EKS-TAG-00188

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00188

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	493.2	1.4E-148	422	681	260

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007739

UniProt Accession

H0ZAY2;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007471	ENSTGUP00000007739	ENSTGUT00000007820

Organism

Taeniopygia guttata

Functional Description

Protein Length

742

Protein Sequence
(FASTA)

IPLAQLADPW QMAVESTAES STENGQQIVD EPMGEDDINQ QTEEGSIKEI AITHHVKEGH 60

EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEDDV KFYLAELALA 180

LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSLEAQSLLR 300

MLFKRNPANR LGAGPDGVEE IKRHAFFSKI DWNKLYRREI HPPFKPATGR PEDTFYFDPE 360

FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI ASDDESQAMQ TVGVHSIVQQ LHRNSIQFTD 420

GYEVKEDIGV GSYSVCKRCV HKASNMEYAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK 480

DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HTQGVVHRDL 540

KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD 600

IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKAKDLVSK 660

MLHVDPHQRL TAAQVLSHPW IVHCDQLPQY QLNRQDAPHL VKGAMAATYS ALNRNQSPVL 720

EPVGRSTLAQ RRGIKKITST AL 742

Nucleotide Sequence
(FASTA)

ATTCCCCTGG CGCAGCTGGC AGACCCTTGG CAAATGGCTG TGGAGAGCAC GGCCGAGAGC 60

AGCACCGAGA ATGGACAGCA AATTGTGGAT GAACCTATGG GAGAAGATGA TATCAACCAA 120

CAGACTGAAG AAGGAAGTAT CAAAGAAATT GCAATAACTC ACCATGTAAA GGAAGGACAT 180

GAGAAAGCAG ACCCTTCACA GTTTGAACTT CTGAAAGTAT TAGGACAAGG ATCCTTTGGA 240

AAGGTCTTCC TTGTCAAAAA AATCTCAGGA TCAGATGCTA GACAGCTTTA TGCAATGAAG 300

GTATTGAAAA AGGCCACCTT GAAAGTTCGA GATCGTGTTC GGACAAAAAT GGAACGTGAT 360

ATCCTAGTAG AAGTTAACCA TCCTTTTATT GTCAAGTTAC ATTATGCTTT TCAAACAGAA 420

GGGAAGCTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ACTTGTTTAC ACGTTTATCC 480

AAAGAGGTGA TGTTCACAGA AGATGACGTT AAATTTTATC TGGCAGAATT AGCACTTGCT 540

TTAGACCATC TACATAGTCT TGGAATAATA TACCGGGATC TAAAACCAGA AAACATCCTG 600

CTTGATGAAG AAGGACATAT CAAATTGACA GATTTTGGCT TAAGTAAGGA GTCAATTGAT 660

CATGAAAAAA AAGCCTACTC TTTCTGTGGA ACAGTGGAAT ATATGGCACC AGAAGTTGTT 720

AACAGACGAG GCCATACACA GAGTGCAGAC TGGTGGTCTT TTGGTGTTTT AATGTTTGAA 780

ATGCTCACTG GTACTCTACC TTTCCAAGGG AAAGACAGAA AAGAAACCAT GACTATGATT 840

CTCAAGGCCA AACTTGGAAT GCCCCAATTC TTGAGTCTTG AAGCACAGAG TCTCCTGCGA 900

ATGCTCTTCA AGAGAAACCC AGCAAACAGA TTAGGAGCAG GTCCAGATGG AGTAGAAGAA 960

ATTAAGAGGC ATGCATTCTT TTCCAAAATA GATTGGAATA AATTGTACCG GAGAGAAATT 1020

CATCCTCCTT TTAAACCTGC AACTGGCAGA CCTGAAGATA CATTTTATTT TGACCCTGAG 1080

TTTACAGCAA AAACTCCAAA AGATTCACCT GGTATTCCAC CCAGTGCTAA TGCACATCAG 1140

CTTTTTCGGG GATTTAGTTT TGTAGCTATT GCATCAGATG ATGAAAGCCA AGCAATGCAG 1200

ACAGTTGGAG TGCATTCAAT TGTCCAGCAG TTGCACAGGA ACAGCATTCA GTTTACTGAT 1260

GGATATGAAG TAAAGGAAGA TATTGGAGTT GGCTCTTATT CTGTCTGCAA GAGATGTGTT 1320

CATAAAGCTT CAAACATGGA ATATGCTGTA AAGATTATTG ACAAGAGTAA AAGAGATCCA 1380

ACAGAAGAGA TTGAAATCCT GCTGCGCTAT GGACAGCATC CAAATATTAT TACTCTGAAA 1440

GATGTGTATG ATGATGGAAA ATATGTGTAT GTAGTAACAG AACTTATGAA AGGAGGAGAA 1500

CTGCTGGATA AAATTCTTAG ACAAAAATTT TTCTCAGAAC GAGAAGCTAG TGCTGTTCTG 1560

TTCACAATAA CAAAAACAGT TGAATATCTC CACACACAGG GGGTTGTTCA CAGAGACCTG 1620

AAGCCTAGCA ATATTCTTTA TGTTGATGAA TCTGGTAATC CAGAATCAAT TAGAATTTGT 1680

GACTTTGGTT TTGCAAAACA ACTGCGAGCA GAAAATGGTC TTCTGATGAC TCCATGCTAC 1740

ACAGCAAATT TTGTTGCACC AGAGGTTTTA AAGAGGCAAG GTTATGATGC TGCATGTGAC 1800

ATATGGAGCC TTGGTGTTCT ACTTTATACC ATGCTCACTG GCTACACTCC TTTTGCAAAT 1860

GGTCCTGATG ATACCCCAGA GGAGATTTTG GCCCGAATAG GAAGTGGGAA GTTCTCCCTC 1920

AGTGGTGGTT ATTGGAACAG TGTTTCAGAC ACAGCTAAGG CAAAAGACCT TGTTTCAAAA 1980

ATGCTTCATG TTGACCCTCA TCAAAGACTG ACTGCAGCCC AAGTTCTCAG TCACCCCTGG 2040

ATAGTTCACT GTGACCAGTT GCCTCAATAC CAGCTGAACA GGCAGGATGC TCCCCATTTA 2100

GTGAAGGGTG CAATGGCAGC AACTTATTCT GCTTTGAATC GTAATCAGTC ACCAGTTTTG 2160

GAACCAGTTG GCCGTTCTAC TCTTGCTCAG AGGAGAGGTA TTAAAAAAAT TACCTCAACA 2220

GCCCTGTGA 2229

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrcvhka+n+e+avkiidkskrd++eeieillry+qhpni+tlkd

Q: 422   YEVKEDIGVGSYSVCKRCVHKASNMEYAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  481

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 482   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHTQGVVHRDLK  541

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 542   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  601

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseea..kdlvskl  238

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++a  kdlvsk+

Q: 602   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAkaKDLVSKM  661

         ************************************************985227******

S: 239   ltvdpakrlkleqllkhswl  258

         l+vdp++rl+++q+l+h+w+

Q: 662   LHVDPHQRLTAAQVLSHPWI  681

         *******************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCVH KASNMEYAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH TQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKAKDLVSKM 240

LHVDPHQRLT AAQVLSHPWI 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013