EKS-TAG-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	334.3	3.7E-100	44	295	252

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011407

UniProt Accession

H0ZLD4;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011069	ENSTGUP00000011407	ENSTGUT00000011531

Organism

Taeniopygia guttata

Functional Description

Protein Length

650

Protein Sequence
(FASTA)

GGGGEAAAAM EEPVRVAPSP EVTAARKQQG VKRHHHKHNL KHRYELQETL GKGTYGKVKR 60

AIERFSGRVV AIKSIRKDKI KDEQDMVHIR REIEIMSSLS HPHIITIYEV FENKDKIVII 120

MEYASKGELY DYISERRRLS ERETRHFFRQ IVSAVHYCHK NGVVHRDLKL ENILLDDNFN 180

IKIADFGLSN LYHKDKFLQT FCGSPLYASP EIVNGRPYRG PEVDSWALGV LLYTLVYGTM 240

PFDGFDHKNL IRQISSGEYR EPTQTSDARG LIRWMLMVNP ERRATIEDIA NHWWVNWGYK 300

SSVCDCDAMR DSESPLLARF IDWHHRSTGL QPETDTKIKC LSKPKGPEVT LERQRSLKKS 360

KKENDIAQSI QEGGAENTTK PTSKRPKGIL KKRSNSEHRS HSAGFIEGVV SPVLPSAFKM 420

EQELCRTGVA IKSVVEGEVA GKYGTKQSSL MPKKGILKKT QQRESGYYSS PERSESSELL 480

DNNDETVNSD TSPGVTEPSR NGSYSHSCRR KGILKHNGKY STNSTEPALI SPDTPTLEAM 540

EEMVLPGDAL PRSYSRPSSV ISDDSILSSD SFDLLDLQEN RPNRQRIRSC VSAENFLQIQ 600

DFEGLQNRPR PQYLKRYRNR LGDSSFSLLT DMDDVTQVYK KALEICNKLN 650

Nucleotide Sequence
(FASTA)

GGCGGCGGCG GCGAGGCGGC GGCGGCCATG GAAGAGCCGG TCCGGGTGGC TCCGTCCCCG 60

GAGGTAACGG CGGCTCGGAA GCAGCAGGGG GTGAAACGGC ATCACCACAA GCACAACCTG 120

AAGCATCGCT ACGAGCTGCA GGAGACCTTG GGCAAAGGCA CCTATGGCAA AGTCAAGCGG 180

GCCATCGAGA GGTTCTCTGG CAGAGTGGTT GCAATAAAAT CCATTCGTAA GGACAAAATT 240

AAGGATGAAC AAGATATGGT TCACATCAGA CGGGAGATTG AGATCATGTC ATCCCTCAGC 300

CACCCTCATA TCATCACCAT ATATGAAGTG TTTGAAAATA AAGATAAGAT TGTTATCATC 360

ATGGAGTATG CAAGTAAAGG AGAGTTGTAC GATTACATTA GTGAGAGGCG GCGATTAAGC 420

GAAAGAGAGA CAAGACACTT CTTCCGACAA ATAGTCTCTG CTGTGCATTA CTGCCACAAG 480

AATGGTGTTG TCCACAGGGA CCTAAAATTG GAAAACATTC TTCTTGATGA CAATTTTAAT 540

ATTAAGATTG CTGATTTTGG ACTCTCCAAC CTTTATCATA AAGACAAGTT TCTGCAGACA 600

TTTTGTGGAA GCCCACTGTA TGCTTCTCCT GAAATAGTTA ATGGACGGCC TTACAGAGGC 660

CCAGAGGTTG ACAGCTGGGC CCTCGGTGTA TTGCTTTACA CTCTGGTTTA TGGAACAATG 720

CCCTTTGATG GCTTCGATCA CAAAAATCTT ATCAGGCAGA TCAGCAGTGG AGAATATCGT 780

GAGCCAACAC AGACCTCAGA TGCTCGTGGT CTTATCAGGT GGATGCTGAT GGTGAACCCT 840

GAACGCCGAG CAACCATTGA AGACATTGCC AACCACTGGT GGGTTAACTG GGGCTACAAG 900

AGCAGTGTTT GTGACTGTGA TGCCATGCGG GACTCCGAGT CCCCACTTCT GGCAAGGTTC 960

ATTGATTGGC ATCACCGTTC TACTGGCCTC CAACCAGAGA CTGATACCAA AATCAAGTGC 1020

CTTTCTAAGC CCAAAGGTCC TGAAGTCACA CTAGAGAGAC AAAGGTCTCT GAAAAAATCA 1080

AAAAAGGAAA ATGACATTGC ACAGTCCATC CAGGAAGGGG GAGCTGAAAA TACAACCAAA 1140

CCAACCTCCA AGAGACCCAA AGGCATCCTG AAGAAAAGGA GTAACAGTGA ACATCGCTCT 1200

CACAGTGCAG GTTTCATTGA AGGAGTTGTC AGCCCAGTGT TACCATCTGC TTTTAAGATG 1260

GAGCAAGAGT TGTGTAGGAC TGGTGTGGCC ATTAAAAGTG TTGTAGAGGG AGAGGTAGCT 1320

GGCAAATATG GCACTAAGCA GTCTTCACTA ATGCCAAAAA AAGGAATCTT AAAGAAGACT 1380

CAGCAGAGGG AGTCTGGCTA CTATTCCTCT CCAGAAAGAA GTGAATCTTC TGAACTCTTG 1440

GACAATAATG ATGAAACAGT AAACAGTGAC ACTTCGCCAG GGGTCACAGA GCCATCCAGA 1500

AATGGGTCTT ACAGCCATTC CTGCAGGCGT AAGGGCATCT TGAAACACAA CGGCAAGTAT 1560

TCCACCAACA GCACTGAACC TGCTTTGATT AGCCCTGACA CACCAACGCT GGAGGCCATG 1620

GAAGAAATGG TCTTGCCTGG GGACGCATTA CCTCGAAGTT ACAGTCGCCC TTCCAGCGTA 1680

ATTAGTGATG ACAGTATTTT GTCCAGTGAC TCATTTGATT TGCTGGATTT GCAAGAAAAC 1740

AGGCCAAACA GGCAGAGAAT ACGGAGCTGT GTGTCTGCTG AAAATTTTCT CCAGATCCAA 1800

GACTTTGAAG GACTTCAGAA CCGCCCACGG CCACAGTATC TAAAGCGTTA CCGCAACCGT 1860

CTGGGGGACA GCAGTTTTTC TCTTCTCACA GACATGGATG ATGTGACTCA GGTCTACAAG 1920

AAAGCCCTAG AGATCTGCAA CAAGCTCAAC 1950

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 44    YELQETLGKGTYGKVKRAIERFSGRVVAIKSIRKDKIkDEQDMVHIRREIEIMSSLSHPH  103

         99**********************************95667788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 104   IITIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  163

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 164   VHRDLKLENILLDDNFNIKIADFGLSNLYHKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  223

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++ +++++ L+r +L+v+pe+

Q: 224   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-TSDARGLIRWMLMVNPER  282

         ****************************************9.6689**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 283   RATIEDIANHWWV  295

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRAIE RFSGRVVAIK SIRKDKIKDE QDMVHIRREI EIMSSLSHPH 60

IITIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNFNIKI ADFGLSNLYH KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QTSDARGLIR WMLMVNPERR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013