EKS-TAG-00230

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00230

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	459.8	2.3E-138	13	297	285

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008001

UniProt Accession

H0ZBP3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007769	ENSTGUP00000008001	ENSTGUT00000008086
ENSTGUG00000007769	ENSTGUP00000008003	ENSTGUT00000008088

Organism

Taeniopygia guttata

Functional Description

Protein Length

905

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGSNANYTE YVATRWYRSP 180

ELLLGAPYGK AVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PAEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILSGVL LDLMKNLLKL DPADRYLTEQ CLNHPSFQTQ 300

RLLDRSGSSP SRSAKRKPYH ADSNTLSNRN QASKSSALQS HHRSNSKDLQ TLGAGGPREE 360

GLPANESFLN GNLPGPAPSP MHAKKPSNTP GSGNKDIANN NMPHLLSPKE PKGKTEFDFN 420

VDTKSSDGSG TKYMKSNTRS QQNRHSFMET SQSKTGTLQP GDKHSRHSYI DTIPQSSKSP 480

SYRTKSKSHG VLTDSKSVGN LSEARAQAAE PNTSRYFPSS CMDLNSPTSP SAPRHGDNRT 540

MLSPSARNNR SEGTLDTRRP PTRHSKTMEE LKLPDHVDGS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVSRDRV RSKGSEGGLS VGQGMAARAN SLQLLSPQPP EMLQRKCVVI 660

WSASFVCSRR PQKYLHEIKQ QNQGGAYHDP HTEDGASTKE NRILYNDPVP RRVGSFYRVP 720

SPRPESTYIE NNVSNRASVL PADSSTVTNH PKRQTTFDTW KTPENLNSHS EQLKEKEKQG 780

FFRAIKKKKK KSQNMPNTEG QDLLALQKAI HSSNHQSSRQ KDWHPEKMTE IQPHSQPLKS 840

LRKLLHLSSN HPVAAEPRFQ PLPSQPAKAS FPEVRIHPMS QSSSSGSSNV RPEPQPKSRP 900

TLQIP 905

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGCGTTGT ACTTAAATGC AGACACAAGG AGACACATGA AATTGTGGCT 120

ATCAAGAAAT TTAAAGACAG TGAAGAAAAT GAAGAAGTCA AAGAAACCAC TTTACGAGAG 180

CTTAAAATGC TTCGCACTTT GAAGCAGGAG AACATTGTGG AGCTGAAGGA AGCCTTCAGA 240

AGAAGAGGAA AATTATACTT AGTTTTTGAA TATGTGGAAA AAAATATGCT TGAGTTGCTA 300

GAAGAAATGC CAAATGGAGT TCCACCAGAA AAAGTGAAAA GCTACATCTA CCAGCTAATT 360

AAAGCAATTC ATTGGTGCCA TAAGAATGAT ATTGTTCACA GAGATATCAA GCCAGAGAAT 420

CTCTTAATAA GCCACAATGA TGTTCTGAAG TTGTGTGACT TCGGCTTTGC TCGAAATCTC 480

TCTGAGGGAA GCAATGCTAA CTATACAGAA TATGTGGCTA CCAGATGGTA CCGCTCACCT 540

GAACTCTTGC TTGGAGCCCC TTATGGCAAG GCTGTGGATA TGTGGTCCGT AGGCTGTATC 600

CTGGGGGAGC TGAGCGACGG GCAGCCCCTG TTCCCTGGCG AGAGTGAGAT TGACCAGCTC 660

TTCACCATTC AGAAGGTGCT GGGCCCACTG CCAGCTGAGC AGATGAAGCT CTTCTACAGC 720

AACCCACGCT TCCATGGCTT GCGGTTTCCA GCAGTCAATC ATCCACAGTC TTTAGAGAGA 780

AGATATTTGG GAATTTTAAG TGGTGTATTG CTTGATCTTA TGAAGAACTT ATTGAAGTTA 840

GATCCAGCAG ATAGATATTT GACAGAACAA TGTTTGAACC ACCCTTCATT TCAAACCCAA 900

AGACTCTTGG ATCGCAGTGG AAGTTCACCT TCACGGTCAG CGAAGAGAAA GCCCTACCAT 960

GCAGACAGCA ACACTTTATC TAACAGAAAT CAAGCCAGCA AAAGTTCTGC TTTGCAGTCA 1020

CACCACAGAT CAAACAGCAA GGATCTGCAG ACACTAGGGG CTGGCGGGCC CAGAGAAGAG 1080

GGGCTTCCAG CAAATGAAAG CTTTTTAAAT GGAAACCTTC CTGGACCTGC ACCTAGCCCA 1140

ATGCACGCAA AAAAACCAAG CAACACTCCT GGATCTGGCA ACAAGGATAT AGCCAATAAT 1200

AACATGCCAC ATCTTCTCAG CCCAAAGGAA CCAAAGGGAA AAACAGAGTT TGATTTTAAT 1260

GTGGACACCA AAAGTTCTGA TGGTTCAGGC ACAAAGTACA TGAAGTCTAA CACCAGATCT 1320

CAGCAGAACC GGCACTCCTT TATGGAAACT TCTCAAAGCA AAACTGGGAC GCTGCAGCCT 1380

GGCGACAAGC ACAGCCGCCA CAGCTACATC GATACCATCC CACAGTCTTC TAAGAGTCCC 1440

TCCTATCGGA CAAAGTCCAA GAGCCATGGA GTTCTGACAG ACTCAAAATC CGTGGGCAAC 1500

CTTTCTGAGG CCAGGGCCCA AGCTGCAGAA CCAAACACCA GTAGGTACTT TCCATCCAGC 1560

TGTATGGACT TGAACTCTCC CACCAGTCCG AGTGCTCCCC GGCACGGTGA TAACAGAACT 1620

ATGCTCAGTC CATCGGCGAG GAATAACCGC AGCGAGGGTA CCCTGGACAC CCGAAGACCG 1680

CCAACAAGGC ACTCCAAAAC AATGGAGGAG TTAAAACTGC CAGATCACGT GGATGGAAGC 1740

CATTCCCACT CTCTATCTGC TCCACATGAA TCTTTTTCCT ATGGTCTAGG TTATACCAGT 1800

CCTTTTTCTT CACAGCAGCG CCCTCATAGA CACTCGATGT ATGTGAGCCG GGACAGAGTG 1860

AGGTCAAAGG GCTCAGAGGG TGGCTTAAGC GTAGGGCAAG GGATGGCAGC CAGAGCAAAC 1920

AGCCTGCAAC TGTTATCTCC ACAGCCTCCA GAGATGTTAC AAAGGAAATG TGTAGTGATT 1980

TGGAGTGCTT CTTTTGTTTG CAGCAGACGT CCTCAAAAAT ATTTACACGA GATCAAGCAG 2040

CAAAACCAAG GTGGAGCATA TCATGATCCA CACACAGAAG ATGGAGCATC TACTAAGGAG 2100

AATAGAATTC TGTATAATGA CCCTGTTCCG AGAAGAGTTG GCAGCTTTTA CAGAGTTCCA 2160

TCTCCGCGTC CCGAGAGTAC CTACATAGAA AACAACGTGT CCAACAGAGC CTCGGTGTTA 2220

CCAGCAGACA GCAGCACGGT GACAAACCAC CCCAAGAGAC AAACCACCTT TGACACCTGG 2280

AAAACTCCTG AAAACCTTAA CAGTCACTCA GAACAGCTCA AGGAGAAAGA AAAGCAAGGT 2340

TTTTTCAGGG CAATAAAAAA GAAAAAGAAG AAATCTCAAA ATATGCCTAA TACTGAAGGT 2400

CAGGACCTCT TGGCATTACA GAAAGCCATT CATTCTTCCA ATCACCAGAG CAGCAGGCAG 2460

AAGGATTGGC ATCCTGAGAA GATGACAGAA ATCCAGCCTC ATAGCCAGCC GTTAAAATCT 2520

CTCCGGAAGC TCTTACACCT CTCTTCAAAC CATCCTGTCG CTGCTGAGCC CCGCTTCCAG 2580

CCCTTACCCA GCCAGCCAGC CAAAGCTTCT TTCCCTGAAG TGCGAATCCA TCCCATGAGT 2640

CAAAGCTCCA GCAGCGGCAG CAGCAACGTG CGGCCAGAGC CGCAGCCAAA GAGCCGGCCA 2700

ACGCTGCAGA TCCCG 2715

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGk+

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGSNANYTEYVATRWYRSPELLLG-APYGKA  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   l+ vlldl+k++lkldpa+r+++e++l+h+ f

Q: 252   VNHPQSLERRYLgILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSF  297

         ***********98899***************************987

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GSNANYTEYV ATRWYRSPEL LLGAPYGKAV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPA EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILSGVLLD LMKNLLKLDP ADRYLTEQCL NHPSF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013