EKS-TAG-00313
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00313
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.61.9E-151692949258
StatusUnreviewed
Ensembl ProteinENSTGUP00000011850
UniProt AccessionH0ZMM7;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000011479ENSTGUP00000011850ENSTGUT00000011979
OrganismTaeniopygia guttata
Functional Description
Protein Length1261
Protein Sequence
(FASTA)
AVCAGTENKL SSLSDLEQQY RALRKYYENC EVVMGNLEIT SIEHNRDLSF LRSIREVTGY 60
VLVALNQFEY LPLENLRIVR GTKLYEERYA LAIFLNYRKD GNFGLRELGL RNLTEILNGG 120
VYVGQNKFLC FADTIHWQDI VRNPWASNFT LVPTNGSSGC GRCHKSCTGR CWGPTENHCQ 180
TLTKTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG ACVTQCPQTF 240
VYNPTTFQLE HNHNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE ENGIKMCKPC 300
TDICPKACDG IGTGSLVSAQ TVDSSNIDKF VNCTKINGNL IFLVTGIHGD PYHTIAAINP 360
EKLNIFQTVR EITGYLNIQS WPENMTDFRV FSNLVTIGGR ALYSGLSLLI LKQQGITSLQ 420
FQSLKQISAG NIYITDNSNL CYYHTVNWSS LFSTPSQKTV IHRNKKAENC TADGMVCNEL 480
CSSDGCWGPG PDQCLSCKRF IRGRTCIDSC NLYDGEFREF ANGSVCVECD PQCEKMEENM 540
ITCYGPGPDH CTKCFHFKDG PNCVEKCPDG LQGANSFIFK YADEDRECHP CHPNCTQGCR 600
GPASHDCIFY PWTRQSTLPQ HARTPLIAAG VIGGLFIIVI MGLTFAVYVR RKSIKKKRAL 660
RRFLETELVE PLTPSGTAPN QAQLRILKET ELKRVKVLGS GAFGTVYKGI WVPEGETVKI 720
PVAIKILNET TGPKANVEFM DEALIMASMD HPHLVRLLGV CLSPTIQLVT QLMPHGCLLD 780
YVHEHKDNIG SQLLLNWCVQ IAKGMMYLEE RRLVHRDLAA RNVLVKSPNH VKITDFGLAR 840
LLEGDEKEYN ADGGKMPIKW MALECIHYRK FTHQSDVWSY GVTIWELMTF GGKPYDGIPT 900
REIPDLLEKG ERLPQPPICT IDVYMVMVKC WMIDADSRPK FKELAAEFSR MARDPQRYLV 960
IQGDDRMKLP SPNDSKFFQN LLDEEDLEDM MDAEEYLVPQ AFNIPPPIYT SRTRIDSNRN 1020
QFVYRDGGYA AEVPMPYRAP GCILPEAPAA QGATAEIFED TCCNGTMQKQ VAALAKEDSS 1080
TQRYSADPTV FMPERVVRGE LDEDGYMTPM RDKPKTDYLN PVEENPFVSR RKNGDLQAVD 1140
NPEYHKAPNG QPKAEDEYVN EPLYLNTFAS TLENAEYLKN NLPEKAKKAF DNPDYWNHSL 1200
PPRSTLQHPD YLQEYSTKYF YKQNGRIRPI VAENPEYLSE FSLKPGTVLP PPPYRHRNTV 1260
V 1261
Nucleotide Sequence
(FASTA)
GCAGTGTGTG CTGGCACTGA GAACAAGCTG AGCTCCCTGT CTGACCTGGA GCAGCAGTAC 60
CGGGCCCTGC GCAAGTATTA TGAGAACTGT GAGGTGGTGA TGGGCAACCT GGAGATCACC 120
AGCATCGAGC ACAACAGAGA CCTCTCCTTC CTGAGGTCTA TCCGAGAAGT GACGGGCTAT 180
GTGCTGGTGG CTTTGAACCA GTTTGAGTAC CTGCCCCTGG AGAACCTGCG CATCGTCCGT 240
GGCACCAAGC TCTACGAGGA GCGCTATGCC CTGGCCATAT TCCTCAACTA CAGGAAGGAT 300
GGCAACTTCG GGCTCAGGGA ACTTGGCTTG AGGAACCTGA CAGAGATACT GAATGGAGGG 360
GTCTATGTTG GCCAGAACAA ATTTCTCTGC TTTGCAGACA CCATTCATTG GCAAGACATC 420
GTGCGTAACC CCTGGGCCTC CAATTTCACT CTGGTTCCAA CCAACGGCAG CTCAGGATGT 480
GGTCGTTGCC ACAAGTCCTG CACAGGACGG TGCTGGGGAC CAACAGAGAA TCACTGCCAG 540
ACCTTGACCA AGACCGTGTG TGCAGAGCAG TGCGACGGAC GCTGCTACGG GCCCTACGTC 600
AGCGACTGCT GCCACCGCGA GTGCGCCGGG GGCTGCTCCG GACCCAAGGA CACCGACTGC 660
TTCGCCTGCA TGAATTTCAA TGACAGTGGT GCCTGTGTCA CACAGTGCCC CCAGACCTTT 720
GTGTACAACC CCACCACCTT CCAGCTGGAG CACAATCACA ACGCCAAGTA CACCTACGGG 780
GCTTTCTGCG TCAAGAAGTG CCCGCACAAC TTTGTGGTAG ATTCCAGCTC TTGTGTCCGG 840
GCATGTCCGA GCTCCAAGAT GGAGGTTGAA GAAAATGGAA TTAAGATGTG CAAGCCCTGC 900
ACTGACATTT GTCCTAAAGC ATGTGATGGC ATTGGGACGG GCAGTTTGGT GTCGGCTCAG 960
ACAGTGGATT CCAGCAACAT TGACAAGTTT GTAAACTGTA CCAAGATCAA TGGCAACCTT 1020
ATCTTCCTTG TCACTGGGAT TCATGGAGAC CCGTATCACA CGATCGCTGC CATCAATCCA 1080
GAGAAATTAA ATATCTTCCA AACAGTGAGA GAGATAACAG GGTATTTGAA CATACAGTCA 1140
TGGCCTGAGA ATATGACAGA CTTCAGGGTG TTTTCTAACT TGGTTACCAT CGGTGGGAGA 1200
GCTCTCTATA GTGGCCTTTC CTTGCTCATC CTAAAGCAAC AAGGCATCAC CTCCCTGCAG 1260
TTCCAGTCCT TGAAGCAAAT CAGTGCTGGC AACATCTACA TCACAGACAA CAGCAATTTG 1320
TGCTACTACC ACACTGTCAA CTGGAGCAGC CTGTTCAGCA CCCCCAGCCA AAAGACAGTG 1380
ATCCACAGGA ACAAAAAGGC AGAGAACTGC ACTGCTGATG GCATGGTGTG CAACGAGCTG 1440
TGCTCCAGCG ACGGCTGCTG GGGGCCAGGG CCAGACCAGT GCCTGTCCTG CAAGCGCTTC 1500
ATCCGGGGCA GGACCTGCAT CGACTCCTGC AACCTCTACG ACGGGGAATT CCGAGAGTTT 1560
GCCAACGGCT CAGTGTGTGT GGAGTGTGAT CCCCAGTGTG AGAAGATGGA GGAAAACATG 1620
ATCACCTGCT ACGGGCCGGG ACCTGACCAC TGCACAAAGT GTTTCCATTT TAAGGATGGT 1680
CCAAATTGTG TGGAAAAATG TCCTGATGGC TTGCAGGGGG CCAACAGCTT CATTTTCAAG 1740
TACGCTGACG AGGATCGGGA GTGCCATCCG TGTCATCCCA ACTGCACCCA AGGGTGTAGA 1800
GGCCCAGCTA GTCATGACTG CATTTTCTAT CCATGGACAC GGCAGTCCAC GCTGCCACAG 1860
CACGCTAGAA CCCCCCTGAT TGCTGCAGGA GTCATTGGTG GCCTCTTCAT CATCGTCATC 1920
ATGGGCCTGA CGTTCGCCGT GTACGTTCGG CGCAAAAGCA TCAAGAAGAA GAGAGCACTG 1980
AGAAGGTTCC TGGAGACTGA GCTGGTGGAA CCCCTGACCC CGAGCGGCAC GGCGCCCAAC 2040
CAAGCCCAGC TCCGCATCCT GAAGGAGACA GAGCTGAAGA GAGTCAAGGT GCTGGGCTCT 2100
GGAGCCTTTG GAACAGTGTA CAAGGGGATC TGGGTCCCTG AGGGAGAAAC AGTAAAGATT 2160
CCTGTGGCCA TCAAGATCCT TAATGAGACC ACTGGTCCGA AAGCCAATGT GGAGTTTATG 2220
GATGAAGCTC TGATCATGGC CAGCATGGAC CACCCACACC TGGTGAGGCT CCTGGGTGTC 2280
TGCCTGAGCC CCACCATCCA GCTGGTCACC CAGCTGATGC CTCACGGCTG CCTCCTGGAT 2340
TATGTCCATG AACATAAGGA CAACATTGGC TCCCAGCTCC TGCTCAACTG GTGTGTCCAA 2400
ATAGCTAAGG GCATGATGTA CCTGGAAGAG AGAAGACTCG TGCACCGGGA CCTGGCAGCC 2460
CGTAATGTCC TGGTGAAATC ACCAAACCAC GTGAAAATCA CTGACTTTGG CTTGGCCAGG 2520
CTTCTGGAAG GGGATGAAAA GGAGTACAAT GCTGATGGGG GAAAGATGCC AATTAAGTGG 2580
ATGGCTCTGG AGTGCATACA CTACAGGAAA TTCACCCATC AGAGTGATGT GTGGAGCTAT 2640
GGGGTGACCA TCTGGGAGCT GATGACCTTT GGTGGGAAGC CCTACGATGG AATCCCAACC 2700
CGAGAGATCC CCGACCTGCT GGAGAAGGGA GAGCGCCTGC CCCAGCCCCC AATCTGCACC 2760
ATTGATGTTT ATATGGTGAT GGTGAAGTGC TGGATGATTG ATGCTGACAG TCGGCCAAAA 2820
TTCAAGGAGC TGGCTGCTGA ATTCTCTAGA ATGGCTCGAG ACCCTCAGAG ATACCTGGTA 2880
ATTCAGGGAG ATGATCGTAT GAAGCTCCCA AGCCCAAATG ACAGCAAGTT CTTCCAAAAT 2940
CTTCTCGATG AGGAAGACCT GGAAGATATG ATGGATGCTG AAGAGTATCT TGTTCCTCAA 3000
GCCTTCAACA TTCCTCCTCC TATCTACACC TCCAGGACAA GAATTGATTC CAACAGAAAC 3060
CAGTTTGTGT ACCGGGACGG CGGCTACGCG GCCGAGGTGC CGATGCCCTA CAGGGCTCCT 3120
GGCTGCATCC TTCCAGAAGC CCCAGCTGCT CAAGGGGCCA CAGCAGAGAT CTTTGAAGAC 3180
ACTTGCTGCA ATGGCACGAT GCAGAAGCAG GTGGCAGCCC TGGCAAAAGA GGACAGCAGC 3240
ACCCAGAGGT ACAGCGCTGA CCCCACCGTC TTCATGCCCG AGCGGGTTGT GCGGGGAGAG 3300
CTGGATGAGG ACGGGTACAT GACACCGATG AGAGACAAAC CCAAAACAGA TTACCTAAAC 3360
CCAGTGGAAG AGAACCCATT TGTTTCCCGA CGAAAGAATG GAGATCTCCA AGCTGTGGAC 3420
AACCCAGAGT ACCACAAGGC TCCAAACGGG CAGCCCAAAG CCGAGGACGA GTACGTGAAC 3480
GAGCCGTTGT ACCTCAACAC CTTCGCCAGC ACCTTGGAAA ACGCCGAGTA CCTGAAGAAC 3540
AATTTGCCAG AGAAAGCCAA GAAGGCCTTT GACAACCCAG ACTACTGGAA CCACAGCCTG 3600
CCCCCACGGA GCACCCTCCA GCACCCGGAC TACCTGCAAG AGTACAGCAC AAAATACTTT 3660
TACAAACAGA ACGGACGGAT CCGGCCCATA GTGGCAGAGA ATCCCGAATA CCTCTCCGAG 3720
TTCTCCCTGA AGCCTGGCAC TGTGCTGCCC CCGCCGCCCT ACAGACACCG GAACACCGTG 3780
GTG 3783
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 692   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  751
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 752   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  811
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 812   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  871
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 872   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  931
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 932   MIDADSRPKFKELAAEFS  949
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-DRM-00152
EKS-EQC-00288
EKS-GAM-00190
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-OCP-00048
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-PTV-00063
EKS-RAN-00313
EKS-SAH-00281
EKS-SUS-00266
EKS-TAR-00389
EKS-TEN-00384
EKS-TUT-00065
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0045165; P:cell fate commitment
GO:0016477; P:cell migration
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013