EKS-TAG-00445

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00445

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	384.8	1.5E-115	242	490	249

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007631

UniProt Accession

H0ZAM6;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007405	ENSTGUP00000007631	ENSTGUT00000007710

Organism

Taeniopygia guttata

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

IAPRSQPATP AMEQFVRKRL TFLTSFWNKL RPRSVTESCS LGYLGSDSVS LNSEATSISF 60

IPKSSLCIAL YAFAARSAEE LSVSAGDKLR VLREEGEYVL ARRLLGEPAM GYVPAAYVAN 120

LSQGTSAHRP WYFSKISRNE AEQLLLSPPN QHGSFLVRDS ESSKGEYSLS VRNHAKVSHF 180

RICKSPRGSL YIQKGHPFPN MEELLAFYTE HWKVIQSPLL QPCSPATPPE RDGWERPRWE 240

FTLRRKLGEG YFGEVWEGLW RNTVPVAIKI IKADMKAEDF TKEIQNLKRL RHEKLIQLHA 300

VCSLEEPVYI ITELMRKGNL HSYLNSPEGK SLGTSHLLNI ACQVADGMRY LEEKHIVHRD 360

LAARNILVGE ELTCKIADFG LARLLKDDIY STSSSTKIPV KWTAPEAANY RTYSLKSDVW 420

SYGILLYEVF TYGQIPYEGM TNQETVRQIT RGYRLPRPSP CPPEIYSIML ECWSGNTEER 480

PTFLALREKL GFIYRRLLSS LS 502

Nucleotide Sequence
(FASTA)

ATAGCCCCCC GCAGCCAGCC AGCCACCCCG GCCATGGAGC AGTTCGTCAG GAAGCGCCTG 60

ACCTTCCTGA CATCCTTCTG GAACAAGCTC CGTCCCCGCT CCGTCACGGA GAGCTGCTCG 120

CTGGGGTATC TCGGCTCCGA TTCCGTTTCG CTGAACTCGG AGGCGACTTC CATCTCCTTC 180

ATCCCCAAGT CCTCTCTCTG TATCGCTTTG TACGCTTTCG CAGCCCGCAG CGCCGAGGAG 240

CTGAGCGTAA GCGCAGGGGA CAAGCTGCGT GTCCTCAGAG AGGAGGGCGA GTATGTGCTG 300

GCCCGGCGGC TGCTGGGGGA GCCGGCCATG GGCTATGTCC CTGCTGCCTA CGTGGCCAAC 360

CTCAGCCAGG GCACCTCCGC TCACCGCCCC TGGTACTTCA GCAAGATCAG CCGAAATGAA 420

GCAGAGCAGC TCCTCCTCTC GCCTCCCAAC CAGCACGGCT CCTTCCTCGT CCGGGACAGC 480

GAGAGCAGCA AGGGCGAATA CTCTCTCTCA GTGCGCAACC ACGCCAAGGT CAGCCACTTC 540

AGAATCTGCA AGAGCCCCAG GGGCAGCCTC TACATCCAGA AGGGACATCC CTTTCCCAAC 600

ATGGAGGAGC TCCTGGCCTT CTACACGGAG CACTGGAAGG TCATCCAGAG CCCCCTGCTG 660

CAGCCCTGCA GCCCCGCGAC TCCCCCCGAG AGGGACGGCT GGGAGCGCCC GCGCTGGGAG 720

TTCACCCTGC GGAGGAAGCT GGGAGAGGGC TACTTTGGAG AGGTGTGGGA AGGGCTGTGG 780

AGGAACACAG TGCCAGTGGC CATCAAGATC ATTAAAGCTG ACATGAAAGC AGAGGACTTC 840

ACCAAGGAGA TTCAGAACCT GAAGCGCCTG AGGCATGAGA AGCTGATCCA GCTGCACGCC 900

GTGTGCTCCC TGGAGGAGCC CGTGTACATC ATCACCGAGC TCATGCGCAA AGGCAACCTC 960

CACAGCTACC TCAACAGTCC TGAAGGGAAG TCCCTGGGCA CCTCCCACCT GCTCAACATC 1020

GCCTGCCAAG TGGCGGATGG GATGAGGTAC CTGGAGGAGA AGCACATTGT CCACAGGGAT 1080

TTGGCAGCCA GAAACATCCT GGTTGGAGAG GAACTCACCT GCAAAATCGC CGATTTCGGA 1140

CTTGCCCGCC TCCTCAAGGA TGACATTTAT TCCACCAGCA GCAGCACTAA AATCCCGGTG 1200

AAGTGGACAG CCCCGGAGGC AGCCAACTAC CGCACCTACT CCCTCAAGTC CGACGTCTGG 1260

TCCTATGGGA TTCTGCTCTA CGAAGTCTTC ACGTATGGAC AGATCCCATA TGAAGGAATG 1320

ACAAACCAAG AAACCGTACG GCAAATCACC AGGGGCTACC GCCTCCCCCG GCCCAGCCCC 1380

TGCCCTCCCG AGATCTACAG CATCATGCTG GAGTGCTGGA GTGGCAACAC GGAGGAGCGT 1440

CCCACCTTCC TGGCCCTGAG GGAGAAGCTG GGCTTCATCT ACAGGCGGCT GCTCAGCTCC 1500

CTCTCCTGA 1509

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

         +l +klGeG+fGevw+g+w+++v+va+k +k  +++ e+f++e+q lk+lrhekl++l+a

Q: 242   TLRRKLGEGYFGEVWEGLWRNTVPVAIKIIKA-DMKAEDFTKEIQNLKRLRHEKLIQLHA  300

         689***************************97.59*************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s eeP+yi+telm+kG+l ++l++ egk+l  ++l+++a+qva+Gm yleek+++hrd

Q: 301   VCSLEEPVYIITELMRKGNLHSYLNSPEGKSLGTSHLLNIACQVADGMRYLEEKHIVHRD  360

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvge+l++k+adfGlarl++dd+y++++++k+P+kWtaPea++++++++ksdvW

Q: 361   LAARNILVGEELTCKIADFGLARLLKDDIYSTSSSTKIPVKWTAPEAANYRTYSLKSDVW  420

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         s+Gill+e++t+G++Py+Gmtn+e+++q++rgyrlprp+ cp e+y+++lecw+ + eer

Q: 421   SYGILLYEVFTYGQIPYEGMTNQETVRQITRGYRLPRPSPCPPEIYSIMLECWSGNTEER  480

         ************************************************************

S: 242   Ptfetlqevl  251

         Ptf +l+e+l

Q: 481   PTFLALREKL  490

         ****999875

Domain Sequence
(FASTA)

TLRRKLGEGY FGEVWEGLWR NTVPVAIKII KADMKAEDFT KEIQNLKRLR HEKLIQLHAV 60

CSLEEPVYII TELMRKGNLH SYLNSPEGKS LGTSHLLNIA CQVADGMRYL EEKHIVHRDL 120

AARNILVGEE LTCKIADFGL ARLLKDDIYS TSSSTKIPVK WTAPEAANYR TYSLKSDVWS 180

YGILLYEVFT YGQIPYEGMT NQETVRQITR GYRLPRPSPC PPEIYSIMLE CWSGNTEERP 240

TFLALREKL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013