EKS-TAG-00494

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00494

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	541.2	4.1E-163	99	356	258

Status

Unreviewed

Ensembl Protein

ENSTGUP00000011889

UniProt Accession

H0ZMR5;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000011521	ENSTGUP00000011889	ENSTGUT00000012019

Organism

Taeniopygia guttata

Functional Description

Protein Length

432

Protein Sequence
(FASTA)

MTVKAAEASG PTLTYSKMRG MVAIIIAFMK QRRMGLNDFI QKIATNSYAC KHPEVQSILK 60

ISQPQEPELM NANPSPPPSP SQQINLGPSS NPHAKPSDFH FLKVIGKGSF GKVLLARHKA 120

EEQFYAVKVL QKKAILKKKE EKHIMSERNV LLKNVKHPFL VGLHFSFQTA DKLYFVLDYI 180

NGGELFYHLQ RERCFLEPRA RFYAAEIASA LGYLHSLNIV YRDLKPENIL LDSQGHIVLT 240

DFGLCKENIE HNGTTSTFCG TPEYLAPEVL HKQPYDRTVD WWCLGAVLYE MLYGLPPFYS 300

RNTAEMYDNI LNKPLQLKPN ITNSARHLLE GLLQKDRTKR LGAKEDFMEI KNHIFFSPIN 360

WDDLINKKIT PPFNPNVSGP SDLRHFDPEF TDEPVPNSIG QSPDSILITA SVKEAAEAFL 420

GFSYAPPVDS FL 432

Nucleotide Sequence
(FASTA)

ATGACCGTGA AGGCAGCTGA GGCGTCTGGT CCTACCTTAA CTTACTCGAA GATGAGGGGG 60

ATGGTGGCTA TCATCATCGC TTTCATGAAG CAGAGAAGAA TGGGTCTAAA CGATTTCATT 120

CAGAAGATAG CCACCAACTC CTATGCATGC AAGCACCCTG AAGTTCAGTC TATCTTGAAA 180

ATCTCTCAGC CTCAAGAGCC TGAACTTATG AATGCTAATC CTTCTCCTCC GCCCAGTCCT 240

TCACAGCAGA TCAATCTCGG CCCATCATCC AACCCACATG CCAAACCATC AGACTTCCAT 300

TTCTTAAAAG TGATTGGAAA AGGCAGTTTT GGGAAGGTCC TTCTTGCACG GCATAAGGCA 360

GAAGAGCAGT TCTATGCTGT TAAAGTCCTG CAGAAAAAAG CAATCCTGAA GAAGAAGGAG 420

GAGAAGCACA TTATGTCAGA GCGCAATGTC TTGCTGAAAA ATGTGAAACA CCCCTTCCTG 480

GTCGGGCTTC ACTTTTCCTT CCAAACTGCG GACAAATTGT ATTTTGTCCT GGATTACATC 540

AATGGTGGAG AGTTGTTCTA CCATCTCCAG AGGGAGCGTT GCTTCCTGGA GCCGAGAGCC 600

CGATTTTATG CTGCTGAAAT TGCCAGTGCA CTGGGCTACC TGCACTCCCT GAACATCGTT 660

TATCGAGACT TGAAGCCAGA GAACATCCTG CTTGATTCAC AGGGGCACAT TGTCTTGACT 720

GACTTTGGAC TCTGCAAAGA AAACATAGAG CACAATGGCA CGACCTCCAC CTTCTGCGGC 780

ACACCAGAGT ATCTTGCTCC TGAAGTTCTG CATAAGCAGC CCTATGACCG GACTGTGGAC 840

TGGTGGTGCC TTGGAGCAGT CCTGTACGAG ATGCTTTATG GCTTGCCACC CTTCTACAGC 900

AGGAACACCG CAGAAATGTA CGACAATATC TTGAACAAAC CTTTGCAGCT GAAGCCAAAT 960

ATTACCAACT CAGCTAGACA TCTTCTGGAA GGTCTCTTGC AGAAGGACAG GACAAAGAGA 1020

CTTGGTGCCA AGGAGGACTT TATGGAGATT AAGAATCACA TCTTCTTCTC CCCAATTAAC 1080

TGGGATGATC TCATTAATAA GAAGATTACA CCCCCTTTTA ACCCAAATGT GAGCGGCCCC 1140

AGTGACCTTC GACACTTTGA TCCAGAGTTT ACAGATGAGC CAGTCCCTAA CTCCATTGGC 1200

CAATCCCCAG ACAGCATCCT CATCACTGCC AGCGTCAAAG AAGCTGCTGA GGCTTTTTTG 1260

GGCTTCTCGT ATGCCCCACC CGTGGACTCT TTCTTGTGA 1299

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 99    FHFLKVIGKGSFGKVLLARHKAEEQFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  158

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 159   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  218

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 219   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  278

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 279   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  338

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgakedf+eiknh+ff

Q: 339   KRLGAKEDFMEIKNHIFF  356

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEQFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKEDFM EIKNHIFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006974	; P:response to DNA damage stimulus

KEGG

tgu:100219883

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013