EKS-TAG-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	537.7	3.9E-162	1000	1267	268

Status

Unreviewed

Ensembl Protein

ENSTGUP00000008956

UniProt Accession

H0ZEE4;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000008636	ENSTGUP00000008956	ENSTGUT00000009053

Organism

Taeniopygia guttata

Functional Description

Protein Length

1363

Protein Sequence
(FASTA)

MKSGAGGGSL AVVWGFLLVF AALCLWPTNG EICGPNVDIR NDIHELKRLE NCTVIEGFLQ 60

ILLISKAEDY RNFRFPKLTV ITDYLLLFRV AGLESLSDLF PNLTVIRGRN LFYNYALVIF 120

EMTNLKEIGL HNLRNITRGA IRIEKNSDLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 180

LCPGTMEEKP LCEKTSINNE YNYRCWTTNH CQKMCPSSCG KRACTDQNEC CHPECLGSCT 240

APDNNTACVA CRNYYYEGVC LPTCPPNTYK FEGWRCVTRE FCSKVPATDA SEYEKFVIHN 300

DECMAECPSG FIRNGSQSMF CSPCEGPCPK ICEDGKTKTI DSVTSAQMLQ GCTILKGNLL 360

INIRRGNNIA SELENFMGLI ETVTGYVKIR HSHALVSLSF LKNLRYILGE EQVDGNYSFY 420

VLDNHNLQQL WDWNHHNLTI SEGKMYFAFN PKLCVSEIYR MEEVSGTKGR QSKGDINPRN 480

NGERASCESK ILHFVSNTTL KNRIKLTWER YRPPDYRDLI SFTVYYKEAP FKNVTEYDGQ 540

DACGSNSWNM VDVDLPPNKE NNPGILLQGL KPWTQYAIYV KAVTLTMMEN HHIHGAKSEI 600

IYIRTNAAVP SIPLDVISAS NSSSQLIVKW NPPSLPNGNL SYYIVRWQQQ PQDSYLYRHN 660

YCSKDKVPIR RYADGTIDTE EATEPTKPEG CGGEKGPCCA CPKTEAEKQA EKEEAEYRKV 720

FENFLHNSIF VPRPDRKRRD VFRIANATLA TRSRNATGTD HFTNASDTEE SEVEYPFFET 780

KVDGKERTVI SHLQPFTLYR IDIHSCNHEA DTLGCSASNF VFARTMPSEG ADNIPGTVSW 840

EAKEENTVYL KWLEPANPNG LILMYEIKYG QHGEEKRECV SRQEYKKLGG AKLTHLNPGN 900

YSARVQATSL AGNGSWTEPI SFYVQPKSAN YGNFLHLVIV LPIVLLFILG ALLVMLYVVN 960

KKRNSDRLGN GVLYASVNPE YFSASDVYVP DEWEVPREKI TMCRELGQGS FGMVYEGIAK 1020

GVVKDEPETR VAIKTVNESA SMRERIEFLN EASVMKEFNC HHVVRLLGVV SQGQPTLVIM 1080

ELMTRGDLKS YLRSLRPDTE NNPGQAPPTL KKMIQMAGEI ADGMAYLNAN KFVHRDLAAR 1140

NCMVAEDFTV KIGDFGMTRD IYETDYYRKG GKGLLPVRWM SPESLKDGVF TTHSDVWSFG 1200

VVLWEIATLA EQPYQGMTNE QVLRFVMEGG LLEKPDNCPD MLFELMRMCW QYNPKMRPSF 1260

LEIIGSIKDE LDPAFKEVSF FYSEENKPPD TEELDLETEN MESIPLDPSS TLQPTDKHSG 1320

HKAENGPGVV VLRASFEERQ PYAHMNGGRK NERALPLPQS SAC 1363

Nucleotide Sequence
(FASTA)

ATGAAGTCTG GCGCTGGAGG AGGGTCCCTC GCCGTCGTCT GGGGGTTCCT GCTCGTTTTC 60

GCCGCACTTT GTCTGTGGCC AACAAATGGG GAAATTTGCG GGCCAAACGT CGACATTCGC 120

AATGATATCC ATGAGCTGAA GCGCCTGGAG AACTGCACGG TGATCGAGGG TTTCCTGCAG 180

ATCCTGCTCA TCTCCAAAGC GGAGGATTAC CGCAACTTCC GCTTCCCAAA GCTCACTGTC 240

ATCACTGACT ACTTGCTGCT GTTCCGTGTG GCAGGCTTGG AAAGCCTCAG TGATCTCTTC 300

CCCAACCTCA CAGTCATTCG TGGCAGGAAC CTCTTCTATA ACTATGCCTT GGTGATCTTT 360

GAAATGACGA ATCTTAAGGA GATTGGGCTT CACAACTTGA GGAACATCAC CCGCGGGGCC 420

ATCCGGATCG AGAAGAACTC TGACCTGTGT TACCTCTCCA CAGTGGACTG GTCTCTCATC 480

CTAGATGCAG TGTCCAATAA CTACATCGTT GGGAATAAAC CTCCAAAGGA ATGTGGGGAC 540

TTGTGTCCAG GAACAATGGA AGAGAAGCCA TTGTGTGAGA AGACATCTAT TAACAATGAG 600

TACAACTACC GCTGCTGGAC CACAAACCAC TGCCAGAAAA TGTGCCCCAG CTCGTGTGGG 660

AAGCGAGCCT GCACAGACCA AAACGAGTGT TGCCACCCCG AGTGCCTGGG GAGCTGCACG 720

GCGCCCGACA ACAACACGGC GTGCGTGGCC TGCCGCAACT ACTACTACGA GGGCGTGTGC 780

CTGCCCACCT GCCCCCCCAA CACCTACAAG TTCGAGGGCT GGCGCTGTGT CACCAGGGAG 840

TTCTGCTCCA AAGTCCCCGC CACGGACGCC AGCGAGTACG AGAAGTTCGT GATTCACAAC 900

GACGAGTGCA TGGCCGAGTG TCCCTCGGGC TTCATCCGCA ACGGCAGCCA AAGCATGTTC 960

TGCAGCCCTT GTGAGGGGCC TTGCCCCAAA ATTTGTGAGG ATGGGAAAAC AAAGACCATT 1020

GACTCAGTGA CATCAGCACA AATGTTGCAG GGATGCACAA TTCTCAAGGG AAATCTGCTG 1080

ATCAACATCC GCCGTGGCAA TAACATTGCC TCAGAACTGG AGAATTTTAT GGGTCTGATT 1140

GAGACAGTAA CAGGGTATGT GAAGATTCGT CATTCCCATG CGTTGGTCTC CCTGTCTTTC 1200

CTGAAGAACC TGCGGTACAT TCTGGGAGAG GAACAGGTGG ATGGGAATTA TTCCTTCTAC 1260

GTGCTTGACA ACCACAATCT TCAGCAGCTG TGGGACTGGA ACCATCATAA CTTGACAATC 1320

AGTGAGGGGA AAATGTACTT TGCATTTAAT CCTAAACTGT GTGTTTCTGA GATTTACCGT 1380

ATGGAGGAGG TTTCAGGAAC CAAGGGACGA CAGAGCAAAG GAGATATAAA TCCAAGGAAC 1440

AATGGGGAGA GAGCCTCTTG TGAAAGCAAA ATTCTGCATT TTGTTTCCAA CACGACGCTC 1500

AAGAACCGGA TTAAACTGAC ATGGGAGCGG TATCGCCCTC CAGATTACAG AGACCTCATC 1560

AGCTTCACTG TTTACTACAA AGAGGCACCA TTCAAAAATG TGACAGAGTA TGACGGGCAA 1620

GATGCCTGTG GCTCCAATAG CTGGAACATG GTTGATGTTG ACCTGCCACC AAACAAGGAG 1680

AACAATCCTG GAATTCTGCT GCAGGGGTTG AAACCTTGGA CTCAGTATGC CATTTATGTC 1740

AAGGCTGTTA CCCTCACAAT GATGGAAAAT CATCATATTC ATGGAGCAAA AAGTGAAATT 1800

ATATATATTC GAACCAATGC TGCAGTGCCA TCCATTCCCC TGGATGTTAT TTCAGCATCC 1860

AACTCCTCAT CCCAGCTGAT TGTGAAATGG AATCCTCCCT CTCTTCCCAA TGGGAACCTC 1920

TCCTACTACA TCGTGCGCTG GCAGCAGCAG CCTCAGGACA GTTACCTGTA CAGACACAAT 1980

TACTGCTCCA AAGATAAAGT CCCAATTCGA AGATATGCTG ATGGGACCAT TGATACAGAA 2040

GAAGCCACTG AGCCCACCAA GCCAGAGGGC TGTGGGGGAG AAAAAGGACC TTGTTGTGCT 2100

TGTCCCAAGA CAGAGGCAGA AAAGCAGGCG GAGAAGGAGG AAGCAGAGTA CCGGAAAGTC 2160

TTTGAGAACT TCCTTCATAA CTCCATCTTT GTCCCCAGGC CTGACCGTAA GCGGAGGGAC 2220

GTGTTCCGAA TCGCCAACGC CACCCTGGCC ACTCGGAGCC GGAACGCGAC CGGGACCGAC 2280

CACTTCACCA ACGCCTCTGA CACGGAGGAG AGCGAGGTGG AATATCCCTT CTTTGAGACC 2340

AAGGTGGATG GCAAGGAGAG GACTGTGATC TCCCATCTCC AGCCTTTCAC TCTTTACCGC 2400

ATCGATATTC ACAGCTGCAA CCACGAGGCC GACACGCTCG GCTGCAGCGC CTCCAACTTC 2460

GTGTTTGCCA GAACGATGCC CTCAGAGGGA GCAGACAACA TTCCAGGAAC GGTATCATGG 2520

GAAGCAAAAG AGGAAAATAC TGTCTACCTG AAGTGGTTGG AGCCTGCAAA TCCAAATGGG 2580

CTGATCCTGA TGTATGAAAT CAAATATGGG CAGCATGGTG AGGAGAAGCG GGAATGTGTT 2640

TCCAGACAGG AATACAAGAA ACTTGGAGGA GCTAAACTAA CTCACTTGAA CCCTGGAAAC 2700

TATTCTGCCA GAGTTCAGGC CACTTCCTTA GCTGGGAATG GGTCCTGGAC TGAGCCCATC 2760

TCTTTCTATG TGCAGCCCAA ATCAGCAAAC TATGGAAACT TCCTGCACTT GGTAATTGTG 2820

CTCCCTATTG TTCTGCTGTT CATCCTTGGG GCATTGCTGG TAATGCTCTA TGTCGTTAAC 2880

AAAAAGAGGA ACAGTGACAG ACTGGGCAAT GGAGTACTTT ATGCTTCTGT GAACCCTGAG 2940

TACTTCAGTG CCTCAGATGT GTATGTTCCT GACGAGTGGG AGGTGCCCCG GGAGAAGATC 3000

ACCATGTGTC GGGAGCTTGG GCAAGGCTCC TTTGGAATGG TGTACGAGGG AATAGCCAAG 3060

GGAGTGGTGA AGGACGAGCC AGAGACCAGG GTGGCCATCA AGACGGTCAA CGAGTCCGCG 3120

AGCATGCGCG AGAGGATCGA GTTCCTGAAC GAGGCCTCGG TGATGAAGGA GTTCAACTGT 3180

CACCATGTGG TTCGGCTGCT TGGTGTTGTT TCTCAGGGCC AGCCTACACT GGTTATCATG 3240

GAGCTGATGA CACGTGGGGA CCTCAAAAGT TACCTGAGAT CATTGAGGCC AGACACAGAG 3300

AACAACCCTG GGCAGGCGCC CCCGACGCTG AAGAAGATGA TCCAGATGGC GGGGGAGATC 3360

GCCGACGGCA TGGCCTATCT CAACGCCAAC AAGTTCGTGC ACAGGGACCT CGCCGCCAGG 3420

AACTGCATGG TGGCCGAGGA CTTCACAGTC AAAATTGGAG ATTTTGGCAT GACGAGAGAC 3480

ATCTACGAGA CAGATTATTA CCGGAAAGGA GGGAAGGGTT TGCTGCCTGT CCGCTGGATG 3540

TCCCCGGAGT CGCTGAAAGA TGGAGTCTTC ACAACGCACT CCGACGTCTG GTCCTTCGGC 3600

GTGGTGCTGT GGGAGATCGC GACGCTGGCG GAGCAGCCGT ACCAGGGCAT GACCAACGAG 3660

CAGGTGCTGC GCTTCGTCAT GGAAGGGGGG CTGCTGGAAA AGCCAGACAA CTGTCCCGAC 3720

ATGCTGTTCG AACTGATGCG CATGTGCTGG CAGTACAACC CGAAAATGAG ACCCTCCTTC 3780

CTGGAAATCA TCGGTAGCAT CAAAGACGAG CTGGACCCGG CCTTCAAAGA GGTCTCCTTC 3840

TTCTACAGTG AAGAGAACAA ACCTCCGGAC ACAGAGGAGC TTGACCTGGA GACTGAAAAC 3900

ATGGAGAGCA TTCCTTTAGA CCCCTCCTCC ACCCTGCAAC CCACTGACAA GCACTCAGGA 3960

CACAAGGCCG AGAACGGCCC CGGCGTGGTG GTGCTGCGGG CCAGCTTCGA GGAGCGCCAG 4020

CCGTACGCAC ACATGAACGG GGGCCGCAAG AACGAGAGGG CCCTGCCGCT GCCCCAGTCC 4080

TCGGCCTGC 4089

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i++ relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as+reriefl+easvmkef+

Q: 1000  ITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  1059

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrp++en+++ app+l+k+iqma+e

Q: 1060  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTENNPGQAPPTLKKMIQMAGE  1119

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1120  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1179

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG++neqvl+fv++gg+lekp+ncp

Q: 1180  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMTNEQVLRFVMEGGLLEKPDNCP  1239

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei+ ++

Q: 1240  DMLFELMRMCWQYNPKMRPSFLEIIGSI  1267

         ************************9875

Domain Sequence
(FASTA)

ITMCRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPDT ENNPGQAPPT LKKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGMTN EQVLRFVMEG GLLEKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIIGSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0043559	; F:insulin binding
GO:0005010	; F:insulin-like growth factor-activated receptor activity
GO:0006955	; P:immune response
GO:0051389	; P:inactivation of MAPKK activity
GO:0048009	; P:insulin-like growth factor receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0045740	; P:positive regulation of DNA replication
GO:0043410	; P:positive regulation of MAPK cascade
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0051262	; P:protein tetramerization
GO:0046328	; P:regulation of JNK cascade

KEGG

tgu:100227374

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013