EKS-TAG-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.7	8.0E-186	367	645	279

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008430

UniProt Accession

H0ZCW9;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000008143	ENSTGUP00000008430	ENSTGUT00000008518

Organism

Taeniopygia guttata

Functional Description

Protein Length

677

Protein Sequence
(FASTA)

ASTNNESSNH SFGSLGSLSD KESETPEKKQ SEPSRGRKRK ADTQSESSQG KNIGGRGHKI 60

SDYFEYQGGN GSSPVRGVPP AIRSPQNSHS APSSVRQNSP SPTSLVFGDH PLTQPKQLSI 120

KITQTDLTML KLAALESNKN QDLEKKEGRI DDLLRANCDL RRQIDEQQKL LEKYKERLNK 180

CISMSKKLLI EKSTQEKLAS REKSMQDRLR LGHFTTVRHG ASFTEQWTDG FAFQNLVKQQ 240

EWVNQQREDI ERQRKLLAKR KPPTTNNSQA PSANSEPKQR KNKAVNGAEN DPFVRPNLPQ 300

LLTLAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN LHIRELKRIN NEDNSQFKDH 360

PTLNERYLLL HLLGRGGFSE VYKAFDLYEQ RYAAVKIHQL NKSWRDEKKE NYHKHACREY 420

RIHKELDHPR IVKLYDYFSL DTDTFCTVLE YCEGNDLDFY LKQHKLMSEK EARSIVMQIV 480

NALRYLNEIK PPIIHYDLKP GNILLVDGTA CGEIKITDFG LSKIMDDDSY GVDGMDLTSQ 540

GAGTYWYLPP ECFVVGKEPP KISNKVDVWS VGVIFFQCLY GRKPFGHNQS QQDILQENTI 600

LKATEVQFPV KPVVSNEAKA FIRRCLAYRK EDRFDVHQLA NDPYLLPHMR RSNSSGNLHM 660

TGLAASPTPP TSSIISY 677

Nucleotide Sequence
(FASTA)

GCCTCAACAA ATAACGAGAG TTCAAATCAC AGCTTTGGAA GCTTGGGATC TTTGAGTGAT 60

AAAGAATCAG AGACTCCAGA GAAGAAACAG TCAGAACCTT CCAGAGGAAG AAAAAGAAAA 120

GCAGACACTC AGAGTGAAAG CAGCCAAGGA AAGAATATTG GGGGACGTGG TCACAAGATT 180

AGTGACTATT TTGAGTACCA AGGTGGAAAC GGCTCGAGTC CAGTGCGAGG CGTACCTCCT 240

GCAATCCGCT CTCCTCAGAA TTCACATTCC GCTCCTTCTT CTGTTCGACA GAATAGTCCT 300

TCTCCTACTT CATTAGTTTT TGGGGACCAC CCTCTCACAC AACCAAAGCA GTTATCTATT 360

AAAATTACTC AGACTGATCT CACAATGCTG AAATTAGCTG CACTAGAAAG TAATAAAAAT 420

CAAGACTTGG AAAAGAAGGA AGGTCGTATA GATGACTTAC TCAGGGCTAA TTGTGATCTT 480

AGAAGACAAA TAGATGAACA ACAAAAACTA CTTGAAAAAT ACAAAGAAAG GTTAAACAAA 540

TGTATTTCAA TGAGCAAGAA GCTTCTAATT GAAAAGAGCA CACAGGAGAA GCTGGCAAGC 600

AGAGAGAAGA GCATGCAAGA CAGATTACGC CTGGGGCATT TTACAACAGT TCGTCATGGT 660

GCTTCATTTA CTGAACAGTG GACAGATGGC TTTGCATTTC AAAATCTTGT GAAGCAGCAA 720

GAGTGGGTGA ATCAACAAAG GGAAGACATT GAAAGGCAAA GAAAGCTCCT GGCCAAGCGA 780

AAGCCTCCAA CTACAAATAA TTCTCAGGCA CCATCTGCCA ATTCTGAACC CAAGCAGAGG 840

AAAAATAAAG CTGTGAATGG GGCAGAAAAC GATCCCTTTG TTAGACCAAA TTTACCACAG 900

CTTTTGACTC TAGCAGAGTA CCATGAACAG GAAGAAATTT TCAAGCTTCG ATTAGGACAT 960

CTCAAAAAGG AGGAAGCTGA AATACAAGCA GAACTTGAAC GTTTGGAGAG AGTTAGGAAT 1020

CTTCACATTA GAGAACTGAA AAGAATAAAT AATGAAGATA ATTCACAATT TAAAGATCAC 1080

CCCACACTGA ATGAGCGGTA TTTGTTACTC CATTTACTTG GCCGAGGTGG CTTCAGTGAA 1140

GTATACAAGG CTTTTGATCT TTATGAACAA AGATATGCTG CTGTGAAGAT TCACCAGCTT 1200

AACAAAAGCT GGAGGGATGA AAAGAAAGAA AACTACCACA AACATGCCTG CAGAGAGTAT 1260

AGAATACACA AAGAACTGGA TCACCCCCGA ATAGTTAAAC TGTATGACTA CTTCTCCCTG 1320

GATACAGATA CGTTTTGCAC GGTTTTAGAA TACTGTGAAG GCAATGACTT GGATTTCTAT 1380

CTCAAGCAAC ATAAACTGAT GTCAGAGAAA GAAGCTAGGT CCATTGTAAT GCAAATAGTA 1440

AATGCACTAC GGTATCTCAA TGAGATCAAA CCCCCTATTA TACACTATGA TCTTAAACCA 1500

GGTAATATCC TTCTTGTAGA TGGAACAGCA TGTGGAGAAA TAAAAATTAC TGATTTTGGT 1560

CTGTCCAAAA TAATGGATGA TGATAGCTAT GGGGTGGATG GAATGGATTT AACTTCACAG 1620

GGAGCAGGAA CTTACTGGTA CTTGCCTCCA GAGTGTTTTG TAGTTGGCAA AGAGCCACCA 1680

AAGATTTCTA ACAAGGTTGA TGTATGGTCA GTTGGAGTAA TCTTTTTCCA ATGCCTTTAT 1740

GGTAGAAAGC CATTTGGCCA CAATCAATCA CAGCAAGATA TCCTACAAGA AAATACAATA 1800

TTAAAAGCCA CAGAAGTTCA ATTCCCTGTC AAACCTGTTG TAAGCAATGA AGCCAAGGCC 1860

TTTATCAGAC GCTGTTTAGC ATACCGAAAA GAGGATAGAT TTGATGTCCA CCAGCTGGCT 1920

AATGATCCTT ATCTTCTCCC TCATATGAGG AGATCAAATT CTTCAGGAAA CTTGCATATG 1980

ACTGGCCTAG CAGCATCCCC TACACCACCT ACTTCAAGCA TTATTTCGTA CTGA 2034

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 367   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  426

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 427   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  486

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 487   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  545

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 546   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  605

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvs+eakafirrclayrkedr+dv+qla+d+yl

Q: 606   VQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLANDPYL  645

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSN EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013