EKS-TAG-00473
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00473
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR567.01.4E-170563897335
StatusUnreviewed
Ensembl ProteinENSTGUP00000007975
UniProt AccessionH0ZBL7;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000007686ENSTGUP00000007975ENSTGUT00000008060
OrganismTaeniopygia guttata
Functional Description
Protein Length948
Protein Sequence
(FASTA)
HSILCFFFFP GGALSPVESL RVVNKGEELR LTCNEERPVT WNFQNSDPSA KARSSNEKEW 60
YTRNATVRDV GRYTCRSNGS IVSSYYVFVK DPNVLFLVDS LIYGKEDSDI LLVCPLTDPN 120
VTNFTLKKCD GRRLPRNMTF IPNPQKGIII KNVQRSFKGC YQCLAKHNGV EKISEKIFLN 180
VRPVHKTLPV ITLSKSYELL KEGEEFEVTC IITDVDSSVQ ASWISLKSGI VTSKSRNLGD 240
YGYERKLTLN IRSVGVNDSG EFTCQAENPF GKTNATVTLK ALAKGFVRLF ATMNTTIDIN 300
AGQNGNLTVE YEAYPKPKEE VWMYMNETLQ NSSDHDVKFK TVGNNSYTSE LHLTRLKGTE 360
GGIYTFFVSN SDASSSVTFN VYVKTKPEIL TLDILSNGVL QCVAAGFPAP TIYWYFCPGT 420
EQRCFDSPTI SPMDVKIGYT NSSVPSFERI LVESTINASM FRSTGTVCCE ASSNGDRSSA 480
FFNFAIKEQI RTHTLFTPLL TAFGVAAGLM CIIVMILVYI YLQKPKYEVQ WKVVEEINGN 540
NYVYIDPTQL PYDHKWEFPR NRLSFGKTLG AGAFGKVVEA TAYGLFKSDA AMTVAVKMLK 600
TSAHLTEREA LMSELKVLSY LGNHINIVNL LGACTVGGPT LVITEYCCYG DLLNFLRRKR 660
DSFICPKHEE HADAAVYENL LHQSEPAADV ANEYMDMKPG VSYAVPPKAD KKRPVKSGSY 720
TDQDVALSMP EDDELALDVE DLLSFSYQVA KGMSFLASKN CIHRDLAARN ILLTHGRITK 780
ICDFGLARDI RNDSNYVVKG NARLPVKWMA PESIFNCVYT FESDVWSYGI LLWELFSLGS 840
SPYPGIPVDS KFYKMIKEGY RMFSPECAPP EMYDIMKSCW DADPLQRPTF KQIVQMIEQQ 900
LSENAPRVYA NFSTPPSSQG NAPDHSVRIN SVGSSASSTQ PLLVREDV 948
Nucleotide Sequence
(FASTA)
CATTCTATTT TGTGCTTTTT TTTTTTCCCA GGTGGTGCAC TGTCCCCTGT AGAGTCTTTA 60
CGGGTTGTGA ATAAAGGGGA GGAATTAAGG CTGACATGCA ATGAGGAGAG ACCCGTGACT 120
TGGAATTTCC AGAACTCGGA CCCATCGGCA AAAGCAAGGA GTTCCAATGA GAAAGAGTGG 180
TACACCAGAA ATGCAACAGT CAGAGATGTA GGCAGGTACA CATGCAGAAG CAATGGGAGT 240
ATTGTCTCCT CCTATTACGT TTTTGTTAAA GATCCAAATG TTCTCTTCCT TGTTGATTCT 300
CTGATCTATG GAAAAGAAGA CAGTGACATC CTGCTAGTGT GTCCACTAAC AGACCCAAAT 360
GTTACGAATT TCACACTGAA AAAATGTGAT GGCAGACGTC TCCCCAGAAA TATGACATTC 420
ATTCCCAATC CCCAGAAAGG CATTATTATA AAGAACGTAC AGAGGTCGTT CAAGGGCTGC 480
TACCAGTGCT TGGCAAAGCA TAATGGAGTT GAGAAGATAT CGGAGAAGAT TTTCTTGAAT 540
GTGAGACCAG TTCACAAAAC TCTTCCTGTC ATCACCTTAT CAAAAAGCTA TGAGCTTCTC 600
AAAGAAGGGG AAGAATTTGA AGTTACATGC ATAATCACAG ATGTGGATAG CAGTGTACAA 660
GCTAGTTGGA TTTCTCTCAA AAGTGGGATT GTTACAAGCA AAAGCAGAAA TTTGGGTGAT 720
TATGGATACG AAAGGAAATT AACATTGAAC ATCCGTTCAG TGGGAGTTAA TGATTCTGGA 780
GAATTCACAT GCCAAGCAGA AAACCCTTTT GGAAAAACCA ATGCCACAGT AACCTTGAAA 840
GCTCTAGCTA AAGGATTTGT CCGTTTGTTT GCAACAATGA ATACCACAAT AGATATAAAT 900
GCAGGTCAAA ATGGAAACTT AACAGTTGAA TATGAGGCAT ATCCAAAACC AAAGGAAGAA 960
GTCTGGATGT ACATGAACGA AACATTGCAG AATTCCTCAG ACCATGATGT CAAGTTCAAG 1020
ACTGTGGGCA ATAACAGTTA CACAAGTGAA CTTCACCTTA CACGACTAAA AGGAACAGAA 1080
GGAGGCATTT ACACATTTTT TGTGTCCAAC TCTGATGCCA GCTCCTCTGT AACATTTAAT 1140
GTCTATGTGA AAACAAAACC TGAGATTCTC ACTCTGGATA TACTTAGCAA TGGTGTTCTC 1200
CAGTGTGTAG CAGCTGGATT CCCAGCCCCT ACCATATACT GGTATTTTTG CCCAGGAACT 1260
GAGCAAAGGT GTTTTGATTC ACCAACAATA TCCCCCATGG ATGTCAAAAT TGGTTACACA 1320
AATTCATCAG TACCGTCATT TGAACGAATC CTGGTTGAAA GCACCATTAA TGCCAGCATG 1380
TTCAGGAGCA CCGGCACCGT GTGCTGTGAG GCCTCCAGCA ATGGGGACAG GAGCTCTGCT 1440
TTCTTCAACT TTGCTATTAA AGAGCAAATC CGTACACATA CCCTTTTCAC CCCTTTACTA 1500
ACTGCATTTG GAGTTGCTGC AGGACTGATG TGCATCATAG TCATGATCCT GGTGTACATA 1560
TATTTGCAGA AACCCAAGTA CGAAGTTCAG TGGAAAGTTG TTGAAGAAAT AAATGGAAAC 1620
AACTATGTTT ACATAGATCC AACACAACTT CCGTATGATC ACAAATGGGA ATTTCCTAGA 1680
AACCGTTTGA GTTTTGGTAA AACCCTTGGC GCTGGAGCTT TTGGGAAAGT TGTTGAAGCC 1740
ACTGCTTATG GTTTATTCAA GTCTGATGCT GCTATGACAG TAGCAGTAAA GATGTTGAAA 1800
ACAAGTGCCC ATTTAACGGA GAGAGAAGCC TTGATGTCAG AGCTCAAAGT GCTGAGTTAC 1860
CTTGGAAACC ACATTAATAT TGTGAATCTG CTTGGAGCTT GCACTGTTGG AGGTCCCACT 1920
CTGGTCATTA CAGAATATTG CTGTTATGGT GATCTCTTAA ATTTTCTGAG ACGGAAACGA 1980
GATTCATTTA TTTGTCCAAA ACATGAAGAA CACGCAGATG CAGCTGTTTA TGAGAACCTT 2040
TTGCATCAGT CAGAGCCTGC AGCTGATGTT GCCAATGAGT ACATGGACAT GAAACCAGGA 2100
GTGTCATATG CAGTCCCACC AAAGGCTGAC AAAAAACGAC CTGTGAAGTC TGGATCCTAC 2160
ACTGATCAGG ATGTTGCCCT TTCTATGCCA GAAGATGATG AACTTGCTTT AGATGTAGAA 2220
GATCTGCTAA GCTTTTCTTA CCAGGTGGCA AAGGGCATGA GCTTCCTTGC CTCCAAAAAC 2280
TGCATTCATA GGGATCTGGC CGCAAGAAAT ATTCTTCTAA CTCATGGTCG AATTACTAAA 2340
ATCTGTGACT TTGGCCTGGC AAGAGATATA AGGAATGACT CAAATTACGT GGTCAAAGGA 2400
AATGCTCGTC TTCCTGTGAA GTGGATGGCA CCTGAAAGTA TTTTCAATTG TGTCTACACC 2460
TTTGAGAGTG ACGTCTGGTC TTACGGGATA TTGCTTTGGG AGCTCTTTTC TTTAGGAAGC 2520
AGCCCCTATC CAGGGATACC CGTGGACTCC AAGTTCTATA AAATGATCAA AGAGGGATAC 2580
AGAATGTTCA GCCCTGAGTG TGCACCACCT GAAATGTATG ACATAATGAA GAGTTGCTGG 2640
GATGCTGATC CCTTACAGAG ACCCACATTT AAACAAATTG TACAGATGAT AGAGCAGCAG 2700
CTTTCAGAAA ATGCCCCCCG GGTTTATGCC AACTTCTCAA CCCCACCTTC CAGTCAAGGA 2760
AATGCTCCAG ATCACTCGGT GAGGATTAAC TCAGTGGGCA GCAGCGCTTC CTCTACACAG 2820
CCTCTCCTGG TACGCGAAGA TGTT 2844
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 563   LSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKTSAHLTEREALMSELKVLSYLG  622
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   + k++e++ ++ +++
Q: 623   NHINIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---CPKHEEHADAAVYEN  679
         ******************************************...677778888888888
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l++ s+ +++  +ey+d+k++vs+  + kadk++  k  s+++++v  ++ e+d
Q: 680   L-----LHQ-SEPAADVANEYMDMKPGVSYAVPPKADKKRPVKSGSYTDQDVALSMPEDD  733
         8.....444.44556899******************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l++edllsfsyqvakGm flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 734   ELALDVEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRND  793
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGillwe+fslGs+pypg++vdskfy
Q: 794   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGILLWELFSLGSSPYPGIPVDSKFY  853
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeGyrm +p+ a+ e+y+im++cw+a+p +rp+fkq+v+++
Q: 854   KMIKEGYRMFSPECAPPEMYDIMKSCWDADPLQRPTFKQIVQMI  897
         *****************************************986
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLFKSDAAM TVAVKMLKTS AHLTEREALM SELKVLSYLG 60
NHINIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FICPKHEEHA DAAVYENLLH 120
QSEPAADVAN EYMDMKPGVS YAVPPKADKK RPVKSGSYTD QDVALSMPED DELALDVEDL 180
LSFSYQVAKG MSFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA 240
RLPVKWMAPE SIFNCVYTFE SDVWSYGILL WELFSLGSSP YPGIPVDSKF YKMIKEGYRM 300
FSPECAPPEM YDIMKSCWDA DPLQRPTFKQ IVQMI 335
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002551; P:mast cell chemotaxis
GO:0043303; P:mast cell degranulation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013