EKS-TAG-00500

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00500

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	396.5	5.3E-119	3	265	263

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007355

UniProt Accession

H0Z9V2;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007111	ENSTGUP00000007355	ENSTGUT00000007428

Organism

Taeniopygia guttata

Functional Description

Protein Length

1038

Protein Sequence
(FASTA)

FEYSKKDLIG HGAFAVVFKG RHRKKTDWEV AIKSINKKNL SKSQILLGKE IKILKELQHE 60

NIVALYDVQE MPNSVFLVME YCNGGDLADY LQAKGTLSED TIRVFLQQIA AAMRILHSKG 120

IIHRDLKPQN ILLSYASRRK SSVSGIRIKI ADFGFARYLH SNMMAATLCG SPMYMAPEVI 180

MSQHYDAKAD LWSIGTVIYQ CLVGKPPFQA NSPQDLRMFY EKNRNLIPSI PRETSAYLAD 240

LLLGLLQRNQ KDRMDFEAFF NHPFLDHVST VKKSCPVPVP TYPGSVSGSS CGSSPCRFAS 300

PPSLPDMQHI QEENLSSPPL GPPNYLQVSK DSASTSSKNS SCDTDDFVLV PHNISSDHSY 360

DMPLGAAGRR ASSEFLMCGG HCQPSVSPRS ETAPIPVPTQ LRNYQRIEQN LSSTASPVSN 420

PHGSPRAGVV RRSNTSPMGF MKMGSCSPVP ADTAQGVGRR LSTGSSRPYS PSPLVGTIPE 480

QLGHCCCGQL QGHESRSRNF SGSPIPPSQS PQSLLMGARL QSAPTLTDIY QNKQKLRKQH 540

SDPVCPSYAG YGYSHSPQPS RPGSLGTSPT KHMGSSPRSS DWLFKTPLPT IIGSPTKATA 600

PFKIPKTQAS SNLLALANRQ GLAETLLQPK DITDPRDFTH FHSSQAADKQ AEQHSKTTFG 660

RSVSTGKLSD QQVKTTLGGQ LYQGSTDSLN TERPMDTAPA GAYGIAMATP SMASGAASSR 720

AVMFTVGSPP SSATPPTCTH MVLRTRTTSV GSNSSGGSLC STSGRVYMGS PPGIYMGSSP 780

PGAEAAPSLK YIPYGTSPPS LEGFITFEAP ELPEETLMER EHTDTLRHLN MMLTFTECVL 840

DLTAVRGGNP DLCTSAVSLY QIQESIVVDQ ISQLSKEWGQ VEQLVLYMKA AQLLASSLHL 900

AKAQVKSGKL NPSTAVKQVV KSLNERYKFC IGMCKKLTEK LNRFFSDKQR FIDEINSVTA 960

EKLIYNCAVE MVQSAALDEM FQQTEDITYR YHKAALLLEG LTKILQDPAD IENVHKYKSS 1020

IERRLSALCY STVAVYEQ 1038

Nucleotide Sequence
(FASTA)

TTTGAGTACA GCAAGAAGGA CCTGATAGGA CACGGAGCCT TTGCTGTGGT CTTCAAAGGT 60

CGCCACCGCA AGAAAACTGA TTGGGAAGTA GCCATAAAGA GTATTAACAA AAAGAACTTG 120

TCGAAGTCAC AAATCCTCCT TGGAAAAGAA ATAAAAATCT TAAAGGAACT TCAGCACGAG 180

AACATTGTAG CTCTTTATGA TGTCCAGGAA ATGCCCAATT CTGTCTTTTT GGTCATGGAG 240

TACTGCAATG GTGGGGACTT GGCAGATTAC TTACAAGCTA AGGGGACTCT GAGTGAGGAC 300

ACCATCCGAG TGTTCCTGCA GCAGATTGCA GCAGCCATGA GGATCCTGCA CAGCAAAGGC 360

ATCATCCACA GGGACCTCAA ACCCCAGAAC ATCCTGCTGT CCTACGCCAG CCGCCGGAAA 420

TCCAGCGTCA GTGGCATACG CATCAAAATA GCTGACTTTG GGTTTGCTCG TTATCTGCAC 480

AGCAACATGA TGGCTGCAAC TCTGTGTGGC TCCCCTATGT ACATGGCCCC TGAAGTGATT 540

ATGTCTCAAC ACTATGATGC TAAAGCAGAC CTGTGGAGCA TAGGAACTGT GATTTATCAG 600

TGTCTTGTTG GAAAGCCACC TTTTCAGGCC AATAGTCCTC AAGATTTGAG AATGTTTTAT 660

GAAAAGAACA GGAATTTGAT TCCTAGCATT CCAAGGGAAA CATCAGCTTA CCTGGCTGAC 720

CTGTTGTTGG GTTTGCTTCA GAGAAACCAA AAGGATAGAA TGGACTTTGA AGCGTTTTTC 780

AACCACCCTT TCCTGGATCA CGTTTCAACA GTGAAAAAAT CTTGTCCTGT ACCAGTGCCC 840

ACATACCCAG GCTCAGTCTC TGGCAGTTCC TGTGGTAGCT CTCCTTGTCG CTTTGCTTCT 900

CCTCCATCTC TGCCAGACAT GCAGCACATT CAAGAAGAAA ATTTGTCTTC CCCTCCACTG 960

GGTCCTCCTA ACTATCTTCA AGTCTCTAAA GACTCTGCCA GTACCAGTAG CAAGAATTCT 1020

TCTTGTGACA CAGATGACTT TGTTCTTGTC CCACACAATA TCTCTTCAGA CCATTCATAT 1080

GATATGCCTT TGGGAGCAGC TGGCAGGCGG GCTTCCAGTG AGTTCTTGAT GTGTGGAGGG 1140

CACTGTCAGC CTTCCGTGTC CCCCCGCAGC GAGACGGCGC CGATCCCGGT GCCCACCCAA 1200

CTCCGGAATT ACCAGCGCAT AGAACAGAAC CTCTCCTCCA CTGCCAGCCC CGTGTCAAAC 1260

CCCCACGGAT CACCCAGAGC CGGGGTTGTG AGGCGCTCCA ACACCAGCCC AATGGGGTTC 1320

ATGAAGATGG GCTCGTGCTC TCCAGTGCCA GCTGACACTG CCCAGGGCGT TGGGCGCAGG 1380

CTGTCCACAG GATCTTCCAG ACCATACTCT CCTTCACCAC TAGTTGGAAC CATACCTGAG 1440

CAGCTTGGGC ACTGTTGTTG TGGACAACTC CAAGGACATG AATCAAGGAG TAGAAACTTC 1500

TCAGGTTCTC CTATACCACC ATCTCAGTCT CCACAGTCAC TTTTGATGGG AGCGAGGTTG 1560

CAGAGTGCTC CTACTCTCAC AGATATCTAC CAAAACAAGC AGAAGCTGAG AAAGCAGCAT 1620

TCAGACCCAG TTTGCCCATC CTATGCTGGG TATGGATACA GTCATTCCCC ACAGCCAAGC 1680

AGGCCAGGTA GCCTGGGAAC ATCCCCTACC AAGCACATGG GATCCTCACC CAGGAGCTCA 1740

GACTGGCTCT TCAAAACCCC ACTGCCAACA ATCATCGGCT CTCCCACTAA GGCAACAGCT 1800

CCTTTCAAAA TACCTAAAAC TCAAGCGTCC TCCAACTTGC TGGCCCTGGC AAATCGTCAG 1860

GGCTTGGCTG AAACCCTGCT GCAGCCTAAA GATATCACTG ACCCAAGGGA CTTCACACAC 1920

TTCCACTCCA GCCAGGCAGC TGACAAACAG GCAGAACAGC ACAGCAAAAC CACCTTTGGC 1980

AGGTCTGTTA GTACTGGGAA GCTGTCAGAC CAACAGGTAA AGACCACCCT TGGGGGCCAG 2040

TTATACCAAG GCAGTACAGA CAGTCTCAAC ACAGAGAGGC CAATGGATAC AGCTCCAGCA 2100

GGAGCCTATG GAATTGCAAT GGCAACTCCA TCCATGGCAA GTGGGGCAGC AAGTTCTCGG 2160

GCTGTCATGT TCACTGTGGG GTCCCCTCCA AGCAGTGCCA CCCCTCCTAC CTGCACCCAC 2220

ATGGTCCTCA GAACCAGAAC CACCTCAGTG GGATCAAACA GCTCTGGAGG GTCTCTGTGC 2280

TCCACTAGTG GCCGTGTTTA TATGGGCTCT CCTCCTGGGA TTTACATGGG CTCCTCTCCT 2340

CCGGGGGCAG AGGCGGCTCC AAGTCTGAAG TACATCCCTT ATGGTACTTC CCCTCCCAGC 2400

CTAGAGGGCT TTATCACTTT TGAAGCTCCT GAATTGCCTG AGGAAACTTT AATGGAGAGA 2460

GAGCACACAG ACACGCTGCG TCACCTAAAC ATGATGCTGA CATTTACAGA GTGTGTTCTG 2520

GATCTGACAG CAGTGAGGGG AGGAAACCCA GACCTGTGCA CTTCTGCTGT GTCACTGTAC 2580

CAGATCCAGG AGAGCATCGT TGTGGATCAG ATCAGCCAGC TCAGCAAAGA ATGGGGACAA 2640

GTGGAGCAGC TGGTGTTGTA TATGAAAGCT GCCCAGTTAC TGGCATCTTC TCTGCATCTT 2700

GCCAAAGCAC AGGTCAAATC TGGCAAACTG AACCCATCCA CTGCTGTTAA GCAAGTTGTG 2760

AAAAGCCTCA ACGAGAGATA CAAATTCTGC ATCGGAATGT GCAAAAAACT GACAGAAAAG 2820

TTGAATCGTT TCTTTTCGGA CAAGCAAAGG TTCATTGATG AAATCAACAG TGTAACTGCA 2880

GAGAAACTCA TCTACAACTG TGCTGTGGAA ATGGTGCAGT CAGCAGCTCT GGATGAGATG 2940

TTCCAGCAAA CTGAAGATAT CACATATCGA TACCACAAGG CAGCCCTGCT GCTGGAGGGA 3000

CTGACTAAAA TACTGCAAGA CCCTGCAGAT ATAGAAAATG TACACAAGTA TAAATCCAGC 3060

ATTGAGCGAA GGCTTTCTGC ACTCTGCTAC AGCACAGTGG CTGTGTATGA GCAG 3114

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ iG+G+favv+kgr+rkkt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 3     YSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  62

         899*********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e+ ++v+lvmeyc+ggdLa++l++k++Lsedt+r+flqq+a+a+++Lhsk+i+

Q: 63    VALYDVQEMPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLQQIAAAMRILHSKGII  122

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 123   HRDLKPQNILLSYASRRKsSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  182

         **************999989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l p+ip+e+s+ l+dll

Q: 183   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRNLIPSIPRETSAYLADLL  242

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 243   LGLLQRNQKDRMDFEAFFNHPFL  265

         *********************96

Domain Sequence
(FASTA)

YSKKDLIGHG AFAVVFKGRH RKKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQEMP NSVFLVMEYC NGGDLADYLQ AKGTLSEDTI RVFLQQIAAA MRILHSKGII 120

HRDLKPQNIL LSYASRRKSS VSGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVIYQCL VGKPPFQANS PQDLRMFYEK NRNLIPSIPR ETSAYLADLL 240

LGLLQRNQKD RMDFEAFFNH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013