EKS-TAG-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.3	6.4E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008489

UniProt Accession

H0ZD28;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3

Gene Synonyms/Alias

AKT3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000008212	ENSTGUP00000008489	ENSTGUT00000008580

Organism

Taeniopygia guttata

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS ADAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFAGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATTGT GAAGGAAGGC TGGGTACAGA AGAGGGGAGA ATATATAAAA 60

AACTGGCGGC CAAGATACTT CCTGCTGAAG ACAGATGGCT CTTTCATAGG CTATAAGGAG 120

AAGCCCCAAG ATGTGGATCT GCCATATCCA CTCAACAACT TTTCAGTGGC AAAATGTCAG 180

CTAATGAAAA CAGAGCGACC AAAGCCGAAC ACATTCATTA TCAGATGTCT TCAGTGGACC 240

ACTGTCATAG AGAGGACGTT CCATGTAGAC ACTCCAGAGG AACGGGAAGA ATGGACAGAA 300

GCAATCCAGG CTGTAGCAGA CAGACTTCAG AGGCAAGAAG AGGAGAGGAT GAACTGCAGT 360

CCAACTTCTC AGATAGACAA TATAGGAGAA GAAGAGATGG ATGCTTCAAC AACCCATCAT 420

AAAAGAAAGA CAATGAATGA TTTTGACTAC TTAAAACTAT TGGGCAAAGG CACGTTTGGC 480

AAAGTTATCT TGGTCCGAGA GAAGGCTAGT GGCAAATACT ATGCTATGAA GATTTTGAAA 540

AAAGAAGTAA TTATTGCAAA GGATGAAGTG GCTCATACTC TTACAGAAAG CAGAGTATTG 600

AAAAACACCA GACACCCTTT TTTAACATCC TTGAAATATT CCTTCCAGAC AAAGGATCGT 660

TTGTGTTTTG TGATGGAGTA TGTTAATGGA GGAGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGAGTGTTCT CAGAGGACCG CACGCGCTTC TATGGTGCAG AAATTGTCTC TGCCCTGGAC 780

TATCTGCATT CTGGGAAGAT TGTGTACCGT GATCTCAAGT TAGAAAATCT AATGTTGGAT 840

AAAGATGGAC ACATAAAAAT TACAGATTTT GGACTTTGCA AAGAAGGAAT CACAGACGCA 900

GCAACTATGA AAACATTCTG TGGTACTCCA GAATACCTGG CACCCGAGGT GTTAGAAGAT 960

AATGACTATG GCCGTGCAGT GGACTGGTGG GGATTAGGAG TGGTCATGTA TGAGATGATG 1020

TGTGGAAGAT TACCCTTCTA CAACCAAGAT CACGAGAAAC TATTTGAACT GATATTAATG 1080

GAGGACATTA AATTTCCTCG AACTCTATCT GCAGATGCAA AATCGTTACT ATCAGGCCTA 1140

CTGATAAAGG ATCCAAATAA GCGACTTGGT GGAGGCCCAG ATGATGCAAA GGAAATCATG 1200

CGTCATAGTT TCTTTGCTGG AGTAAACTGG CAAGATGTAT ATGATAAAAA GCTTGTACCT 1260

CCTTTTAAAC CTCAAGTGAC ATCTGAGACA GACACCAGGT ATTTTGATGA AGAATTTACA 1320

GCTCAGACTA TTACAATAAC ACCACCTGAA AAATATGACG AGGATGGTAT GGACTGCATG 1380

GATAATGAGA GGCGGCCGCA TTTCCCCCAG TTTTCCTACT CTGCAAGTGG ACGAGAATAA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls +aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSADAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSADAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000002	; P:mitochondrial genome maintenance
GO:0007165	; P:signal transduction

KEGG

tgu:100217811

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013