EKS-TAG-00136

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00136

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	485.7	2.2E-146	371	621	251

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008388

UniProt Accession

H0ZCS7;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000008092	ENSTGUP00000008388	ENSTGUT00000008476

Organism

Taeniopygia guttata

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MNTTTILQEI LIKRSQQKKR TSPLNYKERL FVLTKSMLTY YEGRAEKKYR KGSVDISRIK 60

CVEVVKSDGI IPCQNKYPFQ VVYDANTLYI FAPSAQSRDQ WVRNLKEEIK NNSNIMVKYH 120

PKFWTEGIYQ CCRQTEKLAP GCEKYCLFEN RLAQLLPPGC TGVMRRPPPP IPPVEENGNE 180

EEEIVVAMYD FEPTEHHDLR LEKGEEYTVI EKNDIHWWKA RDKYGKQGYI PSNYVTGKKS 240

NNLDQYEWYS RNLNRSKAEQ LLRNEDKEGG FVVRDSSQPG LYTVSLYTKF GGEGSSGIRH 300

YHIKETVTSP KQYYLAEKHL FNSIPEIIEY HSHNAAGLVT RLRYPVTPKR TAAPTTAGFS 360

YEKWEINPSE LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMYEED FIEEAKVMMK 420

LTHPKLVQLY GVCTQQRPIY IVTEFMEHGC LLNYLRQKRG VLSRDTLLTM CQDVCEGMEY 480

LERNSFIHRD LAARNCLVSD SGVVKVSDFG MTRYVLDDQY TSSSGAKFPV KWCPPEVFNY 540

SRFSSKSDVW SFGVLMWEVY TEGKMPFEKS SNYEVVTMVS QGHRLYRPKL ACKQMYEMMM 600

MCWQEKPEER PTFEELLHAI IDIAEGEDAF 630

Nucleotide Sequence
(FASTA)

ATGAATACGA CTACTATCCT ACAAGAGATT TTGATTAAAA GATCACAGCA GAAGAAGAGG 60

ACTTCTCCCT TAAACTACAA AGAGAGACTT TTTGTACTTA CAAAGTCTAT GCTAACATAC 120

TACGAAGGTC GAGCGGAGAA AAAGTACAGA AAAGGATCTG TGGATATTTC AAGGATTAAA 180

TGTGTAGAAG TTGTGAAAAG TGATGGTATT ATTCCATGTC AAAATAAATA TCCTTTTCAG 240

GTTGTATATG ATGCTAATAC ACTTTATATT TTTGCACCGA GTGCACAAAG CCGGGATCAG 300

TGGGTGAGGA ACCTGAAAGA AGAAATAAAG AACAACAGCA ATATAATGGT AAAATATCAT 360

CCTAAATTCT GGACAGAGGG AATTTATCAA TGCTGCAGAC AGACAGAAAA ATTAGCACCT 420

GGCTGTGAAA AATATTGTCT TTTTGAAAAC AGACTAGCCC AGCTTTTGCC TCCAGGATGC 480

ACTGGTGTTA TGCGAAGACC TCCACCACCT ATTCCTCCAG TTGAAGAAAA TGGGAATGAA 540

GAGGAGGAGA TAGTGGTAGC AATGTATGAC TTTGAACCTA CAGAACACCA TGATTTAAGA 600

TTAGAGAAAG GTGAAGAATA TACAGTGATT GAGAAGAACG ACATTCATTG GTGGAAGGCA 660

AGAGATAAAT ACGGAAAACA AGGATATATT CCAAGCAACT ATGTAACAGG AAAGAAGTCC 720

AACAACCTTG ATCAGTATGA GTGGTACAGC AGAAACCTGA ACAGAAGCAA GGCAGAGCAG 780

CTCCTCAGAA ATGAGGATAA AGAAGGTGGT TTTGTGGTGA GAGACTCCAG TCAGCCTGGC 840

CTGTATACTG TTTCCCTTTA CACAAAATTT GGAGGGGAAG GTTCATCAGG AATAAGACAC 900

TATCATATAA AAGAAACGGT GACGTCACCT AAACAGTACT ACCTTGCAGA AAAACATCTC 960

TTTAACTCCA TTCCAGAAAT AATTGAATAT CACAGCCATA ATGCAGCAGG TCTCGTTACC 1020

AGGCTGCGTT ACCCAGTGAC CCCAAAGAGG ACGGCGGCAC CAACAACGGC AGGATTCAGC 1080

TATGAGAAAT GGGAGATTAA TCCCTCAGAA CTGACATTCA TGAGGGAGCT GGGGAGCGGT 1140

CTGTTTGGCG TGGTGCGCCT CGGGAAGTGG CGGGCACAGT ACAAAGTGGC CATCAAGGCT 1200

ATTCGGGAAG GTGCTATGTA TGAAGAGGAC TTCATTGAAG AAGCTAAAGT AATGATGAAG 1260

CTAACACATC CTAAACTAGT TCAGCTGTAT GGTGTGTGCA CACAGCAGAG GCCCATTTAC 1320

ATCGTGACAG AGTTCATGGA GCATGGCTGC CTTCTCAATT ACCTGAGACA AAAACGGGGA 1380

GTTTTGAGTA GAGACACTCT GCTTACTATG TGCCAAGATG TATGTGAGGG AATGGAGTAC 1440

CTGGAAAGGA ACAGCTTTAT CCACAGAGAC CTGGCTGCAA GGAACTGCTT GGTGAGTGAC 1500

TCAGGAGTGG TCAAAGTCTC AGATTTCGGA ATGACAAGGT ATGTCCTGGA TGACCAATAC 1560

ACAAGTTCTT CAGGGGCTAA ATTTCCTGTG AAGTGGTGTC CCCCAGAAGT TTTTAATTAC 1620

AGCCGATTCA GCAGCAAGTC AGATGTCTGG TCATTTGGTG TTTTAATGTG GGAAGTATAT 1680

ACAGAAGGAA AAATGCCTTT TGAAAAAAGC TCCAACTATG AAGTGGTAAC AATGGTTAGC 1740

CAAGGACATC GCTTGTATCG GCCCAAACTG GCCTGTAAGC AGATGTATGA AATGATGATG 1800

ATGTGCTGGC AGGAGAAACC AGAGGAACGC CCGACTTTTG AAGAGTTGCT TCATGCAATC 1860

ATTGACATTG CAGAGGGTGA AGATGCTTTT TGA 1893

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam eedfieeakvmmkl+hpklvqly

Q: 371   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMYEEDFIEEAKVMMKLTHPKLVQLY  430

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++q+piyivte++e+gcllnylr+k++ l++++ll mc+dvcegmeyler+sfihrd

Q: 431   GVCTQQRPIYIVTEFMEHGCLLNYLRQKRGVLSRDTLLTMCQDVCEGMEYLERNSFIHRD  490

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfg++ryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 491   LAARNCLVSDSGVVKVSDFGMTRYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  550

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwev++egk+p+ek sn+evv++vs+g+rlyrpkla k++ye+m+ cw+ekpeer

Q: 551   SFGVLMWEVYTEGKMPFEKSSNYEVVTMVSQGHRLYRPKLACKQMYEMMMMCWQEKPEER  610

         ************************************************************

S: 241   ptfkellsale  251

         ptf+ell+a+

Q: 611   PTFEELLHAII  621

         *******9985

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMYEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQRPIY IVTEFMEHGC LLNYLRQKRG VLSRDTLLTM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVSD SGVVKVSDFG MTRYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVY TEGKMPFEKS SNYEVVTMVS QGHRLYRPKL ACKQMYEMMM MCWQEKPEER 240

PTFEELLHAI I 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013