EPS-TAG-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TAG-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	84.9	6.7E-24	205	483	279

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010565

UniProt Accession

H0ZIZ7;

Protein Name

Protein Synonyms/Alias

Gene Name

TAB1

Gene Synonyms/Alias

TAB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010239	ENSTGUP00000010565	ENSTGUT00000010676

Organism

Taeniopygia guttata

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

MDGGAFGAGK AGGAFDPQAF IRQPQTILRF VSWVFSIVVF GSIVNEGYVN RVDEVEEHCI 60

FNRNPNACNY GITVGVLAFL SCLLYLALDA YFPQISSVKD RKKAVLSDIG VSAFWAFLWF 120

VGFCFLTNQW QASKPEDNPL NEGGDAARAA ITFSFFSIFT WEQQPSWTDD LPSCHLSGVG 180

SAPNRSYSAD GKGTEGHPLE DNWLKFRSEN NCYLYGVFNG YDGNRVTNFV GQRLSAELLL 240

GQLHADHSDA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP HHQLPSQYQK 300

IVERLKVVEQ EISGGAMAIV AVVLNNKLYI ANVGTNRALL CKSTVDGLQV TQLNVDHTTE 360

NEDELFRFSQ LGLDAGKIKQ VGTIRGQEST RRIGDYKVKY GYTDIELLSA AKSKPIIAEP 420

EIHGGHSLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIATEFAKQ TSLDAVAQAV 480

VDRVKRIHCD TFASGGERSK FCPRHEDMTL LVRNFGYPLG EMSQPTLTPT QVLGGRVYPV 540

SVPYSSSQST SKTSVTLSLV MPSQGQMVNG AHSSSTLDEA TPTLTNQSPT VTLQST 596

Nucleotide Sequence
(FASTA)

ATGGACGGGG GCGCCTTCGG AGCGGGGAAA GCCGGCGGCG CCTTCGACCC CCAGGCCTTC 60

ATCCGGCAGC CGCAGACCAT CCTGCGGTTC GTCTCCTGGG TGTTCTCTAT CGTGGTGTTC 120

GGCTCCATTG TCAATGAAGG CTACGTGAAC CGCGTGGATG AGGTAGAAGA GCACTGCATT 180

TTCAACCGCA ATCCCAATGC CTGCAACTAT GGCATTACCG TGGGTGTCCT CGCCTTCCTC 240

AGCTGCCTTC TTTACCTGGC TCTGGATGCC TACTTCCCGC AGATCAGCAG CGTCAAGGAC 300

CGCAAGAAGG CAGTGCTCTC GGACATCGGC GTCTCGGCCT TTTGGGCATT CCTCTGGTTC 360

GTTGGCTTCT GCTTTCTGAC CAACCAGTGG CAAGCTTCAA AACCAGAGGA CAACCCACTG 420

AATGAGGGAG GGGATGCAGC CCGAGCAGCC ATCACGTTCT CGTTCTTCTC CATCTTTACC 480

TGGGAACAAC AGCCCAGTTG GACAGATGAC TTGCCATCCT GCCATCTCTC TGGGGTGGGC 540

TCAGCTCCAA ACCGTTCCTA CAGTGCAGAT GGCAAGGGGA CAGAGGGTCA CCCCTTGGAA 600

GATAACTGGT TAAAATTCAG GAGTGAGAAC AACTGCTACC TCTATGGTGT CTTCAATGGT 660

TATGATGGCA ACCGAGTCAC CAACTTTGTG GGTCAGAGGC TCTCTGCAGA ACTGCTGCTG 720

GGCCAGCTCC ATGCAGATCA CAGCGATGCT GACGTGCGTC GAGTTCTGCT GCAGGCTTTT 780

GATGTGGTGG AAAGAAGTTT CCTGGAGTCC ATTGATGATG CCTTAGCAGA GAAGGCCAGC 840

CTGCAGTCTC AGCTACCAGA GGGTGTCCCT CACCACCAGC TCCCTTCTCA GTACCAGAAG 900

ATTGTGGAGA GATTGAAGGT TGTAGAGCAG GAGATCTCGG GAGGAGCTAT GGCTATTGTG 960

GCCGTTGTTC TCAACAACAA ACTCTACATC GCCAATGTGG GTACCAATCG GGCGCTGCTA 1020

TGCAAGTCCA CGGTGGATGG GCTGCAGGTG ACTCAGCTCA ATGTGGACCA TACGACAGAG 1080

AATGAAGATG AACTTTTTCG CTTCTCTCAG CTGGGCTTGG ATGCAGGGAA AATAAAACAA 1140

GTGGGAACTA TTCGTGGGCA GGAAAGCACT CGGCGCATTG GAGATTACAA AGTCAAGTAC 1200

GGCTATACTG ATATTGAACT GCTCAGTGCT GCTAAATCTA AGCCCATCAT AGCAGAGCCT 1260

GAAATCCACG GAGGGCACTC ACTGGATGGG GTGACGGGCT TCTTGGTGCT CATGTCCGAA 1320

GGGCTCTACA AAGCACTGGA GGCAGCTCAT GGGCCTGGGC AGGCCAACCA GGAAATTGCA 1380

GCCATGATAG CCACAGAGTT TGCCAAGCAG ACGTCACTGG ATGCTGTGGC ACAAGCAGTG 1440

GTGGACCGGG TTAAGCGCAT TCACTGTGAC ACTTTTGCCA GTGGTGGGGA GCGGTCCAAG 1500

TTCTGTCCCC GTCACGAAGA CATGACACTG CTTGTGAGGA ATTTTGGGTA CCCTCTGGGT 1560

GAGATGAGCC AGCCCACGCT GACACCAACG CAAGTCTTAG GAGGCCGTGT CTACCCAGTC 1620

TCTGTGCCAT ATTCCAGCTC CCAGAGCACA AGCAAGACAA GTGTCACGCT GTCTCTTGTC 1680

ATGCCTTCTC AAGGCCAGAT GGTCAATGGT GCCCACAGCA GCTCAACTCT GGATGAAGCC 1740

ACTCCCACCC TCACTAACCA GAGCCCAACT GTGACGCTGC AGTCGACC 1788

Domain Profile

S: 27    kspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlst  86

         k +++++  +++gv++G  g++v++f+ ++l+  l       + ++++v+++l +aF  +

Q: 205   KFRSENN-CYLYGVFNGYDGNRVTNFVGQRLSAELLLGQLHADHSDADVRRVLLQAFDVV  263

         5555555.69*********************97666555558999***************

S: 87    deel...................................kvleeksldidk..sGstavv  109

         ++ +                                   + l+ + ++  +   G+ a v

Q: 264   ERSFlesiddalaekaslqsqlpegvphhqlpsqyqkivERLKVV-EQ--EisGGAMAIV  320

         ****************************99999998553333333.33..35499*****

S: 110   alikdsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvil  162

         a++ ++kly+anvG  ra+Lc++  +   + +l +dH++++edEl R ++ g   g++ +

Q: 321   AVVLNNKLYIANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRFSQLGldaGKIKQ  380

         *********************9663366699*********************97777777

S: 163   kdgaRvlGvLavsRalGdlylk..............pyvtpePevts.hrltsedefliL  207

              + G  + +R +Gd+++k              + +++ePe++  h l+  + fl+L

Q: 381   VG--TIRG-QESTRRIGDYKVKygytdiellsaaksKPIIAEPEIHGgHSLDGVTGFLVL  437

         65..7778.489***********************999*******95488999999****

S: 208   asDGlwdvvs........neeavslvrdvlekkeaeqeaakkLvkl  245

          s Gl++ ++        n+e+ +++     k+++++++a+ +v++

Q: 438   MSEGLYKALEaahgpgqaNQEIAAMIATEFAKQTSLDAVAQAVVDR  483

         *******986333333335666666655555677777777777765

Domain Sequence
(FASTA)

KFRSENNCYL YGVFNGYDGN RVTNFVGQRL SAELLLGQLH ADHSDADVRR VLLQAFDVVE 60

RSFLESIDDA LAEKASLQSQ LPEGVPHHQL PSQYQKIVER LKVVEQEISG GAMAIVAVVL 120

NNKLYIANVG TNRALLCKST VDGLQVTQLN VDHTTENEDE LFRFSQLGLD AGKIKQVGTI 180

RGQESTRRIG DYKVKYGYTD IELLSAAKSK PIIAEPEIHG GHSLDGVTGF LVLMSEGLYK 240

ALEAAHGPGQ ANQEIAAMIA TEFAKQTSLD AVAQAVVDR 279

Keyword

Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR008253	; Marvel.
IPR021128	; MARVEL-like_dom.
IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF01284	; MARVEL; 1.
PF00481	; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS51225

; MARVEL; 1.

Prints

Created Date

20-Feb-2013