CCGCAACCCG GCAAGCCTCA AAACTCCCCT CGGTGCCAGC 2580
CAGGTGCCTT CTCAGCCCCT CCTCGACCGC TCCATCCCCG ACTTCACTGC CTTTACCTCA 2640
GTAGACGACT GGCTGAGCGC TGTGAAGATG AGCCAGTACC GGGACAGCTT CCTGACCGCT 2700
GGCTTCACCT CCCTGCAGCT GGTGGCCCAG ATGACATCCG AAGACCTCCT GAGAATAGGG 2760
GTGACTTTGG CTGGGCACCA GAAGAAGATC CTGAACAGCG TCCAGTCCAT GCGAGTACAG 2820
ATG 2823
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 591   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  650
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengalds l  +d  + +i  v    G    +   s m
Q: 651   NIIRLEGVVTKSRPVMIITEFMENGALDSCLL-QDVLLPSIPCVPAEPGR-RVLDVQSAM  708
         *****************************996.6899999****999996.579999***
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         g   r + + n   +s+++ +v d  +  +l   + a+ + +ggkip+rwtapeaiayrk
Q: 709   GGKVRAVVSTNYPFSSSFLEQVQDRFMQLFL---APASLSHQGGKIPVRWTAPEAIAYRK  765
         ************************9998887...45778899******************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlmldc
Q: 766   FTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDC  825
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rp+f++iv++l
Q: 826   WQKDRNTRPRFTEIVNTL  843
         ***************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSC LLQDVLLPSI PCVPAEPGRR VLDVQSAMGG 120
KVRAVVSTNY PFSSSFLEQV QDRFMQLFLA PASLSHQGGK IPVRWTAPEA IAYRKFTSAS 180
DVWSYGIVMW EVMSFGERPY WDMSNQDVIN AIEQDYRLPP PMDCPAALHQ LMLDCWQKDR 240
NTRPRFTEIV NTL 253
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-FEC-00003
EKS-GAG-00006
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MOD-00007
EKS-MUM-00006
EKS-NOL-00005
EKS-ORC-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-POA-00004
EKS-RAN-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007411; P:axon guidance
GO:0031589; P:cell-substrate adhesion
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 2.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013