EKS-TAG-00508

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00508

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	467.9	8.1E-141	48	310	263

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010612

UniProt Accession

H0ZJ44;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010253	ENSTGUP00000010612	ENSTGUT00000010724

Organism

Taeniopygia guttata

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

CFQDGLDALV YDLDFPALRK NKNIDNFLNR YKDTVNKMRD LRMKAEDYEV VKVIGRGAFG 60

EVQLVRHKSS RRVYAMKLLS KFEMIKRSDS AFFWEERDIM AFANSPWVVQ LFYAFQDDRY 120

LYMVMEYMPG GDLVNLMSNY DVPEKWARFY TAEVVLALDA IHSMGFIHRD VKPDNMLLDK 180

AGHLKLADFG TCMKMNKEGM VRCDTAVGTP DYISPEVLKS QGGDGYYGRE CDWWSVGVFL 240

YEMLVGDTPF YADSLVGTYS KIMNHKNSLT FPDDSDISKE AKNLICAFLT DREVRLGRNG 300

VEEIKRHLFF KNDQWAWETL RDTVAPVVPD LSSDIDTSNF DDLEEDKGEE ETFPIPKAFV 360

GNQLPFVGFT YYSNRRYVRR KQINGVHHYL KISHCVLENM QKMIYELEEQ LHNEMQLKDE 420

MEQKCRSSNI KLDKIMKELD EEGNQRKNLE TTVSQIEKEK MVLQHKINEY QRKFEQENEK 480

RRNVENEVST LKDQMEDLKK ISQNSQISNE KITQLQKQLE EANDLLRTES DTAARLRKGN 540

TEISKSLSQV ESLNRELQER CRVLESTKLQ VEKDYYQLQA ALESERRDRS HGSEIIGELQ 600

VRITALQEEV KNIKNNLERV EAERKQAQDM LNHSEKEKNN LEIDLNYKLK SLQDRLEQEV 660

NEHKVTKARL TDKHQSIEEA RSVAMCEMEK KIREERAARE KAENRIVQAE KQCSMLDFDL 720

KQSQQKLEHL LQQKERLEDE VRNLTLKLEQ ETNKRIMAQN ELKAQAFEAD NLKGSEKQLK 780

QEINTLLEAK RLLEFELAQL AKQYRGNEGQ MRELQDQLEA EQYFSTLYKT QVKELKEEID 840

ERNKETQRKM QELQNEKETL ATQLDLAETK AESERLARAL AEEQYYELNQ ESKKAASRHR 900

QELTDKDIII RRLEETNNTL TKDVDLITKE NTEISEKFKK QEEDYKMKKE EEISNIRMHY 960

EKSINTERTL KTQAVNKLAE IMNRKDFKID RKKANMQDLR KKEKENRKLQ LELNQEKEKF 1020

NQMVVKYQKE LNEMQAQLAE ESTYRNELQM QLDSKESDIE QLRRKIMDLQ QGMDSTSVAS 1080

LPTDETDGNL SESRLEGWLS VPNKGNIRRH GWKKQYVVVS SKKILFYNDE KDKDQSNPSM 1140

VLDIDKLFHV RPVTQGDVYR AETEEIPKIF QILYANEGEC RKDLEVEPVQ PAEKTNFLNH 1200

KGHEFIPTLY HFPANCEACA KPLWHVFKPP AALECRRCHV KCHRDHLDKK EELIAPCKVS 1260

YDVTSARDML LLASCQDEQK KWVTHLVKKI PKTPPSTFVR ASPRTLSTRS SANQSFRKVV 1320

KNTSGKTR 1328

Nucleotide Sequence
(FASTA)

TGTTTTCAGG ATGGATTAGA TGCTTTGGTA TATGACTTGG ATTTTCCTGC CTTAAGAAAA 60

AACAAGAACA TTGATAACTT CTTAAACAGG TATAAAGACA CAGTAAATAA AATGAGAGAT 120

CTGCGCATGA AAGCTGAAGA TTATGAAGTG GTGAAGGTGA TCGGTAGAGG GGCATTTGGG 180

GAGGTTCAGT TGGTAAGGCA TAAATCGTCA AGGAGAGTGT ATGCTATGAA ACTTCTGAGC 240

AAATTTGAGA TGATAAAAAG ATCCGATTCT GCATTCTTCT GGGAAGAAAG GGATATTATG 300

GCTTTTGCTA ATAGTCCATG GGTTGTTCAG TTATTTTACG CATTCCAAGA TGACCGTTAC 360

CTTTACATGG TGATGGAATA CATGCCTGGT GGGGACCTTG TGAATTTAAT GAGTAACTAC 420

GATGTTCCAG AGAAATGGGC AAGATTTTAT ACTGCTGAAG TTGTACTTGC ATTAGATGCA 480

ATTCACTCAA TGGGTTTTAT ACACAGAGAT GTGAAGCCTG ATAATATGCT GCTAGATAAA 540

GCTGGTCATT TAAAATTAGC AGATTTTGGT ACTTGTATGA AGATGAACAA GGAAGGAATG 600

GTACGATGTG ACACGGCTGT TGGAACACCA GACTACATCT CTCCTGAAGT ATTGAAGTCC 660

CAGGGAGGGG ATGGTTACTA TGGGCGGGAA TGTGACTGGT GGTCAGTGGG AGTCTTCTTG 720

TATGAGATGC TTGTAGGTGA TACACCTTTT TATGCTGATT CTTTGGTTGG AACGTACAGT 780

AAGATTATGA ACCATAAGAA CTCCCTTACT TTCCCTGATG ACAGTGACAT TTCTAAAGAG 840

GCAAAAAACC TCATTTGTGC CTTTTTAACT GATAGGGAAG TGAGGCTAGG ACGAAATGGT 900

GTAGAAGAAA TTAAACGGCA CCTTTTCTTC AAAAATGATC AGTGGGCTTG GGAAACACTC 960

AGAGACACTG TAGCACCAGT TGTGCCTGAC TTAAGTAGTG ACATTGACAC TAGTAATTTT 1020

GATGATCTGG AAGAAGACAA AGGAGAGGAA GAAACATTTC CCATACCAAA AGCATTTGTG 1080

GGCAACCAGC TTCCTTTTGT AGGATTTACG TACTACAGCA ACCGTCGGTA TGTGCGCAGA 1140

AAGCAAATTA ATGGTGTACA TCATTATCTT AAAATATCAC ATTGTGTTCT GGAAAATATG 1200

CAAAAGATGA TCTATGAGTT AGAAGAACAG CTACATAATG AAATGCAGTT GAAAGATGAA 1260

ATGGAACAAA AGTGCAGATC TTCTAACATA AAGCTAGACA AGATAATGAA AGAACTGGAT 1320

GAAGAGGGAA ATCAAAGGAA GAACTTGGAA ACAACAGTGT CTCAGATTGA GAAGGAAAAG 1380

ATGGTATTAC AACATAAGAT AAATGAGTAC CAAAGAAAAT TTGAACAAGA GAATGAAAAA 1440

AGACGTAATG TGGAAAATGA AGTGTCCACA CTAAAAGATC AGATGGAAGA CTTGAAAAAA 1500

ATCAGCCAGA ATTCACAAAT TTCAAATGAG AAGATAACAC AGTTACAAAA ACAACTAGAA 1560

GAAGCAAATG ATTTACTGAG GACAGAATCT GACACAGCTG CAAGACTGAG AAAGGGTAAC 1620

ACAGAAATTA GCAAGTCATT AAGTCAGGTA GAATCACTGA ATAGAGAACT ACAGGAAAGG 1680

TGCAGAGTTC TGGAAAGCAC AAAACTGCAG GTGGAGAAAG ATTATTACCA ACTACAAGCA 1740

GCTTTGGAGT CAGAACGAAG GGACAGAAGT CACGGATCTG AAATTATTGG AGAACTACAG 1800

GTTCGGATTA CAGCTTTACA AGAAGAAGTA AAAAACATTA AAAACAATCT TGAAAGAGTG 1860

GAAGCAGAAA GAAAACAAGC ACAGGATATG CTTAATCATT CAGAAAAGGA AAAGAATAAT 1920

TTAGAGATAG ATTTGAACTA CAAGCTGAAA TCCTTACAAG ACCGGCTAGA GCAGGAAGTT 1980

AATGAGCACA AAGTGACTAA AGCGCGGTTA ACTGACAAAC ACCAGTCCAT AGAGGAGGCA 2040

AGATCAGTTG CGATGTGTGA AATGGAAAAA AAGATAAGGG AAGAACGGGC AGCAAGAGAA 2100

AAGGCAGAAA ATCGAATAGT TCAAGCTGAA AAACAGTGTT CCATGTTGGA CTTCGACCTG 2160

AAGCAATCTC AGCAGAAATT GGAACATCTT CTTCAGCAAA AGGAGAGACT GGAAGATGAA 2220

GTAAGGAATC TGACACTTAA GCTAGAACAA GAGACAAATA AGCGAATAAT GGCACAGAAT 2280

GAATTAAAGG CACAAGCTTT TGAAGCTGAT AATTTGAAGG GTTCTGAGAA GCAGCTGAAA 2340

CAGGAAATCA ATACCTTGTT GGAAGCAAAG AGATTACTGG AATTTGAGTT GGCTCAACTT 2400

GCAAAACAGT ACAGAGGAAA TGAAGGTCAG ATGCGTGAGC TTCAGGATCA GCTTGAAGCT 2460

GAGCAGTATT TTTCGACACT TTACAAAACT CAGGTTAAGG AGCTGAAAGA GGAAATTGAT 2520

GAAAGGAATA AAGAAACACA AAGAAAAATG CAGGAGTTGC AAAATGAAAA AGAAACACTT 2580

GCTACACAGT TGGATTTAGC TGAAACCAAA GCTGAGTCAG AACGGTTGGC ACGGGCACTC 2640

GCTGAAGAAC AGTATTATGA ACTGAATCAG GAAAGCAAAA AAGCTGCATC AAGGCACAGA 2700

CAAGAATTGA CTGATAAGGA CATCATCATA AGAAGGCTGG AAGAAACTAA TAACACTTTA 2760

ACCAAAGATG TTGATTTAAT AACAAAGGAA AACACAGAGA TCAGTGAAAA ATTTAAGAAA 2820

CAAGAGGAAG ATTACAAAAT GAAAAAAGAG GAGGAAATCA GTAATATTAG AATGCATTAT 2880

GAGAAGAGCA TAAACACTGA AAGAACTCTG AAGACACAGG CTGTCAACAA ACTGGCTGAG 2940

ATAATGAATC GGAAAGATTT TAAAATAGAC AGAAAGAAAG CTAACATGCA GGATTTGAGG 3000

AAGAAGGAGA AGGAAAACCG AAAGCTTCAA TTAGAACTTA ATCAAGAAAA AGAGAAATTC 3060

AATCAGATGG TTGTGAAATA CCAAAAGGAG CTTAATGAAA TGCAAGCGCA ACTAGCAGAA 3120

GAATCTACGT ACAGGAATGA GCTCCAGATG CAGCTAGACA GTAAAGAGAG TGACATAGAA 3180

CAACTACGAA GGAAAATCAT GGACCTCCAG CAAGGAATGG ATTCTACCAG TGTTGCCAGT 3240

CTTCCAACAG ATGAAACGGA TGGAAATCTT TCAGAATCAA GACTTGAAGG TTGGCTTTCA 3300

GTACCAAACA AAGGAAATAT AAGGCGGCAT GGCTGGAAGA AACAGTATGT TGTGGTGAGC 3360

AGTAAAAAGA TACTGTTCTA CAATGATGAA AAAGACAAGG ACCAGTCTAA TCCATCTATG 3420

GTACTAGATA TAGATAAGCT GTTTCATGTC CGACCTGTAA CTCAAGGAGA TGTATATAGA 3480

GCTGAAACTG AAGAAATTCC TAAAATATTC CAGATTCTCT ATGCTAACGA GGGGGAATGC 3540

AGGAAGGATT TGGAGGTAGA ACCAGTACAG CCGGCAGAGA AGACAAATTT TCTAAATCAC 3600

AAAGGCCACG AATTTATTCC CACATTATAC CACTTTCCAG CCAACTGTGA GGCCTGTGCC 3660

AAACCTCTCT GGCATGTCTT TAAACCCCCT GCTGCCCTAG AATGTCGAAG ATGCCATGTG 3720

AAGTGCCACA GAGATCACTT GGATAAAAAG GAGGAATTAA TTGCACCATG CAAAGTGAGC 3780

TATGATGTAA CTTCAGCAAG AGATATGCTC TTGTTGGCAT CCTGTCAAGA TGAACAGAAG 3840

AAATGGGTGA CACATTTAGT AAAGAAGATC CCTAAGACAC CACCATCTAC TTTTGTTCGT 3900

GCTTCTCCTA GAACTTTGTC TACAAGATCC TCAGCAAACC AGTCATTCAG AAAAGTTGTT 3960

AAAAATACTT CCGGAAAAAC TAGGTGA 3987

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k++++vyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 48    YEVVKVIGRGAFGEVQLVRHKSSRRVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  107

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 108   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  165

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk Gh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 166   FIHRDVKPDNMLLDKAGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  224

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 225   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDSDISKEAKNL  284

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 285   ICAFLTDREVRLGRNGVEEIKRHLFF  310

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSSRRVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKAGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDSDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013