EKS-TAG-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	387.9	2.5E-116	196	494	299

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010438

UniProt Accession

H0ZIM1;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010107	ENSTGUP00000010438	ENSTGUT00000010548

Organism

Taeniopygia guttata

Functional Description

Protein Length

1025

Protein Sequence
(FASTA)

IESLTKIIFL SLAKATQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM KGSTCYGLWE 60

KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN GTYRFCCCST DLCNVNFTEN 120

FPPPDPTDTT PYNSSHSFHR DETIVIALAS VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN 180

MMEAAASEPS LDLDNLKLLE LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY 240

RIPLMEHDNI ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS 300

ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK LTGNRLVRPG 360

EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY ALGLIYWEIF MRCTDLFPGE 420

SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD 480

AEARLTAQCA EERMAELMMI WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS 540

SSSYIEDSIH HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS 600

LSTTNTTGLT PSTGMTTISE MPYSDETNLH TTNVMQPGGP TPVCLQLTEE DLETNKLDPK 660

EVDKNLKESS DENLMEHSLK QFSGPDPLSS TSSSLLYPLI KLAVEVTGQQ DFTQATNGQA 720

CLIPDVPSAQ VYPLPKQQNL PKRPTSLPLN TKNSTKEPRL KFGGKHKSNL KQVETGVAKM 780

NTINAAEPHV VTVTMNGVAG RSHGINSHAG TTPYANGTVP SGQTSSSVAQ RAQEMLQNQF 840

SGEDSRLNIN SSPDEHEPLL RREQQAGHDE GVLDRLVDRR ERPLDNGRTN ANNNNSNPCP 900

DTAAASTQNV VRNPGQTQSR RAQRPNSLDL SATSSLDSSS MQLGDSSQDG KSGSGEKIKK 960

RVKTPYSLKR WRPSTWVIST EPLHCEVNNN GSEQAVPPKS STAVYLAEGG TATTMVSKDA 1020

GVNCL 1025

Nucleotide Sequence
(FASTA)

ATTGAATCAC TGACAAAAAT TATTTTTCTT TCTTTGGCTA AAGCTACTCA GAGTGAGGAG 60

CGGCTGTGTG CATTTAAAGA CCCATATCAG CAGGACCATG GAATCAGTGA GAGCCGAATC 120

TCCCAGGAGA ATGGCACAAT TTTGTGCATG AAAGGTAGTA CCTGCTATGG ACTTTGGGAA 180

AAAACACGAG AAGGAGACAT ACATCTTGTA AAACAAGGTT GCTGGTCTCA TATAGGAGAT 240

CCACAGGAGT GTCACTTTGA AGAGTGTATA GTTACAACCA CCCCTTCCTT GATTCAGAAT 300

GGAACATACC GCTTCTGCTG CTGTAGTACA GACTTGTGTA ATGTCAACTT CACAGAAAAC 360

TTCCCACCTC CTGACCCTAC TGATACAACA CCTTACAATT CTTCTCATTC TTTTCATCGA 420

GATGAGACCA TCGTTATTGC CCTGGCATCT GTGTCTGTAC TGGCTGTTCT GATAGCTGCT 480

CTATTCTTTG GCTACAGGAT GCTTGCAGGA GACCGTAAAC AAGGTTTGCA CAGTATGAAC 540

ATGATGGAGG CAGCAGCATC AGAGCCCTCA TTGGATCTGG ATAACCTGAA GTTGTTGGAG 600

TTGATTGGCC GGGGACGATA TGGAGCAGTG TATAAAGGTT CCCTAGATGA ACGTCCAGTT 660

GCTGTGAAAG TATTTTCTTT TGCTAATCGT CAGAACTTTG TCAATGAGAG GAACATTTAC 720

AGGATTCCAC TGATGGAACA CGATAATATC GCCCGCTTCA TTGTGGGGGA TGAGAGATTC 780

ACTGCAGACG GCCGGATGGA ATATTTATTG GTGATGGAAT ATTACCCCAA TGGTTCTTTA 840

TGCAAATATT TGAGTCTCCA CACAAGTGAC TGGGTGAGCT CTTGTCGTTT GGCTCACTCC 900

ATAACTCGGG GCTTGGCGTA CCTGCACACG GAGCTGCCTC GAGGAGACCA TTACAAGCCT 960

GCGATATCCC ATCGTGACTT GAACAGCCGC AATGTGCTGG TGAAGAACGA CGGGACGTGT 1020

GTCATCAGCG ATTTTGGACT CTCCATGAAG TTAACTGGCA ACAGACTGGT ACGACCGGGT 1080

GAGGAAGACA ATGCAGCCAT CAGTGAGGTC GGTACGATCC GCTATATGGC CCCAGAAGTG 1140

CTTGAAGGAG CAGTGAACTT GAGGGACTGT GAATCTGCTT TGAAACAAGT AGATATGTAT 1200

GCGCTGGGCC TGATCTACTG GGAGATATTC ATGAGATGTA CCGACCTCTT CCCAGGGGAG 1260

TCTGTGCCAG AGTACCAGAT GGCTTTCCAG ACTGAAGTCG GAAACCATCC CACTTTTGAA 1320

GATATGCAAG TCTTGGTGTC TAGAGAGAAG CAAAGACCAA AATTCCCAGA AGCATGGAAG 1380

GAGAACAGCC TGGCTGTGAG ATCACTTAAA GAAACAATTG AAGACTGTTG GGATCAAGAT 1440

GCAGAAGCTC GACTAACAGC ACAGTGTGCT GAGGAGAGAA TGGCAGAGCT CATGATGATT 1500

TGGGAGAGAA ATAAATCAGT TAGTCCAACA GTCAATCCTA TGTCAACTGC CATGCAAAAT 1560

GAGAGGAATC TGTCACATCA TAGACGTGTA TCAAAGATAA GGCCATATCC AGATTATTCT 1620

TCCTCTTCCT ACATTGAAGA TTCAATCCAC CACACTGACA GCATAGTAAA GAACATTTCT 1680

TCTGAACATT CAATGTCCAC CACACCATTG ACTTCAGGAG AAAAGAATAG AAATTCCATT 1740

AACTACGAGC GGCAGCAAGC ACAAGCGCGC ATCCCTAGTC CTGAGACAAG TGTCACCAGT 1800

TTGTCCACCA CCAACACAAC TGGCCTCACT CCCAGCACTG GCATGACCAC CATATCCGAA 1860

ATGCCTTATT CGGATGAAAC AAACTTACAC ACTACAAATG TCATGCAGCC AGGTGGGCCC 1920

ACCCCTGTTT GTCTGCAGCT AACAGAGGAG GACTTGGAGA CAAATAAATT GGATCCAAAA 1980

GAAGTGGATA AGAACCTGAA AGAAAGCTCT GATGAGAATC TGATGGAACA TTCACTTAAG 2040

CAGTTTAGTG GGCCAGATCC GCTGAGCAGC ACTAGTTCCA GCTTGCTTTA TCCACTGATA 2100

AAACTTGCAG TAGAGGTGAC AGGGCAACAG GACTTCACAC AAGCTACCAA TGGTCAGGCA 2160

TGTTTGATTC CTGATGTCCC ATCTGCTCAG GTCTATCCTC TGCCCAAGCA ACAGAACCTT 2220

CCGAAGAGGC CTACTAGCCT CCCTCTAAAC ACCAAAAATT CAACAAAAGA GCCACGGTTA 2280

AAATTTGGTG GCAAGCACAA ATCAAACTTG AAGCAAGTGG AAACAGGCGT TGCCAAGATG 2340

AACACTATCA ATGCTGCAGA ACCTCATGTG GTGACAGTTA CCATGAATGG AGTGGCTGGG 2400

AGGAGCCACG GCATAAACTC TCACGCTGGC ACAACCCCGT ATGCCAATGG CACGGTGCCC 2460

TCCGGCCAGA CCAGCAGCTC GGTAGCACAG AGGGCCCAGG AAATGCTCCA GAACCAGTTC 2520

AGTGGGGAGG ACAGTCGGCT GAATATCAAC TCCAGTCCCG ACGAGCACGA GCCCCTGCTG 2580

AGACGGGAGC AGCAGGCTGG CCACGATGAA GGTGTTCTGG ACCGCCTGGT AGACAGGAGG 2640

GAGCGGCCGC TGGATAATGG CCGAACAAAC GCCAACAACA ACAACAGCAA TCCGTGTCCA 2700

GACACAGCTG CAGCCAGTAC CCAGAATGTA GTGAGAAATC CTGGGCAGAC CCAGAGCAGA 2760

AGAGCACAGA GGCCTAATTC GCTGGATCTG TCAGCCACAA GTAGTTTGGA TAGCAGTAGT 2820

ATGCAGTTAG GTGACTCCTC ACAGGATGGC AAATCAGGCT CAGGAGAGAA GATCAAGAAA 2880

CGTGTGAAAA CTCCGTACTC GCTCAAGCGG TGGCGTCCGT CCACGTGGGT CATCTCCACG 2940

GAGCCGCTGC ACTGCGAGGT CAACAACAAC GGCAGTGAGC AGGCAGTGCC CCCCAAATCC 3000

AGCACGGCTG TGTACCTTGC AGAGGGGGGC ACTGCCACCA CTATGGTCTC TAAGGACGCA 3060

GGGGTGAACT GCCTGTGA 3078

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++++E++iy+ +l++h+ni +fi+

Q: 196   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFVNERNIYRIPLMEHDNIARFIV  255

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 256   GDErFTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSITRGLAYLHTELPRG  315

         **98999*************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +d+aa+s+vGt R

Q: 316   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEDNAAISEVGTIR  374

         .46**********************************9999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 375   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  434

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 435   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  494

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFVN ERNIYRIPLM EHDNIARFIV 60

GDERFTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSITRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0009267	; P:cellular response to starvation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013