EKS-TAG-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.45.2E-157597854258
StatusUnreviewed
Ensembl ProteinENSTGUP00000007981
UniProt AccessionH0ZBM3;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4
Gene Synonyms/Alias EPHA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000007665ENSTGUP00000007981ENSTGUT00000008066
OrganismTaeniopygia guttata
Functional Description
Protein Length962
Protein Sequence
(FASTA)
VTLLDSRSVQ GELGWIASPL EGGWEEVSIM DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIP 60
REGAQRVYIE IKFTLRDCNS LPGVMGTCKE TFNLYYYESN NDKERFIRES QFAKIDTIAA 120
DESFTQVDIG DRIMKLNTEI RDVGPLSKKG FYLAFQDVGA CIALVSVRVF YKKCPLTVRN 180
LAQFPDTITG ADTSSLVEVR GSCVNNSEEK DVPKMYCGAD GEWLVPIGNC LCNAGYEERN 240
GECQACKIGY YKALSTDAAC AKCPPHSYSI WEGSTSCTCD RGFFRAENDA ASMPCTRPPS 300
APQHLISNVN ETSVNLEWSP PQNKGGREDI SYNVVCKRCG AGEPSRCRSC GSGVHFSPQQ 360
NGLKSTKVSI TDLLAHTNYT FEVWAVNGVS KQNPSQDQAV SVTVTTNQAA PSPIALIQAK 420
EITRHSVALA WLEPDRPNGV ILEYEVKYYE KDQNERSYRI VKTASRNTDI KGLNPLTSYV 480
FHVRARTAAG YGDFSGPFEF TTNTVQTGLV FPSPIIGDGT NPTVLLVSVA GSVVLVVILI 540
AAFVISRRRS KYSKAKQEAD EEKHLNQGVR TYVDPFTYED PNQAVREFAK EIDASCIKIE 600
KVIGVGEFGE VCSGRLKVPG KREICVAIKT LKAGYTDKQR RDFLSEASIM GQFDHPNIIH 660
LEGVVTKCKP VMIITEYMEN GSLDAFLRKN DGRFTVIQLV GMLRGIGSGM KYLSDMSYVH 720
RDLAARNILV NSNLVCKVSD FGMSRVLEDD PEAAYTTRGG KIPIRWTAPE AIAYRKFTSA 780
SDVWSYGIVM WEVMSYGERP YWDMSNQDVI KAIEEGYRLP PPMDCPIALH QLMLDCWQKE 840
RSDRPKFGQI VNMLDKLIRN PNSLKRTGSE SSRPSTALLD PSSPEFSAVV SVSDWLQAMK 900
MERYKDNFTA AGYTTLEAVV HMNQEDLARI GITALAHQNK ILSSVQAMRT QMQQMHGRMV 960
PV 962
Nucleotide Sequence
(FASTA)
GTTACCTTGC TGGATTCCAG ATCAGTTCAG GGAGAACTGG GGTGGATAGC AAGTCCCCTG 60
GAAGGAGGGT GGGAGGAAGT GAGCATCATG GATGAGAAGA ACACTCCTAT CCGCACCTAT 120
CAAGTCTGCA ATGTGATGGA GCCCAGTCAG AACAATTGGT TACGAACTGA TTGGATTCCC 180
CGAGAGGGGG CTCAGAGGGT TTATATTGAA ATCAAGTTCA CGCTAAGAGA CTGCAACAGC 240
CTGCCGGGTG TCATGGGAAC TTGCAAAGAG ACTTTCAACC TTTATTACTA CGAATCAAAC 300
AACGATAAAG AGCGTTTTAT TCGCGAGAGC CAGTTTGCCA AGATCGACAC CATTGCTGCT 360
GATGAGAGCT TCACCCAGGT GGACATTGGT GACAGGATCA TGAAGCTGAA TACAGAGATC 420
CGGGATGTGG GACCACTCAG CAAGAAGGGG TTTTATTTGG CTTTCCAGGA CGTCGGTGCC 480
TGCATTGCTT TGGTCTCTGT CCGTGTGTTC TATAAGAAGT GCCCGCTGAC GGTTCGGAAC 540
CTGGCGCAGT TTCCAGACAC CATTACTGGG GCTGACACCT CCTCTCTGGT GGAGGTTCGT 600
GGCTCCTGTG TCAACAACTC GGAAGAGAAG GATGTGCCAA AAATGTACTG TGGGGCAGAT 660
GGAGAATGGC TGGTGCCCAT TGGCAACTGC TTGTGCAATG CTGGCTATGA GGAGCGCAAT 720
GGAGAATGCC AAGCTTGCAA AATCGGATAC TACAAGGCTC TCTCGACAGA TGCTGCCTGT 780
GCCAAATGCC CGCCCCACAG CTACTCCATC TGGGAAGGCT CCACGTCCTG CACCTGCGAC 840
CGCGGCTTCT TCCGAGCCGA AAACGACGCT GCCTCCATGC CCTGCACTCG CCCTCCATCT 900
GCTCCCCAGC ACCTGATTTC CAATGTCAAC GAGACCTCGG TGAACCTGGA GTGGAGCCCG 960
CCCCAGAACA AAGGTGGCCG GGAGGACATC TCCTACAACG TGGTGTGCAA GAGGTGCGGG 1020
GCCGGCGAGC CCAGCCGCTG CCGCTCCTGT GGCAGTGGGG TGCACTTCAG CCCCCAGCAG 1080
AACGGCCTGA AATCCACCAA AGTCTCCATC ACCGACCTCC TGGCACACAC CAACTACACC 1140
TTTGAAGTCT GGGCGGTGAA TGGAGTGTCC AAGCAAAACC CCAGCCAGGA CCAGGCGGTG 1200
TCAGTCACTG TGACAACTAA CCAAGCAGCT CCATCCCCAA TTGCATTGAT CCAGGCTAAG 1260
GAGATAACAA GGCACAGTGT TGCCTTGGCT TGGCTGGAAC CTGACAGGCC AAATGGAGTC 1320
ATCCTGGAGT ATGAGGTCAA ATACTATGAA AAGGACCAGA ACGAGCGCAG CTATCGCATC 1380
GTGAAAACGG CCTCCAGGAA CACCGACATC AAAGGCCTCA ACCCCCTGAC CTCCTACGTG 1440
TTCCATGTGC GTGCCAGGAC AGCAGCAGGC TACGGAGACT TCAGCGGGCC CTTCGAGTTC 1500
ACCACGAACA CAGTGCAGAC AGGACTGGTT TTTCCTTCCC CCATCATTGG CGATGGTACC 1560
AATCCCACAG TGCTGCTTGT TTCAGTGGCT GGCAGTGTTG TTCTTGTGGT CATTCTCATT 1620
GCAGCCTTTG TCATCAGCAG GAGGCGCAGT AAGTACAGCA AGGCAAAGCA AGAGGCAGAT 1680
GAGGAGAAAC ACTTGAACCA AGGTGTTAGA ACATATGTGG ATCCTTTTAC ATATGAGGAT 1740
CCAAACCAAG CTGTGAGGGA ATTTGCCAAA GAAATTGATG CCTCCTGCAT AAAGATTGAA 1800
AAAGTTATTG GTGTGGGGGA GTTTGGTGAA GTCTGCAGTG GACGTCTCAA AGTGCCAGGA 1860
AAAAGAGAGA TCTGTGTTGC TATCAAGACT CTAAAAGCTG GTTACACTGA TAAACAAAGG 1920
AGAGACTTTC TGAGTGAGGC CAGTATCATG GGACAATTTG ACCACCCCAA TATCATCCAC 1980
TTGGAAGGTG TAGTTACTAA ATGTAAACCA GTAATGATCA TAACTGAGTA CATGGAGAAT 2040
GGCTCCTTGG ATGCCTTCCT CAGGAAGAAC GATGGCAGAT TCACAGTCAT CCAGTTGGTG 2100
GGGATGCTGC GTGGCATTGG CTCAGGGATG AAGTACCTGT CTGACATGAG CTACGTGCAC 2160
CGGGACCTCG CTGCTCGCAA CATTCTGGTC AACAGCAACC TGGTCTGCAA AGTGTCTGAC 2220
TTCGGCATGT CCCGCGTCCT GGAGGACGAC CCTGAGGCAG CCTACACCAC ACGGGGGGGC 2280
AAGATCCCCA TCAGGTGGAC AGCTCCCGAG GCCATCGCCT ACCGCAAGTT CACCTCGGCC 2340
AGCGACGTCT GGAGCTACGG CATCGTCATG TGGGAGGTGA TGTCCTACGG GGAGAGACCC 2400
TACTGGGACA TGTCCAACCA AGATGTGATC AAAGCCATCG AGGAAGGGTA CCGGCTGCCC 2460
CCGCCCATGG ACTGCCCCAT CGCCCTGCAC CAGCTGATGC TGGACTGCTG GCAGAAGGAG 2520
CGCAGCGACC GGCCCAAATT TGGGCAGATC GTCAACATGC TGGACAAGCT CATCCGCAAC 2580
CCCAACAGCC TGAAGAGGAC AGGCAGCGAG AGCTCCAGAC CTAGCACAGC CCTGCTGGAT 2640
CCCAGCTCCC CTGAGTTCTC GGCGGTTGTT TCTGTCAGTG ACTGGCTCCA AGCCATGAAA 2700
ATGGAGCGAT ACAAGGATAA CTTCACAGCT GCTGGCTATA CCACCCTAGA GGCTGTGGTG 2760
CATATGAACC AGGAGGACCT GGCCAGGATC GGGATCACAG CCCTGGCGCA CCAGAACAAG 2820
ATCCTGAGCA GCGTGCAAGC GATGCGCACC CAAATGCAAC AGATGCACGG CAGGATGGTT 2880
CCCGTCTGA 2889
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 597   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  656
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 657   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  716
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 717   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  776
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 777   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  836
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 837   WQKERSDRPKFGQIVNML  854
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAE-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-CIS-00002
EKS-DAR-00001
EKS-DRM-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MAM-00001
EKS-MEG-00001
EKS-MOD-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORC-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-PEM-00004
EKS-POA-00001
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013