EKS-TAG-00243
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00243
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE7384.91.8E-11569363295
StatusUnreviewed
Ensembl ProteinENSTGUP00000009682
UniProt AccessionH0ZGH0;
Protein Name
Protein Synonyms/Alias
Gene NameMAP2K1
Gene Synonyms/Alias MAP2K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000009363ENSTGUP00000009682ENSTGUT00000009787
OrganismTaeniopygia guttata
Functional Description
Protein Length395
Protein Sequence
(FASTA)
MPKKKPGPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60
GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLIMARKLIH LEIKPAIRNQ IIRELQVLHE 120
CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180
REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240
SVQSDIWSMG LSLVEMAIGR YPIPPPDSKE LELMFGCPVE GDSPVTETSP RQRAPGRPMS 300
SYGSDSRPPM AIFELLDYIV NEPPPKLPNG VFGSEFQDFV NKCLIKNPAE RADLKQLMIH 360
AFIKRSEAEE VDFAGWLCST IGLNQPSTPT HAAGV 395
Nucleotide Sequence
(FASTA)
ATGCCGAAGA AGAAGCCCGG GCCGATCCAG CTGAACCCCG CTCCGGATGG ATCCGCCGTG 60
AACGGGACCA GCTCTGCGGA GACGAATCTG GAGGCGCTTC AGAAGAAGCT GGAGGAGCTG 120
GAGCTGGATG AGCAGCAGCG CAAGCGCCTG GAGGCGTTCC TCACCCAGAA GCAGAAGGTT 180
GGGGAGCTGA AGGATGATGA CTTTGAGAAG ATCAGTGAGC TGGGAGCAGG GAATGGTGGT 240
GTGGTCTTCA AAGTGTCTCA CAAACCCTCT GGCCTCATAA TGGCAAGAAA GTTAATCCAC 300
CTGGAGATCA AGCCAGCCAT CCGCAACCAG ATCATCCGGG AGCTGCAGGT GCTGCACGAG 360
TGCAACTCCC CCTACATCGT GGGCTTCTAT GGAGCCTTCT ACAGTGATGG GGAGATCTCC 420
ATCTGCATGG AGCACATGGA TGGTGGCTCC TTGGATCAAG TGCTGAAAAA GGCTGGGAGG 480
ATTCCAGAGC AGATCCTGGG CAAAGTTAGC ATTGCGGTAA TAAAAGGACT CACATATCTG 540
AGAGAAAAAC ATAAAATAAT GCACAGAGAT GTTAAACCAT CCAACATTTT GGTAAACTCT 600
AGAGGTGAAA TCAAGCTTTG TGACTTTGGT GTCAGTGGGC AGCTGATAGA TTCCATGGCA 660
AACTCCTTTG TTGGCACACG CTCCTACATG TCTCCCGAGA GGCTGCAGGG CACTCACTAC 720
TCAGTGCAGT CAGACATCTG GAGCATGGGG CTGTCCCTGG TGGAGATGGC CATTGGCAGG 780
TACCCCATTC CCCCTCCTGA CTCCAAGGAG CTGGAGCTGA TGTTTGGCTG CCCCGTGGAG 840
GGAGATTCTC CAGTGACAGA GACCTCGCCC AGGCAACGAG CGCCCGGCCG ACCCATGAGC 900
TCCTATGGAT CAGACAGCAG ACCCCCAATG GCAATCTTTG AACTTCTGGA TTACATCGTC 960
AATGAGCCAC CTCCAAAACT GCCCAATGGT GTCTTTGGTT CTGAATTTCA AGATTTTGTT 1020
AACAAATGTT TAATTAAGAA TCCTGCTGAG AGAGCCGACT TGAAGCAGCT GATGATCCAT 1080
GCTTTCATCA AGAGATCCGA GGCGGAGGAG GTGGATTTTG CGGGGTGGCT CTGCTCCACC 1140
ATCGGCCTTA ACCAGCCCAG CACCCCCACG CACGCCGCCG GCGTC 1185
Domain Profile
S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61
         ek++elGaGnggvV kv+hk+sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv
Q: 69    EKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  127
         799**************************************************.******
S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121
         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek
Q: 128   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  183
         *****************************9....8*************************
S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181
         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv
Q: 184   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  242
         ******************************************************.*****
S: 182   ksdvWslGltlvelatgrypyeklke..................................  207
         +sd+Ws+Gl+lve+a+gryp++++++                                  
Q: 243   QSDIWSMGLSLVEMAIGRYPIPPPDSkelelmfgcpvegdspvtetsprqrapgrpmssy  302
         ************************999*********************************
S: 208   .........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhaf  258
                  i+ell++ivne+ppklp+  f +efq+fv+kCl+k+++eR++lk+l+ haf
Q: 303   gsdsrppmaIFELLDYIVNEPPPKLPNGVFGSEFQDFVNKCLIKNPAERADLKQLMIHAF  362
         ***********************************************************9
S: 259   i  259
         i
Q: 363   I  363
         7
Domain Sequence
(FASTA)
EKISELGAGN GGVVFKVSHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60
FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120
RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180
MGLSLVEMAI GRYPIPPPDS KELELMFGCP VEGDSPVTET SPRQRAPGRP MSSYGSDSRP 240
PMAIFELLDY IVNEPPPKLP NGVFGSEFQD FVNKCLIKNP AERADLKQLM IHAFI 295
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00209
EKS-ANC-00218
EKS-BOT-00227
EKS-CAE-00202
EKS-CAJ-00234
EKS-CAF-00233
EKS-CAP-00253
EKS-CII-00136
EKS-CIS-00012
EKS-DAR-00542
EKS-DIO-00005
EKS-DRM-00116
EKS-EQC-00219
EKS-FEC-00212
EKS-GAM-00131
EKS-GAG-00189
EKS-GAA-00280
EKS-GOG-00224
EKS-HOS-00234
EKS-ICT-00216
EKS-LAC-00239
EKS-LOA-00226
EKS-MAM-00229
EKS-MAE-00004
EKS-MEG-00177
EKS-MOD-00225
EKS-MUM-00232
EKS-MUP-00225
EKS-MYL-00228
EKS-NOL-00211
EKS-OCP-00006
EKS-ORN-00296
EKS-ORA-00198
EKS-ORC-00204
EKS-ORL-00274
EKS-OTG-00232
EKS-PAT-00216
EKS-PES-00202
EKS-PEM-00119
EKS-POA-00220
EKS-PRC-00008
EKS-PTV-00008
EKS-RAN-00225
EKS-SAH-00213
EKS-SUS-00198
EKS-TAR-00291
EKS-TAS-00005
EKS-TEN-00286
EKS-TUB-00009
EKS-XET-00304
EKS-XIM-00289
EKS-SAC-00011
EKS-SCP-00009
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0004728; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050; P:cell cycle arrest
GO:0048870; P:cell motility
GO:0090398; P:cellular senescence
GO:0008285; P:negative regulation of cell proliferation
GO:0045597; P:positive regulation of cell differentiation
KEGG
tgu:100226448;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013