EKS-TAG-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	341.1	3.3E-102	766	1035	270

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007573

UniProt Accession

H0ZAG9;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007339	ENSTGUP00000007573	ENSTGUT00000007651

Organism

Taeniopygia guttata

Functional Description

Protein Length

1068

Protein Sequence
(FASTA)

RNYEAQIRNY RGPDPLEPWD RYLQWAEGCL PLQEKQTCWP GLLEKLVQLF VSDKRYHQDP 60

RFVSYCVKLA EFISSPCQYF EYLHGQGIGV KTSDFYLAWA QLLLKEGNVQ GAAAVLQKGL 120

LNQAQPQENL QQLHCSLQRN DPWNPPLQDT AVVKPLQTSH AANQMAPPKG VSSPNPCKTQ 180

GLDAADSQSF AAGKEVNYVT YVSKSEVAPK PPSGAAGWEQ VPMYDKNLLL CEGSELSFEE 240

LRAKRYFRKY ELLRRQQALE EEQKDSMRKK ESAVLELQAL QQKLDQLTQL SRSLEGTRLE 300

PTVPPPVKPS TSDIPVNCMA PAPGLDVPKG QALVPEQPQF QAPPATAPTR QPAKPLGNHI 360

PATSPWEAPE EKDPAEARAE PGELQNSLLH PAFSAAPAQE QARPDPALPQ SAGQLSHSRA 420

PSGVVLLLCF PASRVGNSSF AYGNASQATP NTSLGGAMGT TTPFKVQPSP TVHTKEALGV 480

LMDMFQTPFL PEPSPLEDSE GQFEAFCIKS GLDGALSVTI VAPATPAFAI FEDEEEKENG 540

RIPQHKNKPE GPRTFGDHPL TDCAAEVSGT TEFLWDDYTV WNGPCSNKAL APSPDNTRDF 600

ARAAQLMSTP FNYLAAPSQP PLQDRACKEN LPQMNLEFSG ELHRQPKPKK LSPVLEHVPE 660

QRGLHVAAAA SQPLHEQTAQ SRTGHSSCLG VDRCSQEMLC GAEQDRTAGS RRPAVLVENP 720

WDKELIGKFL SKLPKPLHTY TNYFEWKSPL PFIKAKTELS LGSSSFHVDC LVGEGAFAQV 780

YQASILDASN PQNNQKVIFK VQKPANPWEF YIATQLVERL SPSMHHLYIH FYSAHFFSNG 840

SVLVGEFHNY GTLLNAVNVY KKLPEKVMPQ ALVIYFAVKI LHMVEELHSC KIIHGDIKPD 900

NFILGERQVF LENNTCDIDG LCHGLTLIDL GQSIDMKLFP EGTAFTARCE TSGFQCVEML 960

TNKPWNYQTD YFGIAATVYC LLFGTYMRLK NDNGVWKPEG TFRRLANAEL WKEFFESLLN 1020

IPSCHNLPSL RILCQKLKDL FCRSYAKEIK FLRNRLVVLL IEHKRSRK 1068

Nucleotide Sequence
(FASTA)

AGGAATTATG AGGCTCAGAT CCGGAACTAC CGAGGGCCCG ACCCGCTGGA GCCGTGGGAC 60

AGGTACCTGC AGTGGGCAGA GGGATGTCTC CCTCTCCAAG AGAAGCAGAC CTGCTGGCCT 120

GGGCTCCTGG AGAAGCTGGT GCAGCTGTTC GTGAGCGACA AGAGGTACCA TCAGGATCCG 180

CGATTTGTGA GCTACTGTGT CAAGCTGGCA GAATTCATAT CTTCCCCGTG CCAGTACTTT 240

GAGTACCTGC ACGGGCAGGG AATCGGAGTC AAGACTTCGG ATTTCTACCT GGCCTGGGCT 300

CAGCTGCTGC TGAAGGAGGG CAACGTGCAG GGAGCAGCAG CTGTGCTCCA AAAAGGGCTC 360

CTCAACCAGG CACAGCCCCA GGAGAACCTG CAACAGCTCC ACTGCTCCCT GCAGAGGAAT 420

GATCCTTGGA ATCCTCCTTT GCAAGACACT GCTGTTGTAA AACCACTTCA GACTTCTCAT 480

GCTGCAAATC AAATGGCTCC TCCAAAAGGT GTTTCAAGTC CTAATCCCTG CAAAACTCAG 540

GGTCTAGATG CTGCTGACTC TCAATCCTTT GCTGCTGGAA AAGAAGTGAA CTACGTCACC 600

TACGTCTCCA AGTCCGAGGT TGCGCCCAAG CCGCCGTCGG GTGCTGCTGG GTGGGAGCAG 660

GTCCCGATGT ACGACAAGAA CCTGCTCCTG TGCGAGGGCT CCGAGCTCTC CTTTGAGGAG 720

CTGAGGGCCA AGAGATACTT CAGGAAATAC GAGCTCCTCA GGAGGCAGCA GGCACTGGAG 780

GAGGAGCAGA AAGACTCCAT GAGGAAAAAG GAATCGGCAG TCCTGGAACT CCAAGCCCTG 840

CAGCAGAAGC TGGACCAGCT CACCCAGCTC TCCAGAAGCC TGGAGGGAAC GAGACTGGAA 900

CCAACAGTGC CCCCACCTGT GAAGCCCAGC ACATCTGACA TCCCAGTGAA CTGTATGGCA 960

CCTGCTCCAG GGCTGGATGT GCCAAAGGGC CAAGCTCTGG TGCCTGAGCA GCCCCAATTC 1020

CAGGCACCAC CAGCAACTGC TCCCACCCGG CAGCCAGCAA AGCCCCTTGG CAACCACATC 1080

CCAGCCACGT CCCCCTGGGA AGCACCGGAG GAGAAGGACC CAGCTGAAGC TCGAGCAGAG 1140

CCTGGGGAGC TCCAGAACAG TTTGCTGCAC CCTGCCTTCA GTGCTGCTCC AGCTCAGGAA 1200

CAGGCTCGTC CTGACCCAGC TCTGCCTCAG AGCGCAGGAC AACTATCCCA CTCCAGGGCT 1260

CCTTCAGGAG TGGTCTTGCT GTTGTGTTTT CCAGCCTCCA GAGTTGGGAA TTCCTCCTTT 1320

GCCTATGGAA ATGCTTCCCA AGCCACCCCC AACACCTCAC TGGGAGGAGC AATGGGGACC 1380

ACAACGCCCT TCAAGGTGCA GCCATCACCC ACAGTCCACA CGAAGGAAGC CTTGGGTGTT 1440

CTCATGGATA TGTTCCAAAC ACCTTTCTTG CCTGAGCCAT CTCCCCTAGA AGACAGTGAG 1500

GGACAATTTG AAGCCTTTTG CATAAAAAGT GGTCTGGATG GAGCCCTGAG CGTCACCATT 1560

GTTGCCCCCG CCACTCCTGC ATTTGCCATT TTTGAGGATG AGGAGGAGAA GGAGAATGGC 1620

AGGATCCCAC AGCACAAGAA CAAACCAGAA GGGCCCAGAA CTTTTGGAGA TCATCCCTTG 1680

ACTGACTGTG CAGCAGAAGT GAGTGGGACC ACGGAATTCC TGTGGGATGA TTACACGGTG 1740

TGGAATGGCC CCTGCAGCAA CAAAGCCCTG GCTCCTAGTC CAGACAACAC CAGGGATTTT 1800

GCCCGAGCTG CCCAGCTCAT GTCCACACCC TTTAATTACC TGGCAGCTCC TTCCCAGCCC 1860

CCTTTGCAGG ACAGAGCCTG TAAGGAAAAT TTGCCCCAAA TGAATTTGGA ATTCTCTGGA 1920

GAACTGCACA GGCAGCCAAA GCCCAAGAAG TTAAGCCCAG TTCTTGAACA CGTCCCAGAA 1980

CAGAGAGGGC TTCATGTTGC TGCAGCTGCT TCCCAACCAC TGCATGAGCA GACAGCTCAA 2040

AGCAGAACTG GACATTCCTC CTGCCTTGGG GTGGATAGAT GTTCCCAGGA GATGCTCTGT 2100

GGAGCCGAGC AGGACAGGAC AGCCGGGAGC AGAAGACCTG CCGTCCTTGT TGAGAACCCC 2160

TGGGACAAGG AATTGATTGG CAAATTCTTG TCGAAACTTC CAAAGCCACT CCACACCTAC 2220

ACCAACTACT TTGAGTGGAA ATCTCCCCTT CCATTCATCA AAGCGAAGAC TGAACTCTCA 2280

CTGGGTTCCA GCTCATTCCA TGTGGACTGC TTGGTTGGAG AAGGAGCTTT TGCCCAAGTC 2340

TATCAAGCTT CCATCCTGGA TGCCAGTAAC CCTCAGAATA ATCAGAAAGT GATATTCAAG 2400

GTCCAGAAAC CTGCCAACCC CTGGGAGTTC TACATTGCAA CCCAGCTGGT GGAGAGGCTG 2460

AGCCCCAGCA TGCACCACCT CTACATCCAC TTTTATTCCG CCCATTTCTT CTCCAACGGC 2520

AGTGTTTTGG TGGGGGAGTT CCACAACTAT GGAACGCTGC TCAATGCCGT CAACGTTTAC 2580

AAGAAGCTCC CAGAGAAGGT GATGCCCCAA GCCCTTGTCA TCTACTTTGC TGTCAAAATC 2640

CTTCACATGG TAGAGGAGCT GCACAGCTGC AAAATCATCC ATGGGGACAT CAAACCTGAC 2700

AATTTCATCC TGGGAGAAAG GCAAGTGTTC CTGGAAAACA ACACGTGTGA TATCGATGGG 2760

CTCTGCCACG GCCTGACCCT CATTGACCTG GGCCAAAGCA TCGACATGAA GCTCTTCCCT 2820

GAGGGAACAG CCTTCACTGC CAGGTGTGAA ACATCTGGAT TCCAGTGCGT GGAAATGCTG 2880

ACCAACAAAC CATGGAACTA CCAGACAGAC TACTTTGGGA TTGCAGCTAC CGTGTACTGC 2940

CTGCTCTTTG GGACCTACAT GCGCCTCAAG AATGACAATG GGGTCTGGAA GCCTGAGGGA 3000

ACCTTCAGGA GGCTTGCCAA TGCTGAGCTG TGGAAAGAGT TCTTTGAGAG CTTGCTGAAC 3060

ATTCCCAGCT GCCACAACCT GCCTTCCCTC AGAATCCTGT GCCAGAAGCT CAAGGATTTA 3120

TTTTGCAGGT CCTACGCTAA GGAAATCAAG TTCCTTCGGA ACAGACTTGT TGTGTTGCTC 3180

ATCGAGCACA AACGCTCACG GAAATAA 3207

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeel  56

         ++++ ++geGa+a+vy+a      + +++++v+ Kv+kpan+WefYI +ql eRl  +++

Q: 766   FHVDCLVGEGAFAQVYQASIldasNPQNNQKVIFKVQKPANPWEFYIATQLVERLS-PSM  824

         68999*************99865556699**************************9.77*

S: 57    lksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiv  116

         ++ +i+++sa+ f+++s+lv e+++ygtll+++n +k+  +kvm+++lv++++v++l++v

Q: 825   HHLYIHFYSAHFFSNGSVLVGEFHNYGTLLNAVNVYKKLPEKVMPQALVIYFAVKILHMV  884

         ************************************************************

S: 117   eklHeveIiHgDlkPdnfllgnr..imdkad..kdkeekglkliDfgrsiDmkllpdgtk  172

         e+lH+++IiHgD+kPdnf+lg+r  + ++     d   +gl liD+g+siDmkl+p+gt+

Q: 885   EELHSCKIIHGDIKPDNFILGERqvFLENNTcdIDGLCHGLTLIDLGQSIDMKLFPEGTA  944

         ********************98844556554125678899********************

S: 173   fkgkaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikr  232

         f+++++t++f+c+eml++k+w+Yq+D+fg+aa++++llfg+y+++++++g wk++ +++r

Q: 945   FTARCETSGFQCVEMLTNKPWNYQTDYFGIAATVYCLLFGTYMRLKNDNGVWKPEGTFRR  1004

         ************************************************************

S: 233   llkkelwekiferlLNisdastlpsleelve  263

         l + elw+++fe lLNi+++++lpsl  l +

Q: 1005  LANAELWKEFFESLLNIPSCHNLPSLRILCQ  1035

         **************************99984

Domain Sequence
(FASTA)

FHVDCLVGEG AFAQVYQASI LDASNPQNNQ KVIFKVQKPA NPWEFYIATQ LVERLSPSMH 60

HLYIHFYSAH FFSNGSVLVG EFHNYGTLLN AVNVYKKLPE KVMPQALVIY FAVKILHMVE 120

ELHSCKIIHG DIKPDNFILG ERQVFLENNT CDIDGLCHGL TLIDLGQSID MKLFPEGTAF 180

TARCETSGFQ CVEMLTNKPW NYQTDYFGIA ATVYCLLFGT YMRLKNDNGV WKPEGTFRRL 240

ANAELWKEFF ESLLNIPSCH NLPSLRILCQ 270

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013