EPS-TAG-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAG-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	184.2	3.3E-54	120	367	248

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007643

UniProt Accession

H0ZAN8;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007416	ENSTGUP00000007643	ENSTGUT00000007722

Organism

Taeniopygia guttata

Functional Description

Protein Length

368

Protein Sequence
(FASTA)

PPAPPPPPPP LPSLPRPLSE YITEEEVEGE CLDLCLQQLY KYNCPSFLAS ALARATSDEV 60

LQSDLSAHFL PKHVDNADGI IQIETVKLAR LVYSKLHEIC SNWVKDFPLQ PKPHRYYETS 120

IHAIKNMRRK MEDKHVCIPD FNMLFNLEDQ EEQAYFAVFD GHGGVDAAIY ASIHLHVNMV 180

HQEMFQHDPA EALCRAFRVT DERFVQKAAR ESLRCGTTGV VTFIRGNMLH VAWLGDSQVM 240

LVRRGQAVEL MKPHKPDRED EKKRIEALGG CVVWFGAWRV NGSLSVSRAI GDAEHKPYIC 300

GDADSASTVL DGSEDYLILA CDGFYDTVNP DEAVVVADHL KENNGDSSMV AHKLVASARD 360

AGSSDNIT 368

Nucleotide Sequence
(FASTA)

CCGCCCGCAC CGCCGCCGCC ACCCCCGCCG CTGCCCTCGC TGCCCCGGCC GCTCTCGGAG 60

TACATCACGG AGGAGGAGGT GGAGGGCGAG TGCCTGGACC TCTGCCTACA GCAGCTCTAC 120

AAGTATAACT GCCCTTCATT CCTGGCCTCT GCTTTGGCCA GAGCAACTTC AGATGAAGTC 180

CTGCAGAGCG ACCTCTCGGC GCATTTCCTG CCCAAGCACG TGGACAACGC CGACGGCATC 240

ATCCAGATCG AGACGGTGAA GTTGGCCCGT TTAGTTTACA GCAAACTGCA CGAGATCTGC 300

AGCAACTGGG TGAAAGATTT CCCCCTGCAG CCCAAGCCCC ACCGCTACTA CGAGACCTCC 360

ATCCACGCCA TCAAGAACAT GCGCAGGAAG ATGGAGGACA AGCACGTCTG CATCCCTGAC 420

TTCAACATGC TCTTCAACCT CGAGGACCAA GAAGAACAAG CTTATTTTGC AGTGTTTGAT 480

GGTCATGGAG GAGTGGATGC TGCCATCTAT GCCTCCATCC ACCTGCACGT GAACATGGTC 540

CACCAGGAGA TGTTCCAGCA CGACCCAGCC GAGGCTCTGT GCCGAGCCTT CCGCGTCACC 600

GACGAGCGCT TCGTGCAGAA GGCAGCCAGG GAGAGTCTGC GCTGTGGAAC CACCGGGGTG 660

GTGACTTTCA TCCGAGGGAA TATGCTGCAT GTGGCTTGGC TGGGGGACTC CCAGGTCATG 720

CTTGTGAGGA GAGGCCAAGC TGTGGAACTG ATGAAACCCC ACAAACCAGA CCGAGAGGAT 780

GAGAAGAAGC GAATCGAGGC CCTGGGTGGA TGCGTGGTCT GGTTTGGAGC CTGGAGGGTG 840

AACGGGAGCC TCTCTGTCTC CAGAGCTATT GGGGACGCTG AGCACAAGCC ATACATCTGT 900

GGGGACGCAG ACTCTGCCTC CACGGTGCTG GATGGCTCTG AAGACTACCT CATTCTGGCC 960

TGTGATGGCT TCTACGACAC AGTCAACCCC GATGAGGCAG TCGTGGTGGC TGACCATCTG 1020

AAGGAGAATA ACGGTGACAG CAGCATGGTA GCACATAAAT TGGTGGCATC TGCTCGGGAT 1080

GCCGGCTCCA GCGACAACAT CACG 1104

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  +

Q: 120   SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNM  179

         567899**************99766555544459***********************888

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

           +       + +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 180   VHQEM----FQHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  233

         88855....5777888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         +GdS+++L r g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 234   LGDSQVMLVRRGQAVELMKPHKPDREDEKKRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  292

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekkeaeqeaak  240

          + kpy+  + +  s+ l+ ++++liLa+DG +d+v++ eav ++ +  e++ + + +a+

Q: 293   AEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVVVADHLKENNGDSSMVAH  352

         ************************************************************

S: 241   kLvklalargskdnv  255

         kLv+ a++ gs+dn+

Q: 353   KLVASARDAGSSDNI  367

         **************9

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNM 60

VHQEMFQHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWLGDSQV 120

MLVRRGQAVE LMKPHKPDRE DEKKRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGSEDYLIL ACDGFYDTVN PDEAVVVADH LKENNGDSSM VAHKLVASAR 240

DAGSSDNI 248

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013