EKS-TAG-00218

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00218

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	400.2	3.5E-120	60	308	249

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008182

UniProt Accession

H0ZC73;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000007934	ENSTGUP00000008182	ENSTGUT00000008267

Organism

Taeniopygia guttata

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRLERAE DFDGSTGEGT ASQLGRVCTS SYRALISAFS RLTRLDDFTC 60

EKIGSGFFSE VFKVRHRTSD QVMALKMNTL NSNRANMLKE VQLMNRLSHP NILRFMGVCV 120

HKGQLHALTE YINCGNLEQL LDGNQHLPWT VRVKLAYDIA MGISYLHYKG IFHRDLTSKN 180

CLIKHDENGY SAIVGDFGLA EKIPDHRLDS QNLPVVGSPF WMAPEVLRDE PYNEKADVFS 240

YGIILCEIIA RIQADPDYLP RTENFGLDYD SFQHMVGDCP PDFLQLAFNC CNMDPKLRPS 300

FADIVKTLEE MLNRLRNEDS ERDRKNLKGR SRRSIDKGPG VKRLSSLDDK IPPKSPRPRR 360

NIWLSRSQSD IFSRKPSRKI NVQDPYYTPS KGLGRKVNPF SAREDLKGGK IKFFDMPSKS 420

VISLVFDLHS P 431

Nucleotide Sequence
(FASTA)

ATGGACCGAA GTAAGCGGAA TTCAATAGCA GGATTTCCAC CACGCTTGGA GCGCGCTGAA 60

GACTTTGATG GTAGCACTGG AGAAGGGACT GCATCCCAGC TAGGAAGAGT TTGTACCTCT 120

TCATACAGAG CCCTGATAAG TGCCTTTTCC AGACTTACTC GTCTTGATGA TTTCACATGT 180

GAGAAAATTG GCTCTGGTTT CTTCTCTGAG GTGTTCAAGG TAAGGCACAG AACTTCAGAC 240

CAGGTAATGG CTTTGAAGAT GAACACACTG AACAGCAACA GAGCAAACAT GCTGAAAGAG 300

GTTCAACTTA TGAATAGACT CTCACATCCG AACATCTTAA GGTTTATGGG TGTCTGTGTG 360

CATAAAGGAC AGCTGCACGC TCTTACGGAG TACATCAATT GTGGTAACCT GGAACAGCTA 420

CTAGATGGCA ACCAGCATCT ACCCTGGACA GTGAGGGTGA AACTGGCATA TGACATTGCT 480

ATGGGAATCA GTTATCTTCA CTATAAAGGC ATTTTCCACC GAGACCTTAC ATCCAAGAAC 540

TGCTTAATCA AACATGATGA GAATGGATAC TCAGCAATAG TTGGAGACTT TGGTTTAGCA 600

GAGAAAATTC CTGATCACAG GCTGGATAGC CAAAATTTAC CAGTTGTGGG TTCACCCTTC 660

TGGATGGCAC CAGAAGTTCT TAGGGATGAG CCCTACAATG AAAAGGCAGA TGTGTTCTCC 720

TATGGCATAA TTCTGTGTGA GATTATAGCA AGAATACAGG CAGACCCAGA CTATCTCCCT 780

CGCACAGAGA ATTTTGGATT AGATTATGAT TCCTTCCAGC ACATGGTGGG AGACTGTCCT 840

CCTGACTTCC TCCAGCTGGC CTTCAACTGC TGTAATATGG ATCCAAAGTT GCGTCCTTCA 900

TTTGCTGATA TTGTCAAAAC ACTGGAGGAA ATGTTAAACC GCCTGAGAAA TGAAGACTCA 960

GAGAGAGACA GAAAGAACTT AAAAGGAAGG AGCAGACGAT CAATTGACAA AGGACCAGGA 1020

GTAAAACGTT TGAGTTCCTT GGATGATAAG ATCCCACCCA AGTCACCCCG TCCGCGGCGG 1080

AATATCTGGT TGTCACGCAG CCAGTCGGAT ATCTTCTCTC GCAAACCTTC CAGGAAGATA 1140

AACGTGCAGG ACCCCTACTA CACACCAAGC AAAGGGTTAG GCCGCAAAGT CAACCCCTTC 1200

AGTGCCCGGG AGGACCTCAA GGGGGGAAAG ATCAAATTCT TTGACATGCC AAGCAAGTCT 1260

GTGATTTCCC TCGTGTTTGA CTTGCATTCT CCA 1293

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hr+s +vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 60    CEKIGSGFFSEVFKVRHRTSDQVMALK--MNTLNSNRANMLKEVQLMNRLSHPNILRFMG  117

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi+ G+l++ll+ +++lpwt+rv+la+dia+G+sylh kgi+hrdl+

Q: 118   VCVHKGQLHALTEYINCGNLEQLLDGNQHLPWTVRVKLAYDIAMGISYLHYKGIFHRDLT  177

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s++v+dfGla          ek+++ + +  +++l vvGsP+wmaPe

Q: 178   SKNCLIKHdenGYSAIVGDFGLA----------EKIPDHRLD--SQNLPVVGSPFWMAPE  225

         *******9777899*********..........999998877..7899************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld+++f++ +v+ dcP++f

Q: 226   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDSFQH-MVG-DCPPDF  283

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+la++cc++dp+ rpsf ++ k+l

Q: 284   LQLAFNCCNMDPKLRPSFADIVKTL  308

         ********************98876

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRTS DQVMALKMNT LNSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHKGQLHALT EYINCGNLEQ LLDGNQHLPW TVRVKLAYDI AMGISYLHYK GIFHRDLTSK 120

NCLIKHDENG YSAIVGDFGL AEKIPDHRLD SQNLPVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DSFQHMVGDC PPDFLQLAFN CCNMDPKLRP 240

SFADIVKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013