EKS-TAG-00176
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00176
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR556.19.7E-168500776277
StatusUnreviewed
Ensembl ProteinENSTGUP00000011617
UniProt AccessionH0ZLZ4;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000011228ENSTGUP00000011617ENSTGUT00000011743
OrganismTaeniopygia guttata
Functional Description
Protein Length840
Protein Sequence
(FASTA)
MGLKSTWRYG NGPGIYSKKM VRWDSGCLIC LVVVTMAGLS LARPSFNLVV EDTTVEPEEP 60
PTKYQISQPD VYSALPGETL ELRCQLRDAV MISWTKDGLP LGPDNRTVII GEYLQIKDAT 120
ARDSGLYACT AVRTLDSDTL YFIVNVTDAL SSGDDEDDND GSEDFVNDSN QMRAPYWTHT 180
DKMEKRLHAV PAANTVKFRC PAMGNPTPTM RWLKNGKEFK QEHRIGGYKV RNQHWSLIME 240
SVVPSDKGNY TCIVENQYGS INHTYHLDVV ERSPHRPILQ AGLPANASAV VGGDVEFVCK 300
VYSDAQPHIQ WIKHVEKNGS KYGPDGLPYL QVLKAAGVNT TDKEIEVLYI RNVTFEDAGE 360
YTCLAGNSIG ISFHTAWLTV LPAPEKEKEY PTSPDYVEIA IYCIGVFLIA CMVLTVILCR 420
MKNTTKKPDF SSQPAVHKLT KRIPLRRQVS ADSSSSMNSN TPLVRITTRL SSAADAPMLA 480
GVSEYELPED PKWEFPRDKL TLGKPLGEGC FGQVVMAEAV GIDKDRPKEA VTVAVKMLKD 540
DATEKDLSDL VSEMEMMKMI GKHKNIINLL GACTQDGPLY VIVEYASKGN LREYLRARRP 600
PGMEYSFDIN RVPEEQMTFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK 660
IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG 720
SPYPGIPVEE LFKLLKEGHR MDKPANCTNE LYMMMRDCWH AVPSHRPTFK QLVEDLDRIL 780
TLTTNEEYLD LSGPLEQYSP SYPDTRSSCS SGDDSVFSPD PMPYEPCLPK YQHMNGSVKT 840
Nucleotide Sequence
(FASTA)
ATGGGATTAA AGTCCACATG GAGATATGGA AATGGACCAG GAATTTACTC TAAAAAGATG 60
GTCCGCTGGG ATTCGGGTTG CCTTATCTGC CTGGTGGTGG TCACCATGGC TGGACTTTCC 120
CTGGCTCGAC CTTCATTTAA TTTAGTTGTT GAAGACACCA CGGTGGAACC TGAAGAGCCA 180
CCAACCAAAT ACCAAATCTC TCAGCCAGAT GTTTACTCAG CACTTCCAGG AGAGACGCTT 240
GAGTTGCGCT GTCAATTGAG AGACGCCGTC ATGATCAGTT GGACTAAGGA TGGGCTCCCT 300
TTGGGGCCTG ACAATAGGAC AGTGATTATT GGGGAGTACT TACAAATTAA GGATGCCACA 360
GCCAGAGATT CGGGCCTCTA TGCTTGCACT GCTGTTAGGA CCCTAGACAG TGATACTCTG 420
TACTTCATTG TAAATGTTAC AGATGCTCTT TCCTCTGGGG ATGATGAAGA TGACAATGAT 480
GGGTCCGAGG ACTTTGTGAA TGACAGCAAC CAGATGAGGG CGCCTTACTG GACACACACG 540
GACAAAATGG AGAAGAGGCT CCACGCCGTG CCGGCCGCCA ACACCGTCAA GTTCCGCTGC 600
CCGGCCATGG GAAACCCAAC GCCCACCATG CGCTGGCTGA AAAACGGGAA GGAGTTCAAG 660
CAGGAGCATC GCATTGGCGG CTACAAGGTC CGTAACCAGC ACTGGAGCCT CATCATGGAG 720
AGTGTGGTGC CGTCGGACAA GGGGAACTAC ACCTGCATAG TGGAGAACCA GTACGGGTCC 780
ATCAACCACA CCTACCACCT CGACGTGGTT GAGCGCTCCC CGCACCGGCC CATCCTGCAG 840
GCGGGGCTCC CCGCCAACGC CTCCGCCGTG GTCGGGGGGG ACGTGGAGTT TGTCTGCAAG 900
GTCTACAGCG ATGCCCAGCC CCACATCCAG TGGATAAAGC ACGTGGAGAA GAACGGCAGT 960
AAATACGGGC CAGATGGGCT GCCTTATCTC CAGGTTTTAA AGGCTGCCGG TGTTAACACC 1020
ACGGACAAAG AAATTGAGGT TCTCTATATA CGGAATGTAA CTTTTGAGGA TGCTGGGGAG 1080
TATACATGCT TGGCGGGTAA TTCTATTGGG ATATCCTTTC ACACTGCATG GTTGACAGTT 1140
CTGCCAGCTC CTGAGAAAGA AAAGGAATAC CCAACCTCTC CAGACTACGT GGAAATAGCA 1200
ATTTACTGCA TAGGGGTGTT CCTGATAGCC TGCATGGTGC TGACAGTGAT CCTGTGCCGC 1260
ATGAAGAACA CCACCAAGAA GCCGGATTTC AGCAGCCAGC CCGCTGTCCA CAAGCTGACC 1320
AAGCGAATCC CCCTGCGCAG ACAGGTGTCG GCCGACTCCA GCTCCTCCAT GAACTCCAAC 1380
ACGCCTCTGG TGAGGATCAC CACCCGCCTC TCCTCCGCCG CTGATGCCCC CATGCTGGCA 1440
GGAGTCTCGG AGTATGAGCT GCCAGAAGAC CCCAAGTGGG AATTCCCAAG AGATAAGCTG 1500
ACGCTGGGCA AACCCCTGGG AGAAGGTTGC TTTGGCCAAG TGGTCATGGC TGAAGCGGTG 1560
GGGATTGACA AAGACAGGCC CAAAGAAGCA GTGACCGTGG CAGTGAAGAT GTTGAAAGAT 1620
GATGCCACAG AAAAAGACCT GTCTGATTTG GTGTCAGAGA TGGAGATGAT GAAGATGATT 1680
GGGAAGCATA AAAATATCAT CAATCTTCTT GGAGCCTGTA CCCAGGACGG CCCTTTGTAT 1740
GTGATAGTGG AATATGCTTC CAAGGGGAAC CTGCGGGAGT ACCTGCGAGC GCGCCGCCCG 1800
CCCGGCATGG AGTACTCCTT CGACATCAAC AGGGTGCCCG AGGAGCAGAT GACATTCAAG 1860
GACCTGGTCT CCTGCACCTA CCAGCTGGCA CGAGGCATGG AGTACCTGGC TTCCCAAAAA 1920
TGCATCCATC GAGACTTGGC TGCAAGAAAT GTTTTGGTAA CGGAGAACAA TGTCATGAAA 1980
ATAGCAGACT TTGGTTTAGC CAGAGACATC AACAATATAG ATTATTATAA AAAGACTACT 2040
AATGGACGGC TTCCAGTAAA GTGGATGGCT CCAGAAGCTC TGTTTGACAG AGTTTACACA 2100
CATCAAAGTG ATGTTTGGTC ATTTGGTGTG TTGATGTGGG AGATCTTCAC CTTAGGAGGG 2160
TCTCCCTACC CAGGAATCCC AGTGGAGGAA CTTTTTAAGC TGCTGAAAGA AGGGCACCGG 2220
ATGGATAAAC CTGCCAACTG CACCAACGAG CTCTATATGA TGATGAGAGA TTGCTGGCAT 2280
GCTGTGCCTT CTCACAGACC CACTTTCAAA CAGTTGGTGG AGGACTTGGA TCGGATTCTC 2340
ACTCTCACAA CTAATGAGGA GTATCTGGAC CTCAGTGGAC CTCTGGAACA GTATTCACCC 2400
AGCTACCCCG ACACGAGGAG CTCGTGTTCC TCGGGGGACG ACTCCGTGTT CTCTCCCGAC 2460
CCGATGCCTT ACGAACCTTG TCTCCCCAAG TACCAGCACA TGAACGGGAG CGTGAAAACA 2520
TGA 2523
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkd++k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 500   LTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  559
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s d ++++eeq+t+
Q: 560   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  619
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 620   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  679
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 680   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  739
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 740   RMDKPANCTNELYMMMRDCWHAVPSHRPTFKQLVEDL  776
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW HAVPSHRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CII-00090
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0045165; P:cell fate commitment
GO:0007267; P:cell-cell signaling
GO:0050673; P:epithelial cell proliferation
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0035265; P:organ growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013