EKS-TAG-00441

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00441

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	441.8	5.9E-133	248	498	251

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011433

UniProt Accession

H0ZLG0;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011056	ENSTGUP00000011433	ENSTGUT00000011557

Organism

Taeniopygia guttata

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGCIKSKRKE NLHGDGLDLK NQPVRKTERT IYVRDPTSNK QQRPGNPEAQ LLPGQRFVNQ 60

DAEEQGVIVV ALYPYDGIHE EDLSFKKGEK LKVIEESGEW WRAKSLTTRK EGFIPSNYVA 120

KVNTLETEEW FFKDITRKDA ERQLLAPGNG PGAFLIRESE TLKGNYSLSI RDYDPEHGDV 180

IKHYKIRSLD NGGFYISPRI TFPNINDMIK HYQKQSDGLC RKLEKACISP KPQKPWDKDA 240

WEIPRESIKL VKKLGAGQFG EVWMGYYHNS TKVAVKTLKP GTMSVQAFLE EANLMKTLQH 300

DKLVRLYAVV TKEEPIYIIT EFMAKGSLLD FLKSDEGSKL LLPKLIDFSA QIAEGMAYIE 360

RKNYIHRDLR AANVLVSDLL MCKIADFGLA RVIEDNEYTA REGAKFPIKW TAPEAINYGS 420

FTIKSDVWSF GILLYEIVTY GKIPYPGMSN SDVMVALQRG YRMPRMETCP AELYDIMKTC 480

WKDKAEERPT FDYLQSVLDD FYTATEGQYQ QQP 513

Nucleotide Sequence
(FASTA)

ATGGGGTGTA TAAAATCAAA AAGGAAAGAG AATCTGCATG GAGATGGGCT AGATTTGAAG 60

AATCAACCAG TACGTAAAAC TGAACGAACT ATTTATGTGA GGGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGGAAATCC AGAAGCACAG CTCTTACCAG GACAGAGGTT TGTCAATCAA 180

GATGCAGAGG AGCAGGGAGT CATTGTGGTA GCTTTGTATC CCTATGATGG CATTCATGAA 240

GAGGACTTGT CCTTCAAAAA AGGAGAAAAA CTGAAAGTTA TTGAAGAATC TGGAGAATGG 300

TGGAGAGCAA AATCTCTCAC AACGAGAAAA GAAGGTTTCA TTCCCAGCAA CTATGTAGCA 360

AAAGTAAACA CCCTGGAAAC AGAAGAATGG TTCTTCAAAG ACATAACCCG AAAAGATGCT 420

GAAAGACAAC TCCTGGCTCC TGGAAATGGT CCTGGAGCTT TCCTTATCAG AGAAAGTGAA 480

ACGTTAAAAG GTAACTATTC TCTCTCCATA CGAGACTATG ATCCGGAGCA TGGCGATGTT 540

ATTAAGCACT ACAAAATCAG GAGTCTAGAC AATGGAGGAT TTTACATCTC TCCAAGAATA 600

ACTTTTCCTA ACATCAATGA TATGATCAAA CATTATCAAA AGCAATCAGA TGGCTTATGC 660

AGAAAGTTGG AAAAAGCTTG TATTAGTCCC AAACCTCAAA AACCATGGGA TAAAGATGCA 720

TGGGAAATTC CACGGGAATC AATTAAGTTA GTGAAGAAAC TTGGAGCTGG TCAGTTTGGA 780

GAAGTCTGGA TGGGTTATTA TCATAACAGC ACCAAAGTGG CTGTGAAGAC TCTGAAGCCT 840

GGAACAATGT CTGTGCAAGC CTTCCTGGAG GAAGCCAACC TCATGAAAAC ACTTCAGCAT 900

GATAAGCTTG TTAGGCTTTA TGCTGTAGTG ACCAAAGAAG AGCCTATTTA TATTATAACA 960

GAATTCATGG CAAAAGGAAG TTTGCTGGAT TTTCTGAAGA GTGATGAAGG AAGTAAATTG 1020

TTGCTTCCAA AGCTAATTGA CTTTTCTGCT CAGATTGCAG AAGGGATGGC ATACATAGAG 1080

AGAAAAAATT ATATCCATCG AGATTTGAGA GCAGCAAATG TTCTGGTTTC AGACTTACTG 1140

ATGTGCAAAA TTGCTGATTT TGGACTAGCA AGAGTGATCG AAGACAATGA ATACACAGCA 1200

AGGGAAGGTG CAAAATTCCC TATTAAATGG ACGGCACCAG AGGCAATTAA CTATGGATCT 1260

TTCACTATTA AATCTGATGT GTGGTCATTT GGAATTCTCC TGTATGAAAT TGTTACATAT 1320

GGGAAGATTC CTTATCCAGG TATGAGCAAT TCAGATGTGA TGGTTGCTCT TCAGCGTGGG 1380

TACCGAATGC CACGCATGGA AACCTGCCCA GCTGAGCTTT ATGATATCAT GAAAACGTGC 1440

TGGAAAGACA AAGCAGAAGA GAGGCCAACC TTTGATTATC TACAAAGTGT GCTTGATGAC 1500

TTCTACACAG CAACAGAAGG GCAGTATCAA CAACAGCCAT AG 1542

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvkklG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 248   IKLVKKLGAGQFGEVWMGYYHNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  307

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg+kl lpkl+d++aq+aeGmay+e+kn+ihr

Q: 308   AVVTKEEPIYIITEFMAKGSLLDFLKSDEGSKLLLPKLIDFSAQIAEGMAYIERKNYIHR  367

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv++ l++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 368   DLRAANVLVSDLLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  427

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypGm+n++v+ +++rgyr+pr+e+cp+ely+++++cwk ++ee

Q: 428   WSFGILLYEIVTYGKIPYPGMSNSDVMVALQRGYRMPRMETCPAELYDIMKTCWKDKAEE  487

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 488   RPTFDYLQSVL  498

         ********986

Domain Sequence
(FASTA)

IKLVKKLGAG QFGEVWMGYY HNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTKEEPIY IITEFMAKGS LLDFLKSDEG SKLLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS DLLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180

WSFGILLYEI VTYGKIPYPG MSNSDVMVAL QRGYRMPRME TCPAELYDIM KTCWKDKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0001782	; P:B cell homeostasis
GO:0050853	; P:B cell receptor signaling pathway
GO:0071300	; P:cellular response to retinoic acid
GO:0002774	; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431	; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556	; P:intracellular signal transduction
GO:0030889	; P:negative regulation of B cell proliferation
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0070667	; P:negative regulation of mast cell proliferation
GO:0002762	; P:negative regulation of myeloid leukocyte differentiation
GO:0034136	; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144	; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0002576	; P:platelet degranulation
GO:0030335	; P:positive regulation of cell migration
GO:2000670	; P:positive regulation of dendritic cell apoptotic process
GO:0070668	; P:positive regulation of mast cell proliferation
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304	; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531	; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902	; P:regulation of B cell apoptotic process
GO:0050855	; P:regulation of B cell receptor signaling pathway
GO:0033628	; P:regulation of cell adhesion mediated by integrin
GO:0050707	; P:regulation of cytokine secretion
GO:0045646	; P:regulation of erythrocyte differentiation
GO:0050727	; P:regulation of inflammatory response
GO:0043304	; P:regulation of mast cell degranulation
GO:0090025	; P:regulation of monocyte chemotaxis
GO:0090330	; P:regulation of platelet aggregation
GO:0006974	; P:response to DNA damage stimulus
GO:0009725	; P:response to hormone stimulus
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013