EKS-TAG-00476
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00476
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR501.21.5E-150593893301
StatusUnreviewed
Ensembl ProteinENSTGUP00000008023
UniProt AccessionH0ZBR5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000007756ENSTGUP00000008023ENSTGUT00000008108
OrganismTaeniopygia guttata
Functional Description
Protein Length1086
Protein Sequence
(FASTA)
MGTYPQMLLI LGCFLTGPFL TFCQLPLPTI VPNRNEMVVQ LYSNFTLKCS GDSEVSWQYP 60
VTEGNHRIDI RHEENNSGFF VTVLEVGNAS AAHTGLYVCY YNHTQVEDGE VEGKDIYIYV 120
PDPDMPFVPS IPEDQFILVE EGDPAVIPCR TSDPDAQVTL VNNLDKPVHA LYDTKQGFIG 180
NFPAGSYMCK TMVKGVEFKS DEFLIYIIRA TSQLPVEIEA LKTVYKTGET IVVTCVVFDN 240
EVVNLQWNYP GKVKEKGLIK LDDIKVPSQK LVYTLTIPEA SVKDTGDYEC TARHATKEVK 300
ENKKVAITVH DKGFVHLEPQ FSPLEAVNLH EVKNFVVDVQ AYPAPKMYWL KDNVTLIENL 360
TEIVTTSGRV QETRFQSILK LIRAKEEDSG YYTLVAENED EIKRYTFSLL IQVPALISAL 420
VDDHHGSAGG QTVRCLAEGT PLPDVEWLVC KDIKKCNNDT SWTILTNNIS DIHMEAHLDE 480
KNMVESQVTF QKVEETLAVR CVARNDLGAV TRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVIIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DNFLNRHPEK PKKDLDIFGM NPADESTRSY 720
VILSFENTGE YMDMKQADTT QYVPMLERKE GSKYSDIQRS VYDRPASYKK KSMSESEVKN 780
LLSDDSSEGL SLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGMYSIKFFQ 900
FILFYINSAY KNICMKSTVR CSSVWDFRFH CHRALLLHLP KLIIFSMLMN HSCPSEERQP 960
YYEKIHLDFK SDHPAVTRMR GDCDNAYIGV TYKNEDKLKD RESGFDEQRL SADSGYIIPL 1020
PDIDPVSEDE LGKRNRHSSQ TSEESAIETG SSSSTFIKRE DETIEDIDMM DDIGIDSSDL 1080
VEDSFL 1086
Nucleotide Sequence
(FASTA)
ATGGGTACTT ACCCACAGAT GCTCCTGATC CTGGGATGTT TCCTCACAGG ACCGTTCCTA 60
ACATTTTGCC AGCTTCCTCT GCCAACTATT GTTCCCAATA GGAATGAAAT GGTGGTACAG 120
CTGTATTCCA ATTTCACACT CAAATGCTCT GGGGACAGCG AAGTGAGCTG GCAGTACCCA 180
GTGACCGAGG GAAACCACAG GATAGACATT AGACACGAAG AGAACAACAG CGGCTTCTTC 240
GTGACAGTGC TCGAAGTAGG AAATGCCTCG GCTGCCCATA CGGGCTTGTA TGTTTGCTAC 300
TATAACCACA CACAAGTGGA GGATGGGGAG GTGGAAGGGA AGGACATCTA CATCTATGTG 360
CCTGACCCAG ACATGCCTTT TGTTCCTTCT ATACCAGAAG ACCAGTTCAT CCTAGTAGAA 420
GAAGGTGATC CTGCAGTTAT CCCTTGTCGG ACAAGTGACC CAGATGCTCA AGTGACTTTA 480
GTTAACAATT TAGACAAGCC TGTGCATGCT TTATATGACA CCAAACAAGG CTTCATAGGG 540
AATTTTCCTG CAGGCTCATA CATGTGCAAA ACAATGGTTA AGGGCGTGGA GTTCAAGTCT 600
GATGAGTTCC TCATCTATAT CATAAGAGCT ACTTCACAGC TGCCTGTTGA AATTGAAGCT 660
CTTAAAACTG TCTACAAAAC AGGCGAGACC ATCGTAGTAA CTTGTGTGGT CTTTGACAAT 720
GAGGTGGTTA ATTTACAGTG GAATTATCCT GGGAAAGTGA AAGAAAAAGG TCTGATAAAA 780
CTTGATGATA TCAAAGTGCC ATCGCAGAAG CTGGTTTACA CCCTGACCAT TCCTGAGGCA 840
TCAGTGAAAG ACACAGGCGA TTATGAATGT ACCGCTCGGC ATGCAACCAA GGAGGTTAAG 900
GAAAATAAGA AAGTAGCCAT TACAGTTCAT GACAAAGGCT TTGTTCACCT GGAGCCTCAG 960
TTCAGCCCTC TGGAAGCTGT CAACCTGCAT GAAGTCAAAA ACTTTGTTGT CGATGTGCAG 1020
GCTTACCCAG CACCAAAAAT GTACTGGTTG AAGGATAATG TGACTCTGAT TGAAAATCTT 1080
ACAGAGATTG TTACTACATC AGGAAGAGTC CAGGAAACGA GGTTTCAGAG TATTTTAAAA 1140
TTGATACGGG CCAAGGAGGA AGACAGTGGA TACTATACTT TGGTTGCTGA AAATGAAGAT 1200
GAGATTAAAA GATACACCTT CTCATTGCTC ATACAAGTTC CAGCTCTGAT CTCAGCCCTC 1260
GTGGATGATC ACCATGGCTC TGCAGGTGGG CAGACAGTGA GATGCTTGGC AGAGGGGACC 1320
CCACTTCCCG ATGTGGAATG GCTGGTTTGC AAGGACATTA AAAAGTGCAA CAATGACACC 1380
TCATGGACCA TTTTGACTAA CAATATCTCT GATATACATA TGGAAGCACA CTTGGATGAG 1440
AAAAATATGG TGGAAAGCCA GGTGACCTTC CAGAAGGTAG AGGAAACCCT GGCTGTGCGA 1500
TGTGTGGCAA GGAATGACCT CGGTGCTGTT ACTCGAGAAC TGAAGCTTGT GGCTCCCACC 1560
TTGAGGTCAG AGCTAACCGT GGCTGCTGCT GTCTTAGTGC TGTTAGTGAT TGTGATAATT 1620
TCCCTGATTG TCCTGGTTAT CATATGGAAA CAGAAGCCAA GGTATGAGAT TAGATGGAGA 1680
GTCATTGAGT CTATTAGCCC TGATGGCCAC GAGTACATTT ATGTGGACCC AATGCAACTG 1740
CCTTATGACT CCAGATGGGA GTTTCCTCGA GATGGGTTAG TGCTTGGTCG GATCCTTGGT 1800
TCGGGAGCAT TTGGAAAAGT AGTTGAAGGG ACTGCATATG GATTGAGTCG CTCTCAACCG 1860
GTGATGAAAG TGGCTGTGAA AATGCTGAAA CCTACAGCTA GATCCAGCGA AAAACAGGCA 1920
CTCATGTCTG AACTGAAAAT AATGACACAT CTTGGCCCCC ACTTGAATAT TGTGAATCTG 1980
CTTGGAGCTT GTACAAAATC AGGTCCTATT TACATCATTA CTGAATACTG TTTTTATGGC 2040
GATTTGGTGA ACTACCTGCA TAAGAATAGG GACAATTTCC TGAATCGACA CCCAGAAAAG 2100
CCTAAAAAAG ATTTGGATAT CTTTGGGATG AACCCTGCTG ATGAAAGCAC AAGAAGCTAT 2160
GTGATACTAT CGTTTGAAAA CACTGGAGAA TACATGGACA TGAAACAAGC TGATACCACT 2220
CAGTATGTAC CAATGCTGGA AAGGAAGGAG GGCTCTAAAT ACTCTGATAT TCAGAGATCT 2280
GTGTATGATC GGCCTGCTTC ATATAAGAAG AAATCCATGT CAGAATCAGA AGTCAAAAAC 2340
CTTCTTTCAG ATGATAGTTC AGAGGGCCTC AGCCTACTGG ATTTGCTGAG CTTCACCTAC 2400
CAGGTTGCAC GGGGAATGGA ATTCTTGGCT TCTAAGAATT GTGTGCACCG TGACTTGGCC 2460
GCTCGGAATG TCCTCCTGGC TCAAGGAAAA ATTGTGAAGA TCTGTGACTT TGGGCTGGCT 2520
AGAGACATCA TGCATGATTC CAACTATGTC TCCAAGGGCA GTACTTTCCT CCCAGTAAAA 2580
TGGATGGCAC CTGAAAGTAT TTTTGACAAC TTGTACACAA CATTAAGTGA TGTCTGGTCT 2640
TATGGCATTC TGCTGTGGGA AATATTTTCT CTTGGTATGT ACTCAATTAA GTTTTTTCAA 2700
TTCATACTGT TCTACATAAA TTCTGCATAT AAAAATATAT GCATGAAATC CACTGTTAGA 2760
TGTTCTTCTG TATGGGATTT CAGATTCCAC TGCCACAGAG CTTTGCTCCT GCATCTTCCA 2820
AAACTTATAA TATTTTCTAT GCTAATGAAT CACAGCTGCC CATCTGAAGA AAGGCAGCCT 2880
TACTATGAGA AGATTCATCT GGACTTCAAA AGTGACCACC CAGCTGTCAC ACGCATGAGA 2940
GGGGACTGTG ACAATGCTTA CATCGGTGTA ACTTACAAGA ATGAAGACAA GCTAAAGGAC 3000
AGGGAGAGTG GATTTGATGA GCAGAGGCTG AGTGCTGACA GTGGATACAT CATTCCCCTG 3060
CCTGACATTG ACCCTGTTTC TGAAGATGAG CTTGGCAAAA GAAACAGACA CAGTTCACAG 3120
ACATCTGAAG AAAGTGCCAT TGAAACTGGT TCCAGTAGCT CTACCTTCAT CAAGAGAGAG 3180
GACGAGACCA TTGAGGACAT TGACATGATG GACGACATTG GGATCGACTC CTCAGACCTG 3240
GTGGAGGACA GCTTCCTGTA A 3261
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl+++ ek   ++++ld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLNRHPEK---PKKDLDIFG  709
         **********************************************99...899999999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s+rs+++ls+e+++ey+d+k++                +sd+++s +d++as+k
Q: 710   MnPADESTRSYVILSFENTGEYMDMKQAdttqyvpmlerkegskYSDIQRSVYDRPASYK  769
         99*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+ e+evk+ l+++ se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMSESEVKNLLSDDSSEGLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGs  287
         slG+
Q: 890   SLGM  893
         ***7
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLNRHPEKPK KDLDIFGMNP 120
ADESTRSYVI LSFENTGEYM DMKQADTTQY VPMLERKEGS KYSDIQRSVY DRPASYKKKS 180
MSESEVKNLL SDDSSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
M 301
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0010544; P:negative regulation of platelet activation
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013