EKS-TAG-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	366.0	9.6E-110	6	270	265

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011251

UniProt Accession

H0ZKX8;

Protein Name

Protein Synonyms/Alias

Gene Name

TNIK

Gene Synonyms/Alias

TNIK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010875	ENSTGUP00000011251	ENSTGUT00000011372

Organism

Taeniopygia guttata

Functional Description

Protein Length

1345

Protein Sequence
(FASTA)

DPAGIFELVE LVGNGTYGQV YKGRHVKTGQ LAAIKVMDVT GDEEEEIKQE INMLKKYSHH 60

RNIATYYGAF IKKNPPGMDD QLWLVMEFCG AGSVTDLIKN TKGNTLKEEW IAYICREILR 120

GLSHLHQHKV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD RTVGRRNTFI GTPYWMAPEV 180

IACDENPDAT YDFKSDLWSL GITAIEMAEG APPLCDMHPM RALFLIPRNP APRLKSKKWS 240

KKFQSFIESC LVKNHSQRPT TEQLMKHPFI RDQPNERQVR IQLKDHIDRT KKKRGEKDET 300

EYEYSGSEEE EEENDSGEPS SILNLPGEST LRRDFLRLQL ANKERSEALR RQQLEQQQRE 360

NEEHKRQLLA ERQKRIEEQK EQRRRLEEQQ RREKELRKQQ EREQRRHYEE QMRREEERRR 420

AEHEQEYIRR QLEEEQRQLE ILQQQLLQEQ ALLLEYKRKQ LEEQRQAERL QRQLQQERDY 480

LVSLQQQQQQ QRQDQRPAEK KPLYHYKEGI NASEKPAWAK EVEERSRLNR QSSPAMPHKV 540

ANRISDPNLP PRSESFSISG VQPARTPPLL RPVDPQIPHL VTVKSQGSSL SGSQSLHEQP 600

AKGLAGFQEA LTVTSHRTEM PRQNSDPTSE NPPLPPRIEK FDRSSWLRQE EDIPPKVPQR 660

TTSISPALAR KNSPGNGSAL GPRLGSQPIR ASNPDLRRTE TIVESPLQRT SSGSSSSSST 720

PSSQPSSQGG SQPGSQAGSS ERNRVRGNTK PEGSPVLSHE PAKVKQEDNR DVTRPSRPAS 780

YKKAIDEDLT ALAKELRELR IEETNRPLKK VTDYSSSSEE SESSEEEEED GENETHDGTV 840

PVSDIPRLIP TGIPGSNEPY NLGMVTTHGL ETSHADTFSN ISREGTLMVR ETSGEKKRSG 900

HAASNGFAGH INLPDLVQQS HSPAGTPTEA LGRVSTHAQD MDSVPEYGMG SSTKASFTPF 960

VDTRVYQTSP TDEDEDEDEE SSANPLFTSE LLRQEQAKLN EARKISVVNV NPTNIRPHSD 1020

TPEIRKYKKR FNSEILCAAL WGVNLLVGTE NGLMLLDRSG QGKVYNLINR RRFQQMDVLE 1080

GLNVLVTISG KKNKLRVYYL SWLRNRILHN DPEVEKKQGW ITVGDLEGCI HYKVVKYERI 1140

KFLVIALKNA VEIYAWAPKP YHKFMAFKSF ADLQHKPLLV DLTVEEGQRL KVIFGSHTGF 1200

HVIDVDSGNS YDIYIPSHIQ GNITPHAIVI LPKTDGMEML VCYEDEGVYV NTYGRITKDV 1260

VLQWGEMPTS VAYIHSNQIM GWGEKAIEIR SVETGHLDGV FMHKRAQRLK FLCERNDKVF 1320

FASVRSGGSS QVFFMTLNRN SMMNW 1345

Nucleotide Sequence
(FASTA)

GATCCTGCAG GAATCTTTGA ATTGGTAGAG CTCGTTGGCA ATGGTACCTA CGGGCAGGTC 60

TATAAGGGTC GTCATGTTAA AACAGGCCAG CTTGCTGCTA TTAAGGTTAT GGACGTCACC 120

GGGGATGAAG AGGAAGAGAT CAAACAAGAA ATTAACATGC TAAAAAAGTA TTCTCATCAC 180

CGAAATATTG CTACATACTA TGGTGCTTTT ATTAAAAAGA ACCCACCAGG AATGGATGAT 240

CAGCTCTGGC TGGTGATGGA GTTCTGCGGC GCGGGCTCCG TCACTGACCT CATCAAGAAC 300

ACGAAGGGGA ACACCTTGAA GGAGGAGTGG ATTGCCTACA TCTGCAGAGA GATTTTGCGG 360

GGCTTGAGTC ATCTACACCA GCACAAAGTA ATTCATCGGG ACATCAAGGG ACAGAACGTA 420

TTGCTGACAG AAAATGCAGA AGTGAAACTA GTGGATTTTG GTGTCAGTGC CCAGCTGGAC 480

AGGACGGTGG GCAGGAGGAA CACCTTCATT GGCACGCCTT ACTGGATGGC CCCCGAGGTC 540

ATCGCCTGCG ACGAAAATCC CGATGCCACT TACGACTTCA AGAGTGACTT GTGGTCTCTG 600

GGGATAACAG CCATCGAGAT GGCCGAAGGT GCTCCCCCTC TGTGTGACAT GCATCCCATG 660

AGAGCCCTCT TCCTCATCCC CCGCAACCCG GCCCCGAGGT TGAAATCAAA GAAGTGGTCT 720

AAAAAGTTTC AGTCCTTCAT TGAGAGCTGC CTAGTGAAGA ACCACAGCCA GAGACCGACC 780

ACGGAGCAGC TGATGAAGCA CCCCTTCATC CGAGACCAGC CCAACGAGAG GCAGGTCCGC 840

ATCCAGCTCA AGGACCACAT CGACAGGACT AAAAAGAAGC GAGGAGAGAA AGATGAGACA 900

GAGTATGAGT ACAGTGGAAG TGAGGAGGAG GAGGAGGAAA ACGACTCTGG AGAGCCGAGC 960

TCCATCCTCA ACCTGCCCGG GGAGTCGACG CTGCGGCGGG ATTTCCTGCG GCTGCAGCTG 1020

GCCAACAAGG AGCGCTCGGA GGCTCTGCGG CGGCAGCAGC TGGAGCAGCA GCAGCGAGAG 1080

AACGAGGAGC ACAAGAGGCA GTTGTTGGCC GAGCGGCAGA AGCGCATCGA GGAGCAGAAG 1140

GAGCAGAGGA GAAGGCTGGA GGAGCAACAG AGGCGGGAGA AGGAGCTGCG GAAGCAGCAG 1200

GAGCGGGAGC AGCGCCGGCA CTACGAGGAG CAGATGCGGC GAGAGGAGGA GCGGCGGCGC 1260

GCAGAGCACG AGCAGGAGTA CATCAGGCGA CAGTTAGAGG AGGAGCAGAG ACAGTTAGAG 1320

ATCCTGCAGC AGCAGTTGTT GCAGGAGCAA GCGCTACTTC TGGAGTACAA GCGCAAGCAG 1380

CTGGAGGAGC AGCGGCAGGC GGAGAGGCTG CAGAGGCAGC TCCAGCAGGA GCGGGACTAC 1440

CTGGTGTCCC TGCAGCAGCA GCAGCAGCAG CAGAGGCAGG ACCAGAGGCC AGCAGAGAAG 1500

AAACCCCTCT ACCACTACAA AGAAGGGATA AATGCCAGCG AGAAGCCAGC GTGGGCCAAG 1560

GAGGTGGAGG AGCGCTCCCG GCTCAATCGC CAGAGCTCGC CGGCCATGCC CCATAAGGTG 1620

GCCAACAGGA TCTCTGACCC CAACCTGCCT CCTCGCTCCG AGTCCTTCAG CATCAGCGGC 1680

GTGCAGCCAG CCCGGACCCC ACCCCTGCTC CGGCCCGTGG ACCCGCAGAT TCCACATCTG 1740

GTCACTGTGA AATCCCAAGG AAGCTCCTTG TCTGGGTCTC AGTCACTGCA TGAACAGCCT 1800

GCAAAGGGAC TGGCTGGGTT TCAGGAGGCT CTGACGGTGA CCTCTCACCG CACTGAGATG 1860

CCAAGGCAGA ACTCGGACCC CACCTCAGAA AACCCTCCTC TGCCCCCTCG CATTGAAAAG 1920

TTTGACCGAA GTTCTTGGTT ACGGCAGGAG GAAGACATTC CACCAAAGGT GCCTCAACGA 1980

ACCACTTCCA TATCCCCTGC CCTGGCAAGG AAGAACTCCC CAGGCAATGG CAGCGCCCTG 2040

GGGCCCCGCC TGGGCTCCCA GCCCATTCGG GCAAGCAACC CAGACCTGAG GAGGACAGAG 2100

ACCATCGTGG AGAGCCCCTT GCAGAGGACC AGCAGTGGCA GCTCCTCCAG CTCCAGCACT 2160

CCCAGCTCCC AGCCCAGCTC CCAGGGTGGA TCCCAGCCTG GCTCCCAGGC TGGCTCCAGC 2220

GAGCGCAACA GAGTTCGAGG GAACACCAAG CCCGAAGGGT CCCCTGTGCT CTCCCATGAG 2280

CCCGCCAAGG TCAAGCAGGA GGACAACAGG GACGTGACAC GACCGAGCCG ACCCGCTAGC 2340

TATAAGAAAG CTATAGATGA GGATCTGACG GCTTTGGCCA AAGAGTTGAG GGAGCTGCGC 2400

ATCGAGGAGA CCAACCGGCC CCTGAAGAAG GTGACAGACT ATTCCTCCTC CAGCGAGGAG 2460

TCGGAGAGCA GCGAGGAGGA GGAGGAGGAT GGGGAGAACG AGACACATGA TGGGACCGTG 2520

CCTGTCAGTG ACATCCCACG GCTCATACCA ACAGGAATTC CTGGAAGCAA CGAGCCGTAC 2580

AACCTGGGAA TGGTGACAAC CCACGGGCTC GAGACTTCCC ACGCAGATAC GTTTAGCAAT 2640

ATTTCAAGGG AAGGGACTTT AATGGTGAGG GAGACCTCTG GTGAAAAAAA GCGTTCTGGC 2700

CACGCAGCCA GCAATGGCTT TGCAGGTCAC ATCAATCTGC CTGACCTGGT GCAGCAAAGC 2760

CACTCGCCGG CGGGCACGCC GACCGAGGCC CTGGGGCGAG TCTCCACGCA TGCGCAGGAC 2820

ATGGACTCGG TGCCTGAATA TGGTATGGGA AGTAGCACCA AAGCCTCTTT CACTCCCTTT 2880

GTGGACACCA GAGTGTATCA GACCTCGCCT ACTGATGAAG ATGAAGATGA GGATGAAGAG 2940

TCATCTGCTA ATCCCCTGTT CACCAGCGAG CTGCTCAGGC AGGAGCAGGC CAAGCTGAAC 3000

GAGGCGCGCA AGATCTCGGT GGTGAACGTG AACCCCACCA ACATCCGTCC CCACAGCGAC 3060

ACCCCGGAGA TCCGCAAGTA CAAGAAGCGC TTCAACTCGG AGATCCTCTG TGCTGCTCTG 3120

TGGGGTGTGA ATCTGCTGGT GGGCACGGAG AACGGCCTGA TGCTGCTGGA TCGGAGTGGG 3180

CAGGGCAAGG TCTACAACCT CATCAACAGG CGGCGGTTCC AGCAGATGGA CGTCCTCGAG 3240

GGCCTCAACG TCCTCGTGAC AATATCAGGA AAGAAGAACA AGCTGCGTGT GTACTACCTG 3300

TCCTGGCTGA GAAACAGGAT TTTACACAAT GACCCTGAGG TGGAGAAGAA GCAGGGCTGG 3360

ATCACAGTTG GGGACCTGGA GGGATGCATC CACTACAAAG TTGTGAAATA TGAAAGAATC 3420

AAGTTCTTGG TGATTGCCTT AAAGAACGCT GTAGAGATCT ACGCTTGGGC TCCTAAACCA 3480

TATCACAAGT TTATGGCATT TAAGTCTTTT GCAGATCTCC AGCACAAGCC GTTGCTCGTG 3540

GATCTGACTG TAGAAGAAGG TCAAAGGCTG AAGGTTATCT TTGGATCCCA CACTGGTTTC 3600

CATGTGATTG ATGTAGATTC TGGGAACTCC TATGATATCT ATATACCATC TCACATTCAG 3660

GGCAATATCA CTCCCCACGC CATTGTCATC CTGCCCAAGA CGGACGGGAT GGAGATGTTG 3720

GTGTGCTATG AGGACGAGGG GGTCTATGTG AACACCTACG GACGGATAAC TAAAGACGTG 3780

GTGCTCCAGT GGGGAGAAAT GCCTACTTCC GTGGCCTACA TTCATTCCAA TCAAATAATG 3840

GGCTGGGGAG AGAAAGCGAT TGAAATCCGG TCAGTGGAGA CAGGACATTT GGATGGAGTA 3900

TTTATGCACA AGAGAGCTCA AAGGTTGAAG TTTCTATGTG AAAGAAATGA TAAGGTATTT 3960

TTTGCATCGG TGAGATCCGG AGGAAGCAGC CAAGTGTTTT TCATGACCCT CAACAGAAAC 4020

TCCATGATGA ACTGGTAA 4038

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni

Q: 6     FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  64

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++

Q: 65    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  124

         ************************************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 125   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  184

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f

Q: 185   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  243

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++f+e+cl kn ++Rp++++l+kh+F+

Q: 244   QSFIESCLVKNHSQRPTTEQLMKHPFI  270

         **************************7

Domain Sequence
(FASTA)

FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120

HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240

FIESCLVKNH SQRPTTEQLM KHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0007256	; P:activation of JNKK activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013