EKS-TAG-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	383.1	5.8E-115	65	326	262

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007758

UniProt Accession

H0ZB01;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K3

Gene Synonyms/Alias

MAP2K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007502	ENSTGUP00000007758	ENSTGUT00000007839

Organism

Taeniopygia guttata

Functional Description

Protein Length

348

Protein Sequence
(FASTA)

GAPARAAPPA AVPERRGFGK KKRDLRITCV PIKPPVANTT PPRNLDSRTF ITIGDKNFEV 60

EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NTQEQKRLLM DLDISMRTVD 120

CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYKKVLEKKK TIPEDILGKM AVSIVRALEH 180

LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE 240

LNQKGYNVKS DVWSLGITMI ELAILRFPYE SWGTPFQQLK QVVEEPSPQL PPERFSKEFV 300

DFTAQCLRKN PAERMNYLEL MEHPFFTLHD TKETDMASFV TEILGEDS 348

Nucleotide Sequence
(FASTA)

GGCGCCCCCG CGCGGGCGGC ACCGCCAGCA GCGGTACCGG AACGGCGCGG GTTCGGCAAG 60

AAGAAGCGGG ATCTGAGGAT AACATGTGTC CCCATCAAAC CACCCGTGGC CAACACAACG 120

CCCCCGAGGA ACTTGGACTC CAGGACGTTC ATTACCATTG GAGATAAAAA CTTCGAGGTG 180

GAAGCTGATG ACCTGGTGAC CATTTCGGAG CTGGGCCGTG GGGCCTACGG CGTGGTGGAG 240

AAGGTGCGGC ACGCGCAGAG CGGCACCATC ATGGCCGTGA AGAGAATCCG AGCCACTGTG 300

AACACGCAGG AGCAGAAGAG GTTGTTGATG GACCTGGACA TCTCCATGAG GACGGTCGAC 360

TGCTTCTACA CAGTCACCTT CTACGGAGCC CTCTTCCGTG AGGGTGACGT GTGGATCTGC 420

ATGGAACTCA TGGACACTTC CCTAGATAAA TTCTACAAGA AAGTACTGGA GAAGAAGAAG 480

ACCATCCCTG AAGACATTTT GGGGAAAATG GCTGTGTCTA TTGTACGAGC TCTGGAGCAC 540

CTGCACAGTA AACTCTCTGT AATCCATAGA GACGTGAAAC CTTCCAACGT GCTGATCAAC 600

AAGGAGGGGC ACGTGAAGAT GTGCGACTTT GGGATCAGTG GCTACTTGGT GGACTCTGTT 660

GCCAAGACCA TGGATGCTGG CTGCAAACCC TACATGGCTC CAGAAAGAAT AAACCCTGAG 720

CTGAACCAGA AGGGCTACAA CGTGAAGTCG GATGTCTGGA GCCTTGGGAT CACAATGATT 780

GAACTGGCCA TTCTCCGCTT CCCGTACGAG TCCTGGGGGA CGCCCTTCCA GCAGCTCAAG 840

CAGGTGGTGG AGGAGCCCTC GCCCCAGCTG CCCCCTGAAC GCTTCTCCAA GGAGTTTGTG 900

GACTTCACAG CACAGTGCTT GAGGAAGAAC CCAGCTGAGC GAATGAACTA TTTGGAACTT 960

ATGGAACACC CGTTCTTCAC CTTGCACGAC ACCAAAGAGA CTGACATGGC CTCCTTTGTG 1020

ACAGAGATCC TCGGGGAAGA CTCCTAA 1047

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l +++elG+G++gvVekv+h +sg+i+avK+ir++++++eqk++l++l++ +++ ++ y+

Q: 65    LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYT  124

         56899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++kkvlekkk+ipe++lgk+av++v+ale+l++

Q: 125   VTFYGALFREGDVWICMELMD-TSLDKFYKKVLEKKKTIPEDILGKMAVSIVRALEHLHS  183

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n++G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 184   KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMdAGCKPYMAPERINPelnQ  243

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Y+vksdvWslG+t++ela+ r+pye++ +++++lk++v+e++p+lp e+fs+ef++f

Q: 244   KGYNVKSDVWSLGITMIELAILRFPYESWGTPFQQLKQVVEEPSPQLPPERFSKEFVDFT  303

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++Cl+k+++eR+++ el++h+f+

Q: 304   AQCLRKNPAERMNYLELMEHPFF  326

         *********************96

Domain Sequence
(FASTA)

LVTISELGRG AYGVVEKVRH AQSGTIMAVK RIRATVNTQE QKRLLMDLDI SMRTVDCFYT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKK VLEKKKTIPE DILGKMAVSI VRALEHLHSK 120

LSVIHRDVKP SNVLINKEGH VKMCDFGISG YLVDSVAKTM DAGCKPYMAP ERINPELNQK 180

GYNVKSDVWS LGITMIELAI LRFPYESWGT PFQQLKQVVE EPSPQLPPER FSKEFVDFTA 240

QCLRKNPAER MNYLELMEHP FF 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006954	; P:inflammatory response
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0042035	; P:regulation of cytokine biosynthetic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013