EKS-TAG-00201

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00201

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	441.7	8.2E-133	259	527	269

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011303

UniProt Accession

H0ZL30;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000010959	ENSTGUP00000011303	ENSTGUT00000011425

Organism

Taeniopygia guttata

Functional Description

Protein Length

601

Protein Sequence
(FASTA)

MPTQRDGGAG STMSAPGGLG SSLGGDGAHQ VRVKAYYKGD IMITYFEPSI SFEGLCSEVR 60

DMCSFDNEQL FTMKWIDEEG DPCTVSSQLE LEEAFRLYEL NKDSELLIHV FPCVPERPGM 120

PCPGEDKSIY RRGARRWRKL YCANGHTFQA KRFNRRAHCA ICTDRIWGLG RQGYKCINCK 180

LLVHKKCHKL VNTECGRHAL QPEPIMPMDP TSVHSDNVET VIPYNPSSHE SLDHVGEEKE 240

AMSIRESGKA SSSLGLQDFD LLRVIGRGSY AKVLLVRLKK TERIYAMKVV KKELVNDDED 300

IDWVQTEKHV FEQASNHPFL VGLHSCFQTE SRLFFVIEYV NGGDLMFHMQ RQRKLPEEHA 360

RFYSAEISLA LNYLHERGII YRDLKLDNVL LDSEGHIKLT DYGMCKEGLR PGDTTSTFCG 420

TPNYIAPEIL RGEDYGFSVD WWALGVLMFE MMAGRSPFDI VGSSDNPDQN TEDYLFQVIL 480

EKQIRIPRSL SVKAAGVLKS FLNKDPKERL GCHPQTGFAD IQGHPFFRNV DWDLMEQKQV 540

VPPFKPNISG EFGLDNFDSQ FTNEPVQLTP DDDDIVKKID QSEFEGFEYI NPLLMSAEEC 600

V 601

Nucleotide Sequence
(FASTA)

ATGCCGACGC AGCGGGACGG CGGCGCCGGG AGCACCATGT CGGCTCCGGG CGGCCTCGGG 60

AGCAGCCTCG GCGGGGACGG CGCCCACCAG GTCCGGGTGA AAGCCTACTA CAAGGGGGAC 120

ATCATGATAA CCTATTTTGA GCCTTCCATC TCCTTTGAGG GACTGTGCAG TGAAGTTCGA 180

GACATGTGCT CCTTTGACAA CGAGCAGCTT TTCACCATGA AATGGATTGA TGAGGAAGGA 240

GATCCATGTA CTGTTTCCTC TCAGCTGGAG TTAGAAGAGG CCTTTCGGTT GTATGAACTA 300

AACAAGGATT CAGAGCTTCT GATCCATGTA TTTCCTTGTG TCCCAGAGCG GCCTGGCATG 360

CCCTGTCCAG GAGAAGATAA GTCCATTTAT CGCCGAGGCG CCCGCCGGTG GCGAAAGCTC 420

TATTGTGCAA ATGGTCACAC TTTCCAAGCC AAACGATTTA ACAGGAGAGC TCACTGTGCC 480

ATCTGCACTG ACCGGATTTG GGGCCTGGGG CGCCAGGGCT ACAAATGCAT CAACTGCAAA 540

CTCCTCGTTC ACAAGAAGTG TCACAAACTC GTCAACACTG AGTGTGGCCG ACACGCTCTA 600

CAGCCAGAGC CAATAATGCC TATGGATCCA ACATCAGTGC ATTCTGATAA TGTAGAAACA 660

GTGATACCAT ACAATCCCTC AAGTCATGAG AGCCTGGACC ATGTTGGTGA AGAAAAAGAG 720

GCAATGAGCA TTAGGGAAAG TGGCAAAGCT TCCTCCAGTC TGGGCCTGCA GGATTTTGAT 780

TTGCTCCGGG TGATTGGAAG GGGCAGCTAT GCCAAAGTGC TGCTGGTTCG ACTGAAGAAA 840

ACCGAGCGCA TTTATGCCAT GAAGGTGGTG AAGAAAGAGC TCGTCAACGA TGATGAGGAT 900

ATTGATTGGG TTCAGACAGA GAAACACGTC TTTGAACAGG CCTCAAATCA TCCCTTTCTG 960

GTCGGACTGC ACTCTTGCTT CCAGACAGAA AGCAGGTTGT TCTTTGTTAT AGAGTATGTC 1020

AATGGAGGAG ATCTGATGTT CCACATGCAG AGGCAGAGGA AGCTGCCAGA GGAACATGCC 1080

AGGTTTTATT CTGCTGAAAT CAGTCTAGCA CTGAACTATT TACATGAGCG AGGGATAATC 1140

TACAGGGATT TAAAACTGGA TAATGTGCTT CTAGATTCTG AAGGGCATAT TAAACTCACA 1200

GATTATGGCA TGTGCAAGGA GGGTCTGAGG CCTGGTGACA CAACCAGCAC ATTCTGTGGG 1260

ACTCCAAACT ATATTGCACC TGAAATTCTC CGGGGAGAGG ATTATGGCTT CAGCGTGGAC 1320

TGGTGGGCCC TTGGTGTGCT GATGTTTGAG ATGATGGCAG GCCGGTCGCC GTTCGACATT 1380

GTCGGGAGTT CTGACAACCC TGATCAGAAC ACAGAGGATT ATCTCTTCCA AGTAATTTTG 1440

GAAAAACAGA TCCGAATTCC CCGATCCCTC TCGGTGAAAG CAGCAGGTGT TCTAAAGAGT 1500

TTCCTTAACA AGGATCCAAA GGAACGCTTG GGCTGCCATC CTCAGACAGG ATTTGCAGAT 1560

ATCCAGGGAC ATCCCTTCTT CCGTAACGTT GATTGGGATC TGATGGAGCA AAAGCAAGTG 1620

GTGCCTCCAT TTAAACCAAA TATATCTGGA GAATTTGGTC TGGATAACTT TGATTCCCAA 1680

TTCACCAATG AACCTGTGCA GCTCACTCCA GATGATGATG ATATTGTGAA GAAGATTGAC 1740

CAGTCTGAAT TTGAAGGCTT TGAATACATA AATCCTCTTT TGATGTCAGC TGAGGAATGT 1800

GTC 1803

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 259   FDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  318

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 319   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  378

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 379   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  438

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+ +l

Q: 439   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAAGVL  498

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         k++l+kdp++rlG++ ++g +di+ h+ff

Q: 499   KSFLNKDPKERLGCHpQTGFADIQGHPFF  527

         **************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAAGVL 240

KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0043220	; C:Schmidt-Lanterman incisure
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0007015	; P:actin filament organization
GO:0045216	; P:cell-cell junction organization
GO:0035089	; P:establishment of apical/basal cell polarity
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0046326	; P:positive regulation of glucose import
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013