EPS-TAG-00077

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAG-00077

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	428.3	3.5E-129	65	265	201

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007291

UniProt Accession

H0Z9N8;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CB

Gene Synonyms/Alias

PPP3CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007056	ENSTGUP00000007291	ENSTGUT00000007363

Organism

Taeniopygia guttata

Functional Description

Protein Length

497

Protein Sequence
(FASTA)

AVPFPPTHRL TSEEVFDTDG RPRVDILKNH LIKEGRVDEE IALRIINEGA AILRREKTMI 60

EVEAPITVCG DIHGQFFDLM KLFEVGGSPA NTRYLFLGDY VDRGYFSIEC VLYLWVLKIL 120

YPSTLFLLRG NHECRHLTEY FTFKQECKIK YSERVYDACM EAFDCLPLAA LLNQQFLCVH 180

GGLSPEINTL DDIRRLDRFK EPPAFGPMCD LLWSDPSEDF GNENSPEHFS HNTVRGCSYF 240

YSYPAVCEFL QNNNLLSIIR AHEAQDAGYR MYRKSQTTGF PSLITIFSAP NYLDVYNNKA 300

AVLKYENNVM NIRQFNCSPH PYWLPNFMDV FTWSLPFVGE KVTEMLVNVL SICSDDELMT 360

EGEDQFDVGT AAARKEIIRN KIRAIGKMAR VFSVLREESE SVLTLKGLTP TGMLPSGVLA 420

GGRQTLQSAT VEAIEAEKAI RGFSPQHKIC SFEEAKGLDR INERMPPRKD TLQQDGINTV 480

NTANANGNNG TGNNNAQ 497

Nucleotide Sequence
(FASTA)

GCTGTCCCTT TTCCACCAAC ACATCGCTTG ACATCTGAAG AAGTGTTTGA CACAGATGGA 60

AGACCAAGGG TTGACATTTT GAAGAACCAC TTGATAAAGG AAGGTCGAGT GGACGAAGAA 120

ATTGCACTTA GAATCATCAA TGAGGGTGCT GCAATATTAC GGAGGGAAAA AACTATGATA 180

GAAGTTGAAG CTCCAATTAC AGTGTGTGGT GATATTCATG GCCAGTTCTT TGATCTAATG 240

AAGCTGTTTG AAGTGGGAGG ATCACCTGCT AACACAAGAT ACCTCTTCCT CGGTGACTAT 300

GTAGACAGAG GTTATTTTAG TATAGAGTGC GTGCTGTACT TATGGGTCCT GAAAATTCTT 360

TACCCAAGCA CATTGTTTCT TTTGAGAGGC AACCATGAAT GCAGACACCT AACAGAGTAT 420

TTTACCTTTA AGCAAGAATG TAAAATAAAG TATTCTGAAA GAGTCTATGA TGCTTGTATG 480

GAAGCTTTTG ATTGTCTCCC TCTTGCTGCT CTCTTGAATC AACAGTTTCT TTGTGTTCAT 540

GGTGGACTTT CACCAGAAAT TAATACACTA GATGACATTA GGAGATTAGA TAGATTCAAA 600

GAGCCTCCAG CATTTGGACC AATGTGTGAC TTATTGTGGT CAGATCCTTC AGAAGATTTT 660

GGAAATGAAA ATTCACCAGA GCATTTCAGT CATAACACAG TCAGGGGATG CTCCTACTTT 720

TATAGCTATC CAGCAGTTTG TGAATTTTTG CAAAATAATA ATTTGTTGTC AATCATTAGA 780

GCACATGAAG CACAAGATGC AGGTTATAGA ATGTACAGGA AAAGTCAAAC TACAGGGTTC 840

CCATCTTTAA TAACAATTTT TTCAGCACCT AATTACCTGG ATGTCTACAA TAATAAAGCT 900

GCTGTATTAA AATATGAAAA CAATGTGATG AATATTCGTC AGTTCAATTG TTCTCCTCAT 960

CCTTACTGGC TACCAAATTT TATGGATGTT TTCACATGGT CTTTGCCTTT TGTTGGAGAA 1020

AAAGTAACAG AAATGTTGGT GAATGTTTTG AGCATTTGCT CTGATGATGA GCTGATGACA 1080

GAGGGAGAAG ATCAATTTGA CGTAGGTACA GCTGCTGCAC GGAAGGAAAT AATCAGAAAC 1140

AAAATTCGTG CAATTGGCAA GATGGCAAGA GTCTTCTCTG TTCTCAGGGA GGAGAGTGAA 1200

AGTGTGCTGA CACTCAAGGG TTTGACTCCC ACTGGAATGT TACCTAGTGG AGTGTTGGCT 1260

GGAGGACGTC AGACCCTGCA AAGTGCCACT GTAGAGGCAA TTGAGGCTGA AAAAGCAATA 1320

CGAGGATTCT CTCCGCAACA TAAAATCTGC AGTTTTGAAG AAGCAAAAGG TTTGGATAGG 1380

ATCAATGAGA GAATGCCACC AAGAAAAGAT ACTCTTCAGC AAGATGGTAT TAATACTGTA 1440

AACACAGCAA ATGCCAATGG AAACAATGGA ACTGGCAACA ACAATGCACA GTGA 1494

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+tvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl++lkilyp+t

Q: 65    PITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST  124

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservydac+eafd+lplaallnqqflcvhggls

Q: 125   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMEAFDCLPLAALLNQQFLCVHGGLS  184

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++tlddir+ldrfkeppa+g+mcdllwsdp edfgne+s e+f+hn+vrgcsyfysy+

Q: 185   PEINTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNENSPEHFSHNTVRGCSYFYSYP  244

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+nnllsiiraheaq

Q: 245   AVCEFLQNNNLLSIIRAHEAQ  265

         ********************8

Domain Sequence
(FASTA)

PITVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WVLKILYPST 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYDACMEAFD CLPLAALLNQ QFLCVHGGLS 120

PEINTLDDIR RLDRFKEPPA FGPMCDLLWS DPSEDFGNEN SPEHFSHNTV RGCSYFYSYP 180

AVCEFLQNNN LLSIIRAHEA Q 201

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005509	; F:calcium ion binding
GO:0005516	; F:calmodulin binding
GO:0008144	; F:drug binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0030346	; F:protein phosphatase 2B binding
GO:0035690	; P:cellular response to drug

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013