EKS-TAG-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	367.6	3.6E-110	68	329	262

Status

Unreviewed

Ensembl Protein

ENSTGUP00000007910

UniProt Accession

H0ZBF2;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1

Gene Synonyms/Alias

RPS6KB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007657	ENSTGUP00000007910	ENSTGUT00000007995

Organism

Taeniopygia guttata

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MAGVFDIDLD QPEEAGSDEE LEEGGQLSES MDHGGVGQYD LGMEHCEKFE ISETSVNRGP 60

EKIRPECFEL LRVLGKGGYG KVFQVRKVTG ANTGKIFAMK VLKKAMIVRN AKDTAHTKAE 120

RNILEEVKHP FIVDLIYAFQ TGGKLYLILE YLSGGELFMQ LEREGIFMED TACFYLAEIS 180

MALGHLHQKG IIYRDLKPEN IMLNHQGHVK LTDFGLCKES IHDGTVTHTF CGTIEYMAPE 240

ILMRSGHNRA VDWWSLGALM YDMLTGAPPF TGENRKKTID KILKCKLNLP PYLTQEARDL 300

LKKLLKRNAA SRLGAGPGDA GEVQAHAFFR HINWDELLAR KVEPPFKPLL QSEEDVSQFD 360

SKFTRQTPVD SPDDSTLSES ANQVFLGFTY VAPSVLESVK EKFSFEPKIR SPRRFIGSPR 420

TPVSPVKFSP GEFWGRGASA GASNTQTPVE YPMETSGIEQ MDVTVCGEAS APLPIRQPNS 480

GPYKKQAFPM ISKRPEHLRM NL 502

Nucleotide Sequence
(FASTA)

ATGGCGGGAG TGTTCGACAT CGACCTGGAC CAGCCCGAGG AGGCGGGCTC AGACGAGGAG 60

CTGGAGGAGG GGGGGCAGTT AAGTGAGAGC ATGGACCATG GAGGAGTTGG CCAATATGAC 120

CTTGGGATGG AACATTGTGA AAAATTTGAG ATTTCAGAGA CCAGCGTGAA CAGAGGCCCC 180

GAGAAGATCC GCCCCGAGTG CTTCGAGCTA CTGCGCGTGC TGGGCAAGGG CGGCTACGGC 240

AAGGTGTTTC AAGTACGAAA AGTAACCGGA GCAAACACCG GGAAAATATT TGCCATGAAA 300

GTTCTTAAAA AGGCAATGAT TGTAAGGAAT GCCAAGGATA CAGCTCACAC GAAAGCAGAG 360

AGGAATATAC TGGAGGAAGT GAAACATCCC TTCATTGTAG ACTTAATTTA TGCCTTTCAG 420

ACTGGTGGAA AACTCTACCT CATCCTTGAG TATCTCAGTG GAGGAGAATT ATTTATGCAG 480

TTAGAGAGAG AAGGGATATT TATGGAAGAC ACAGCCTGCT TTTACTTGGC AGAAATCTCC 540

ATGGCACTGG GGCACTTGCA TCAAAAAGGA ATCATCTACC GGGATCTGAA GCCAGAAAAT 600

ATCATGCTTA ATCATCAAGG TCATGTAAAA CTGACTGACT TCGGGTTATG TAAAGAATCC 660

ATTCACGATG GAACAGTCAC ACACACATTC TGTGGAACAA TTGAATACAT GGCCCCTGAA 720

ATCTTGATGA GGAGTGGGCA TAACCGTGCT GTGGACTGGT GGAGTTTGGG GGCATTAATG 780

TATGACATGC TGACTGGAGC ACCTCCTTTC ACTGGGGAGA ACAGAAAGAA AACAATTGAC 840

AAGATTCTCA AGTGTAAACT CAACTTGCCT CCCTACCTCA CACAAGAAGC CAGAGATCTG 900

CTTAAAAAGC TGCTAAAAAG AAATGCTGCC TCACGTCTAG GAGCTGGTCC TGGAGATGCT 960

GGAGAAGTTC AGGCTCACGC CTTCTTCAGA CACATCAACT GGGACGAGCT GCTGGCACGC 1020

AAGGTGGAAC CTCCTTTTAA ACCCTTATTG CAATCTGAAG AGGATGTGAG CCAGTTTGAT 1080

TCAAAGTTTA CACGTCAGAC ACCTGTTGAT AGCCCAGATG ACTCAACTCT CAGTGAAAGT 1140

GCCAACCAGG TTTTTCTGGG TTTTACGTAT GTGGCTCCAT CTGTACTCGA AAGCGTAAAA 1200

GAGAAATTTT CTTTTGAACC AAAAATTCGA TCACCTCGCA GATTCATAGG TAGCCCTAGG 1260

ACACCAGTCA GCCCTGTCAA GTTTTCCCCT GGGGAATTCT GGGGAAGAGG TGCTTCTGCC 1320

GGCGCATCCA ACACCCAGAC ACCTGTGGAA TACCCGATGG AGACCAGTGG AATAGAACAA 1380

ATGGATGTGA CAGTCTGTGG AGAGGCTTCA GCACCACTTC CAATCCGGCA ACCAAACTCT 1440

GGGCCCTACA AAAAACAGGC TTTTCCCATG ATTTCCAAAC GACCGGAGCA CTTGCGCATG 1500

AATCTATGA 1509

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 68    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  127

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 128   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  187

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 188   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  246

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 247   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  302

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ a+Rlga   +a e+++h f+

Q: 303   KLLKRNAASRLGAgpgDAGEVQAHAFF  329

         *************999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240

NAASRLGAGP GDAGEVQAHA FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004435	; F:phosphatidylinositol phospholipase C activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0006629	; P:lipid metabolic process

KEGG

tgu:100226155

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR001711	; PLipase_C_Pinositol-sp_Y.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50008	; PIPLC_Y_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013