EKS-TAG-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	321.6	3.8E-96	863	1127	265

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010323

UniProt Accession

H0ZIA6;

Protein Name

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000009979	ENSTGUP00000010323	ENSTGUT00000010432

Organism

Taeniopygia guttata

Functional Description

Protein Length

1134

Protein Sequence
(FASTA)

MAFCAKMRST RKNELNLEAQ HQGLEILFYL QDKAPICYSS GEFTSEELCI EAAQRCSVSP 60

LCHNLFALYD ENKRLWYAPN QVFKVEEKSS FRLHYRMRYY FTNWHGTSES EPSVWRHSPR 120

RAKAYDRKLA PEGTPILDSD SLEYIFAQGQ YDLVKGLAPI RDPKNDQEVH EIENECLGMA 180

VLAISHDAIK KNMKLPELPK DISYKHYIPE TLNRTIRQRN FLTRIRINNV FKHFLKEFNN 240

KTICNNSVSP RDLKVKYLST MEILTKYYGA EIFETSFLLI SAENEVNKFN CGDNERYEVM 300

VSGNNGIQWR LKPSPVPTEK EKKKKSDSKS KKVEEKHKLR EAWNSFSYFP EITHIVIRDC 360

AVSVNKQDNK RMELRLGSHA EALSFTSLVD GYFRLTADAH HYLCTDVAPP LIQHNIKNGC 420

HGPICTEYAI NKLRQEGNEV GMYVLRWSCT DFNHILMTVT CLESSERVMN NSGPYKNFQI 480

EVKKGEYFLH GSNKSFASLK DLMDHLKGQI LRTDNISFTL KRCCQPRPRE ISNLLVATKK 540

AQEWQPVYPM GQLSFHRIRK EEIVQGEHLG RGTRTQIYSG MLSLKDDENE GYQNEREIRV 600

LLKVLDPSHR DISLAFFETA SMMRQVSHKH IVLLHGVCVR DLENIMVEEF VECGPLDLFM 660

HKKSEVLTTP WKFKVAKQLA SALSYLDKDL VHGNVCTKNI LLAREGIDTE YGPFIKLSDP 720

GIPITVLSRQ ERVERIPWIA PECVEDSKNL SIAADKWSFG TTLWEICYNG ETPLKDKTLA 780

EKERFYEGHF VLATPSCKEL ADLMKQCMNY DPHQRPFFRA IMRDINKLEE QNPDIVSEKK 840

PVTEVDPTLF EKRFLKRIPT PKSGHFGKVE LCRYDPEGDN TGEQVAVKSL KPESGGNHIA 900

DLKKEIEILR NLYHDNIVKY KGICTEDGGS GIKLIMEFLP SGSLKEYLPR NKNKINLKQL 960

LRYAVQICRG MDYLGSCQYV HRDLAARNVL VESENRVKIG DFGLTKAIET DKEYYTVKDD 1020

RDSPVFWYAP ECLLQSKFYI ASDVWSFGVT LYELLTYCDS ECSPMAEFLK MIGPTQGQMT 1080

VARLVRVLQD DKRLPRPPTC PEEVDQLMRK CWIYKHDERT TFHNLIQGFE TIMS 1134

Nucleotide Sequence
(FASTA)

ATGGCTTTCT GTGCAAAAAT GAGGAGCACC AGGAAAAACG AGCTCAACCT GGAAGCTCAA 60

CACCAGGGGC TGGAAATTCT CTTCTACCTG CAGGACAAAG CCCCCATCTG TTACTCCAGT 120

GGCGAGTTCA CCTCGGAGGA GCTGTGCATT GAGGCTGCCC AGAGGTGTTC TGTGTCCCCT 180

CTGTGCCACA ACCTCTTTGC TCTGTATGAT GAGAACAAAA GGCTCTGGTA TGCACCAAAC 240

CAGGTCTTCA AGGTGGAGGA AAAATCATCC TTCCGGCTCC ATTATCGCAT GAGATATTAT 300

TTCACCAACT GGCATGGGAC CAGCGAGAGC GAGCCCTCGG TGTGGAGACA CTCGCCCCGG 360

AGGGCCAAGG CCTATGACAG GAAGCTGGCC CCAGAGGGGA CCCCCATCCT GGATTCTGAT 420

TCCCTGGAGT ACATCTTTGC ACAGGGCCAG TATGACCTGG TGAAGGGCCT GGCACCCATC 480

CGAGATCCCA AAAACGACCA GGAGGTCCAT GAGATTGAGA ATGAGTGTCT GGGCATGGCT 540

GTCCTGGCCA TCTCCCACGA TGCCATCAAG AAAAACATGA AGTTGCCAGA GCTTCCCAAG 600

GACATCAGTT ACAAGCATTA TATCCCTGAG ACTCTGAACA GGACCATCAG GCAGAGGAAT 660

TTCTTGACCA GGATTCGGAT CAATAACGTT TTCAAGCATT TCCTGAAGGA GTTCAACAAC 720

AAAACCATCT GCAACAACAG CGTCTCCCCG CGGGACCTGA AGGTGAAATA CTTATCCACC 780

ATGGAGATCC TGACCAAATA CTACGGGGCA GAGATCTTTG AGACCTCGTT TCTGCTGATT 840

TCTGCTGAGA ACGAGGTGAA CAAATTCAAC TGTGGAGACA ACGAGAGGTA CGAGGTGATG 900

GTGAGCGGCA ACAACGGCAT CCAGTGGAGG CTCAAGCCCA GTCCTGTCCC AACAGAGAAA 960

GAGAAGAAGA AAAAATCCGA CAGCAAAAGC AAAAAGGTGG AGGAGAAGCA CAAACTGCGG 1020

GAGGCGTGGA ACAGCTTCTC CTACTTCCCT GAGATCACCC ACATCGTCAT CAGGGACTGC 1080

GCCGTCAGCG TCAACAAGCA GGACAACAAA AGGATGGAGC TGAGGCTGGG CTCGCACGCC 1140

GAGGCGCTGT CCTTCACCTC GCTGGTCGAT GGCTACTTCA GGCTCACGGC AGATGCCCAC 1200

CACTACCTGT GCACAGACGT GGCTCCTCCC CTCATCCAGC ACAACATCAA AAACGGCTGC 1260

CACGGCCCCA TCTGCACGGA ATATGCCATC AACAAGCTGA GGCAGGAGGG CAACGAGGTG 1320

GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTCAACC ACATCCTCAT GACTGTGACG 1380

TGCCTGGAGA GCTCCGAGAG GGTGATGAAT AACTCAGGCC CCTACAAGAA CTTCCAGATC 1440

GAGGTGAAGA AAGGGGAGTA CTTCCTCCAT GGCTCCAACA AATCCTTTGC ATCCTTGAAA 1500

GACCTCATGG ATCACCTGAA GGGACAAATC CTGCGGACAG ACAACATCAG CTTCACCCTG 1560

AAGAGGTGCT GCCAGCCCAG ACCCAGAGAA ATCTCCAACT TGCTGGTGGC AACCAAGAAG 1620

GCCCAGGAGT GGCAGCCAGT GTATCCCATG GGGCAGCTGA GCTTCCACCG GATCCGCAAG 1680

GAGGAGATCG TGCAGGGAGA ACACCTGGGA AGAGGGACCA GGACCCAGAT TTACTCAGGG 1740

ATGCTCAGCC TCAAGGATGA TGAGAACGAA GGGTACCAGA ATGAAAGAGA GATCCGAGTC 1800

CTCCTCAAAG TCCTGGACCC CAGCCACAGA GACATTTCCT TGGCCTTCTT TGAGACCGCC 1860

AGCATGATGA GACAAGTGTC CCACAAACAC ATCGTGCTGC TGCACGGCGT CTGCGTCCGC 1920

GACCTGGAGA ATATCATGGT TGAAGAGTTT GTTGAGTGTG GACCTCTGGA TCTCTTCATG 1980

CATAAGAAAA GTGAAGTTCT CACAACCCCA TGGAAATTCA AAGTGGCCAA ACAGCTTGCA 2040

AGTGCTCTGA GCTACCTGGA CAAGGATTTG GTGCATGGCA ATGTGTGCAC CAAGAACATC 2100

CTGCTGGCCA GGGAGGGCAT TGACACCGAG TATGGGCCTT TCATAAAGCT GAGTGACCCA 2160

GGAATCCCCA TCACCGTGCT GTCCAGGCAA GAGCGTGTTG AGCGGATCCC CTGGATTGCA 2220

CCTGAGTGCG TTGAGGATTC CAAGAACCTC AGCATTGCTG CAGATAAGTG GAGTTTTGGT 2280

ACAACCCTGT GGGAAATCTG CTATAATGGA GAAACTCCAC TGAAAGACAA GACCTTAGCA 2340

GAGAAGGAGA GGTTCTACGA GGGGCACTTT GTGCTGGCCA CGCCGTCCTG CAAGGAGCTG 2400

GCAGACCTGA TGAAGCAGTG CATGAACTAC GACCCCCACC AGAGACCCTT CTTCAGGGCC 2460

ATCATGAGGG ACATCAACAA ACTGGAGGAG CAGAATCCCG ATATTGTCTC GGAGAAGAAA 2520

CCCGTCACCG AGGTGGATCC CACCCTCTTT GAGAAGAGGT TCTTGAAAAG GATCCCGACA 2580

CCCAAATCAG GCCACTTTGG CAAGGTGGAA CTGTGCAGAT ATGACCCAGA AGGTGACAAC 2640

ACCGGGGAGC AGGTGGCAGT GAAATCCCTG AAGCCCGAGA GTGGAGGGAA TCACATCGCT 2700

GACCTGAAGA AGGAAATTGA AATCCTGAGG AATCTTTATC ACGACAACAT CGTCAAATAC 2760

AAGGGGATTT GCACAGAAGA TGGAGGAAGC GGGATTAAAC TCATCATGGA ATTCCTTCCC 2820

TCTGGGAGCC TGAAGGAGTA TCTCCCACGG AACAAGAACA AGATCAACCT CAAGCAGCTG 2880

CTCAGATACG CAGTTCAGAT CTGCAGGGGC ATGGACTACC TGGGCTCCTG TCAGTACGTG 2940

CACCGTGACC TGGCAGCGAG AAATGTCCTG GTGGAGAGTG AGAACAGGGT GAAGATTGGG 3000

GACTTTGGGC TGACCAAGGC CATCGAGACG GATAAGGAAT ATTACACCGT CAAGGACGAC 3060

CGCGACAGCC CCGTCTTCTG GTACGCCCCG GAGTGTTTGC TGCAGAGCAA GTTCTACATC 3120

GCCTCCGACG TCTGGTCCTT CGGGGTGACG CTCTACGAGC TGCTCACCTA CTGCGACTCC 3180

GAGTGCAGCC CCATGGCAGA ATTCCTGAAG ATGATCGGCC CCACGCAGGG ACAGATGACG 3240

GTGGCACGGC TCGTGCGGGT CCTGCAGGAC GACAAACGGC TGCCACGGCC ACCCACCTGT 3300

CCTGAGGAGG TGGATCAGCT GATGAGGAAG TGCTGGATCT ACAAACACGA CGAACGCACC 3360

ACCTTCCACA ACCTGATCCA AGGATTTGAA ACAATTATGA GT 3402

Domain Profile

S: 9     kgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlshehivklkg  67

          g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h++ivk+kg

Q: 863   SGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYHDNIVKYKG  922

         59**********************************************************

S: 68    vcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLedkklvhr  125

         +c+++g    +l+me+++sGsL++yL+++k++++l++ll +a q++++m+YL++ ++vhr

Q: 923   ICTEDGGSgiKLIMEFLPSGSLKEYLPRNKNKINLKQLLRYAVQICRGMDYLGSCQYVHR  982

         *****9999***************************************************

S: 126   dvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlapeclsea  184

         d+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+apecl ++

Q: 983   DLAARNVLVESENR------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWYAPECLLQS  1036

         **************......****************************************

S: 185   knlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklelleekerlp  232

         k +++asdvWsFgvtlyellt c++++sp    l++++++       r++++l++ +rlp

Q: 1037  K-FYIASDVWSFGVTLYELLTyCDSECSPmaefLKMIGPTqgqmtvaRLVRVLQDDKRLP  1095

         *.*******************************99999999*******************

S: 233   kpk.cpaelaelmtnclsyepsqrpsFraile  263

         +p+ cp+e+ +lm++c+ y+ ++r++F+++++

Q: 1096  RPPtCPEEVDQLMRKCWIYKHDERTTFHNLIQ  1127

         *****************************986

Domain Sequence
(FASTA)

SGHFGKVELC RYDPEGDNTG EQVAVKSLKP ESGGNHIADL KKEIEILRNL YHDNIVKYKG 60

ICTEDGGSGI KLIMEFLPSG SLKEYLPRNK NKINLKQLLR YAVQICRGMD YLGSCQYVHR 120

DLAARNVLVE SENRVKIGDF GLTKAIETDK EYYTVKDDRD SPVFWYAPEC LLQSKFYIAS 180

DVWSFGVTLY ELLTYCDSEC SPMAEFLKMI GPTQGQMTVA RLVRVLQDDK RLPRPPTCPE 240

EVDQLMRKCW IYKHDERTTF HNLIQ 265

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013