EKS-TAG-00499

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00499

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	457.1	1.0E-137	117	367	251

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008714

UniProt Accession

H0ZDQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKA

Gene Synonyms/Alias

AURKA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000008457	ENSTGUP00000008714	ENSTGUT00000008807

Organism

Taeniopygia guttata

Functional Description

Protein Length

371

Protein Sequence
(FASTA)

GDAPRRVPVS QHSAQSRSLT SGAPARVLCP ANFAQRVPVQ PQKPVLSTQK QPSDQPAQQL 60

RPKVPQQAAV RPQAASKGSE KPPQAAAPAQ NPEAESTSKQ KTEETKKKRM QWSLDDFEIG 120

RPLGKGKFGN VYLAREKQSK FILALKVLFK TQLEEAGVEH QLRREVEIQS HLRHPNILRL 180

YGYFHDVTRV YLILEHAPRG EVYRELQRLS KFDEQRTATY ITELADALSY CHSKRVIHRD 240

IKPENLLLGS NGELKIADFG WSVHAPSSRR TTLCGTLDYL PPEMIEGRTH DEKVDIWSLG 300

VLCYEFLVGK PPFETETYQE TYRAISRVEF KFPPFVTEGA RDLISRLLKH NPFHRLPLKD 360

VLLHPWITAN S 371

Nucleotide Sequence
(FASTA)

GGGGATGCCC CCAGACGCGT CCCCGTGTCG CAGCACTCAG CCCAGAGCCG CTCACTGACC 60

AGTGGAGCTC CAGCCCGAGT TCTGTGTCCT GCAAACTTCG CCCAGCGAGT CCCCGTGCAA 120

CCCCAAAAAC CTGTTCTGTC CACCCAAAAA CAACCCAGCG ACCAACCAGC GCAGCAGCTC 180

CGACCCAAAG TGCCCCAGCA GGCCGCTGTG AGACCTCAGG CTGCAAGCAA GGGCAGTGAG 240

AAACCTCCCC AGGCTGCAGC ACCTGCACAA AATCCTGAAG CAGAAAGCAC CTCTAAACAG 300

AAAACTGAAG AGACCAAGAA GAAAAGAATG CAATGGTCCC TTGATGATTT TGAAATTGGT 360

CGTCCTCTGG GGAAAGGAAA ATTTGGGAAT GTGTACCTGG CACGTGAAAA ACAGAGCAAA 420

TTTATTCTTG CACTGAAAGT GCTCTTTAAA ACACAGCTTG AGGAAGCTGG TGTAGAGCAT 480

CAACTACGAA GAGAAGTGGA AATACAGTCT CATCTTAGGC ACCCCAACAT TCTCAGATTA 540

TATGGCTACT TCCATGATGT GACAAGAGTC TACCTGATCC TGGAGCACGC ACCTCGTGGG 600

GAAGTCTACA GGGAGCTTCA GAGGCTCAGC AAGTTCGATG AGCAAAGAAC TGCTACTTAC 660

ATCACAGAAC TTGCAGATGC CCTCTCCTAC TGTCACTCCA AGCGTGTGAT CCACAGAGAC 720

ATCAAGCCAG AGAACTTGCT GCTAGGATCA AATGGAGAGT TAAAAATTGC TGACTTTGGG 780

TGGTCTGTGC ATGCTCCATC TTCTAGGAGA ACAACTCTCT GTGGGACACT TGACTACCTG 840

CCTCCTGAAA TGATTGAGGG AAGAACACAT GATGAAAAGG TGGATATTTG GAGTCTGGGA 900

GTTCTGTGCT ACGAGTTCCT TGTAGGGAAA CCACCTTTTG AAACAGAAAC CTATCAAGAA 960

ACCTACAGAG CTATTTCCAG GGTGGAATTC AAGTTTCCTC CATTTGTAAC AGAAGGTGCA 1020

AGGGATTTAA TTTCCAGGCT CCTGAAGCAC AACCCCTTCC ATCGCCTGCC CCTGAAGGAT 1080

GTGCTTCTCC ATCCCTGGAT CACAGCAAAC TCT 1113

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarek+skfi+alkvlfk+qle++gve+qlrre+eiqshl+hpn

Q: 117   FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKTQLEEAGVEHQLRREVEIQSHLRHPN  176

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrlygyfhd +rvylile+aprGe+y+elq+ +k+deqr+a+yi+eladalsy+h+k+v

Q: 177   ILRLYGYFHDVTRVYLILEHAPRGEVYRELQRLSKFDEQRTATYITELADALSYCHSKRV  236

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllgs+gelk+adfGwsvhapss+r+tlcGtldylppem+egr++dekvd+

Q: 237   IHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRTHDEKVDI  296

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w+lGvlcye+lvGkppfe+e+++ety+ i++v++k+p +v++ga+dlis+llk++p +rl

Q: 297   WSLGVLCYEFLVGKPPFETETYQETYRAISRVEFKFPPFVTEGARDLISRLLKHNPFHRL  356

         ************************************************************

S: 241   tladvlahpwi  251

         +l+dvl hpwi

Q: 357   PLKDVLLHPWI  367

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KQSKFILALK VLFKTQLEEA GVEHQLRREV EIQSHLRHPN 60

ILRLYGYFHD VTRVYLILEH APRGEVYREL QRLSKFDEQR TATYITELAD ALSYCHSKRV 120

IHRDIKPENL LLGSNGELKI ADFGWSVHAP SSRRTTLCGT LDYLPPEMIE GRTHDEKVDI 180

WSLGVLCYEF LVGKPPFETE TYQETYRAIS RVEFKFPPFV TEGARDLISR LLKHNPFHRL 240

PLKDVLLHPW I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005876	; C:spindle microtubule
GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000278	; P:mitotic cell cycle
GO:0031647	; P:regulation of protein stability

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013