EKS-TAG-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	313.2	1.2E-93	2	230	229

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010249

UniProt Accession

H0ZI32;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP4K4

Gene Synonyms/Alias

MAP4K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000009900	ENSTGUP00000010249	ENSTGUT00000010358

Organism

Taeniopygia guttata

Functional Description

Protein Length

1260

Protein Sequence
(FASTA)

KDEEEEIKLE INMLKKYSHH RNIATYYGAF IKKSPPGHDD QLWLVMEFCG AGSITDLVKN 60

TKGNTLKEDW IAYISREILR GLAHLHAHHV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD 120

RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDLWSC GITAIEMAEG APPLCDMHPM 180

RALFLIPRNP PPRLKSKKWS KKFFSFIEGC LVKNYMQRPS TEQLLKHPFI RDQPNERQVR 240

IQLKDHIDRT RKKRGEKDET EYEYSGSEEE EEEVPEQEGE PSSIVNVPGE STLRRDFLRL 300

QQENKERSEA LRRQQLLQEQ QLREQEEYKR QLLAERQKRI EQQKEQRRRL EEQQRREREA 360

RRQQEREQRR REQEEKRRLE EMERRRKEEE ERRRAEEEKR RVEREQEYIR RQLEEEQRHL 420

EILQQQLLQE QAMLLEYRWR EMEEHRQAER LQRQLQQEQA YLLSLQHDHR RQQQQQQQQQ 480

QQQQERNKQS YHTPEPKSHY EPAERAREVE ERFRKTNQGS PEAQSKQMGK VLEPPVPSRS 540

ESFSNGNSEP AQPALQRPME PQVQWSHLAS LKNNVSPVSR SHSFSDPSPK FAHHHLRSQD 600

PYPPSRSEVL NQSSDSKSEV PDPTQKAWAR SDSDEVPPRV PVRTTSRSPV LSRRDSPLQG 660

SGQQNNQAGQ RNSTSNIEPR LLWERVEKLV PRPGSGSSSG SSNSGSQPGS HPGSQSGSGE 720

RFRMRSSSKS EGSPSQRHES APKKPEEKKE VFRPIKPASQ QDLTALAKEL RAVEDVRPPH 780

KVTDYSSSSE ESGTTDEEDD DMEQEGADES TSGPDDVRAV STLNLSNGET ESVKTMIVHD 840

DVESEPALTP SKEGTLIVRQ TQSASNTLQK HKSSSSFTPF IDPRLLQISP SSGTTVTSVV 900

GFSSEAMRSE AIRQDPTRKG SVVNVNPTNT RPQSDTPEIR KYKKRFNSEI PCAALWGVNL 960

LVGTESGLML LDRSGQGKVY PLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN 1020

KILHNDPEVE KKQGWTTVGD LEGCVHYKVV KYERIKFLVI ALKSSVEVYA WAPKPYHKFM 1080

AFKSFGELVH KPLLVDLTVE EGQRLKVIYG SCAGFHAVDV DSGSVYDIYL PTHIQSSIQP 1140

HAIIILPNTD GMELLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIR SNQIMGWGEK 1200

AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVYFM TLGRTSLLSW 1260

Nucleotide Sequence
(FASTA)

AAGGATGAAG AAGAAGAAAT CAAACTGGAG ATTAATATGC TAAAGAAATA TTCACATCAT 60

AGAAATATTG CAACTTATTA TGGTGCTTTC ATTAAGAAAA GTCCTCCAGG ACATGATGAC 120

CAACTGTGGC TTGTTATGGA GTTTTGTGGA GCTGGGTCTA TCACAGACCT TGTGAAGAAC 180

ACAAAAGGGA ATACCCTGAA AGAAGACTGG ATAGCATATA TCTCCAGAGA GATTCTCCGG 240

GGGTTGGCAC ATCTTCATGC CCATCATGTG ATTCACAGGG ATATCAAAGG GCAAAACGTA 300

TTATTAACAG AGAATGCAGA AGTGAAACTT GTGGATTTTG GTGTGAGCGC TCAGCTGGAC 360

AGGACAGTTG GCAGGAGAAA CACTTTTATT GGGACTCCGT ACTGGATGGC TCCAGAAGTT 420

ATTGCCTGTG ATGAGAATCC AGATGCTACG TATGATTACA GAAGTGACCT TTGGTCGTGT 480

GGCATTACGG CCATAGAGAT GGCAGAAGGA GCTCCCCCAC TTTGTGACAT GCACCCCATG 540

AGGGCACTCT TTCTGATACC CAGGAACCCT CCCCCACGGT TAAAATCCAA GAAATGGTCG 600

AAAAAGTTTT TCAGCTTTAT AGAAGGTTGT CTAGTGAAGA ATTACATGCA GCGACCTTCT 660

ACCGAACAAC TGTTGAAACA TCCCTTTATA CGTGACCAGC CAAATGAAAG GCAAGTCCGA 720

ATCCAGCTTA AGGACCATAT AGACAGGACC AGGAAGAAGA GAGGAGAGAA AGATGAGACG 780

GAGTATGAAT ATAGTGGAAG TGAGGAAGAA GAGGAGGAAG TGCCTGAACA AGAAGGAGAG 840

CCAAGTTCCA TTGTCAATGT GCCTGGAGAA TCAACCCTCC GACGTGATTT CCTGAGATTG 900

CAGCAGGAAA ACAAGGAACG GTCCGAGGCC CTTCGGAGAC AGCAGCTGCT GCAGGAGCAG 960

CAGCTCCGGG AGCAGGAGGA GTACAAGAGG CAGCTGCTGG CAGAGAGGCA GAAACGCATC 1020

GAGCAGCAGA AGGAGCAGAG GCGGCGGTTA GAAGAGCAAC AAAGAAGAGA AAGGGAAGCT 1080

CGAAGGCAAC AAGAGCGTGA GCAAAGGCGG AGAGAACAGG AGGAAAAAAG ACGTCTGGAA 1140

GAAATGGAGA GGAGGCGTAA GGAGGAGGAA GAGAGAAGAA GAGCAGAGGA GGAAAAGAGG 1200

AGGGTAGAAA GGGAGCAGGA GTATATCAGG CGACAGCTAG AAGAGGAGCA GCGGCACTTG 1260

GAAATTCTAC AGCAGCAGCT GCTCCAGGAG CAGGCCATGT TACTGGAATA CAGGTGGCGA 1320

GAGATGGAGG AACACCGACA GGCAGAGCGA CTCCAGCGCC AGTTGCAGCA GGAGCAAGCC 1380

TATCTCCTGT CGCTGCAGCA CGATCACAGG CGGCAGCAAC AGCAGCAGCA GCAGCAACAG 1440

CAGCAGCAGC AAGAAAGAAA TAAACAAAGC TATCATACCC CTGAGCCAAA ATCCCACTAT 1500

GAGCCTGCTG AAAGAGCACG TGAGGTGGAG GAGAGATTTA GAAAAACTAA TCAGGGCTCC 1560

CCTGAAGCAC AGTCTAAACA GATGGGCAAA GTGTTGGAGC CACCAGTGCC TTCAAGATCG 1620

GAGTCCTTTT CCAATGGAAA CTCAGAACCT GCTCAGCCTG CCCTGCAGAG GCCAATGGAG 1680

CCCCAGGTAC AGTGGTCCCA TCTGGCATCT CTCAAGAACA ATGTTTCCCC TGTCTCGCGA 1740

TCCCATTCCT TCAGTGACCC TTCTCCCAAA TTTGCTCATC ACCATCTTCG TTCCCAGGAC 1800

CCATATCCAC CTTCACGCAG TGAAGTGCTT AATCAGAGTT CTGACTCTAA GTCGGAGGTA 1860

CCCGACCCCA CCCAAAAGGC TTGGGCTAGA TCAGACAGTG ACGAGGTGCC TCCAAGGGTA 1920

CCTGTGAGAA CAACGTCGCG ATCGCCAGTC CTGTCCCGCC GTGATTCCCC ACTGCAGGGC 1980

AGTGGGCAGC AAAATAACCA AGCAGGTCAA AGAAATTCCA CGAGCAATAT AGAGCCTCGT 2040

TTGCTGTGGG AAAGGGTGGA GAAGCTTGTA CCAAGGCCAG GCAGTGGCAG TTCTTCTGGC 2100

TCAAGCAACT CTGGCTCACA ACCTGGCTCC CACCCTGGCT CTCAGAGCGG GTCTGGAGAG 2160

CGGTTCAGGA TGAGATCATC ATCCAAATCA GAGGGTTCGC CATCACAGCG CCATGAAAGT 2220

GCACCTAAAA AGCCTGAAGA GAAAAAGGAA GTCTTCAGAC CTATCAAGCC TGCTTCCCAA 2280

CAGGATTTAA CTGCATTGGC GAAGGAGCTG CGAGCAGTAG AGGATGTGCG ACCTCCACAT 2340

AAAGTAACAG ATTACTCATC CTCAAGTGAG GAGTCAGGGA CAACAGACGA GGAAGATGAT 2400

GATATGGAAC AAGAAGGAGC AGATGAATCT ACTTCTGGAC CAGATGATGT CCGAGCAGTG 2460

TCAACATTGA ACTTGAGCAA TGGTGAAACA GAGTCAGTAA AAACCATGAT TGTCCATGAT 2520

GATGTGGAGA GTGAACCTGC CTTGACTCCT TCTAAGGAGG GCACCTTAAT TGTTCGACAG 2580

ACTCAGTCCG CTAGTAACAC ACTCCAGAAA CACAAATCTT CCTCCTCCTT TACACCTTTT 2640

ATAGACCCCA GATTACTACA GATTTCTCCA TCTAGTGGGA CAACTGTGAC TTCTGTGGTA 2700

GGATTTTCTA GTGAAGCAAT GAGATCAGAG GCAATAAGGC AAGACCCTAC ACGGAAAGGA 2760

TCAGTTGTCA ATGTGAATCC CACAAATACG CGGCCACAGA GTGACACACC AGAGATTCGC 2820

AAATACAAGA AGAGATTCAA TTCCGAGATA CCGTGTGCAG CGTTATGGGG AGTGAACTTG 2880

TTGGTGGGCA CTGAAAGTGG TCTGATGTTA CTAGACAGAA GTGGGCAGGG GAAGGTTTAT 2940

CCACTCATCA ATCGAAGACG ATTCCAGCAA ATGGATGTAC TTGAAGGGCT GAATGTCTTG 3000

GTGACAATTT CTGGTAAGAA GAACAAGTTG CGAGTTTACT ATTTGTCATG GTTAAGAAAT 3060

AAAATCCTTC ACAATGATCC TGAAGTAGAA AAGAAACAGG GCTGGACAAC GGTGGGTGAC 3120

TTGGAAGGCT GTGTGCACTA TAAAGTTGTA AAATATGAAC GAATCAAGTT CTTGGTAATT 3180

GCATTGAAGA GTTCTGTGGA AGTCTATGCA TGGGCACCAA AGCCATACCA TAAATTTATG 3240

GCCTTTAAGT CATTTGGAGA ATTGGTACAT AAGCCATTGC TGGTGGATCT AACTGTAGAA 3300

GAGGGTCAGA GACTAAAAGT GATCTATGGC TCCTGCGCTG GCTTCCATGC TGTTGATGTG 3360

GATTCAGGAT CGGTCTATGA TATTTATCTA CCAACACATA TCCAGAGTAG TATCCAACCT 3420

CATGCAATCA TCATCCTCCC AAACACGGAT GGAATGGAGC TGCTGGTCTG CTACGAGGAT 3480

GAAGGAGTTT ATGTCAACAC ATATGGAAGG ATAACCAAGG ATGTGGTTCT GCAGTGGGGG 3540

GAAATGCCAA CTTCAGTTGC ATACATCCGA TCTAACCAGA TCATGGGCTG GGGAGAAAAA 3600

GCTATCGAGA TACGGTCGGT GGAAACTGGA CACTTGGATG GTGTGTTCAT GCACAAAAGG 3660

GCACAAAGAC TCAAATTCTT ATGTGAACGC AACGACAAGG TTTTCTTTGC CTCCGTGCGG 3720

TCAGGTGGAA GCAGTCAAGT CTATTTCATG ACCCTTGGCA GGACTTCACT TCTGAGCTGG 3780

Domain Profile

S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90

         +++ee++ ei++lkk++h +ni +y+++f+k      +++lwlvme++ +Gs++dlvk++

Q: 2     DEEEEIKLEINMLKKYSHhRNIATYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKNT  61

         7899************998*****************9***********************

S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150

         + ++lkE++iayi re+l++L++lH+++viHrdik++n+Llte++eVkL+dfgv+aql++

Q: 62    KGNTLKEDWIAYISREILRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR  121

         ************************************************************

S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207

         t+ +r+t++gtpywmAPEvia++   + +Yd+++D+ws+GItaie+aeg+pP++d++p++

Q: 122   TVGRRNTFIGTPYWMAPEVIACDenpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR  181

         ***********************999999*******************************

S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         al++i++n+pp+lksk k+sk+f +f+e cl kn+ +Rps+++llkh+F+

Q: 182   ALFLIPRNPPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI  230

         *************888.********************************7

Domain Sequence
(FASTA)

DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 60

KGNTLKEDWI AYISREILRG LAHLHAHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 120

TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 180

ALFLIPRNPP PRLKSKKWSK KFFSFIEGCL VKNYMQRPST EQLLKHPFI 229

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0046328	; P:regulation of JNK cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013