EKS-TAG-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	331.7	2.8E-99	34	292	259

Status

Unreviewed

Ensembl Protein

ENSTGUP00000010727

UniProt Accession

H0ZJF9;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010378	ENSTGUP00000010727	ENSTGUT00000010840

Organism

Taeniopygia guttata

Functional Description

Protein Length

1216

Protein Sequence
(FASTA)

MSFFNFRKIF KLGGEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVFK AQNKETKVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHAN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTEP QIKVVCRQTL EALNYLHENK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADIWS LGITLIEMAQ IEPPHHELNP 240

MRVLLKIAKS DPPTLAQPSK WSSDFKDFLK KCLEKNVDAR WSATQLLQHP FVTVTSNKPI 300

RELIAEAKAE VTEEVEDGKD EDEEEETENS LQLPAEKRAS SDLSIASSEE DKLSQNASVL 360

ESLSEKTESN AIEDKTTGDE SEDIKFRKTA DNIHDASVSD VKVQNGSLPT GEDEQGKMVP 420

AEKNTESLEK MLEDIEPHKG GKELDVEIKN EPNLEKENSM ADEQIEDDKL KVVPVTVTED 480

RVETEEGISK ATGEKEEEKR MDLLDGEEEK VPAENRDTEQ KEDKGEAQKE AVIDTTTDAL 540

PNATVKVSDE EKELINHGID NIKEIGAIAE TPISDGDKIP EVEDKPVENQ AKQVHEIISS 600

EEILPESQDT VIEVDKKLAE SENEGISNIN STEETKIKDS GKDIDQKTLQ TKPEDIPDKL 660

VDKEHPAVTS DEIMKNKLQD AVSEQVDDSE VTPVPSISIS TEENEKIKTD NQGNTETLQQ 720

LESENLKEND ADSGTGSTAD NSSIDLNLSI SSFLSKNKET GSISLQETRR QKKTLKKTRK 780

FVVDGVEVSV TTSKIVTEND SKSEEMRFLR RQELRELRLL QKEEQRAQQQ LSNKLLQQRE 840

QMYRRFEQEM TSKKRQYDQE IENLEKQQKQ TIERLEQEHT NRLRDEAKRI KAEQEKELSK 900

FQNVLKNKKK EVLCEVEKAP KELRKELMKR KKEELAQSQH AQEQEFVQKQ QQELDASLKK 960

IIQQQKTELA TIERDCLNNK QQLMRAREAA FWELEERHLQ EKHQLLKQQL KDQYFMQRHQ 1020

LLKRHEKETE QMQRYNQRLI EELKNKQTQE RARLPKIQRS EAKTRMAMFK KSLRINSFAS 1080

PDQDREKIKQ FAVQEEKRQK NERLAQHQKH ENQMRDLQLQ CEANIRELHQ LQNEKCHLLV 1140

EHETQKLKEL DEEHSQELKE WREKLRPRKK MLEEEFARKL QEQEVFFKMT GESECLNPST 1200

RISKFYPIPS LHSTGS 1216

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAACTTTCG TAAGATCTTC AAGCTGGGCG GCGAGAAGAA GAAGAAACAA 60

TACGAGCACG TCAAGAGGGA TTTGAACCCT GAGGAGTTCT GGGAAATCAT AGGAGAGCTG 120

GGCGACGGTG CTTTCGGTAA AGTGTTCAAG GCTCAGAACA AAGAAACTAA AGTTCTGGCT 180

GCTGCAAAAG TGATAGATAC TAAATCAGAA GAAGAACTTG AAGATTACAT GGTGGAGATT 240

GATATTTTAG CATCCTGTGA TCATGCTAAT ATTGTCAAGC TCCTAGATGC TTTCTACTAT 300

GAAAACAATC TGTGGATCCT GATTGAATTT TGTGCAGGAG GAGCAGTAGA TGCAGTAATG 360

TTGGAGCTTG AAAGGCCATT AACAGAGCCA CAGATCAAAG TGGTGTGCAG GCAGACACTG 420

GAAGCACTGA ACTACTTGCA TGAGAATAAG ATCATCCACA GAGATCTAAA AGCTGGCAAT 480

ATTCTTTTCA CATTAGATGG AGACATTAAA CTAGCGGATT TTGGAGTATC AGCTAAAAAC 540

ACCAGAACAA TACAAAGAAG AGACTCCTTT ATTGGCACAC CGTATTGGAT GGCTCCAGAA 600

GTAGTAATGT GTGAGACCTC TAAAGACAGA CCATATGATT ACAAGGCTGA TATCTGGTCT 660

CTTGGCATTA CTTTAATAGA AATGGCTCAA ATAGAGCCAC CTCATCATGA ACTAAATCCC 720

ATGCGAGTGC TGCTGAAAAT CGCAAAATCT GATCCGCCGA CATTGGCACA GCCTTCAAAG 780

TGGTCATCAG ATTTTAAAGA TTTTCTGAAG AAATGTTTGG AAAAGAATGT AGATGCGAGG 840

TGGAGTGCAA CTCAACTTCT ACAGCATCCA TTTGTTACTG TTACTTCAAA TAAACCAATA 900

AGAGAATTGA TTGCAGAAGC TAAGGCTGAA GTTACAGAAG AAGTTGAAGA TGGTAAAGAT 960

GAGGATGAAG AAGAAGAAAC AGAAAATTCT CTGCAGTTAC CTGCAGAGAA ACGTGCATCC 1020

TCTGACCTTA GTATTGCCAG CTCTGAAGAG GATAAACTTT CACAGAATGC TTCTGTCCTG 1080

GAATCTCTCT CTGAGAAAAC AGAAAGTAAT GCAATTGAGG ACAAAACAAC TGGAGATGAA 1140

TCTGAGGACA TTAAATTTAG AAAAACAGCT GATAATATAC ATGATGCTTC CGTTAGTGAT 1200

GTGAAAGTGC AGAACGGTTC TTTGCCAACT GGTGAAGATG AACAAGGCAA AATGGTGCCA 1260

GCAGAAAAGA ATACAGAGAG CCTGGAAAAA ATGCTTGAGG ATATAGAACC CCATAAAGGA 1320

GGTAAAGAAC TTGATGTGGA AATAAAGAAT GAACCTAACT TAGAGAAAGA AAATTCCATG 1380

GCAGATGAAC AGATAGAAGA TGACAAACTG AAAGTAGTAC CTGTGACTGT AACTGAAGAT 1440

AGGGTAGAAA CTGAAGAAGG CATTTCTAAG GCAACTGGTG AAAAAGAAGA GGAGAAGAGA 1500

ATGGATCTCT TGGATGGTGA GGAAGAAAAG GTCCCTGCAG AAAATAGAGA TACAGAGCAA 1560

AAGGAAGATA AAGGTGAAGC TCAGAAAGAG GCAGTAATAG ATACCACTAC AGACGCTCTG 1620

CCTAATGCTA CAGTTAAAGT GTCTGATGAA GAAAAGGAAC TAATAAACCA TGGAATTGAC 1680

AACATTAAGG AGATAGGTGC TATTGCTGAA ACACCCATCA GTGATGGGGA TAAAATACCT 1740

GAGGTGGAGG ATAAGCCAGT GGAAAATCAG GCTAAGCAGG TCCATGAGAT TATCAGCTCT 1800

GAAGAAATTC TACCAGAAAG CCAAGATACA GTGATCGAAG TAGACAAGAA ACTGGCAGAA 1860

AGTGAAAATG AGGGTATCAG TAATATAAAC AGCACAGAGG AAACAAAGAT CAAAGACTCT 1920

GGAAAAGATA TAGACCAGAA GACATTACAG ACTAAACCTG AGGATATTCC TGATAAACTG 1980

GTAGACAAAG AACATCCAGC CGTTACCTCA GATGAAATAA TGAAGAATAA ACTTCAAGAT 2040

GCTGTCAGTG AACAAGTTGA TGACTCTGAA GTCACTCCAG TCCCCAGTAT TAGTATTAGC 2100

ACTGAAGAAA ATGAGAAGAT CAAAACAGAT AATCAAGGCA ATACTGAGAC TTTGCAGCAA 2160

CTGGAATCGG AGAATTTGAA GGAAAATGAT GCGGATTCAG GCACTGGGTC TACAGCTGAT 2220

AACAGCAGCA TTGATTTGAA CTTGTCCATT TCTAGTTTCC TTAGTAAAAA CAAAGAGACA 2280

GGATCAATAT CTTTACAGGA AACTAGAAGG CAGAAGAAAA CATTAAAGAA AACTCGGAAG 2340

TTTGTTGTTG ATGGAGTAGA AGTGAGTGTG ACCACATCAA AAATAGTTAC TGAAAATGAT 2400

TCAAAAAGTG AAGAAATGCG ATTTTTACGA CGTCAAGAGC TCAGAGAGCT GAGACTTCTT 2460

CAGAAAGAGG AGCAGAGAGC TCAACAGCAG CTCAGCAATA AGCTTCTGCA GCAGCGAGAG 2520

CAGATGTACA GACGTTTTGA ACAGGAAATG ACAAGTAAAA AGCGACAGTA TGATCAAGAG 2580

ATAGAGAACC TGGAAAAGCA GCAGAAGCAG ACGATCGAGC GCCTGGAGCA GGAGCACACA 2640

AATCGCTTAC GGGATGAAGC AAAGCGCATC AAGGCTGAGC AGGAGAAGGA GTTGTCCAAA 2700

TTCCAGAATG TGCTGAAAAA CAAAAAAAAG GAGGTTTTAT GTGAAGTGGA GAAAGCACCA 2760

AAAGAGCTGA GAAAAGAGCT CATGAAACGC AAGAAAGAGG AGCTTGCACA AAGCCAGCAT 2820

GCTCAGGAGC AGGAATTTGT GCAGAAACAG CAACAAGAAT TGGATGCATC TCTGAAGAAA 2880

ATAATTCAGC AGCAGAAGAC GGAACTGGCC ACCATAGAAC GAGATTGCCT CAACAACAAA 2940

CAGCAGCTCA TGAGAGCTCG TGAAGCTGCA TTCTGGGAGC TGGAGGAGAG GCACCTACAG 3000

GAGAAACACC AGCTCCTCAA GCAGCAGCTC AAGGATCAGT ACTTCATGCA GAGGCACCAG 3060

CTGCTTAAGA GGCATGAGAA AGAAACAGAA CAAATGCAGA GGTATAATCA ACGCCTTATA 3120

GAGGAGTTGA AGAACAAGCA AACTCAGGAA AGAGCCAGGC TGCCTAAAAT CCAGCGAAGT 3180

GAAGCAAAGA CTAGGATGGC CATGTTTAAG AAAAGTTTAA GAATCAATTC ATTTGCCTCT 3240

CCAGACCAAG ATCGTGAAAA AATTAAGCAG TTTGCTGTTC AAGAAGAAAA GAGGCAGAAG 3300

AACGAGAGAC TGGCGCAGCA TCAAAAACAC GAAAACCAAA TGCGGGACCT TCAGTTGCAG 3360

TGTGAAGCAA ACATCAGGGA ACTGCATCAG TTACAGAATG AAAAATGCCA TCTACTGGTT 3420

GAGCATGAGA CTCAGAAGCT AAAAGAGCTG GATGAAGAGC ACAGTCAAGA ACTGAAGGAA 3480

TGGAGAGAGA AATTGAGACC GAGAAAAAAG ATGCTGGAAG AAGAATTTGC CAGAAAACTG 3540

CAGGAACAGG AAGTTTTCTT TAAAATGACT GGAGAATCTG AATGCCTTAA TCCCTCAACA 3600

CGGATTTCCA AATTCTACCC AATCCCCAGC CTTCACTCCA CTGGGTCATA A 3651

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkv++a++k+t+ l+a k+i+++++e+le+++ ei +l +++h niv+

Q: 34    WEIIGELGDGAFGKVFKAQNKETKVLAAAKVIDTKSEEELEDYMVEIDILASCDHANIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E qi++++r++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTEPQIKVVCRQTLEALNYLHENKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaDiwslGIt+ie+a+ epP+++l+p+++llki+k++pp+l +++k+s+ fk+f++kc

Q: 213   DYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLAQPSKWSSDFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+sa++ll+h+F+

Q: 273   LEKNVDARWSATQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVFKAQN KETKVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHANIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTEPQIK VVCRQTLEAL NYLHENKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADIWSLGI TLIEMAQIEP PHHELNPMRV LLKIAKSDPP TLAQPSKWSS DFKDFLKKCL 240

EKNVDARWSA TQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013