EKS-TAG-00448

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00448

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	349.8	8.0E-105	11	268	258

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011709

UniProt Accession

H0ZM86;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K9

Gene Synonyms/Alias

MAP3K9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011356	ENSTGUP00000011709	ENSTGUT00000011837

Organism

Taeniopygia guttata

Functional Description

Protein Length

967

Protein Sequence
(FASTA)

VLEIDFSELV LEEIIGIGGF GKVYRAVWIG DEVAVKAARY DPDEDISQTI ENVRQEAKLF 60

AMLKHPNIIA LRGVCLKEPN LCLIMEFARG GSLNRVLSGK RIPPDILVNW AVQIARGMNY 120

LHEEAIVPII HRDLKSSNIL ILEKVENGDL SNKMLKITDF GLAREWHKTT KMSAAGTYAW 180

MAPEVIRSSM FSKGSDVWSY GVLLWELLTG EVPFRGIDGL AVAYGVAMNK LALPIPSTCP 240

EPFAKLMEDC WNPDPHSRPS FATILDHLTA IEESGFFEMP KDSFHSLQED WKQEIQEMFD 300

QLRAKEKELR TWEEELSRAA VEQKNHEELL RRREQELAER EIDILERELN IIIHQLCQEK 360

PRVKKRMGKF KRSRLKLKDG NHISLPSDFQ HKFTVQASPT MDKRKSLISS CSSPPASPTI 420

IPRLRAIQLT PAESSKTWGR STVLLKEEGE EEEKRGQKKK GRTWGPSSLC HKELGAGEEG 480

DSEQFIKLQS VNLPCNRCFT VCLKALVEGC KQWSSSAPNL GKIQRTAPAF PGFTSLAEMD 540

DEDSECFNGE GKVHPSPVHN QSYLCIPFQK NEEWDGPSSD ANEESTPVNS ATSTPQLTPT 600

NSLKRSGSHH KRCEIALLGC GAVLAAAGLG FDLLEAGKCQ LLIEEEPEMP KEEKKKRDSI 660

FQRAGRPRRS TSPPSRKIFK KDDPLLLLGE PSTSLTLLSL SSISECNSTR SLLRSDSDEI 720

VVYEMPVSPV TVKAPLPAIT NPLVNVQIER FKQDPNQSLT PTHVTVSSHT QQSGHRRTPS 780

DGAIKGSGLV VNGGCPSSSC LTGALGAGVL KTPSPSRDPS EVPRLPDPNL VFPPTPRRWN 840

AQQDPTLERP KTLEFLPRPR PAASRQRLDP WWFVSPSNAK GESSANSSST DTPSNLDSCF 900

ASSSSTVEER PGLPALLPFQ VGPPAEERTL LDMDAEGQSQ DSTIPLCRSE LNTHKAAAYE 960

LKQEYWS 967

Nucleotide Sequence
(FASTA)

GTCCTAGAGA TCGACTTCTC AGAGCTTGTT CTGGAAGAAA TCATTGGCAT AGGGGGCTTC 60

GGAAAAGTGT ATCGAGCTGT ATGGATAGGA GATGAGGTTG CTGTCAAGGC AGCTCGCTAT 120

GACCCTGATG AGGACATCAG CCAGACCATT GAGAATGTCC GCCAAGAGGC CAAGCTCTTT 180

GCAATGCTAA AACATCCCAA CATCATTGCC CTCAGGGGTG TGTGTTTGAA GGAACCTAAT 240

CTTTGCCTGA TCATGGAGTT TGCCCGCGGA GGATCGCTCA ATAGGGTGTT GTCTGGTAAA 300

AGGATACCTC CTGACATACT GGTGAACTGG GCAGTGCAGA TTGCCAGGGG AATGAACTAC 360

CTGCACGAGG AAGCAATTGT TCCCATAATT CACCGTGACC TCAAGTCCAG CAACATACTG 420

ATACTCGAAA AGGTGGAAAA TGGAGATCTG AGCAACAAGA TGTTGAAGAT CACGGATTTC 480

GGCTTGGCCA GGGAGTGGCA TAAAACTACC AAAATGAGCG CAGCTGGGAC ATATGCCTGG 540

ATGGCTCCTG AGGTCATCCG CTCTTCCATG TTCTCCAAAG GCAGCGATGT TTGGAGTTAT 600

GGTGTGCTGC TTTGGGAACT GCTGACAGGA GAAGTACCAT TCCGAGGAAT TGATGGTCTT 660

GCAGTAGCAT ATGGTGTTGC TATGAATAAG CTTGCCCTTC CAATCCCTTC CACGTGTCCT 720

GAGCCTTTTG CCAAACTCAT GGAAGATTGC TGGAACCCTG ACCCACACTC ACGACCTTCC 780

TTTGCCACTA TCCTAGACCA TCTTACTGCC ATAGAAGAGT CTGGTTTTTT TGAAATGCCC 840

AAAGATTCCT TCCACTCTCT GCAGGAAGAC TGGAAACAAG AGATCCAAGA GATGTTTGAT 900

CAGCTTAGAG CCAAAGAAAA GGAGCTGCGC ACATGGGAAG AAGAGCTGTC TCGTGCTGCT 960

GTTGAACAGA AGAACCATGA GGAGCTGCTA CGAAGGCGGG AACAGGAACT GGCAGAACGT 1020

GAGATTGACA TTCTGGAAAG GGAGCTCAAC ATCATCATCC ACCAGCTGTG TCAGGAGAAG 1080

CCTCGGGTCA AGAAACGCAT GGGGAAGTTC AAGAGGAGCC GGCTCAAGTT AAAGGATGGC 1140

AATCATATCA GTTTGCCTTC AGATTTCCAG CATAAATTCA CTGTGCAGGC TTCTCCAACA 1200

ATGGACAAAA GGAAAAGCTT GATCAGTAGC TGCTCCAGCC CTCCTGCAAG TCCTACCATT 1260

ATTCCCAGAC TCAGGGCCAT ACAGTTGACA CCCGCTGAAA GCAGTAAAAC GTGGGGACGA 1320

AGCACAGTCC TTCTAAAGGA GGAAGGAGAG GAAGAAGAGA AGAGAGGCCA GAAGAAAAAG 1380

GGACGCACTT GGGGACCAAG CTCACTTTGT CACAAGGAGC TAGGTGCAGG AGAAGAGGGA 1440

GATTCAGAAC AGTTTATAAA ATTACAATCA GTTAATTTGC CTTGCAACAG ATGTTTCACT 1500

GTCTGTCTGA AAGCTCTGGT AGAAGGATGC AAGCAGTGGT CATCCAGTGC ACCAAATCTT 1560

GGGAAGATCC AGAGAACTGC ACCTGCTTTT CCAGGATTCA CCAGCTTAGC AGAGATGGAT 1620

GATGAGGACA GCGAATGTTT TAATGGAGAG GGCAAAGTGC ACCCTTCACC TGTGCACAAT 1680

CAGTCATACC TCTGCATCCC ATTTCAGAAG AATGAAGAAT GGGATGGCCC TTCTAGTGAT 1740

GCCAATGAGG AGTCCACCCC TGTAAACTCT GCTACCAGTA CCCCACAGCT GACACCCACC 1800

AACAGCCTCA AACGTAGCGG CTCCCACCAC AAACGATGTG AGATTGCATT GCTTGGCTGT 1860

GGAGCAGTGC TGGCTGCTGC AGGCCTGGGT TTTGATCTTT TAGAAGCAGG GAAGTGTCAG 1920

CTGCTGATTG AGGAAGAGCC AGAGATGCCC AAGGAAGAGA AGAAGAAGCG TGACAGCATT 1980

TTTCAGCGAG CTGGCCGCCC ACGCAGGAGC ACTAGTCCAC CTTCCCGGAA GATCTTCAAG 2040

AAGGATGATC CCCTGTTGTT GCTAGGCGAG CCATCCACAT CCCTCACCCT TCTTTCCCTG 2100

TCTTCTATTT CCGAATGTAA TTCCACCCGG TCCCTGCTGC GCTCGGACAG TGATGAGATT 2160

GTGGTTTATG AGATGCCTGT TAGCCCAGTG ACAGTCAAGG CTCCCTTGCC AGCCATTACA 2220

AACCCCCTGG TCAATGTCCA GATTGAGAGG TTCAAACAAG ACCCCAACCA GTCCCTGACC 2280

CCCACACACG TGACGGTCTC TTCTCACACC CAGCAAAGCG GACACAGGCG CACACCTTCT 2340

GATGGAGCCA TCAAAGGGAG TGGACTGGTT GTCAATGGTG GATGCCCTTC CAGTAGCTGT 2400

TTAACTGGAG CACTGGGAGC AGGTGTGTTA AAAACACCTA GTCCAAGCAG AGATCCCAGT 2460

GAGGTCCCTC GGCTGCCAGA CCCCAACCTT GTTTTTCCTC CAACCCCGAG ACGATGGAAT 2520

GCACAGCAGG ATCCCACACT GGAAAGACCC AAGACACTGG AGTTCCTACC CCGGCCACGT 2580

CCTGCAGCCA GTCGGCAGCG CCTTGATCCC TGGTGGTTTG TGTCACCCAG CAATGCCAAG 2640

GGTGAATCTT CTGCCAACAG TTCAAGTACT GATACTCCAA GCAATCTGGA CTCTTGTTTT 2700

GCTAGTAGCA GCAGCACTGT AGAAGAGAGA CCTGGACTGC CTGCACTGCT TCCTTTCCAG 2760

GTGGGTCCTC CTGCAGAGGA GCGGACACTG TTGGACATGG ATGCTGAGGG GCAGAGCCAG 2820

GACAGCACCA TTCCGCTATG CAGAAGTGAA CTTAACACAC ACAAAGCTGC AGCATATGAA 2880

CTCAAGCAAG AATACTGGTC TTAA 2904

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+a w ++evavK++r +  e  ++++e++++eakl+++l+hpnii+

Q: 11    LEEIIGIGGFGKVYRAVWIGDEVAVKAARYDPDEdiSQTIENVRQEAKLFAMLKHPNIIA  70

         589***************************99998999**********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l+Gvcl+epnl+l+me+++ggsL++vl++   ++i+++ lv+wa+qiArGm+YLh+ea +

Q: 71    LRGVCLKEPNLCLIMEFARGGSLNRVLSG---KRIPPDILVNWAVQIARGMNYLHEEAIV  127

         *****************************...99**************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         +iihrdLks+n+L+       + ++k lki+dFG are++k+tkmsaagt+awmaPEv++

Q: 128   PIIHRDLKSSNILIlekvengDLSNKMLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR  187

         *******************99999************************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++ +s+ sDvwSygv+LWellt+evP+++++ la+ay+va+++l lpips+cpe+++kLm

Q: 188   SSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLM  247

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

         ++cwn dp++Rpsf++i+++l

Q: 248   EDCWNPDPHSRPSFATILDHL  268

         *****************9876

Domain Sequence
(FASTA)

LEEIIGIGGF GKVYRAVWIG DEVAVKAARY DPDEDISQTI ENVRQEAKLF AMLKHPNIIA 60

LRGVCLKEPN LCLIMEFARG GSLNRVLSGK RIPPDILVNW AVQIARGMNY LHEEAIVPII 120

HRDLKSSNIL ILEKVENGDL SNKMLKITDF GLAREWHKTT KMSAAGTYAW MAPEVIRSSM 180

FSKGSDVWSY GVLLWELLTG EVPFRGIDGL AVAYGVAMNK LALPIPSTCP EPFAKLMEDC 240

WNPDPHSRPS FATILDHL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation
GO:0038032	; P:termination of G-protein coupled receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR016231	; MAPKKK9/10/11.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016137	; Regulat_G_prot_signal_superfam.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013