EKS-TAG-00175
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00175
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR561.81.8E-169471747277
StatusUnreviewed
Ensembl ProteinENSTGUP00000010939
UniProt AccessionH0ZK19;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000010583ENSTGUP00000010939ENSTGUT00000011053
OrganismTaeniopygia guttata
Functional Description
Protein Length811
Protein Sequence
(FASTA)
MRAAWGSVWC LCLAAAVGGM PAARRGGGKA AAAARSGGQP AEYLRSETAF LEELVFGNGD 60
TIELSCNTQG SSVSVFWFKD GIGIAPTNRT HIGQKLLKII NVSYDDSGLY SCKPRHSNEV 120
LGNFTVRVTD SPSSGDDEDD DDESEDTGVP FWTRPDKMEK KLLAVPAANT VRFRCPAGGN 180
PTPSIYWLKN GKEFKGEHRI GGIKLRHQQW SLVMESVVPS DRGNYTCVVE NKYGNIRHTY 240
QLDVLERSPH RPILQAGLPA NQTVVVGSNV EFHCKVYSDA QPHIQWLKHV EVNGSKYGPD 300
GTPYVTVLKT AGVNTTDKEL EILYLRNVTF EDAGEYTCLA GNSIGFSHHS AWLTVLPAEE 360
LMEMDDSGSV YTGILSYGTG FFLLLLVLVL VIVWRMKMPN KKAMNTPTVQ KVSKFPLKRQ 420
QVSLESNSSM NSNTPLVRIT RLSSSDGPML ANVSELELPP DPKWELTRSR LTLGKPLGEG 480
CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD LVSEMEMMKM IGKHKNIINL 540
LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF KDLVSCAYQV 600
ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT TNGRLPVKWM 660
APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTH 720
DLYMIMRECW HAVPSQRPTF KQLVEDLDRV LTVTSTDEYL DLSVPFEQYS PAGQDTHSTC 780
SSGDDSVFAH DLLPDEPCLP KRPPCNGVIR T 811
Nucleotide Sequence
(FASTA)
ATGCGGGCGG CCTGGGGCTC CGTCTGGTGC CTGTGCCTGG CGGCGGCCGT CGGCGGGATG 60
CCGGCGGCGC GGCGGGGCGG CGGCAAGGCG GCGGCGGCGG CGAGGAGCGG CGGGCAGCCG 120
GCAGAATACT TGAGGAGCGA GACCGCCTTT CTGGAAGAGT TGGTGTTTGG AAATGGAGAT 180
ACCATTGAAC TTTCCTGTAA CACCCAAGGC TCTTCCGTGT CTGTTTTCTG GTTTAAAGAT 240
GGTATTGGAA TTGCACCTAC CAACAGAACT CATATTGGAC AAAAACTGTT GAAGATAATC 300
AATGTGTCAT ATGATGACTC GGGGCTGTAC AGTTGCAAGC CAAGGCATTC CAACGAAGTC 360
CTAGGAAACT TTACAGTCAG AGTTACAGAT TCCCCTTCAT CAGGTGATGA TGAGGATGAC 420
GATGATGAGT CAGAAGATAC AGGTGTCCCC TTCTGGACCC GGCCCGATAA GATGGAGAAG 480
AAGCTGCTGG CAGTTCCTGC CGCCAACACC GTTCGCTTCC GATGTCCGGC GGGTGGAAAC 540
CCAACTCCTT CCATCTACTG GCTGAAAAAT GGCAAGGAGT TCAAAGGGGA GCACAGGATT 600
GGGGGCATTA AGCTGCGACA CCAGCAGTGG AGCCTGGTGA TGGAGAGCGT TGTGCCGTCA 660
GATCGAGGGA ATTACACCTG CGTCGTGGAG AACAAATACG GCAACATTAG GCACACCTAC 720
CAGCTGGATG TGCTAGAAAG GTCGCCCCAC CGACCAATCC TGCAGGCAGG GCTCCCTGCC 780
AACCAGACTG TGGTGGTAGG GAGCAATGTG GAATTTCACT GCAAGGTCTA CAGCGATGCC 840
CAGCCTCACA TCCAGTGGCT GAAACACGTG GAAGTCAATG GCAGCAAATA TGGACCCGAT 900
GGAACCCCGT ATGTCACAGT GCTGAAGACG GCAGGTGTTA ACACAACGGA TAAGGAGCTA 960
GAGATTCTGT ACTTGCGAAA TGTTACTTTT GAGGATGCTG GGGAATATAC TTGTCTCGCA 1020
GGGAATTCTA TTGGGTTCTC ACATCACTCT GCTTGGCTGA CGGTGCTACC AGCCGAGGAG 1080
CTCATGGAGA TGGATGATTC GGGCTCAGTG TACACTGGCA TTCTCAGTTA TGGCACTGGC 1140
TTTTTCCTCC TTCTCCTGGT GCTGGTCTTG GTGATTGTCT GGAGGATGAA AATGCCAAAC 1200
AAAAAAGCCA TGAACACCCC CACTGTTCAG AAAGTCTCCA AATTCCCACT CAAGAGACAG 1260
CAGGTGTCGC TGGAGTCCAA CTCTTCCATG AATTCCAACA CGCCCCTGGT CCGGATCACG 1320
CGCCTCTCCT CCAGCGATGG GCCGATGCTG GCCAATGTTT CCGAGCTGGA ACTACCTCCA 1380
GATCCCAAGT GGGAACTGAC ACGGTCTCGC CTGACCTTGG GGAAGCCGCT TGGCGAGGGG 1440
TGTTTTGGCC AAGTGGTGAT GGCAGAAGCG ATTGGGATTG ATAAGGACAA GCCCAACAAG 1500
GCCATCACAG TTGCTGTCAA GATGCTAAAA GATGATGCCA CAGACAAAGA CCTTTCTGAC 1560
CTGGTCTCTG AGATGGAAAT GATGAAAATG ATTGGGAAGC ACAAAAACAT TATTAACCTC 1620
CTTGGTGCCT GCACGCAGGA CGGACCACTC TACGTGTTGG TGGAATACGC GTCAAAGGGG 1680
AACTTGCGGG AATACCTCAG GGCACGTCGC CCACCTGGCA TGGACTATTC CTTTGACACC 1740
TGCAAGCTGC CCGAGGAGCA GCTGACGTTT AAGGACCTGG TTTCCTGTGC CTACCAGGTG 1800
GCACGGGGCA TGGAGTACCT GGCATCTCAG AAATGCATTC ATCGAGACTT GGCAGCCAGG 1860
AACGTGTTAG TCACTGAAGA TAATGTGATG AAAATAGCTG ATTTTGGCCT CGCCAGAGAT 1920
GTTCACAACA TTGACTATTA CAAGAAAACC ACCAATGGTC GGCTGCCTGT GAAATGGATG 1980
GCTCCAGAAG CCTTGTTTGA CCGGGTCTAT ACTCACCAGA GCGATGTCTG GTCTTTTGGA 2040
GTGCTACTAT GGGAGATCTT CACTTTGGGA GGGTCTCCAT ACCCAGGAAT TCCTGTTGAG 2100
GAGCTCTTCA AGCTCTTGAA GGAAGGCCAT CGGATGGACA AACCTGCAAA CTGCACCCAT 2160
GATTTGTACA TGATCATGCG GGAGTGCTGG CACGCCGTCC CCTCGCAGCG ACCCACCTTC 2220
AAGCAGCTGG TGGAAGACCT GGACAGGGTC CTCACCGTGA CATCCACCGA TGAGTACCTG 2280
GACCTCTCGG TGCCCTTCGA GCAGTACTCG CCGGCCGGCC AGGACACCCA CAGCACCTGC 2340
TCCTCAGGGG ACGACTCGGT CTTTGCACAT GACCTGCTGC CCGATGAGCC CTGCCTGCCC 2400
AAGCGCCCGC CCTGCAACGG CGTCATCCGG ACGTGA 2436
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkdk++k++tvavkmlk+datdkdl+dlvseme++k+
Q: 471   LTLGKPLGEGCFGQVVMAEAIGIDKDKPNKAITVAVKMLKDDATDKDLSDLVSEMEMMKM  530
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k +eeqlt+
Q: 531   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  590
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt
Q: 591   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKT  650
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 651   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  710
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 711   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  747
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDKPNK AITVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-DRM-00072
EKS-EQC-00146
EKS-GAG-00124
EKS-GAA-00177
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PEM-00080
EKS-RAN-00146
EKS-SAH-00141
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0009898; C:internal side of plasma membrane
GO:0005764; C:lysosome
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0030154; P:cell differentiation
GO:0000165; P:MAPK cascade
GO:0043066; P:negative regulation of apoptotic process
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0045879; P:negative regulation of smoothened signaling pathway
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597; P:positive regulation of cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518; P:positive regulation of phospholipase activity
GO:0031398; P:positive regulation of protein ubiquitination
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777; P:protein autophosphorylation
GO:0048678; P:response to axon injury
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013